CA2294646A1 - Sous-unite de telomerase catalytique humaine et son utilisation therapeutique et diagnostique - Google Patents

Sous-unite de telomerase catalytique humaine et son utilisation therapeutique et diagnostique Download PDF

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Publication number
CA2294646A1
CA2294646A1 CA002294646A CA2294646A CA2294646A1 CA 2294646 A1 CA2294646 A1 CA 2294646A1 CA 002294646 A CA002294646 A CA 002294646A CA 2294646 A CA2294646 A CA 2294646A CA 2294646 A1 CA2294646 A1 CA 2294646A1
Authority
CA
Canada
Prior art keywords
telomerase
sequence
leu
arg
htc
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002294646A
Other languages
English (en)
Inventor
Gustav Hagen
Hans-Ulrich Siegmund
Walter Weichel
Maresa Wick
Dmitry Zubov
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE1998116496 external-priority patent/DE19816496A1/de
Application filed by Individual filed Critical Individual
Publication of CA2294646A1 publication Critical patent/CA2294646A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

L'invention concerne la séquence nucléotide et la séquence protéine qui en dérive, codant pour la sous-unité de télomérase catalytique humaine. L'invention concerne en outre des procédés impliquant une utilisation pharmaceutique, thérapeutique ou diagnostique de ce gène/protéine, principalement pour le traitement du cancer et du vieillissement.
CA002294646A 1997-06-20 1998-06-09 Sous-unite de telomerase catalytique humaine et son utilisation therapeutique et diagnostique Abandoned CA2294646A1 (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
DE19726329 1997-06-20
DE19813274 1998-03-26
DE19816496.3 1998-04-14
DE19813274.3 1998-04-14
DE1998116496 DE19816496A1 (de) 1998-04-14 1998-04-14 Humane katalytische Telomerase-Untereinheit und deren diagnostische und therapeutische Verwendung
DE19726329.1 1998-04-14
PCT/EP1998/003468 WO1998059040A2 (fr) 1997-06-20 1998-06-09 Sous-unite de telomerase catalytique humaine et son utilisation therapeutique et diagnostique

Publications (1)

Publication Number Publication Date
CA2294646A1 true CA2294646A1 (fr) 1998-12-30

Family

ID=27217480

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002294646A Abandoned CA2294646A1 (fr) 1997-06-20 1998-06-09 Sous-unite de telomerase catalytique humaine et son utilisation therapeutique et diagnostique

Country Status (5)

Country Link
EP (1) EP0990037A2 (fr)
JP (1) JP2002508662A (fr)
AU (1) AU745420B2 (fr)
CA (1) CA2294646A1 (fr)
WO (1) WO1998059040A2 (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE219151T1 (de) 1995-11-16 2002-06-15 Michael W Dahm Verfahren zur quantifizierung von tumorzellen in einer körperflüssigkeit und dazu geeignete testkits
US6808880B2 (en) 1996-10-01 2004-10-26 Geron Corporation Method for detecting polynucleotides encoding telomerase
US6610839B1 (en) 1997-08-14 2003-08-26 Geron Corporation Promoter for telomerase reverse transcriptase
US6093809A (en) 1996-10-01 2000-07-25 University Technology Corporation Telomerase
US7585622B1 (en) 1996-10-01 2009-09-08 Geron Corporation Increasing the proliferative capacity of cells using telomerase reverse transcriptase
DE69739497D1 (de) * 1996-10-01 2009-08-27 Geron Corp Menschlische Telomerase katalytische Untereinheit
US6475789B1 (en) 1996-10-01 2002-11-05 University Technology Corporation Human telomerase catalytic subunit: diagnostic and therapeutic methods
US6261836B1 (en) 1996-10-01 2001-07-17 Geron Corporation Telomerase
US7413864B2 (en) 1997-04-18 2008-08-19 Geron Corporation Treating cancer using a telomerase vaccine
US7622549B2 (en) 1997-04-18 2009-11-24 Geron Corporation Human telomerase reverse transcriptase polypeptides
EP1571215A3 (fr) * 1997-07-01 2007-10-31 Cambia Biosystems LLC Gènes et protéines de télomérases de vertèbres et leurs utilisations
US7378244B2 (en) 1997-10-01 2008-05-27 Geron Corporation Telomerase promoters sequences for screening telomerase modulators
WO1999027113A1 (fr) * 1997-11-26 1999-06-03 Geron Corporation Transcriptase inverse de telomerase de souris
DE19804372A1 (de) * 1998-02-04 1999-08-05 Michael W Dr Dr Dahm Verfahren zur quantitativen Bestimmung von Tumorzellen in einer Körperflüssigkeit und dazu geeignete Testkits
US7402307B2 (en) 1998-03-31 2008-07-22 Geron Corporation Method for identifying and killing cancer cells
JP2002509716A (ja) 1998-03-31 2002-04-02 ユニバーシティ テクノロジー コーポレイション テロメラーゼ抗原に対する免疫応答を惹起するための方法および組成物
DE19916929A1 (de) 1999-04-15 2000-10-19 Bayer Ag Ein automatisierbarer Schnelltest zum Nachweis von Krebserkrankungen auf der Basis von Telomerase(hTC) mRNA mit spezifischen Primern und Sonden
RU2473691C2 (ru) 2006-10-12 2013-01-27 Институто Ди Ричерке Ди Биолоджиа Молеколаре П.Анджелетти Спа Слитый белок теломеразной обратной транскриптазы, кодирующие его нуклеотиды и их применение

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10505488A (ja) * 1994-07-07 1998-06-02 ジェロン コーポレイション 哺乳動物のテロメラーゼ
EP0799315A2 (fr) * 1994-12-19 1997-10-08 Cold Spring Harbor Laboratory Fraction proteinique de la telomerase
EP0832190A1 (fr) * 1995-06-07 1998-04-01 Cold Spring Harbor Laboratory Oligonucleotides essentiels de la telomerase de vertebre
US5747317A (en) * 1996-07-08 1998-05-05 Tularik Inc. Human telomerase RNA interacting protein gene
DE69739497D1 (de) * 1996-10-01 2009-08-27 Geron Corp Menschlische Telomerase katalytische Untereinheit
US7390891B1 (en) * 1996-11-15 2008-06-24 Amgen Inc. Polynucleotides encoding a telomerase component TP2
WO1998037181A2 (fr) * 1997-02-20 1998-08-27 Whitehead Institute For Biomedical Research Gene de sous-unite catalytique de telomerase et proteine codee

Also Published As

Publication number Publication date
WO1998059040A2 (fr) 1998-12-30
AU8214998A (en) 1999-01-04
AU745420B2 (en) 2002-03-21
JP2002508662A (ja) 2002-03-19
WO1998059040A3 (fr) 1999-07-22
EP0990037A2 (fr) 2000-04-05

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