CA2318365A1 - Polyketides and their synthesis - Google Patents

Polyketides and their synthesis Download PDF

Info

Publication number
CA2318365A1
CA2318365A1 CA002318365A CA2318365A CA2318365A1 CA 2318365 A1 CA2318365 A1 CA 2318365A1 CA 002318365 A CA002318365 A CA 002318365A CA 2318365 A CA2318365 A CA 2318365A CA 2318365 A1 CA2318365 A1 CA 2318365A1
Authority
CA
Canada
Prior art keywords
pks
gene
module
nucleic acid
polyketide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002318365A
Other languages
English (en)
French (fr)
Inventor
Ines Ute Bohm
Antony David Buss
Peter Francis Leadlay
Christine Janet Rowe
James Staunton
Barrie Wilkinson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9800675.2A external-priority patent/GB9800675D0/en
Priority claimed from GBGB9800879.0A external-priority patent/GB9800879D0/en
Application filed by Individual filed Critical Individual
Publication of CA2318365A1 publication Critical patent/CA2318365A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Polyoxymethylene Polymers And Polymers With Carbon-To-Carbon Bonds (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
CA002318365A 1998-01-14 1999-01-14 Polyketides and their synthesis Abandoned CA2318365A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB9800675.2A GB9800675D0 (en) 1998-01-14 1998-01-14 Polyketides and their synthesis
GB9800675.2 1998-01-14
GBGB9800879.0A GB9800879D0 (en) 1998-01-15 1998-01-15 Polyketides and their synthesis
GB9800879.0 1998-01-15
PCT/GB1999/000117 WO1999036546A1 (en) 1998-01-14 1999-01-14 Polyketides and their synthesis

Publications (1)

Publication Number Publication Date
CA2318365A1 true CA2318365A1 (en) 1999-07-22

Family

ID=26312934

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002318365A Abandoned CA2318365A1 (en) 1998-01-14 1999-01-14 Polyketides and their synthesis

Country Status (6)

Country Link
EP (1) EP1045912A1 (de)
JP (1) JP2002508968A (de)
AU (1) AU2066799A (de)
CA (1) CA2318365A1 (de)
HR (1) HRP20000474A2 (de)
WO (1) WO1999036546A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6358712B1 (en) 1999-01-05 2002-03-19 Trustee Of Boston University Ordered gene assembly
GB0327720D0 (en) 2003-11-28 2003-12-31 Biotica Tech Ltd Erythromycins and process for their preparation

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993013663A1 (en) * 1992-01-17 1993-07-22 Abbott Laboratories Method of directing biosynthesis of specific polyketides
JP3063943B2 (ja) * 1992-02-26 2000-07-12 明治製菓株式会社 血漿中において抗菌活性の持続する新規１６員環マクロリド誘導体及びその合成中間体とそれらの製造法
AU731301B2 (en) * 1996-07-05 2001-03-29 Biotica Technology Limited Erythromycins and process for their preparation

Also Published As

Publication number Publication date
AU2066799A (en) 1999-08-02
WO1999036546A1 (en) 1999-07-22
JP2002508968A (ja) 2002-03-26
HRP20000474A2 (en) 2000-12-31
EP1045912A1 (de) 2000-10-25

Similar Documents

Publication Publication Date Title
EP0910633B1 (de) Hybridpolyketidesynthase I Gen
JP4489947B2 (ja) ポリケチドとその合成
JP2003512013A (ja) 組換えオレアンドライドポリケチドシンターゼ
CA2318365A1 (en) Polyketides and their synthesis
US6960453B1 (en) Hybrid polyketide synthases combining heterologous loading and extender modules
EP1414969A2 (de) Biosynthetische gene zur herstellung von butenyl-spinosyn-haltigem insektizid
EP1183369A1 (de) Polyketide und ihre herstellung
AU2008201937A1 (en) Biosynthetic genes for butenyl-spinosyn insecticide production
JP2009213479A (ja) ポリケチド類及びそれらの合成
AU2002305118A1 (en) Biosynthetic genes for butenyl-spinosyn insecticide production

Legal Events

Date Code Title Description
FZDE Discontinued