CA2301499C - T-cell membrane protein (tirc7), peptides and antibodies derived therefrom and uses thereof - Google Patents

T-cell membrane protein (tirc7), peptides and antibodies derived therefrom and uses thereof Download PDF

Info

Publication number
CA2301499C
CA2301499C CA2301499A CA2301499A CA2301499C CA 2301499 C CA2301499 C CA 2301499C CA 2301499 A CA2301499 A CA 2301499A CA 2301499 A CA2301499 A CA 2301499A CA 2301499 C CA2301499 C CA 2301499C
Authority
CA
Canada
Prior art keywords
cell
tirc7
leu
protein
ala
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2301499A
Other languages
English (en)
French (fr)
Other versions
CA2301499A1 (en
Inventor
Nalan Utku
Steven R. Gullans
Edgar L. Milford
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Brigham and Womens Hospital Inc
Original Assignee
Brigham and Womens Hospital Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19738710A external-priority patent/DE19738710A1/de
Application filed by Brigham and Womens Hospital Inc filed Critical Brigham and Womens Hospital Inc
Publication of CA2301499A1 publication Critical patent/CA2301499A1/en
Application granted granted Critical
Publication of CA2301499C publication Critical patent/CA2301499C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Transplantation (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CA2301499A 1997-08-29 1998-08-28 T-cell membrane protein (tirc7), peptides and antibodies derived therefrom and uses thereof Expired - Fee Related CA2301499C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE19738710A DE19738710A1 (de) 1997-08-29 1997-08-29 Verwendung von TIRC7 zur Herstellung von Mitteln zur Inhibition der Immunantwort
DE19738710.1 1997-08-29
DE29802653 1998-02-12
DE29802653.8 1998-02-12
PCT/EP1998/005462 WO1999011782A1 (en) 1997-08-29 1998-08-28 T-cell membrane protein (tirc7), peptides and antibodies derived therefrom and uses thereof

Publications (2)

Publication Number Publication Date
CA2301499A1 CA2301499A1 (en) 1999-03-11
CA2301499C true CA2301499C (en) 2010-01-26

Family

ID=26039678

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2301499A Expired - Fee Related CA2301499C (en) 1997-08-29 1998-08-28 T-cell membrane protein (tirc7), peptides and antibodies derived therefrom and uses thereof

Country Status (10)

Country Link
EP (2) EP0996726B1 (enExample)
JP (1) JP4459435B2 (enExample)
AT (1) ATE256185T1 (enExample)
AU (1) AU751151C (enExample)
CA (1) CA2301499C (enExample)
DE (1) DE69820449T2 (enExample)
DK (1) DK0996726T3 (enExample)
ES (1) ES2213295T3 (enExample)
PT (1) PT996726E (enExample)
WO (1) WO1999011782A1 (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL134830A0 (en) * 2000-03-01 2001-05-20 Chay 13 Medical Res Group N V Peptides and immunostimulatory and anti-bacterial pharmaceutical compositions containing them
AU2001263888A1 (en) * 2000-05-03 2001-11-12 Genpat77 Pharmacogenetics Ag Uses of tgap7 for the modulation of leucocyte activation
US20040072780A1 (en) * 2000-10-30 2004-04-15 Nalan Utku Methods for obtaining inhibitors of tirc7 ligand binding and uses thereof
US6905827B2 (en) 2001-06-08 2005-06-14 Expression Diagnostics, Inc. Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases
US7026121B1 (en) 2001-06-08 2006-04-11 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
US20050048067A1 (en) * 2001-09-17 2005-03-03 Nalan Utku Peptides capable of modulating immune response
EP1448227A2 (en) * 2001-11-27 2004-08-25 GenPat77 Pharmacogenetics AG Use of t-cell immune response cdna 7 (tirc7) for modulation of angiogenesis and/or neovascularization
EP1492817A2 (en) * 2001-12-21 2005-01-05 GenPat77 Pharmacogenetics AG Therapeutic monoclonal anti-tirc7 antibodies for use in immune related and other diseases
JP2005531282A (ja) 2001-12-21 2005-10-20 ゲンパト７７ ファーマコジェネティクス エージー 炎症性疾患の治療に用いる抗ｔｉｒｃ７抗体
EP1492555A2 (en) * 2002-02-04 2005-01-05 Nalan Utku Compositions and methods for modulation of effects on phagocyte and lymphoid cell population
US20050221424A1 (en) * 2002-04-26 2005-10-06 Nalan Utku Bispecific molecules for use in therapy and diagnosis of immune related and other diseases
WO2003093318A1 (en) * 2002-04-29 2003-11-13 Genpat77 Pharmacogenetics Ag Novel antibody binding tcr and tirc7 and its use in therapy and diagnosis
CN101268373A (zh) * 2005-05-17 2008-09-17 塞尔艾克特制药有限公司 作为检测早期免疫激活的标记物的tirc7
WO2006122792A1 (en) * 2005-05-17 2006-11-23 Genpat77 Pharmacogenetics Ag Peptides capable of modulating the function of tirc7
DE202011103324U1 (de) 2011-07-12 2012-01-02 Nekonal S.A.R.L. Therapeutische anti-TIRC7 Antikörper für die Verwendung in Immun und anderen Krankheiten
CA3033645A1 (en) 2016-08-09 2018-02-15 Nekonal S.A.R.L. Tirc7 based diagnostic and therapy of cancer
CA3033620A1 (en) 2016-08-10 2018-02-15 Nekonal S.A.R.L. Tirc7 based diagnostic and therapy of solid cancer
US20220288120A1 (en) 2019-08-14 2022-09-15 Nekonal S.A.R.L. Method for producing engineered tirc7 specific t-regulatory cells (tregs)

Also Published As

Publication number Publication date
ES2213295T3 (es) 2004-08-16
WO1999011782A1 (en) 1999-03-11
EP1350848A3 (en) 2004-02-04
ATE256185T1 (de) 2003-12-15
EP0996726B1 (en) 2003-12-10
EP1350848A2 (en) 2003-10-08
PT996726E (pt) 2004-04-30
EP0996726A1 (en) 2000-05-03
AU751151C (en) 2006-09-14
DE69820449T2 (de) 2005-03-10
JP2001514852A (ja) 2001-09-18
JP4459435B2 (ja) 2010-04-28
AU751151B2 (en) 2002-08-08
CA2301499A1 (en) 1999-03-11
DE69820449D1 (de) 2004-01-22
AU9265498A (en) 1999-03-22
DK0996726T3 (da) 2004-04-13

Similar Documents

Publication Publication Date Title
CA2301499C (en) T-cell membrane protein (tirc7), peptides and antibodies derived therefrom and uses thereof
JP3703834B2 (ja) 活性化ｃｄ４▲上＋▼ｔ細胞の表層上のレセプターに対するリガンド（ａｃｔ−４−ｌ）
EP0726952B1 (en) Receptor on the surface of activated t-cells:acts-4
US7931901B2 (en) T-cell membrane protein (TIRC7), peptides and antibodies derived therefrom and uses thereof
US20110189181A1 (en) Use of agents derived from CEACAM1 for the treatment of inflammatory diseases
US5646251A (en) Alloreaction-associated antigen (ARAG): a novel member of the immunoglobulin gene superfamily
EP0795014A1 (en) Purified genes encoding mammalian cell surface antigens; proteins and antibodies
CA2525499C (en) Ligand (act-4-l) to a receptor on the surface of activated cd4+ t-cells
HK1001462B (en) Ligand (act-4-l) to a receptor on the surface of activated cd4+ t-cells
MXPA97003956A (en) Purified genes that codify antigens of surface of mammali cells, proteins and antibody
HK1001464B (en) Receptor on the surface of activated t-cells:acts-4
AU1843699A (en) Ligand (ACT-4-L) to a receptor on the surface of activated CD4+T-cells
MXPA01007843A (en) Novel polypeptides involved in immune response

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20130828