EP1023293A4 - Composes anti-bacteriens d'aryloxymethyle carbapenem - Google Patents

Composes anti-bacteriens d'aryloxymethyle carbapenem

Info

Publication number
EP1023293A4
EP1023293A4 EP98951912A EP98951912A EP1023293A4 EP 1023293 A4 EP1023293 A4 EP 1023293A4 EP 98951912 A EP98951912 A EP 98951912A EP 98951912 A EP98951912 A EP 98951912A EP 1023293 A4 EP1023293 A4 EP 1023293A4
Authority
EP
European Patent Office
Prior art keywords
aryloxymethyl
carbapenem antibacterials
carbapenem
antibacterials
aryloxymethyl carbapenem
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98951912A
Other languages
German (de)
English (en)
Other versions
EP1023293A1 (fr
Inventor
Frank P Dininno
Helen Chen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9806433.0A external-priority patent/GB9806433D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP1023293A1 publication Critical patent/EP1023293A1/fr
Publication of EP1023293A4 publication Critical patent/EP1023293A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/14—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
EP98951912A 1997-09-17 1998-09-14 Composes anti-bacteriens d'aryloxymethyle carbapenem Withdrawn EP1023293A4 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US5911197P 1997-09-17 1997-09-17
US59111P 1997-09-17
GBGB9806433.0A GB9806433D0 (en) 1998-03-25 1998-03-25 Carbapenem antibacterial compounds,compositions containing such compounds and methods of treatment
GB9806433 1998-03-25
PCT/US1998/019015 WO1999014217A1 (fr) 1997-09-17 1998-09-14 Composes anti-bacteriens d'aryloxymethyle carbapenem

Publications (2)

Publication Number Publication Date
EP1023293A1 EP1023293A1 (fr) 2000-08-02
EP1023293A4 true EP1023293A4 (fr) 2002-11-20

Family

ID=26313360

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98951912A Withdrawn EP1023293A4 (fr) 1997-09-17 1998-09-14 Composes anti-bacteriens d'aryloxymethyle carbapenem

Country Status (5)

Country Link
EP (1) EP1023293A4 (fr)
JP (1) JP2002503638A (fr)
AU (1) AU9774298A (fr)
CA (1) CA2304267A1 (fr)
WO (1) WO1999014217A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6284753B2 (en) * 1998-06-02 2001-09-04 Merck & Co., Inc. Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment
KR20120099727A (ko) * 2004-06-10 2012-09-11 포브 신서시스 인코포레이티드 그램-양성 카바페넴 항균제 및 그의 제조방법
CN106279178B (zh) * 2016-07-18 2019-01-18 华东理工大学 耐碳青霉烯类抗生素病菌的荧光探针及合成方法与应用
US11820751B2 (en) 2021-01-27 2023-11-21 Vandria Sa Urolithin derivatives and methods of use thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0464900A2 (fr) * 1990-06-26 1992-01-08 Merck & Co. Inc. 2-Biphényl-carbapénèmes
EP0467434A1 (fr) * 1990-06-26 1992-01-22 Merck & Co. Inc. 2-Biphenyl-carbapénèmes antibactériens
EP0480715A1 (fr) * 1990-10-11 1992-04-15 Merck & Co. Inc. Composés intermédiaires pour la préparation des 2-(substitué-dibenzofuranyl- et dibenzothiényl)-carbapénèmes comme agents antibactériens
EP0695753A1 (fr) * 1994-08-05 1996-02-07 Zeneca Limited Dérivés de carbapénème contenant un substituant bicyclique, procédé pour leur préparation et leur application

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0464900A2 (fr) * 1990-06-26 1992-01-08 Merck & Co. Inc. 2-Biphényl-carbapénèmes
EP0467434A1 (fr) * 1990-06-26 1992-01-22 Merck & Co. Inc. 2-Biphenyl-carbapénèmes antibactériens
EP0480715A1 (fr) * 1990-10-11 1992-04-15 Merck & Co. Inc. Composés intermédiaires pour la préparation des 2-(substitué-dibenzofuranyl- et dibenzothiényl)-carbapénèmes comme agents antibactériens
EP0695753A1 (fr) * 1994-08-05 1996-02-07 Zeneca Limited Dérivés de carbapénème contenant un substituant bicyclique, procédé pour leur préparation et leur application

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9914217A1 *

Also Published As

Publication number Publication date
WO1999014217A1 (fr) 1999-03-25
EP1023293A1 (fr) 2000-08-02
JP2002503638A (ja) 2002-02-05
AU9774298A (en) 1999-04-05
CA2304267A1 (fr) 1999-03-25

Similar Documents

Publication Publication Date Title
GB9517450D0 (en) Toothbrush
AU6805498A (en) Toothbrush
GB9505914D0 (en) Toothbrush
AU9067698A (en) Toothbrush
AU7426798A (en) Toothbrush
GB9515596D0 (en) Toothbrush
GB2299499B (en) Toothbrush
GB9714129D0 (en) Azetidines
SG74666A1 (en) Beta-ketoester
AU5778998A (en) Toothbrush
EG20921A (en) Toothbrushes
AU2234397A (en) Toothbrush
GB2297478B (en) Toothbrush
GB9501009D0 (en) Toothbrush
AU126652S (en) Toothbrush
EP1015453A4 (fr) Antibacteriens du type 3-(iodophenoxymethyl) carbapenem
EP1023293A4 (fr) Composes anti-bacteriens d'aryloxymethyle carbapenem
AU4132297A (en) Toothbrush
GB9515629D0 (en) Toothbrush
EP1082325A4 (fr) Antibacteriens penemes, a base de naphtosulfamylmethyle
GB9501983D0 (en) Closeable toothbrush
GB9525236D0 (en) Block toy
GB2301769B (en) Toothbrushes
CA76175S (en) Toothbrush
CA75683S (en) Toothbrush

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20000417

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

AX Request for extension of the european patent

Free format text: AL PAYMENT 20000417;LT PAYMENT 20000417;LV PAYMENT 20000417;MK PAYMENT 20000417;RO PAYMENT 20000417;SI PAYMENT 20000417

A4 Supplementary search report drawn up and despatched

Effective date: 20021009

AK Designated contracting states

Kind code of ref document: A4

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

RIC1 Information provided on ipc code assigned before grant

Free format text: 7C 07D 477/14 A, 7C 07D 519/00 B, 7C 07D 519/06 B, 7A 61K 31/40 B, 7C 07D 519/00 J, 7C 07D 487:00 J, 7C 07D 477:00 J

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20021228