CA2300370A1 - Cristal de l'anticorps sm3 (fragment) et de l'epitope de reconnaissance, sa preparation, support de donnees codees contenant ses coordonnees et son utilisation diagnostique ou medicale - Google Patents
Cristal de l'anticorps sm3 (fragment) et de l'epitope de reconnaissance, sa preparation, support de donnees codees contenant ses coordonnees et son utilisation diagnostique ou medicale Download PDFInfo
- Publication number
- CA2300370A1 CA2300370A1 CA002300370A CA2300370A CA2300370A1 CA 2300370 A1 CA2300370 A1 CA 2300370A1 CA 002300370 A CA002300370 A CA 002300370A CA 2300370 A CA2300370 A CA 2300370A CA 2300370 A1 CA2300370 A1 CA 2300370A1
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- Prior art keywords
- peptide
- mimic
- antibody
- muc1
- epitope
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 238000004255 ion exchange chromatography Methods 0.000 description 1
- 239000000644 isotonic solution Substances 0.000 description 1
- 229910001629 magnesium chloride Inorganic materials 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012900 molecular simulation Methods 0.000 description 1
- 229940051875 mucins Drugs 0.000 description 1
- 201000006417 multiple sclerosis Diseases 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 238000010899 nucleation Methods 0.000 description 1
- 229920002113 octoxynol Polymers 0.000 description 1
- 238000011275 oncology therapy Methods 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 238000002823 phage display Methods 0.000 description 1
- 239000008024 pharmaceutical diluent Substances 0.000 description 1
- YBYRMVIVWMBXKQ-UHFFFAOYSA-N phenylmethanesulfonyl fluoride Chemical compound FS(=O)(=O)CC1=CC=CC=C1 YBYRMVIVWMBXKQ-UHFFFAOYSA-N 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000012846 protein folding Effects 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 230000008707 rearrangement Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000006258 serine-glycosylation Effects 0.000 description 1
- 238000002922 simulated annealing Methods 0.000 description 1
- 235000020183 skimmed milk Nutrition 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000008174 sterile solution Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 230000005469 synchrotron radiation Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000000293 three-dimensional nuclear magnetic resonance spectroscopy Methods 0.000 description 1
- 230000006262 threonine-glycosylation Effects 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 238000012876 topography Methods 0.000 description 1
- 108091007466 transmembrane glycoproteins Proteins 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4727—Mucins, e.g. human intestinal mucin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Pharmacology & Pharmacy (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
L'invention concerne un procédé de préparation d'un cristal comprenant l'utilisation de cadmium. Des facteurs de structure ou des coordonnées structurelles obtenues à partir du cristal de l'anticorps SM3 lié à un épitope peuvent être utilisés pour construire des analogues de cet anticorps ou de cet épitope. De tels analogues peuvent être utilisés dans le diagnostic ou le traitement du cancer.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9717946.9A GB9717946D0 (en) | 1997-08-22 | 1997-08-22 | Novel chemical entity |
| GB9717946.9 | 1997-08-22 | ||
| PCT/GB1998/002542 WO1999010379A1 (fr) | 1997-08-22 | 1998-08-24 | Cristal de l'anticorps sm3 (fragment) et de l'epitope de reconnaissance, sa preparation, support de donnees codees contenant ses coordonnees et son utilisation diagnostique ou medicale |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2300370A1 true CA2300370A1 (fr) | 1999-03-04 |
Family
ID=10817964
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002300370A Abandoned CA2300370A1 (fr) | 1997-08-22 | 1998-08-24 | Cristal de l'anticorps sm3 (fragment) et de l'epitope de reconnaissance, sa preparation, support de donnees codees contenant ses coordonnees et son utilisation diagnostique ou medicale |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0996634A1 (fr) |
| JP (1) | JP2001514188A (fr) |
| AU (1) | AU751386B2 (fr) |
| CA (1) | CA2300370A1 (fr) |
| GB (1) | GB9717946D0 (fr) |
| IL (1) | IL134547A0 (fr) |
| NO (1) | NO20000845L (fr) |
| WO (1) | WO1999010379A1 (fr) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007044033A2 (fr) | 2004-12-07 | 2007-04-19 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Récepteur non restreint par le cmh cloné de l'antigène spécifique de tumeur muc1 pour applications thérapeutiques et diagnostiques |
| CA2638905A1 (fr) * | 2006-01-23 | 2007-08-02 | Joseph P. Errico | Procedes et compositions de developpement d'un medicament cible |
| WO2007102787A1 (fr) * | 2006-03-06 | 2007-09-13 | Agency For Science, Technology & Research | Procédés d'identification de cellules souches embryonnaires humaines et expression de la protéine de type podocalyxine (podxl) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1339204C (fr) * | 1987-01-07 | 1997-08-05 | Joyce Taylor-Papadimitriou | Polypeptides, anticorps et sondes a noyau de mucine |
| EP0442926A1 (fr) * | 1988-11-10 | 1991-08-28 | Imperial Cancer Research Technology Limited | Polypeptides |
| US5353236A (en) * | 1992-04-23 | 1994-10-04 | The Board Of Trustees Of The Leland Stanford University | High-resolution crystallographic modelling of a macromolecule |
| US5453937A (en) * | 1993-04-28 | 1995-09-26 | Immunex Corporation | Method and system for protein modeling |
-
1997
- 1997-08-22 GB GBGB9717946.9A patent/GB9717946D0/en active Pending
-
1998
- 1998-08-24 EP EP98940371A patent/EP0996634A1/fr not_active Withdrawn
- 1998-08-24 IL IL13454798A patent/IL134547A0/xx unknown
- 1998-08-24 WO PCT/GB1998/002542 patent/WO1999010379A1/fr not_active Application Discontinuation
- 1998-08-24 CA CA002300370A patent/CA2300370A1/fr not_active Abandoned
- 1998-08-24 AU AU88711/98A patent/AU751386B2/en not_active Ceased
- 1998-08-24 JP JP2000507705A patent/JP2001514188A/ja active Pending
-
2000
- 2000-02-21 NO NO20000845A patent/NO20000845L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU751386B2 (en) | 2002-08-15 |
| NO20000845D0 (no) | 2000-02-21 |
| AU8871198A (en) | 1999-03-16 |
| EP0996634A1 (fr) | 2000-05-03 |
| WO1999010379A1 (fr) | 1999-03-04 |
| JP2001514188A (ja) | 2001-09-11 |
| IL134547A0 (en) | 2001-04-30 |
| NO20000845L (no) | 2000-04-25 |
| GB9717946D0 (en) | 1997-10-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued | ||
| FZDE | Discontinued |
Effective date: 20050824 |