CA2319115A1 - Methodes pour identifier les peptides antimicrobiens interagissant avec l'enoyl acp reductase - Google Patents

Methodes pour identifier les peptides antimicrobiens interagissant avec l'enoyl acp reductase Download PDF

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Publication number
CA2319115A1
CA2319115A1 CA002319115A CA2319115A CA2319115A1 CA 2319115 A1 CA2319115 A1 CA 2319115A1 CA 002319115 A CA002319115 A CA 002319115A CA 2319115 A CA2319115 A CA 2319115A CA 2319115 A1 CA2319115 A1 CA 2319115A1
Authority
CA
Canada
Prior art keywords
polypeptide
compound
triclosan
antimicrobial
mutant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002319115A
Other languages
English (en)
Inventor
Stuart B. Levy
Laura M. Mcmurry
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tufts University
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2319115A1 publication Critical patent/CA2319115A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/001—Oxidoreductases (1.) acting on the CH-CH group of donors (1.3)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/18—Testing for antimicrobial activity of a material

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Procédés et mutants servant à identifier un composé antimicrobien exerçant une interaction avec un polypeptide ER. Ce procédé consiste, en particulier, à identifier par criblage un composé antimicrobien au moyen de cellules mutantes ou de polypeptides FabI ou InhA.
CA002319115A 1998-01-23 1999-01-22 Methodes pour identifier les peptides antimicrobiens interagissant avec l'enoyl acp reductase Abandoned CA2319115A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US7224498P 1998-01-23 1998-01-23
US60/072,244 1998-01-23
US1344098A 1998-01-26 1998-01-26
US09/013,440 1998-01-26
PCT/US1999/001288 WO1999037800A1 (fr) 1998-01-23 1999-01-22 Composes antimicrobiens

Publications (1)

Publication Number Publication Date
CA2319115A1 true CA2319115A1 (fr) 1999-07-29

Family

ID=26684842

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002319115A Abandoned CA2319115A1 (fr) 1998-01-23 1999-01-22 Methodes pour identifier les peptides antimicrobiens interagissant avec l'enoyl acp reductase

Country Status (6)

Country Link
EP (1) EP1049799A1 (fr)
JP (1) JP2002510463A (fr)
AU (1) AU2332499A (fr)
CA (1) CA2319115A1 (fr)
IL (1) IL137444A0 (fr)
WO (1) WO1999037800A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6713043B2 (en) 1996-02-29 2004-03-30 The Trustees Of Columbia University In The City Of New York Antimicrobial activity of gemfibrozil
US6346391B1 (en) 1999-07-22 2002-02-12 Trustees Of Tufts College Methods of reducing microbial resistance to drugs
US6951729B1 (en) * 1999-10-27 2005-10-04 Affinium Pharmaceuticals, Inc. High throughput screening method for biological agents affecting fatty acid biosynthesis
US6531291B1 (en) 1999-11-10 2003-03-11 The Trustees Of Columbia University In The City Of New York Antimicrobial activity of gemfibrozil and related compounds and derivatives and metabolites thereof
JP5314286B2 (ja) * 2006-02-10 2013-10-16 学校法人東海大学 緑膿菌の薬剤排出ポンプの機能を阻害する方法及び薬剤
GB2509159B (en) 2012-12-21 2017-07-26 Oxoid Ltd Triclosan derivatives and uses thereof
PT3297666T (pt) 2015-05-22 2019-09-06 Consejo Superior Investigacion Adjuvante e vacina molecular

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5702935A (en) * 1994-04-28 1997-12-30 Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University Method and compounds for inhibiting lipid biosynthesis of bacteria and plants
BR9603085A (pt) * 1996-07-12 1998-05-05 Cosmeticos Natural Ind Com Sabonete antisséptico líquido para cuidado da pele
DE69735225T2 (de) * 1996-08-28 2006-11-02 Affinium Pharmaceuticals, Inc., Toronto Fab I Enoyl-ACP-Reduktase aus Staphylokokken

Also Published As

Publication number Publication date
WO1999037800A1 (fr) 1999-07-29
IL137444A0 (en) 2001-07-24
AU2332499A (en) 1999-08-09
JP2002510463A (ja) 2002-04-09
EP1049799A1 (fr) 2000-11-08

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued