CA2295474A1 - 123 human secreted proteins - Google Patents
123 human secreted proteins Download PDFInfo
- Publication number
- CA2295474A1 CA2295474A1 CA002295474A CA2295474A CA2295474A1 CA 2295474 A1 CA2295474 A1 CA 2295474A1 CA 002295474 A CA002295474 A CA 002295474A CA 2295474 A CA2295474 A CA 2295474A CA 2295474 A1 CA2295474 A1 CA 2295474A1
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- Biochemistry (AREA)
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Applications Claiming Priority (65)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5279597P | 1997-07-08 | 1997-07-08 | |
| US5193197P | 1997-07-08 | 1997-07-08 | |
| US5192997P | 1997-07-08 | 1997-07-08 | |
| US5192597P | 1997-07-08 | 1997-07-08 | |
| US5280397P | 1997-07-08 | 1997-07-08 | |
| US5192897P | 1997-07-08 | 1997-07-08 | |
| US5279397P | 1997-07-08 | 1997-07-08 | |
| US5191897P | 1997-07-08 | 1997-07-08 | |
| US5273397P | 1997-07-08 | 1997-07-08 | |
| US5192697P | 1997-07-08 | 1997-07-08 | |
| US5191697P | 1997-07-08 | 1997-07-08 | |
| US5193097P | 1997-07-08 | 1997-07-08 | |
| US5192097P | 1997-07-08 | 1997-07-08 | |
| US5193297P | 1997-07-08 | 1997-07-08 | |
| US5273297P | 1997-07-08 | 1997-07-08 | |
| US5191997P | 1997-07-08 | 1997-07-08 | |
| US60/051,918 | 1997-07-08 | ||
| US60/052,793 | 1997-07-08 | ||
| US60/052,803 | 1997-07-08 | ||
| US60/051,916 | 1997-07-08 | ||
| US60/051,932 | 1997-07-08 | ||
| US60/051,928 | 1997-07-08 | ||
| US60/051,929 | 1997-07-08 | ||
| US60/051,930 | 1997-07-08 | ||
| US60/052,732 | 1997-07-08 | ||
| US60/051,931 | 1997-07-08 | ||
| US60/051,926 | 1997-07-08 | ||
| US60/052,795 | 1997-07-08 | ||
| US60/051,920 | 1997-07-08 | ||
| US60/052,733 | 1997-07-08 | ||
| US60/051,925 | 1997-07-08 | ||
| US5594797P | 1997-08-18 | 1997-08-18 | |
| US5595097P | 1997-08-18 | 1997-08-18 | |
| US5572297P | 1997-08-18 | 1997-08-18 | |
| US5636097P | 1997-08-18 | 1997-08-18 | |
| US5595397P | 1997-08-18 | 1997-08-18 | |
| US5594997P | 1997-08-18 | 1997-08-18 | |
| US5595497P | 1997-08-18 | 1997-08-18 | |
| US5594897P | 1997-08-18 | 1997-08-18 | |
| US5568497P | 1997-08-18 | 1997-08-18 | |
| US5572397P | 1997-08-18 | 1997-08-18 | |
| US5596497P | 1997-08-18 | 1997-08-18 | |
| US5598497P | 1997-08-18 | 1997-08-18 | |
| US60/055,723 | 1997-08-18 | ||
| US60/056,360 | 1997-08-18 | ||
| US60/055,948 | 1997-08-18 | ||
| US60/055,950 | 1997-08-18 | ||
| US60/055,964 | 1997-08-18 | ||
| US60/055,954 | 1997-08-18 | ||
| US60/055,722 | 1997-08-18 | ||
| US60/055,684 | 1997-08-18 | ||
| US60/055,953 | 1997-08-18 | ||
| US60/055,949 | 1997-08-18 | ||
| US60/055,947 | 1997-08-18 | ||
| US5866497P | 1997-09-12 | 1997-09-12 | |
| US5866097P | 1997-09-12 | 1997-09-12 | |
| US5866197P | 1997-09-12 | 1997-09-12 | |
| US5878597P | 1997-09-12 | 1997-09-12 | |
| US60/058,785 | 1997-09-12 | ||
| US60/058,660 | 1997-09-12 | ||
| US60/058,664 | 1997-09-12 | ||
| US60/058,661 | 1997-09-12 | ||
| US60/051,919 | 1997-10-02 | ||
| US60/055,984 | 1997-10-02 | ||
| PCT/US1998/013684 WO1999002546A1 (en) | 1997-07-08 | 1998-07-07 | 123 human secreted proteins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2295474A1 true CA2295474A1 (en) | 1999-01-21 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002295474A Abandoned CA2295474A1 (en) | 1997-07-08 | 1998-07-07 | 123 human secreted proteins |
Country Status (5)
| Country | Link |
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| US (3) | US6342581B1 (enExample) |
| EP (1) | EP1000084A4 (enExample) |
| JP (1) | JP2002513295A (enExample) |
| CA (1) | CA2295474A1 (enExample) |
| WO (1) | WO1999002546A1 (enExample) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999002546A1 (en) | 1997-07-08 | 1999-01-21 | Human Genome Sciences, Inc. | 123 human secreted proteins |
| WO2000047602A1 (en) * | 1999-02-10 | 2000-08-17 | Human Genome Sciences, Inc. | 33 human secreted proteins |
| PT1003861E (pt) * | 1997-08-01 | 2007-01-31 | Schering Corp | Proteínas de membrana de células de mamíferos;reagentes relacionados |
| EP0949332A3 (en) * | 1998-04-01 | 2001-03-28 | Smithkline Beecham Plc | HSSCRG1 polypeptides |
| WO1999060124A2 (en) * | 1998-05-15 | 1999-11-25 | Fei Huang | Differentiation-associated sequences and methods of use therefor |
| US6753154B1 (en) * | 1998-06-26 | 2004-06-22 | The Regents Of The University Of California | Human AZU-1 gene, variants thereof and expressed gene products |
| EP1114153A2 (en) * | 1998-09-18 | 2001-07-11 | The Rockefeller University | Lynx, a novel family of receptor ligands in the central nervous system, corresponding nucleic acids and proteins and uses therof |
| BR9914465A (pt) * | 1998-09-29 | 2001-10-09 | Gamida Cell Ltd | Métodos para controlar a proliferação e a diferenciação de células-tronco e células progenitoras e uma composição farmacêutica para induzir a diferenciação em uma população de células |
| US6544946B1 (en) | 1999-02-19 | 2003-04-08 | Zymogenetics, Inc. | Inhibitors for use in hemostasis and immune function |
| EP1382345A3 (en) | 1999-02-19 | 2004-01-28 | Zymogenetics Inc | Uses of inhibitors of hemostasis |
| EP1181037A4 (en) * | 1999-05-01 | 2006-01-18 | Genaera Corp | FACTORS ASSOCIATED WITH ASTHMA AS TARGETS FOR TREATING ATOPIC ALLERGIES, ESPECIALLY ASTHMA AND RELATED DISORDERS |
| WO2000073448A1 (en) * | 1999-05-27 | 2000-12-07 | Zymogenetics, Inc. | Adipocyte complement related protein homolog zacrp7 |
| CA2377263A1 (en) * | 1999-06-23 | 2000-12-28 | Curagen Corporation | Polynucleotides and polypeptides encoded thereby |
| AU1392801A (en) * | 1999-11-10 | 2001-06-06 | Smithkline Beecham Biologicals (Sa) | Casb7434, an antigen over-expressed in colon cancer |
| EP1239035A4 (en) * | 1999-12-17 | 2005-04-06 | Mitsubishi Pharma Corp | PROTEIN AND GEN |
| WO2001068806A2 (en) * | 2000-03-10 | 2001-09-20 | Millennium Pharmaceuticals, Inc. | 26934, a novel cytidine deaminase-like molecule and uses thereof |
| US20030096315A1 (en) | 2000-05-03 | 2003-05-22 | Sanders Mitchell C. | Device for detecting bacterial contamination and method of use |
| US20020111302A1 (en) * | 2000-11-30 | 2002-08-15 | Y. Tom Tang | Novel nucleic acids and polypeptides |
| WO2002080852A2 (en) * | 2001-04-04 | 2002-10-17 | Digital Gene Technologies, Inc. | Genes expressed in intestinal epithelium and peyer's patch m cells |
| IL152904A0 (en) * | 2002-01-24 | 2003-06-24 | Gamida Cell Ltd | Utilization of retinoid and vitamin d receptor antagonists for expansion of renewable stem cell populations |
| WO2003062404A1 (en) * | 2002-01-25 | 2003-07-31 | Gamida-Cell Ltd. | Methods of expanding stem and progenitor cells and expanded cell populations obtained thereby |
| EP1576181B1 (en) * | 2002-01-31 | 2013-08-14 | Systagenix Wound Management IP Co. BV. | Method for detecting pathogenic bacteria in wounds |
| WO2003074546A2 (de) * | 2002-03-01 | 2003-09-12 | Erdmann Volker A | Streptavidin-bindungspeptid |
| GB0208925D0 (en) * | 2002-04-12 | 2002-05-29 | Univ Sheffield | Polypeptide |
| EP1557466B1 (en) * | 2002-09-27 | 2009-09-02 | Dainippon Sumitomo Pharma Co., Ltd. | Tumor antigen protein and utilization thereof |
| ATE440284T1 (de) * | 2003-01-09 | 2009-09-15 | Beth Israel Hospital | Verwendung von adiponectin zur diagnose von krebs |
| AU2004225575B2 (en) * | 2003-01-31 | 2008-02-21 | Ethicon, Inc. | Method for detecting escherichia coli |
| WO2004072268A2 (en) * | 2003-02-12 | 2004-08-26 | Mayo Foundation For Medical Education And Research | Pkhdl1, a homolog of the autosomal recessive kidney disease gene |
| US7312197B2 (en) * | 2003-02-24 | 2007-12-25 | University Of Maryland, Baltimore | Method of modifying glucose activity using polypeptides selectively expressed in fat tissue |
| US20050075543A1 (en) * | 2003-10-03 | 2005-04-07 | Calabrese Charles A. | Method of anonymous medical testing and providing the patient with the test results |
| JP4864715B2 (ja) | 2003-11-03 | 2012-02-01 | エチコン・インコーポレーテツド | 細菌の広域スペクトルの検出に有用な方法、ペプチドおよびバイオセンサー |
| US20070210713A1 (en) * | 2004-04-08 | 2007-09-13 | Sen Engineering Co., Ltd. | Dielectric Barrier Discharge Excimer Light Source |
| WO2006030442A2 (en) * | 2004-09-16 | 2006-03-23 | Gamida-Cell Ltd. | Methods of ex vivo progenitor and stem cell expansion by co-culture with mesenchymal cells |
| JP5041231B2 (ja) * | 2005-02-15 | 2012-10-03 | 東亞合成株式会社 | 抗菌ペプチド及びその利用 |
| US8846393B2 (en) | 2005-11-29 | 2014-09-30 | Gamida-Cell Ltd. | Methods of improving stem cell homing and engraftment |
| US8058014B2 (en) * | 2006-09-29 | 2011-11-15 | University Of Maryland, Baltimore | Method of diagnosing or predicting disease states in a subject using omentin 1 and omentin 2 |
| BRPI0720219A2 (pt) | 2006-12-08 | 2013-12-24 | Univ Iowa State Res Found Inc | Genes de planta envolvidos em absorção e metabolismo de nitrato |
| RU2607569C2 (ru) * | 2008-03-31 | 2017-01-10 | Дженентек, Инк. | Композиции и способы для лечения и диагностики астмы |
| US8082730B2 (en) * | 2008-05-20 | 2011-12-27 | Caterpillar Inc. | Engine system having particulate reduction device and method |
| US9260499B2 (en) | 2008-10-20 | 2016-02-16 | Sapporo Medical University | Tumor antigen peptide and use thereof |
| KR101615474B1 (ko) | 2010-12-16 | 2016-04-25 | 제넨테크, 인크. | Th2 억제에 관한 진단 및 치료 |
| EP2714096B1 (en) | 2011-06-03 | 2018-02-28 | Ophidion Inc. | Compositions and methods for transport across the blood brain barrier |
| JP6348848B2 (ja) | 2012-02-13 | 2018-06-27 | ガミダ セル リミテッド | 間葉系幹細胞の増殖 |
| US9567569B2 (en) | 2012-07-23 | 2017-02-14 | Gamida Cell Ltd. | Methods of culturing and expanding mesenchymal stem cells |
| US9175266B2 (en) | 2012-07-23 | 2015-11-03 | Gamida Cell Ltd. | Enhancement of natural killer (NK) cell proliferation and activity |
| EP2970884A4 (en) | 2013-03-14 | 2016-11-02 | Univ Florida | DI-AMINO ACID-REINFORCED PROTEINS ASSOCIATED WITH ALS |
| WO2016196324A1 (en) | 2015-05-29 | 2016-12-08 | University Of Floridia Research Foundation, Inc. | Methods for diagnosing huntington's disease |
| US10940161B2 (en) | 2016-04-04 | 2021-03-09 | University Of Florida Research Foundation, Incorporated | Manipulation of EIF3 to modulate repeat associated non-ATG (RAN) translation |
| MX389549B (es) * | 2016-04-06 | 2025-03-20 | Plant Health Care Inc | Peptidos derivados de inductores de respuesta de hipersensibilidad y su uso. |
| JP7526455B2 (ja) | 2017-04-17 | 2024-08-01 | ユニバーシティー オブ フロリダ リサーチ ファンデーション, インク. | PKRおよびeIF2A-P経路によるRANタンパク質翻訳の調節 |
| CN110753555A (zh) | 2017-04-19 | 2020-02-04 | 得克萨斯州大学系统董事会 | 表达工程化抗原受体的免疫细胞 |
| JP7350337B2 (ja) | 2017-09-26 | 2023-09-26 | ユニバーシティー オブ フロリダ リサーチ ファンデーション, インク. | 神経障害の処置においてranタンパク質レベルを低下させるためのメトホルミンおよびそのアナログの使用 |
| EP3755349A4 (en) | 2018-02-21 | 2021-11-17 | Board of Regents, The University of Texas System | PROCESS FOR ACTIVATION AND EXPANSION OF NATURAL KILLER CELLS AND THEIR USES |
| JP7620988B2 (ja) | 2019-09-20 | 2025-01-24 | ユニバーシティー オブ フロリダ リサーチ ファンデーション, インク. | 血清および組織ライセートからのranタンパク質に対する抗体の検出 |
| CN114349826B (zh) * | 2022-02-14 | 2023-05-30 | 山东省科学院生物研究所 | 抗菌肽cgs7及其制备方法和应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5580753A (en) * | 1989-05-23 | 1996-12-03 | Ludwig Institute For Cancer Research | DNA encoding the human cytokine, interleukin-9 |
| NZ301067A (en) * | 1994-12-06 | 1998-03-25 | Immunex Corp | Cytokine designated lerk-7 for activating tyrosine kinases |
| US5707829A (en) * | 1995-08-11 | 1998-01-13 | Genetics Institute, Inc. | DNA sequences and secreted proteins encoded thereby |
| WO1999002546A1 (en) | 1997-07-08 | 1999-01-21 | Human Genome Sciences, Inc. | 123 human secreted proteins |
| DE19733389C2 (de) | 1997-08-01 | 1999-08-19 | Deutsches Krebsforsch | Mittel zur Expression und zum Nachweis eines ein HPOL-Epitop und ein Polypeptid enthaltenden Fusionspolypeptids |
| DE69835751T2 (de) | 1997-08-01 | 2007-10-04 | Serono Genetics Institute S.A. | 5' ests für proteine, die nicht gewebespezifisch sind |
| US6416973B1 (en) | 1997-08-01 | 2002-07-09 | Schering Corporation | Nucleic acids encoding mammalian cell membrane protein MDL-1 |
| EP1114153A2 (en) | 1998-09-18 | 2001-07-11 | The Rockefeller University | Lynx, a novel family of receptor ligands in the central nervous system, corresponding nucleic acids and proteins and uses therof |
| EP1414845A4 (en) | 2001-03-21 | 2009-07-08 | Human Genome Sciences | SEPARATE HUMAN PROTEINS |
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1998
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- 1998-07-07 JP JP50874499A patent/JP2002513295A/ja not_active Withdrawn
- 1998-07-07 EP EP98935509A patent/EP1000084A4/en not_active Withdrawn
- 1998-07-07 CA CA002295474A patent/CA2295474A1/en not_active Abandoned
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1999
- 1999-01-08 US US09/227,357 patent/US6342581B1/en not_active Expired - Fee Related
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2001
- 2001-10-25 US US09/983,802 patent/US7105644B2/en not_active Expired - Fee Related
- 2001-10-30 US US09/984,490 patent/US20030064412A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20030022185A1 (en) | 2003-01-30 |
| EP1000084A4 (en) | 2003-03-26 |
| JP2002513295A (ja) | 2002-05-08 |
| WO1999002546A1 (en) | 1999-01-21 |
| US6342581B1 (en) | 2002-01-29 |
| US7105644B2 (en) | 2006-09-12 |
| EP1000084A1 (en) | 2000-05-17 |
| US20030064412A1 (en) | 2003-04-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |