CA2305394C - Apport local d'inhibiteurs de phosphodiesterases, dans le traitement du dysfonctionnement erectile - Google Patents

Apport local d'inhibiteurs de phosphodiesterases, dans le traitement du dysfonctionnement erectile Download PDF

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Publication number
CA2305394C
CA2305394C CA002305394A CA2305394A CA2305394C CA 2305394 C CA2305394 C CA 2305394C CA 002305394 A CA002305394 A CA 002305394A CA 2305394 A CA2305394 A CA 2305394A CA 2305394 C CA2305394 C CA 2305394C
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Prior art keywords
phosphodiesterase inhibitor
phosphodiesterase
type
use according
formulation
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Expired - Lifetime
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CA002305394A
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CA2305394A1 (fr
Inventor
Paul C. Doherty, Jr.
Virgil A. Place
William L. Smith
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Vivus LLC
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Vivus LLC
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Priority claimed from US09/181,070 external-priority patent/US6037346A/en
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Publication of CA2305394A1 publication Critical patent/CA2305394A1/fr
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4704—2-Quinolinones, e.g. carbostyril
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    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
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    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Abstract

L'invention concerne un procédé de traitement du dysfonctionnement érectile chez un individu mâle mammifère. Ce procédé consiste à apporter localement un inhibiteur des phosphodiestérases, ou un sel, ester, amide ou dérivé de celui-ci, acceptable sur le plan pharmacologique, dans le cadre d'un schéma posologique efficace. Un mode préféré d'administration est un mode transurétral. L'invention concerne également des formulations et des coffrets pharmaceutiques.
CA002305394A 1997-10-28 1998-10-28 Apport local d'inhibiteurs de phosphodiesterases, dans le traitement du dysfonctionnement erectile Expired - Lifetime CA2305394C (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US95881697A 1997-10-28 1997-10-28
US08/958,816 1997-10-28
US09/181,070 US6037346A (en) 1997-10-28 1998-10-27 Local administration of phosphodiesterase inhibitors for the treatment of erectile dysfunction
US09/181,070 1998-10-27
PCT/US1998/022928 WO1999021558A2 (fr) 1997-10-28 1998-10-28 Apport local d'inhibiteurs de phosphodiesterases, dans le traitement du dysfonctionnement erectile

Publications (2)

Publication Number Publication Date
CA2305394A1 CA2305394A1 (fr) 1999-05-06
CA2305394C true CA2305394C (fr) 2006-12-12

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Family Applications (1)

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CA002305394A Expired - Lifetime CA2305394C (fr) 1997-10-28 1998-10-28 Apport local d'inhibiteurs de phosphodiesterases, dans le traitement du dysfonctionnement erectile

Country Status (5)

Country Link
EP (1) EP1027054A4 (fr)
JP (1) JP2003525845A (fr)
AU (1) AU734734B2 (fr)
CA (1) CA2305394C (fr)
WO (1) WO1999021558A2 (fr)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6331543B1 (en) 1996-11-01 2001-12-18 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use
US6103765A (en) 1997-07-09 2000-08-15 Androsolutions, Inc. Methods for treating male erectile dysfunction
JP2001509480A (ja) 1997-07-09 2001-07-24 アンドロソリューションズ，インク． 男性勃起機能不全を治療するための改良された方法及び組成物
US6403597B1 (en) 1997-10-28 2002-06-11 Vivus, Inc. Administration of phosphodiesterase inhibitors for the treatment of premature ejaculation
US6548490B1 (en) 1997-10-28 2003-04-15 Vivus, Inc. Transmucosal administration of phosphodiesterase inhibitors for the treatment of erectile dysfunction
US6472425B1 (en) 1997-10-31 2002-10-29 Nitromed, Inc. Methods for treating female sexual dysfunctions
US6541487B1 (en) * 1998-05-01 2003-04-01 R.T. Alamo Ventures I, Llc PDE III inhibitors for treating sexual dysfunction
DE19834506A1 (de) * 1998-07-31 2000-02-03 Hexal Ag Transmucosales therapeutisches System zur Anwendung von Sildenafil
CN1163230C (zh) * 1998-12-07 2004-08-25 日产化学工业株式会社 勃起功能障碍治疗剂
IT1312310B1 (it) * 1999-05-07 2002-04-15 Recordati Ind Chimica E Farma Uso di antagonisti selettivi del recettore adrenergico a 1b per ilmiglioramento della disfunzione sessuale
IL130968A (en) 1999-07-15 2002-12-01 Shmuel Simon Pharmaceutical composition comprising sildenafil or its analogs, useful for the treatment of tinnitus and hearing loss
US6323241B1 (en) * 2000-01-10 2001-11-27 Nexmed (Holdings) Inc. Prostaglandin compositions and methods of treatment for male erectile dysfunction
AU2001273636A1 (en) 2000-06-27 2002-01-08 Qualilife Pharmaceuticals Inc. Compositions and methods for treating females sexual response
US6503894B1 (en) 2000-08-30 2003-01-07 Unimed Pharmaceuticals, Inc. Pharmaceutical composition and method for treating hypogonadism
US6821978B2 (en) 2000-09-19 2004-11-23 Schering Corporation Xanthine phosphodiesterase V inhibitors
FI20002755A0 (fi) * 2000-12-15 2000-12-15 Orion Yhtymae Oyj Menetelmä erektiilin dysfunktion hoitamiseen
WO2002049649A2 (fr) * 2000-12-19 2002-06-27 Merck Patent Gmbh Formulation pharmaceutique contenant des thienopyrimidines et des antithrombotiques, des inhibiteurs calciques, des prostaglandines ou des derives de prostaglandine (2)
SK8192003A3 (en) * 2000-12-19 2003-10-07 Merck Patent Gmbh Pharmaceutical formulation containing pyrazolo[4,3-d]pyrimidines and antithrombotic agents, calcium-antagonists, prostaglandins or prostaglandin derivatives
HUP0303289A2 (hu) * 2000-12-19 2004-01-28 Merck Patent Gmbh. Tienopirimidineket és trombózisellenes szereket, kalcium antagonistákat, prosztaglandinokat vagy prosztaglandinszármazékokat tartalmazó gyógyszerkészítmények
EP1224933A1 (fr) * 2001-01-19 2002-07-24 Sanofi-Synthelabo Nouvelle combinaison d'actifs avec alfuzosine et apomorphine
WO2003042216A1 (fr) 2001-11-09 2003-05-22 Schering Corporation Inhibiteurs de la phosphodiesterase v de derives polycycliques de guanine
EP2298278B1 (fr) 2002-06-07 2015-11-11 Dyax Corp. Prévention et réduction de perte sanguine et la réponse inflammatoire
AU2003207089A1 (en) * 2003-02-14 2004-09-06 Takeda Pharmaceutical Company Limited Preparation for topical administration
PT1663281E (pt) * 2003-08-29 2014-03-17 Dyax Corp Inibidores de proteases poli-peguilados
US7235530B2 (en) 2004-09-27 2007-06-26 Dyax Corporation Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
EA011391B1 (ru) * 2004-10-18 2009-02-27 Полимун Сайнтифик Иммунбиологише Форшунг Гмбх Липосомная композиция, содержащая активное вещество для релаксации гладкой мускулатуры, получение этой композиции и ее терапевтическое применение
CA2677690C (fr) * 2007-02-12 2012-05-15 James V. Winkler Traitement destine a une ejaculation precoce et aux troubles de l'erection comorbides
KR20100050488A (ko) * 2007-06-26 2010-05-13 솔베이 파마슈티칼스 비. 브이 전구약물로서 실데나필 ｎ-옥사이드
CN106459210A (zh) 2014-03-27 2017-02-22 戴埃克斯有限公司 用于治疗糖尿病黄斑性水肿的组合物和方法
WO2021027943A1 (fr) * 2019-08-14 2021-02-18 正大天晴药业集团南京顺欣制药有限公司 Dérivé de pyrimidinopyridazinone et son utilisation médicale

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4801587A (en) * 1987-03-02 1989-01-31 Gene Voss Impotence ointment
FR2649613B1 (fr) * 1989-07-11 1991-09-27 Virag Ronald Medicament vaso-actif
US5242391A (en) * 1990-04-25 1993-09-07 Alza Corporation Urethral insert for treatment of erectile dysfunction
US5250534A (en) * 1990-06-20 1993-10-05 Pfizer Inc. Pyrazolopyrimidinone antianginal agents
GB9114760D0 (en) * 1991-07-09 1991-08-28 Pfizer Ltd Therapeutic agents
GB9301192D0 (en) * 1993-06-09 1993-06-09 Trott Francis W Flower shaped mechanised table
GB9423910D0 (en) * 1994-11-26 1995-01-11 Pfizer Ltd Therapeutic agents
WO1998019672A1 (fr) * 1996-11-01 1998-05-14 Nitromed Inc. Composes nitroses et nitrosyles inhibiteurs de la phosphodiesterase, compositions comprenant ces composes et utilisations correspondantes
EP0941221B1 (fr) * 1996-11-20 2003-02-26 ALTANA Pharma AG Dihydrobenzofuranes substitues utilises en tant qu'inhibiteurs de la phosphodiesterase (pde)
EP1027057A4 (fr) * 1997-10-28 2003-01-02 Vivus Inc Traitement du dysfonctionnement sexuel chez la femme

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AU1125499A (en) 1999-05-17
EP1027054A1 (fr) 2000-08-16
JP2003525845A (ja) 2003-09-02
CA2305394A1 (fr) 1999-05-06
WO1999021558A3 (fr) 2000-10-26
WO1999021558A2 (fr) 1999-05-06
EP1027054A4 (fr) 2002-11-04

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