CA2295098A1 - Calcium blockers to treat proliferative vitreoretinopathy - Google Patents
Calcium blockers to treat proliferative vitreoretinopathy Download PDFInfo
- Publication number
- CA2295098A1 CA2295098A1 CA002295098A CA2295098A CA2295098A1 CA 2295098 A1 CA2295098 A1 CA 2295098A1 CA 002295098 A CA002295098 A CA 002295098A CA 2295098 A CA2295098 A CA 2295098A CA 2295098 A1 CA2295098 A1 CA 2295098A1
- Authority
- CA
- Canada
- Prior art keywords
- compound
- patient
- glutamate
- retinal
- proliferative vitreoretinopathy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 230000006785 proliferative vitreoretinopathy Effects 0.000 title claims abstract description 21
- 206010038934 Retinopathy proliferative Diseases 0.000 title claims abstract description 20
- 208000002158 Proliferative Vitreoretinopathy Diseases 0.000 title claims abstract description 19
- 208000021971 neovascular inflammatory vitreoretinopathy Diseases 0.000 title claims abstract description 19
- 239000011575 calcium Substances 0.000 title description 10
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 title description 4
- 229910052791 calcium Inorganic materials 0.000 title description 4
- 150000001875 compounds Chemical class 0.000 claims abstract description 45
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Ophthalmology & Optometry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| US60/051,962 | 1997-06-30 | ||
| PCT/US1998/012414 WO1999000129A1 (en) | 1997-06-30 | 1998-06-15 | Calcium blockers to treat proliferative vitreoretinopathy |
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| CA2295098A1 true CA2295098A1 (en) | 1999-01-07 |
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| CA002295098A Abandoned CA2295098A1 (en) | 1997-06-30 | 1998-06-15 | Calcium blockers to treat proliferative vitreoretinopathy |
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| CA (1) | CA2295098A1 (https=) |
| WO (1) | WO1999000129A1 (https=) |
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| US20050009884A1 (en) * | 1997-06-30 | 2005-01-13 | Dreyer Evan B. | Calcium blockers to treat proliferative retinal diseases |
| WO2000007584A2 (en) * | 1998-08-04 | 2000-02-17 | Wisconsin Alumni Research Foundation | Method of reducing retinal ganglion cell degeneration |
| US6509355B1 (en) * | 1998-10-27 | 2003-01-21 | Alcon Laboratories, Inc. | Treatment of disorders of the outer retina |
| CA2356382A1 (en) * | 1998-12-24 | 2000-07-06 | R-Tech Ueno, Ltd. | Agent for treating visual cell function disorder |
| US6864232B1 (en) | 1998-12-24 | 2005-03-08 | Sucampo Ag | Agent for treating visual cell function disorder |
| JP2002182418A (ja) * | 2000-12-11 | 2002-06-26 | Konica Corp | 画像形成方法、画像形成装置 |
| FR2822706A1 (fr) * | 2001-03-29 | 2002-10-04 | Univ Pasteur | Utilisation de composes organiques antagonistes de recepteurs pour le traitement de la degenerescence retinienne |
| US8557855B2 (en) * | 2002-07-03 | 2013-10-15 | Allergan, Inc. | Methods of using ryanodine antagonists in treating neural injury |
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| US20050147584A1 (en) * | 2004-01-05 | 2005-07-07 | Allergan, Inc. | Compositions and methods comprising memantine and polyanionic polymers |
| US20050250737A1 (en) * | 2003-11-12 | 2005-11-10 | Allergan, Inc. | Therapeutic ophthalmic compositions containing retinal friendly excipients and related methods |
| US20050101582A1 (en) | 2003-11-12 | 2005-05-12 | Allergan, Inc. | Compositions and methods for treating a posterior segment of an eye |
| US20060141049A1 (en) * | 2003-11-12 | 2006-06-29 | Allergan, Inc. | Triamcinolone compositions for intravitreal administration to treat ocular conditions |
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| US20050277698A1 (en) * | 2004-01-05 | 2005-12-15 | Hughes Patrick M | Memantine delivery to the back of the eye |
| EP1706095B1 (en) | 2004-01-20 | 2008-12-24 | Allergan, Inc. | Compositions for localized therapy of the eye, comprising preferably triamcinolone acetonide and hyaluronic acid |
| NZ550088A (en) * | 2004-04-06 | 2009-08-28 | Angiogenetics Sweden Ab | Angiogenesis-affecting compounds and methods of use thereof |
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| US7122128B2 (en) * | 2004-04-29 | 2006-10-17 | General Electric Company | Phosphors containing borate of terbium, alkaline-earth, and Group-3 metals, and light sources incorporating the same |
| US8673341B2 (en) * | 2004-04-30 | 2014-03-18 | Allergan, Inc. | Intraocular pressure reduction with intracameral bimatoprost implants |
| US7771742B2 (en) | 2004-04-30 | 2010-08-10 | Allergan, Inc. | Sustained release intraocular implants containing tyrosine kinase inhibitors and related methods |
| US8455656B2 (en) | 2004-04-30 | 2013-06-04 | Allergan, Inc. | Kinase inhibitors |
| US8591885B2 (en) * | 2004-04-30 | 2013-11-26 | Allergan, Inc. | Carbonic anhydrase inhibitor sustained release intraocular drug delivery systems |
| US7799336B2 (en) | 2004-04-30 | 2010-09-21 | Allergan, Inc. | Hypotensive lipid-containing biodegradable intraocular implants and related methods |
| US9498457B2 (en) | 2004-04-30 | 2016-11-22 | Allergan, Inc. | Hypotensive prostamide-containing biodegradable intraocular implants and related implants |
| US8722097B2 (en) | 2004-04-30 | 2014-05-13 | Allergan, Inc. | Oil-in-water method for making polymeric implants containing a hypotensive lipid |
| US20050244462A1 (en) * | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Devices and methods for treating a mammalian eye |
| US8119154B2 (en) * | 2004-04-30 | 2012-02-21 | Allergan, Inc. | Sustained release intraocular implants and related methods |
| US20050244471A1 (en) * | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Estradiol derivative and estratopone containing sustained release intraocular implants and related methods |
| US20050244466A1 (en) * | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Photodynamic therapy in conjunction with intraocular implants |
| US8512738B2 (en) | 2004-04-30 | 2013-08-20 | Allergan, Inc. | Biodegradable intravitreal tyrosine kinase implants |
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| US8147865B2 (en) * | 2004-04-30 | 2012-04-03 | Allergan, Inc. | Steroid-containing sustained release intraocular implants and related methods |
| US20070059336A1 (en) * | 2004-04-30 | 2007-03-15 | Allergan, Inc. | Anti-angiogenic sustained release intraocular implants and related methods |
| WO2005110374A1 (en) * | 2004-04-30 | 2005-11-24 | Allergan, Inc. | Intraocular drug delivery systems containing a therapeutic component, a cyclodextrin, and a polymeric component |
| US20050244458A1 (en) | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Sustained release intraocular implants and methods for treating ocular neuropathies |
| US8425929B2 (en) * | 2004-04-30 | 2013-04-23 | Allergan, Inc. | Sustained release intraocular implants and methods for preventing retinal dysfunction |
| US7993634B2 (en) | 2004-04-30 | 2011-08-09 | Allergan, Inc. | Oil-in-oil emulsified polymeric implants containing a hypotensive lipid and related methods |
| US20050244478A1 (en) * | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Anti-excititoxic sustained release intraocular implants and related methods |
| CA2573668A1 (en) * | 2004-07-12 | 2006-02-16 | Allergan, Inc. | Ophthalmic compositions and methods for treating ophthalmic conditions |
| EP1776097A1 (en) * | 2004-07-26 | 2007-04-25 | Allergan, Inc. | Methods of treating ophthalmic conditions |
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| US4755388A (en) * | 1984-11-09 | 1988-07-05 | The Regents Of The University Of California | Liposome-encapsulated 5-fluoropyrimidines and methods for their use |
| WO1990006123A1 (en) * | 1988-12-05 | 1990-06-14 | Houston Biotechnology Incorporated | Therapeutic use of calcium entry blockers in retinal or optic nerve dysfunction |
| ZA906583B (en) * | 1989-08-21 | 1991-09-25 | Beth Israel Hospital | Method and composition for the treatment of cutaneous,ocular,and mucosal hypersensitivity,inflammatory,and hyperproliferative conditions using topical preparations of nifedipine |
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| FR2717080B1 (fr) | 1994-03-09 | 1996-12-13 | Synthelabo | Utilisation de l'éliprodil et de ses énantiomères pour la préparation de médicaments utiles dans le traitement des neuropathies périphériques et des maladies neurodégénératives centrales. |
| US5516522A (en) * | 1994-03-14 | 1996-05-14 | Board Of Supervisors Of Louisiana State University | Biodegradable porous device for long-term drug delivery with constant rate release and method of making the same |
| US5597809A (en) * | 1994-06-23 | 1997-01-28 | Massachusetts Eye & Ear Infirmary | Treatment of optic neuritis |
| US5710165A (en) * | 1994-07-06 | 1998-01-20 | Synthelabo | Use of polyamine antagonists for the treatment of glaucoma |
| US5431907A (en) * | 1994-08-03 | 1995-07-11 | Abelson; Mark B. | Treatment of vascular disorders of the posterior segment of the eye by topical administration of calcium channel blocking agents |
| US5623051A (en) * | 1994-11-10 | 1997-04-22 | University Of Washington | Methods and compositions for screening for presynaptic calcium channel blockers |
| US5604244A (en) | 1995-06-07 | 1997-02-18 | Alcon Laboratories, Inc. | Intraocular irrigating solution containing a polyamine antagonist |
| FR2738567B1 (fr) | 1995-09-08 | 1997-10-17 | Synthelabo | Derives de alpha-phenylpiperidine-1-propanol, leur preparation et leur application en therapeutique |
| SI0848707T1 (en) | 1995-09-08 | 2000-02-29 | Sanofi-Synthelabo | 4-(cycloalkyl)piperidines and 4-(cycloalkylalkyl)-piperidines derivatives, preparation thereof and therapeutical applications thereof |
| FR2738568B1 (fr) | 1995-09-08 | 1997-10-17 | Synthelabo | Derives de 4-(cycloalkyl)piperidines et 4-(cycloalkylalkyl) piperidines, leur preparation et leur application en therapeutique |
| EP0994709A4 (en) | 1997-06-30 | 2006-02-01 | Allergan Inc | CALCIUM BLOCKER FOR THE TREATMENT OF PROLIFERATIVE VITREORETINOPATHY |
| US6509355B1 (en) | 1998-10-27 | 2003-01-21 | Alcon Laboratories, Inc. | Treatment of disorders of the outer retina |
| US6482854B1 (en) | 1999-03-25 | 2002-11-19 | Massachusetts Eye And Ear Infirmary | Glaucoma treatment |
-
1998
- 1998-06-15 EP EP98930231A patent/EP0994709A4/en not_active Ceased
- 1998-06-15 AU AU79672/98A patent/AU727080B2/en not_active Ceased
- 1998-06-15 WO PCT/US1998/012414 patent/WO1999000129A1/en not_active Ceased
- 1998-06-15 CA CA002295098A patent/CA2295098A1/en not_active Abandoned
- 1998-06-15 JP JP50558099A patent/JP2002511868A/ja not_active Ceased
- 1998-06-15 US US09/445,832 patent/US6380261B1/en not_active Expired - Lifetime
-
2002
- 2002-01-02 US US10/038,215 patent/US6573280B2/en not_active Expired - Fee Related
-
2003
- 2003-05-12 US US10/436,902 patent/US7230032B2/en not_active Expired - Fee Related
-
2004
- 2004-07-06 US US10/885,422 patent/US8101635B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20050192322A1 (en) | 2005-09-01 |
| US7230032B2 (en) | 2007-06-12 |
| EP0994709A1 (en) | 2000-04-26 |
| US6573280B2 (en) | 2003-06-03 |
| AU7967298A (en) | 1999-01-19 |
| AU727080B2 (en) | 2000-11-30 |
| EP0994709A4 (en) | 2006-02-01 |
| US20030060510A1 (en) | 2003-03-27 |
| US8101635B2 (en) | 2012-01-24 |
| WO1999000129A1 (en) | 1999-01-07 |
| US6380261B1 (en) | 2002-04-30 |
| JP2002511868A (ja) | 2002-04-16 |
| US20030199551A1 (en) | 2003-10-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |