CA2318855C - Spectrometrie de masse a guide d'ions multipolaire - Google Patents
Spectrometrie de masse a guide d'ions multipolaire Download PDFInfo
- Publication number
- CA2318855C CA2318855C CA002318855A CA2318855A CA2318855C CA 2318855 C CA2318855 C CA 2318855C CA 002318855 A CA002318855 A CA 002318855A CA 2318855 A CA2318855 A CA 2318855A CA 2318855 C CA2318855 C CA 2318855C
- Authority
- CA
- Canada
- Prior art keywords
- ion
- ion guide
- ions
- segment
- vacuum
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000005405 multipole Effects 0.000 title claims abstract description 320
- 238000004949 mass spectrometry Methods 0.000 title description 6
- 150000002500 ions Chemical class 0.000 claims abstract description 1336
- 238000005040 ion trap Methods 0.000 claims abstract description 31
- 238000005086 pumping Methods 0.000 claims description 114
- 230000007935 neutral effect Effects 0.000 claims description 35
- 238000000065 atmospheric pressure chemical ionisation Methods 0.000 claims description 33
- 238000009616 inductively coupled plasma Methods 0.000 claims description 9
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- 239000007789 gas Substances 0.000 description 104
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- 238000000034 method Methods 0.000 description 60
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- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
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- 241001674048 Phthiraptera Species 0.000 description 1
- 101100247669 Quaranfil virus (isolate QrfV/Tick/Afghanistan/EG_T_377/1968) PB1 gene Proteins 0.000 description 1
- 101150025928 Segment-1 gene Proteins 0.000 description 1
- 101100242902 Thogoto virus (isolate SiAr 126) Segment 1 gene Proteins 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
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- 229910052786 argon Inorganic materials 0.000 description 1
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- 239000001307 helium Substances 0.000 description 1
- 229910052734 helium Inorganic materials 0.000 description 1
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/26—Mass spectrometers or separator tubes
- H01J49/34—Dynamic spectrometers
- H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
- H01J49/4205—Device types
- H01J49/422—Two-dimensional RF ion traps
- H01J49/4225—Multipole linear ion traps, e.g. quadrupoles, hexapoles
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/06—Electron- or ion-optical arrangements
- H01J49/062—Ion guides
- H01J49/063—Multipole ion guides, e.g. quadrupoles, hexapoles
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Electron Tubes For Measurement (AREA)
Abstract
L'invention se rapporte à des guides d'ions multipolaires (6) conçus avec un ou plusieurs segments (1, 2, 3, 4) et positionnés dans une région (72) de vide poussé, qui fonctionnent en modes de sélection masse/charge et de fragmentation d'ions. Ces guides d'ions multipolaires individuels sont montés dans un ensemble linéaire ne comportant pas d'électrode entre chaque paire de guides d'ions multipolaires. Au moins une partie de chaque guide d'ions multipolaire monté dans un ensemble linéaire réside dans une région de vide à pression de fond élevée. Au moins un guide d'ions (4) peut être conçu de façon à se prolonger sans interruption d'un étage de vide (72) à un autre (73). Des ensembles individuels de sources de tension à radiofréquence, à courant continu +/- et à fréquence séculaire délivrent des potentiels aux tiges de chaque guide d'ions multipolaire et permettent ainsi la mise en oeuvre des fonctions d'émission d'ions, de piégeage d'ions, de sélection masse/charge et de fragmentation d'ions, de façon indépendante dans chaque guide d'ions. La présence d'une pression de fond élevée le long de l'ensemble linéaire des guides d'ions multipolaires permet la fragmentation des ions par Dissociation Induite par Collisions (CID) grâce à l'accélération axiale des ions d'un guide d'ions multipolaire vers un guide d'ions adjacent, ce qui est analogue à une fonction quadripolaire triple. Les ions peuvent également être fragmentés dans un ou plusieurs guides d'ions multipolaires au moyen d'une excitation à la fréquence de résonance CID, ce qui équivaut à une fragmentation des ions dans des pièges à ions quadripolaires à trois dimensions.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7237498P | 1998-01-23 | 1998-01-23 | |
| US60/072,374 | 1998-01-23 | ||
| US8724698P | 1998-05-29 | 1998-05-29 | |
| US60/087,246 | 1999-01-22 | ||
| PCT/US1999/001335 WO1999038193A1 (fr) | 1998-01-23 | 1999-01-22 | Spectrometrie de masse a guide d'ions multipolaire |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2318855A1 CA2318855A1 (fr) | 1999-07-29 |
| CA2318855C true CA2318855C (fr) | 2006-07-11 |
Family
ID=26753301
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002318855A Expired - Lifetime CA2318855C (fr) | 1998-01-23 | 1999-01-22 | Spectrometrie de masse a guide d'ions multipolaire |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1057209B1 (fr) |
| JP (1) | JP2002502085A (fr) |
| AT (1) | ATE535008T1 (fr) |
| AU (1) | AU2334199A (fr) |
| CA (1) | CA2318855C (fr) |
| WO (1) | WO1999038193A1 (fr) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2626383C (fr) * | 1998-05-29 | 2011-07-19 | Craig M. Whitehouse | Spectrometrie de masse avec guides d'ions multipolaires |
| GB9820210D0 (en) * | 1998-09-16 | 1998-11-11 | Vg Elemental Limited | Means for removing unwanted ions from an ion transport system and mass spectrometer |
| GB2364168B (en) * | 2000-06-09 | 2002-06-26 | Micromass Ltd | Methods and apparatus for mass spectrometry |
| CA2340150C (fr) * | 2000-06-09 | 2005-11-22 | Micromass Limited | Methodes et appareil pour la spectrometrie de masse |
| WO2002048699A2 (fr) * | 2000-12-14 | 2002-06-20 | Mds Inc. Doing Business As Mds Sciex | Appareil et procede permettant une spectrometrie msn dans un systeme de spectrometrie de masse en tandem |
| US20020115056A1 (en) | 2000-12-26 | 2002-08-22 | Goodlett David R. | Rapid and quantitative proteome analysis and related methods |
| US6803565B2 (en) * | 2001-05-18 | 2004-10-12 | Battelle Memorial Institute | Ionization source utilizing a multi-capillary inlet and method of operation |
| US6956205B2 (en) | 2001-06-15 | 2005-10-18 | Bruker Daltonics, Inc. | Means and method for guiding ions in a mass spectrometer |
| JP3990889B2 (ja) * | 2001-10-10 | 2007-10-17 | 株式会社日立ハイテクノロジーズ | 質量分析装置およびこれを用いる計測システム |
| US7049580B2 (en) * | 2002-04-05 | 2006-05-23 | Mds Inc. | Fragmentation of ions by resonant excitation in a high order multipole field, low pressure ion trap |
| GB0210930D0 (en) | 2002-05-13 | 2002-06-19 | Thermo Electron Corp | Improved mass spectrometer and mass filters therefor |
| GB2390478B (en) * | 2002-05-17 | 2004-06-02 | Micromass Ltd | Mass spectrometer |
| GB0305796D0 (en) | 2002-07-24 | 2003-04-16 | Micromass Ltd | Method of mass spectrometry and a mass spectrometer |
| EP2385543B1 (fr) * | 2003-01-24 | 2013-05-08 | Thermo Finnigan Llc | Contrôle de la population ionique dans un analyseur de masse |
| CA2518568C (fr) * | 2003-04-09 | 2012-09-25 | Mds Inc., Doing Business Through Its Mds Sciex Division | Exclusion du signal de fond dynamique de donnees de chromatographie/spectrometrie de masse, acquisition de donnees |
| US20050242281A1 (en) * | 2004-04-30 | 2005-11-03 | Gangqiang Li | Unevenly segmented multipole |
| US7084398B2 (en) * | 2004-05-05 | 2006-08-01 | Sciex Division Of Mds Inc. | Method and apparatus for selective axial ejection |
| GB2427067B (en) * | 2005-03-29 | 2010-02-24 | Thermo Finnigan Llc | Improvements relating to ion trapping |
| DE102005061425B4 (de) * | 2005-12-22 | 2009-06-10 | Bruker Daltonik Gmbh | Rückgesteuerte Fragmentierung in Ionenfallen-Massenspektrometern |
| EP1971998B1 (fr) | 2006-01-11 | 2019-05-08 | DH Technologies Development Pte. Ltd. | Fragmentation d'ions en spectrometrie de masse |
| GB0624679D0 (en) * | 2006-12-11 | 2007-01-17 | Shimadzu Corp | A time-of-flight mass spectrometer and a method of analysing ions in a time-of-flight mass spectrometer |
| GB2497799B (en) * | 2011-12-21 | 2016-06-22 | Thermo Fisher Scient (Bremen) Gmbh | Collision cell multipole |
| JP6044385B2 (ja) * | 2013-02-26 | 2016-12-14 | 株式会社島津製作所 | タンデム型質量分析装置 |
| DE112015002415B4 (de) | 2014-06-25 | 2020-01-02 | Hitachi High-Technologies Corporation | Massenspektrometer |
| GB2534569A (en) * | 2015-01-27 | 2016-08-03 | Shimadzu Corp | Method of controlling a DC power supply |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3410997A (en) * | 1964-09-08 | 1968-11-12 | Bell & Howell Co | Multipole mass filter |
| US4328420A (en) * | 1980-07-28 | 1982-05-04 | French John B | Tandem mass spectrometer with open structure AC-only rod sections, and method of operating a mass spectrometer system |
| US4814613A (en) * | 1987-03-06 | 1989-03-21 | Extrel Corporation | Collision cell for triple quadrupole tandem mass spectrometry |
| ES2331494T3 (es) * | 1994-02-28 | 2010-01-05 | Perkinelmer Health Sciences, Inc. | Guia de iones multipolar para espectrometria de masas. |
| DE19517507C1 (de) * | 1995-05-12 | 1996-08-08 | Bruker Franzen Analytik Gmbh | Hochfrequenz-Ionenleitsystem |
| EP0843887A1 (fr) * | 1995-08-11 | 1998-05-27 | Mds Health Group Limited | Spectrometre a champ axial |
| JP3818671B2 (ja) * | 1996-06-06 | 2006-09-06 | エムディーエス インコーポレーテッド | 多重極子質量分光計の軸方向射出方法 |
-
1999
- 1999-01-22 WO PCT/US1999/001335 patent/WO1999038193A1/fr active Application Filing
- 1999-01-22 EP EP99903281A patent/EP1057209B1/fr not_active Expired - Lifetime
- 1999-01-22 AU AU23341/99A patent/AU2334199A/en not_active Abandoned
- 1999-01-22 CA CA002318855A patent/CA2318855C/fr not_active Expired - Lifetime
- 1999-01-22 JP JP2000528994A patent/JP2002502085A/ja active Pending
- 1999-01-22 AT AT99903281T patent/ATE535008T1/de active
Also Published As
| Publication number | Publication date |
|---|---|
| WO1999038193A1 (fr) | 1999-07-29 |
| EP1057209A1 (fr) | 2000-12-06 |
| AU2334199A (en) | 1999-08-09 |
| JP2002502085A (ja) | 2002-01-22 |
| EP1057209A4 (fr) | 2006-02-01 |
| ATE535008T1 (de) | 2011-12-15 |
| CA2318855A1 (fr) | 1999-07-29 |
| EP1057209B1 (fr) | 2011-11-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKEX | Expiry |
Effective date: 20190122 |