CA2304267A1 - Composes anti-bacteriens d'aryloxymethyle carbapenem - Google Patents
Composes anti-bacteriens d'aryloxymethyle carbapenem Download PDFInfo
- Publication number
- CA2304267A1 CA2304267A1 CA002304267A CA2304267A CA2304267A1 CA 2304267 A1 CA2304267 A1 CA 2304267A1 CA 002304267 A CA002304267 A CA 002304267A CA 2304267 A CA2304267 A CA 2304267A CA 2304267 A1 CA2304267 A1 CA 2304267A1
- Authority
- CA
- Canada
- Prior art keywords
- groups
- substituted
- unsubstituted
- compound
- nmr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/14—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Cette invention se rapporte à des agents anti-bactériens de carbapenem représentés par la formule (I), ainsi qu'à des sels et hydrates de ces agents. Cette invention concerne également des compositions pharmaceutiques et des méthodes de traitement.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5911197P | 1997-09-17 | 1997-09-17 | |
US60/059,111 | 1997-09-17 | ||
GBGB9806433.0A GB9806433D0 (en) | 1998-03-25 | 1998-03-25 | Carbapenem antibacterial compounds,compositions containing such compounds and methods of treatment |
GB9806433.0 | 1998-03-25 | ||
PCT/US1998/019015 WO1999014217A1 (fr) | 1997-09-17 | 1998-09-14 | Composes anti-bacteriens d'aryloxymethyle carbapenem |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2304267A1 true CA2304267A1 (fr) | 1999-03-25 |
Family
ID=26313360
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002304267A Abandoned CA2304267A1 (fr) | 1997-09-17 | 1998-09-14 | Composes anti-bacteriens d'aryloxymethyle carbapenem |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1023293A4 (fr) |
JP (1) | JP2002503638A (fr) |
AU (1) | AU9774298A (fr) |
CA (1) | CA2304267A1 (fr) |
WO (1) | WO1999014217A1 (fr) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6284753B2 (en) * | 1998-06-02 | 2001-09-04 | Merck & Co., Inc. | Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment |
US7632828B2 (en) * | 2004-06-10 | 2009-12-15 | Fob Synthesis, Inc. | Gram-positive carbapenem antibacterials and processes for their preparation |
CN106279178B (zh) * | 2016-07-18 | 2019-01-18 | 华东理工大学 | 耐碳青霉烯类抗生素病菌的荧光探针及合成方法与应用 |
CN117015530A (zh) | 2021-01-27 | 2023-11-07 | 范徳利亚股份公司 | 尿石素衍生物及其使用方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0467434A1 (fr) * | 1990-06-26 | 1992-01-22 | Merck & Co. Inc. | 2-Biphenyl-carbapénèmes antibactériens |
EP0464900A3 (en) * | 1990-06-26 | 1992-07-22 | Merck & Co. Inc. | 2-biphenyl-carbapenems |
US5132420A (en) * | 1990-10-11 | 1992-07-21 | Merck & Co., Inc. | Intermediates for preparing 2-(substituted-dibenzo-furanyl and dibenzothienyl) carbapenem antibacterial agents |
EP0695753A1 (fr) * | 1994-08-05 | 1996-02-07 | Zeneca Limited | Dérivés de carbapénème contenant un substituant bicyclique, procédé pour leur préparation et leur application |
-
1998
- 1998-09-14 AU AU97742/98A patent/AU9774298A/en not_active Abandoned
- 1998-09-14 EP EP98951912A patent/EP1023293A4/fr not_active Withdrawn
- 1998-09-14 JP JP2000511766A patent/JP2002503638A/ja not_active Withdrawn
- 1998-09-14 CA CA002304267A patent/CA2304267A1/fr not_active Abandoned
- 1998-09-14 WO PCT/US1998/019015 patent/WO1999014217A1/fr not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
AU9774298A (en) | 1999-04-05 |
JP2002503638A (ja) | 2002-02-05 |
EP1023293A1 (fr) | 2000-08-02 |
WO1999014217A1 (fr) | 1999-03-25 |
EP1023293A4 (fr) | 2002-11-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Dead |