CA2318855C - Mass spectrometry with multipole ion guide - Google Patents
Mass spectrometry with multipole ion guide Download PDFInfo
- Publication number
- CA2318855C CA2318855C CA002318855A CA2318855A CA2318855C CA 2318855 C CA2318855 C CA 2318855C CA 002318855 A CA002318855 A CA 002318855A CA 2318855 A CA2318855 A CA 2318855A CA 2318855 C CA2318855 C CA 2318855C
- Authority
- CA
- Canada
- Prior art keywords
- ion
- ion guide
- ions
- segment
- vacuum
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000005405 multipole Effects 0.000 title claims abstract description 320
- 238000004949 mass spectrometry Methods 0.000 title description 6
- 150000002500 ions Chemical class 0.000 claims abstract description 1336
- 238000005040 ion trap Methods 0.000 claims abstract description 31
- 238000005086 pumping Methods 0.000 claims description 114
- 230000007935 neutral effect Effects 0.000 claims description 35
- 238000000065 atmospheric pressure chemical ionisation Methods 0.000 claims description 33
- 238000009616 inductively coupled plasma Methods 0.000 claims description 9
- 239000013626 chemical specie Substances 0.000 claims description 4
- 239000000126 substance Substances 0.000 claims description 3
- 230000036961 partial effect Effects 0.000 claims description 2
- 238000013467 fragmentation Methods 0.000 abstract description 159
- 238000006062 fragmentation reaction Methods 0.000 abstract description 159
- 230000006870 function Effects 0.000 abstract description 57
- 230000005284 excitation Effects 0.000 abstract description 40
- 230000005540 biological transmission Effects 0.000 abstract description 29
- 238000010494 dissociation reaction Methods 0.000 abstract description 6
- 230000005593 dissociations Effects 0.000 abstract description 6
- 239000007789 gas Substances 0.000 description 104
- 238000004458 analytical method Methods 0.000 description 76
- 238000000034 method Methods 0.000 description 60
- 238000004885 tandem mass spectrometry Methods 0.000 description 54
- 239000008186 active pharmaceutical agent Substances 0.000 description 48
- 238000000429 assembly Methods 0.000 description 46
- 230000000712 assembly Effects 0.000 description 46
- 239000012634 fragment Substances 0.000 description 44
- 230000001133 acceleration Effects 0.000 description 40
- 238000010884 ion-beam technique Methods 0.000 description 36
- 239000000523 sample Substances 0.000 description 34
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- 238000002474 experimental method Methods 0.000 description 23
- 238000005192 partition Methods 0.000 description 21
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- 238000004252 FT/ICR mass spectrometry Methods 0.000 description 7
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- 230000037427 ion transport Effects 0.000 description 3
- 238000000534 ion trap mass spectrometry Methods 0.000 description 3
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- 239000006199 nebulizer Substances 0.000 description 3
- 230000000979 retarding effect Effects 0.000 description 3
- 241000894007 species Species 0.000 description 3
- 238000001196 time-of-flight mass spectrum Methods 0.000 description 3
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
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- 241001674048 Phthiraptera Species 0.000 description 1
- 101100247669 Quaranfil virus (isolate QrfV/Tick/Afghanistan/EG_T_377/1968) PB1 gene Proteins 0.000 description 1
- 101150025928 Segment-1 gene Proteins 0.000 description 1
- 101100242902 Thogoto virus (isolate SiAr 126) Segment 1 gene Proteins 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 238000012442 analytical experiment Methods 0.000 description 1
- 229910052786 argon Inorganic materials 0.000 description 1
- 230000004323 axial length Effects 0.000 description 1
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- 230000002457 bidirectional effect Effects 0.000 description 1
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- 238000004590 computer program Methods 0.000 description 1
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- 238000003795 desorption Methods 0.000 description 1
- 230000001066 destructive effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000000165 glow discharge ionisation Methods 0.000 description 1
- 239000001307 helium Substances 0.000 description 1
- 229910052734 helium Inorganic materials 0.000 description 1
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 1
- 230000003116 impacting effect Effects 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
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- 238000000752 ionisation method Methods 0.000 description 1
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- 229910052757 nitrogen Inorganic materials 0.000 description 1
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- 230000003252 repetitive effect Effects 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
- 238000002098 selective ion monitoring Methods 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
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- 239000007921 spray Substances 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/26—Mass spectrometers or separator tubes
- H01J49/34—Dynamic spectrometers
- H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
- H01J49/4205—Device types
- H01J49/422—Two-dimensional RF ion traps
- H01J49/4225—Multipole linear ion traps, e.g. quadrupoles, hexapoles
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/06—Electron- or ion-optical arrangements
- H01J49/062—Ion guides
- H01J49/063—Multipole ion guides, e.g. quadrupoles, hexapoles
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Electron Tubes For Measurement (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7237498P | 1998-01-23 | 1998-01-23 | |
| US8724698P | 1998-05-29 | 1998-05-29 | |
| US60/087,246 | 1998-05-29 | ||
| US60/072,374 | 1998-05-29 | ||
| PCT/US1999/001335 WO1999038193A1 (en) | 1998-01-23 | 1999-01-22 | Mass spectrometry with multipole ion guide |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2318855A1 CA2318855A1 (en) | 1999-07-29 |
| CA2318855C true CA2318855C (en) | 2006-07-11 |
Family
ID=26753301
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002318855A Expired - Lifetime CA2318855C (en) | 1998-01-23 | 1999-01-22 | Mass spectrometry with multipole ion guide |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1057209B1 (de) |
| JP (1) | JP2002502085A (de) |
| AT (1) | ATE535008T1 (de) |
| AU (1) | AU2334199A (de) |
| CA (1) | CA2318855C (de) |
| WO (1) | WO1999038193A1 (de) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2626383C (en) * | 1998-05-29 | 2011-07-19 | Craig M. Whitehouse | Mass spectrometry with multipole ion guides |
| GB9820210D0 (en) | 1998-09-16 | 1998-11-11 | Vg Elemental Limited | Means for removing unwanted ions from an ion transport system and mass spectrometer |
| US6586727B2 (en) * | 2000-06-09 | 2003-07-01 | Micromass Limited | Methods and apparatus for mass spectrometry |
| CA2340150C (en) * | 2000-06-09 | 2005-11-22 | Micromass Limited | Methods and apparatus for mass spectrometry |
| CA2431809C (en) * | 2000-12-14 | 2013-07-02 | Mds Inc., Doing Business As Mds Sciex | Apparatus and method for msnth in a tandem mass spectrometer system |
| US20020115056A1 (en) | 2000-12-26 | 2002-08-22 | Goodlett David R. | Rapid and quantitative proteome analysis and related methods |
| US6803565B2 (en) * | 2001-05-18 | 2004-10-12 | Battelle Memorial Institute | Ionization source utilizing a multi-capillary inlet and method of operation |
| US6956205B2 (en) | 2001-06-15 | 2005-10-18 | Bruker Daltonics, Inc. | Means and method for guiding ions in a mass spectrometer |
| JP3990889B2 (ja) * | 2001-10-10 | 2007-10-17 | 株式会社日立ハイテクノロジーズ | 質量分析装置およびこれを用いる計測システム |
| US7049580B2 (en) * | 2002-04-05 | 2006-05-23 | Mds Inc. | Fragmentation of ions by resonant excitation in a high order multipole field, low pressure ion trap |
| GB0210930D0 (en) | 2002-05-13 | 2002-06-19 | Thermo Electron Corp | Improved mass spectrometer and mass filters therefor |
| GB2390478B (en) * | 2002-05-17 | 2004-06-02 | Micromass Ltd | Mass spectrometer |
| GB0305796D0 (en) | 2002-07-24 | 2003-04-16 | Micromass Ltd | Method of mass spectrometry and a mass spectrometer |
| EP2385543B1 (de) * | 2003-01-24 | 2013-05-08 | Thermo Finnigan Llc | Steuerung von Ionenpopulation in einem Massenanalysegerät |
| JP4676955B2 (ja) * | 2003-04-09 | 2011-04-27 | エムディーエス インコーポレイテッド | クロマトグラフィ／質量分析／質量分析装置における動的信号選択 |
| US20050242281A1 (en) * | 2004-04-30 | 2005-11-03 | Gangqiang Li | Unevenly segmented multipole |
| WO2005106922A1 (en) * | 2004-05-05 | 2005-11-10 | Mds Inc. , Doing Business As Mds Sciex | Method and apparatus for mass selective axial ejection |
| US7034293B2 (en) * | 2004-05-26 | 2006-04-25 | Varian, Inc. | Linear ion trap apparatus and method utilizing an asymmetrical trapping field |
| GB2427067B (en) | 2005-03-29 | 2010-02-24 | Thermo Finnigan Llc | Improvements relating to ion trapping |
| DE102005061425B4 (de) * | 2005-12-22 | 2009-06-10 | Bruker Daltonik Gmbh | Rückgesteuerte Fragmentierung in Ionenfallen-Massenspektrometern |
| EP1971998B1 (de) | 2006-01-11 | 2019-05-08 | DH Technologies Development Pte. Ltd. | Fragmentierung von ionen in der massenspektrometrie |
| GB0624679D0 (en) * | 2006-12-11 | 2007-01-17 | Shimadzu Corp | A time-of-flight mass spectrometer and a method of analysing ions in a time-of-flight mass spectrometer |
| GB2497799B (en) * | 2011-12-21 | 2016-06-22 | Thermo Fisher Scient (Bremen) Gmbh | Collision cell multipole |
| JP6044385B2 (ja) * | 2013-02-26 | 2016-12-14 | 株式会社島津製作所 | タンデム型質量分析装置 |
| DE112015002415B4 (de) | 2014-06-25 | 2020-01-02 | Hitachi High-Technologies Corporation | Massenspektrometer |
| GB2534569A (en) * | 2015-01-27 | 2016-08-03 | Shimadzu Corp | Method of controlling a DC power supply |
| EP3895205A1 (de) * | 2018-12-13 | 2021-10-20 | DH Technologies Development Pte. Ltd. | Effektive potenzialanpassung an grenzen von segmentierten quadrupolen in einem massenspektrometer |
| GB2631679B (en) * | 2023-05-26 | 2025-08-27 | Thermo Fisher Scient Bremen Gmbh | High-voltage RF generator for ion optics |
| GB2630625B (en) * | 2023-06-01 | 2025-07-16 | Edinburgh Instruments Ltd | Apparatus and method |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3410997A (en) * | 1964-09-08 | 1968-11-12 | Bell & Howell Co | Multipole mass filter |
| US4328420A (en) * | 1980-07-28 | 1982-05-04 | French John B | Tandem mass spectrometer with open structure AC-only rod sections, and method of operating a mass spectrometer system |
| US4814613A (en) * | 1987-03-06 | 1989-03-21 | Extrel Corporation | Collision cell for triple quadrupole tandem mass spectrometry |
| JP3671354B2 (ja) * | 1994-02-28 | 2005-07-13 | アナリチカ オブ ブランフォード，インコーポレーテッド | 質量分析用の多重極イオンガイド |
| DE19517507C1 (de) * | 1995-05-12 | 1996-08-08 | Bruker Franzen Analytik Gmbh | Hochfrequenz-Ionenleitsystem |
| EP0843887A1 (de) * | 1995-08-11 | 1998-05-27 | Mds Health Group Limited | Spektrometer mit axialfeld |
| JP3818671B2 (ja) * | 1996-06-06 | 2006-09-06 | エムディーエス インコーポレーテッド | 多重極子質量分光計の軸方向射出方法 |
-
1999
- 1999-01-22 JP JP2000528994A patent/JP2002502085A/ja active Pending
- 1999-01-22 AT AT99903281T patent/ATE535008T1/de active
- 1999-01-22 AU AU23341/99A patent/AU2334199A/en not_active Abandoned
- 1999-01-22 EP EP99903281A patent/EP1057209B1/de not_active Expired - Lifetime
- 1999-01-22 WO PCT/US1999/001335 patent/WO1999038193A1/en not_active Ceased
- 1999-01-22 CA CA002318855A patent/CA2318855C/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1057209A1 (de) | 2000-12-06 |
| EP1057209B1 (de) | 2011-11-23 |
| CA2318855A1 (en) | 1999-07-29 |
| ATE535008T1 (de) | 2011-12-15 |
| WO1999038193A1 (en) | 1999-07-29 |
| EP1057209A4 (de) | 2006-02-01 |
| JP2002502085A (ja) | 2002-01-22 |
| AU2334199A (en) | 1999-08-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKEX | Expiry |
Effective date: 20190122 |