CA2300203A1 - Systeme microfluidique a regulation electrofluidique et electrothermique - Google Patents

Systeme microfluidique a regulation electrofluidique et electrothermique Download PDF

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Publication number
CA2300203A1
CA2300203A1 CA002300203A CA2300203A CA2300203A1 CA 2300203 A1 CA2300203 A1 CA 2300203A1 CA 002300203 A CA002300203 A CA 002300203A CA 2300203 A CA2300203 A CA 2300203A CA 2300203 A1 CA2300203 A1 CA 2300203A1
Authority
CA
Canada
Prior art keywords
channel
fluid
temperature
current
substrate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002300203A
Other languages
English (en)
Inventor
Calvin Y. H. Chow
Anne R. Kopf-Sill
J. Wallace Parce
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Caliper Life Sciences Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/977,528 external-priority patent/US5965410A/en
Application filed by Individual filed Critical Individual
Priority to CA002510539A priority Critical patent/CA2510539A1/fr
Publication of CA2300203A1 publication Critical patent/CA2300203A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44756—Apparatus specially adapted therefor
    • G01N27/44791—Microapparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/143—Quality control, feedback systems
    • B01L2200/147—Employing temperature sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1822—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using Peltier elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1833—Means for temperature control using electrical currents in the sample itself
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1838—Means for temperature control using fluid heat transfer medium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Electrochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Devices For Use In Laboratory Experiments (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)

Abstract

La présente invention concerne un procédé et un dispositif de transport et/ou de surveillance d'un fluide dans un dispositif multiport utilisé dans un système microfluidique. Le dispositif multiport inclut un substrat comprenant une configuration définie du canal. Une première région du canal, définie dans le substrat, comporte un premier port et un second port permettant de transporter entre eux le fluide. Une seconde région du canal, également définie dans le substrat, comporte un premier port et un second port permettant d'appliquer un courant électrique servant à réchauffer le fluide ou à surveiller entre eux un paramètre du fluide. Selon certaines réalisations, le premier canal coupe le second canal. Les aspects chauffage ou surveillance de l'invention conviennent à une multitude de réactions biologiques, y compris l'amplification en chaîne par polymérase et la ligation répétitive d'oligonucléotides.
CA002300203A 1997-09-02 1998-08-27 Systeme microfluidique a regulation electrofluidique et electrothermique Abandoned CA2300203A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA002510539A CA2510539A1 (fr) 1997-09-02 1998-08-27 Systeme microfluidique a regulation electrofluidique et electrothermique

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US5605897P 1997-09-02 1997-09-02
US08/977,528 US5965410A (en) 1997-09-02 1997-11-25 Electrical current for controlling fluid parameters in microchannels
US8353298P 1998-04-29 1998-04-29
US08/977,528 1998-04-29
US60/056,058 1998-04-29
US60/083,532 1998-04-29
PCT/US1998/017910 WO1999012016A1 (fr) 1997-09-02 1998-08-27 Systeme microfluidique a regulation electrofluidique et electrothermique

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA002510539A Division CA2510539A1 (fr) 1997-09-02 1998-08-27 Systeme microfluidique a regulation electrofluidique et electrothermique

Publications (1)

Publication Number Publication Date
CA2300203A1 true CA2300203A1 (fr) 1999-03-11

Family

ID=27368961

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002300203A Abandoned CA2300203A1 (fr) 1997-09-02 1998-08-27 Systeme microfluidique a regulation electrofluidique et electrothermique

Country Status (5)

Country Link
EP (1) EP1009995A4 (fr)
JP (1) JP2001515204A (fr)
AU (1) AU746098B2 (fr)
CA (1) CA2300203A1 (fr)
WO (1) WO1999012016A1 (fr)

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EP1009995A1 (fr) 2000-06-21
AU9210398A (en) 1999-03-22
AU746098B2 (en) 2002-04-18
WO1999012016A1 (fr) 1999-03-11
EP1009995A4 (fr) 2007-05-02
JP2001515204A (ja) 2001-09-18

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