CA2323058C - Methods for the diagnosis and treatment of lung cancer by detection of proto-oncogene overexpression - Google Patents

Methods for the diagnosis and treatment of lung cancer by detection of proto-oncogene overexpression Download PDF

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Publication number
CA2323058C
CA2323058C CA2323058A CA2323058A CA2323058C CA 2323058 C CA2323058 C CA 2323058C CA 2323058 A CA2323058 A CA 2323058A CA 2323058 A CA2323058 A CA 2323058A CA 2323058 C CA2323058 C CA 2323058C
Authority
CA
Canada
Prior art keywords
cell
proto
oncogene
lung
probe
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2323058A
Other languages
English (en)
French (fr)
Other versions
CA2323058A1 (en
Inventor
Jin Jen
Gary A. Beaudry
Stephen L. Madden
Arthur H. Bertelsen
David Sidransky
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Johns Hopkins University
Esoterix Genetic Laboratories LLC
Original Assignee
Genzyme Corp
Johns Hopkins University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Corp, Johns Hopkins University filed Critical Genzyme Corp
Priority to CA2735260A priority Critical patent/CA2735260A1/en
Publication of CA2323058A1 publication Critical patent/CA2323058A1/en
Application granted granted Critical
Publication of CA2323058C publication Critical patent/CA2323058C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/136Screening for pharmacological compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • General Engineering & Computer Science (AREA)
  • Hospice & Palliative Care (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
CA2323058A 1998-03-31 1999-03-30 Methods for the diagnosis and treatment of lung cancer by detection of proto-oncogene overexpression Expired - Fee Related CA2323058C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2735260A CA2735260A1 (en) 1998-03-31 1999-03-30 Methods for the diagnosis and treatment of lung cancer by detection of proto-oncogene overexpression

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8004498P 1998-03-31 1998-03-31
US60/080,044 1998-03-31
PCT/US1999/006947 WO1999049774A2 (en) 1998-03-31 1999-03-30 Methods for the diagnosis and treatment of lung cancer

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA2735260A Division CA2735260A1 (en) 1998-03-31 1999-03-30 Methods for the diagnosis and treatment of lung cancer by detection of proto-oncogene overexpression

Publications (2)

Publication Number Publication Date
CA2323058A1 CA2323058A1 (en) 1999-10-07
CA2323058C true CA2323058C (en) 2011-03-29

Family

ID=22154908

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2323058A Expired - Fee Related CA2323058C (en) 1998-03-31 1999-03-30 Methods for the diagnosis and treatment of lung cancer by detection of proto-oncogene overexpression
CA2735260A Abandoned CA2735260A1 (en) 1998-03-31 1999-03-30 Methods for the diagnosis and treatment of lung cancer by detection of proto-oncogene overexpression

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2735260A Abandoned CA2735260A1 (en) 1998-03-31 1999-03-30 Methods for the diagnosis and treatment of lung cancer by detection of proto-oncogene overexpression

Country Status (7)

Country Link
US (3) US20070218511A1 (https=)
EP (1) EP1095183B1 (https=)
JP (3) JP2002509706A (https=)
AT (1) ATE546544T1 (https=)
AU (1) AU3217599A (https=)
CA (2) CA2323058C (https=)
WO (1) WO1999049774A2 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002079504A2 (en) * 2001-03-30 2002-10-10 Dalhousie University Neotic and endoapoptotic cells and detection of neosis and endoapoptosis
US7202045B2 (en) * 2001-09-19 2007-04-10 Regents Of The University Of Michigan Detection and treatment of cancers of the lung
EP2075340A3 (en) * 2003-09-30 2009-07-08 Sbarro Health Research Organization Gene modulation by RB2/p 130 expression
JP6702932B2 (ja) * 2017-12-27 2020-06-03 富士フイルム株式会社 細胞撮像制御装置および方法並びにプログラム

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL154598B (nl) * 1970-11-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking.
US3817837A (en) * 1971-05-14 1974-06-18 Syva Corp Enzyme amplification assay
US3939350A (en) * 1974-04-29 1976-02-17 Board Of Trustees Of The Leland Stanford Junior University Fluorescent immunoassay employing total reflection for activation
US3996345A (en) * 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4277437A (en) * 1978-04-05 1981-07-07 Syva Company Kit for carrying out chemically induced fluorescence immunoassay
US4275149A (en) * 1978-11-24 1981-06-23 Syva Company Macromolecular environment control in specific receptor assays
US4366241A (en) * 1980-08-07 1982-12-28 Syva Company Concentrating zone method in heterogeneous immunoassays
DE3424893A1 (de) * 1984-07-06 1986-02-06 Agfa-Gevaert Ag, 5090 Leverkusen Photographisches silberhalogenidaufzeichnungsmaterial
US5274087A (en) * 1986-08-13 1993-12-28 Molecular Diagnostics, Inc. cDNA coding for carcinoembryonic antigen (CEA)
US5223482A (en) * 1986-11-17 1993-06-29 Scios Nova Inc. Recombinant Alzheimer's protease inhibitory amyloid protein and method of use
JPH0253486A (ja) * 1988-08-19 1990-02-22 Rikagaku Kenkyusho ヒトmyb関連遺伝子
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US6040138A (en) 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
US5464764A (en) 1989-08-22 1995-11-07 University Of Utah Research Foundation Positive-negative selection methods and vectors
US5578444A (en) * 1991-06-27 1996-11-26 Genelabs Technologies, Inc. Sequence-directed DNA-binding molecules compositions and methods
US5412087A (en) 1992-04-24 1995-05-02 Affymax Technologies N.V. Spatially-addressable immobilization of oligonucleotides and other biological polymers on surfaces
US6114114A (en) 1992-07-17 2000-09-05 Incyte Pharmaceuticals, Inc. Comparative gene transcript analysis
AU5136693A (en) * 1992-10-01 1994-04-26 Thomas Jefferson University Antisense oligonucleotides to b myb proto-oncogene
US5578832A (en) 1994-09-02 1996-11-26 Affymetrix, Inc. Method and apparatus for imaging a sample on a device
US5631734A (en) 1994-02-10 1997-05-20 Affymetrix, Inc. Method and apparatus for detection of fluorescently labeled materials
US5734039A (en) * 1994-09-15 1998-03-31 Thomas Jefferson University Antisense oligonucleotides targeting cooperating oncogenes
US5795716A (en) 1994-10-21 1998-08-18 Chee; Mark S. Computer-aided visualization and analysis system for sequence evaluation
US5695980A (en) * 1995-06-06 1997-12-09 Human Genome Sciences Polynucleotides, vectors, cells and an expression method for human MutT2
CA2178022A1 (en) 1995-06-01 1996-12-02 Michael Hayden Mouse model for huntington's disease and related dna sequences
US5695937A (en) * 1995-09-12 1997-12-09 The Johns Hopkins University School Of Medicine Method for serial analysis of gene expression
US5888796A (en) * 1996-01-31 1999-03-30 St. Louis University Clone of a nucleotide sequence encoding a protein having two functions
US5985567A (en) * 1997-08-15 1999-11-16 Beckman Coulter, Inc. Hybridization detection by pretreating bound single-stranded probes
JP2002509707A (ja) * 1998-03-31 2002-04-02 ジェンザイム・コーポレーション 肺腫瘍細胞を同定するための組成物および方法
US20040166527A1 (en) * 1999-03-30 2004-08-26 Beaudry Gary A. Compositions and methods for the identification of lung tumor cells
EP2075340A3 (en) * 2003-09-30 2009-07-08 Sbarro Health Research Organization Gene modulation by RB2/p 130 expression

Also Published As

Publication number Publication date
US20070218511A1 (en) 2007-09-20
EP1095183B1 (en) 2012-02-22
WO1999049774A9 (en) 2000-02-24
US8067240B2 (en) 2011-11-29
CA2323058A1 (en) 1999-10-07
US20110091892A1 (en) 2011-04-21
WO1999049774A2 (en) 1999-10-07
JP2002509706A (ja) 2002-04-02
EP1095183A4 (en) 2004-09-15
US20100062443A1 (en) 2010-03-11
JP2009171985A (ja) 2009-08-06
EP1095183A2 (en) 2001-05-02
JP2012147796A (ja) 2012-08-09
US7846667B2 (en) 2010-12-07
AU3217599A (en) 1999-10-18
ATE546544T1 (de) 2012-03-15
WO1999049774A3 (en) 1999-12-29
CA2735260A1 (en) 1999-10-07

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Effective date: 20150330