CA2297988A1 - Inhibiteurs de metalloproteases heterocycliques hybrides et substitues par de l'acide hydroxamique - Google Patents
Inhibiteurs de metalloproteases heterocycliques hybrides et substitues par de l'acide hydroxamique Download PDFInfo
- Publication number
- CA2297988A1 CA2297988A1 CA002297988A CA2297988A CA2297988A1 CA 2297988 A1 CA2297988 A1 CA 2297988A1 CA 002297988 A CA002297988 A CA 002297988A CA 2297988 A CA2297988 A CA 2297988A CA 2297988 A1 CA2297988 A1 CA 2297988A1
- Authority
- CA
- Canada
- Prior art keywords
- radicals
- alkyl
- radical
- aryl
- heteroaryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Virology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Cette invention concerne de nouveaux composés hétérocycliques hybrides et substitués par de l'acide hydroxamique qui correspondent à la formule (I) et sont efficaces pour la prophylaxie et le traitement d'inflammations, de la dégradation tissulaire et des affections apparentées. Cette invention concerne de nouveaux composés, des analogues, des promédicaments et leurs sels pharmaceutiquement acceptables, des compositions pharmaceutiques ainsi que des procédés pour la prophylaxie et le traitement d'inflammations, de la dégradation tissulaire et des affections apparentées. L'invention se rapporte également à des processus permettant d'obtenir ces composés ainsi qu'à des produits intermédiaires utiles dans ces processus (I).
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5475397P | 1997-08-04 | 1997-08-04 | |
US60/054,753 | 1997-08-04 | ||
US12851298A | 1998-08-03 | 1998-08-03 | |
US09/128,512 | 1998-08-03 | ||
PCT/US1998/016147 WO1999006410A1 (fr) | 1997-08-04 | 1998-08-04 | Inhibiteurs de metalloproteases heterocycliques hybrides et substitues par de l'acide hydroxamique |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2297988A1 true CA2297988A1 (fr) | 1999-02-11 |
Family
ID=26733456
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002297988A Abandoned CA2297988A1 (fr) | 1997-08-04 | 1998-08-04 | Inhibiteurs de metalloproteases heterocycliques hybrides et substitues par de l'acide hydroxamique |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1003751A1 (fr) |
JP (1) | JP2003524572A (fr) |
AU (1) | AU8766498A (fr) |
CA (1) | CA2297988A1 (fr) |
WO (1) | WO1999006410A1 (fr) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000023443A1 (fr) * | 1998-10-22 | 2000-04-27 | Akzo Nobel N.V. | Derives de tetrahydropyridopyridine, et produits intermediaires permettant de produire lesdits derives |
FR2795730B1 (fr) * | 1999-07-01 | 2001-08-31 | Adir | Nouveaux inhibiteurs de metalloproteases, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
EP1219607B1 (fr) * | 1999-09-02 | 2011-04-06 | Shionogi & Co., Ltd. | Inhibiteur d'integrase contenant des derives heterocycliques aromatiques |
US6808902B1 (en) | 1999-11-12 | 2004-10-26 | Amgen Inc. | Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules |
DK2270052T3 (en) | 2001-06-26 | 2018-07-02 | Amgen Inc | Antibodies to OPGL |
KR20060052867A (ko) * | 2003-07-23 | 2006-05-19 | 엑셀리시스, 인코포레이티드 | 약제로서의 아제핀 유도체 |
DE102004004974A1 (de) * | 2004-01-31 | 2005-08-18 | Aventis Pharma Deutschland Gmbh | Thieno-Iminosäure-Derivate als Inhibitoren von Matrix-Metalloproteinasen |
DE102005002500A1 (de) | 2005-01-19 | 2006-07-27 | Sanofi-Aventis Deutschland Gmbh | Tetrahydrofuranderivate als Inhibitoren von Matrix-Metalloproteinasen |
SG121932A1 (en) * | 2005-07-27 | 2006-05-26 | Takenaka Corp | Mobile building platform |
NZ584279A (en) | 2007-09-19 | 2011-11-25 | 4Sc Ag | Novel tetrahydrofusedpyridines as histone deacetylase inhibitors |
EP2318361B1 (fr) * | 2008-07-14 | 2015-09-23 | Novartis AG | Inhibiteurs sélectifs de mmp-12 et mmp-13 à base d acide hydroxamique |
US10531655B2 (en) | 2011-12-02 | 2020-01-14 | The Regents Of The University Of California | Reperfusion protection solution and uses thereof |
AU2019352741A1 (en) | 2018-10-04 | 2021-05-06 | Assistance Publique-Hôpitaux De Paris (Aphp) | EGFR inhibitors for treating keratodermas |
CN113387959B (zh) * | 2021-06-24 | 2023-05-05 | 烟台理工学院 | 一种噻吩并[3,2-c]吡啶-6-羧酸甲酯的合成方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100475206B1 (ko) * | 1995-11-13 | 2005-12-16 | 훽스트 악티엔게젤샤프트 | 사이클릭및헤테로사이클릭N-치환된α-이미노하이드록삼산및카복실산 |
FR2748026B1 (fr) * | 1996-04-26 | 1998-06-05 | Adir | Nouveaux inhibiteurs de metalloproteases, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
-
1998
- 1998-08-04 WO PCT/US1998/016147 patent/WO1999006410A1/fr not_active Application Discontinuation
- 1998-08-04 CA CA002297988A patent/CA2297988A1/fr not_active Abandoned
- 1998-08-04 AU AU87664/98A patent/AU8766498A/en not_active Abandoned
- 1998-08-04 JP JP2000505168A patent/JP2003524572A/ja not_active Withdrawn
- 1998-08-04 EP EP98939182A patent/EP1003751A1/fr not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
EP1003751A1 (fr) | 2000-05-31 |
JP2003524572A (ja) | 2003-08-19 |
AU8766498A (en) | 1999-02-22 |
WO1999006410A1 (fr) | 1999-02-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
FZDE | Dead |