CA2324422A1 - Variants de serine-proteases ayant des deletions et des substitutions d'acides amines - Google Patents
Variants de serine-proteases ayant des deletions et des substitutions d'acides amines Download PDFInfo
- Publication number
- CA2324422A1 CA2324422A1 CA002324422A CA2324422A CA2324422A1 CA 2324422 A1 CA2324422 A1 CA 2324422A1 CA 002324422 A CA002324422 A CA 002324422A CA 2324422 A CA2324422 A CA 2324422A CA 2324422 A1 CA2324422 A1 CA 2324422A1
- Authority
- CA
- Canada
- Prior art keywords
- ala
- gly
- asn
- variants
- leu
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
- C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0208—Tissues; Wipes; Patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/86—Products or compounds obtained by genetic engineering
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
Abstract
Cette invention se rapporte à des variants de sérine-protéases ayant une immunogénicité inférieure à celle des protéases du type sauvage correspondantes. Cette invention se rapporte plus particulièrement à des variants ayant une séquence d'acides aminés modifiée par rapport à une séquence d'acides aminés de type sauvage, cette séquence d'acides aminés modifiée comportant une délétion et, éventuellement, une substitution d'une ou de plusieurs positions spécifiquement identifiées correspondant à la subtilisine BPN'. Cette invention se rapporte en outre à des gènes mutants codant ces variants et à des compositions de produits de nettoyage et de produits de soins personnels comprenant ces variants.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7947798P | 1998-03-26 | 1998-03-26 | |
US60/079,477 | 1998-03-26 | ||
PCT/IB1999/000520 WO1999049057A1 (fr) | 1998-03-26 | 1999-03-25 | Variants de serine-proteases ayant des deletions et des substitutions d'acides amines |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2324422A1 true CA2324422A1 (fr) | 1999-09-30 |
Family
ID=22150818
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002324422A Abandoned CA2324422A1 (fr) | 1998-03-26 | 1999-03-25 | Variants de serine-proteases ayant des deletions et des substitutions d'acides amines |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP1082443A1 (fr) |
JP (1) | JP2002518993A (fr) |
KR (1) | KR20010052223A (fr) |
CN (1) | CN1303437A (fr) |
AR (1) | AR023021A1 (fr) |
AU (1) | AU750336B2 (fr) |
BR (1) | BR9909147A (fr) |
CA (1) | CA2324422A1 (fr) |
WO (1) | WO1999049057A1 (fr) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001007575A2 (fr) * | 1999-07-22 | 2001-02-01 | The Procter & Gamble Company | Variants de protease subtilisine possedant des suppressions et des substitutions d'acides amines dans certaines regions de sites antigeniques |
US6803222B2 (en) | 2000-11-22 | 2004-10-12 | Kao Corporation | Alkaline proteases |
DE10360805A1 (de) | 2003-12-23 | 2005-07-28 | Henkel Kgaa | Neue Alkalische Protease und Wasch- und Reinigungsmittel, enthaltend diese neue Alkalische Protease |
DE102007003143A1 (de) | 2007-01-16 | 2008-07-17 | Henkel Kgaa | Neue Alkalische Protease aus Bacillus gibsonii und Wasch- und Reinigungsmittel enthaltend diese neue Alkalische Protease |
DE102007032111B4 (de) | 2007-07-09 | 2017-07-20 | Henkel Ag & Co. Kgaa | Neue Proteasen und Wasch- und Reinigungsmittel enthaltend diese Proteasen |
DE102007036756A1 (de) | 2007-08-03 | 2009-02-05 | Henkel Ag & Co. Kgaa | Neue Proteasen und Wasch- und Reinigungsmittel, enthaltend diese neuen Proteasen |
DE102007051092A1 (de) | 2007-10-24 | 2009-04-30 | Henkel Ag & Co. Kgaa | Subtilisin aus Becillus pumilus und Wasch- und Reinigungsmittel enthaltend dieses neue Subtilisin |
CN105238801A (zh) * | 2009-04-24 | 2016-01-13 | 丹尼斯科美国公司 | 具有修饰的原区的蛋白酶 |
BR112012006497A2 (pt) * | 2009-09-25 | 2015-09-08 | Novozymes As | uso de uma variante de subtilisina, composição de lavagem de pratos, e, uso de uma composição. |
WO2013076269A1 (fr) * | 2011-11-25 | 2013-05-30 | Novozymes A/S | Variants de subtilase et polynucléotides codants pour ceux-ci |
CN102839165B (zh) * | 2012-09-26 | 2014-12-10 | 金普诺安生物科技(苏州)有限公司 | 基因突变型重组蛋白酶k及其工业化生产方法 |
KR20230144058A (ko) * | 2021-02-12 | 2023-10-13 | 프레제니우스 카비 입섬 에스. 알. 엘. | 서브틸리신 변이체 및 그의 용도 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0353250B1 (fr) * | 1987-04-06 | 1999-09-08 | Novo Nordisk A/S | Stabilisation de proteines par mise au point des interactions electrostatiques aux sites de liaison d'ions metalliques |
WO1991000334A1 (fr) * | 1989-06-26 | 1991-01-10 | Unilever Plc | Compositions detergentes a base d'enzymes |
CA2331936C (fr) * | 1990-12-05 | 2007-07-31 | Novozymes A/S | Proteines a mutation d'epitopes; procede de fabrication |
US5567601A (en) * | 1993-06-01 | 1996-10-22 | University Of Maryland | Subtilisin mutants lacking a primary calcium binding site |
AU2742499A (en) * | 1998-03-26 | 1999-10-18 | Procter & Gamble Company, The | Serine protease variants having amino acid substitutions |
-
1999
- 1999-03-25 KR KR1020007010692A patent/KR20010052223A/ko not_active Application Discontinuation
- 1999-03-25 CN CN99806571A patent/CN1303437A/zh active Pending
- 1999-03-25 WO PCT/IB1999/000520 patent/WO1999049057A1/fr not_active Application Discontinuation
- 1999-03-25 JP JP2000538017A patent/JP2002518993A/ja not_active Withdrawn
- 1999-03-25 BR BR9909147-0A patent/BR9909147A/pt not_active IP Right Cessation
- 1999-03-25 CA CA002324422A patent/CA2324422A1/fr not_active Abandoned
- 1999-03-25 AU AU27426/99A patent/AU750336B2/en not_active Ceased
- 1999-03-25 EP EP99907806A patent/EP1082443A1/fr not_active Withdrawn
- 1999-03-26 AR ARP990101373A patent/AR023021A1/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP1082443A1 (fr) | 2001-03-14 |
CN1303437A (zh) | 2001-07-11 |
AU750336B2 (en) | 2002-07-18 |
BR9909147A (pt) | 2000-12-05 |
AR023021A1 (es) | 2002-09-04 |
JP2002518993A (ja) | 2002-07-02 |
KR20010052223A (ko) | 2001-06-25 |
AU2742699A (en) | 1999-10-18 |
WO1999049057A1 (fr) | 1999-09-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US6569663B1 (en) | Serine protease variants having amino acid substitutions | |
US6495136B1 (en) | Proteases having modified amino acid sequences conjugated to addition moieties | |
US6586223B1 (en) | Subtilisin protease variants having amino acid substitutions in defined epitope regions | |
US6586224B1 (en) | Subtilisin protease variants having amino acid deletions and substitutions in defined epitope regions | |
AU750336B2 (en) | Serine protease variants having amino acid deletions and substitutions | |
US6566115B1 (en) | Protease conjugates having sterically protected clip sites | |
US6908757B1 (en) | Serine protease variants having amino acid deletions and substitutions | |
AU5928300A (en) | Protease conjugates having sterically protected epitope regions | |
MXPA00009442A (en) | Serine protease variants having amino acid deletions and substitutions | |
CZ20003397A3 (cs) | Varianta serinové proteázy; prostředek pro osobní hygienu, čistící prostředek, mutovaný gen | |
MXPA00009434A (en) | Serine protease variants having amino acid substitutions | |
AU5928200A (en) | Intramolecularly cross-linked subtilisin proteases having reduced immunogenicity | |
CZ20003394A3 (cs) | Varianta serinové proteázy, mutovaný gen, prostředek pro osobní hygienu | |
MXPA00009385A (en) | Protease conjugates |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
FZDE | Dead |