CA2294344A1 - Alpha 1a adrenergic receptor antagonists - Google Patents

Alpha 1a adrenergic receptor antagonists Download PDF

Info

Publication number
CA2294344A1
CA2294344A1 CA002294344A CA2294344A CA2294344A1 CA 2294344 A1 CA2294344 A1 CA 2294344A1 CA 002294344 A CA002294344 A CA 002294344A CA 2294344 A CA2294344 A CA 2294344A CA 2294344 A1 CA2294344 A1 CA 2294344A1
Authority
CA
Canada
Prior art keywords
alkyl
hydrogen
cycloalkyl
alpha
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002294344A
Other languages
English (en)
French (fr)
Inventor
Michael A. Patane
Mark G. Bock
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9800234.8A external-priority patent/GB9800234D0/en
Application filed by Individual filed Critical Individual
Publication of CA2294344A1 publication Critical patent/CA2294344A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA002294344A 1997-06-18 1998-06-17 Alpha 1a adrenergic receptor antagonists Abandoned CA2294344A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US5012697P 1997-06-18 1997-06-18
US60/050,126 1997-06-18
GB9800234.8 1998-01-06
GBGB9800234.8A GB9800234D0 (en) 1998-01-06 1998-01-06 Alpha 1a adrenergic receptor antagonists
PCT/US1998/012678 WO1998057642A1 (en) 1997-06-18 1998-06-17 ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS

Publications (1)

Publication Number Publication Date
CA2294344A1 true CA2294344A1 (en) 1998-12-23

Family

ID=26312905

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002294344A Abandoned CA2294344A1 (en) 1997-06-18 1998-06-17 Alpha 1a adrenergic receptor antagonists

Country Status (5)

Country Link
EP (1) EP1003512A1 (ja)
JP (1) JP2002505685A (ja)
AU (1) AU7976698A (ja)
CA (1) CA2294344A1 (ja)
WO (1) WO1998057642A1 (ja)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH1017566A (ja) * 1996-07-05 1998-01-20 Nippon Bayeragrochem Kk １，２，３−ベンゾチアジアゾール誘導体及び植物病害防除剤
US6207444B1 (en) 1997-08-05 2001-03-27 Merck & Co., Inc. Enzymatic process of making alpha 1a adrenergic receptor antagonists using protease
WO2000006565A1 (en) 1998-07-30 2000-02-10 Merck & Co., Inc. ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS
US6228870B1 (en) 1998-11-10 2001-05-08 Merck & Co., Inc. Oxazolidinones useful as alpha 1a adrenoceptor antagonists
US6319932B1 (en) 1998-11-10 2001-11-20 Merck & Co., Inc. Oxazolidinones useful as alpha 1A adrenoceptor antagonists
US6358959B1 (en) * 1999-01-26 2002-03-19 Merck & Co., Inc. Polyazanaphthalenone derivatives useful as alpha 1a adrenoceptor antagonists
GB2355457A (en) 1999-09-30 2001-04-25 Merck & Co Inc Novel spirotricyclic substituted azacycloalkane derivatives useful as alpha 1a adrenoceptor antagonists
GB2355264A (en) 1999-09-30 2001-04-18 Merck & Co Inc Spirohydantoin derivatives useful as alpha 1a adrenoceptor antagonists
GB2355263A (en) 1999-09-30 2001-04-18 Merck & Co Inc Lactam and cyclic urea derivatives useful as alpha 1a adrenoceptor antagonists
GB2355456A (en) 1999-09-30 2001-04-25 Merck & Co Inc Novel arylhydantoin derivatives useful as alpha 1a adrenoceptor antagonists
MX2007016545A (es) * 2005-06-30 2008-02-21 Prosidion Ltd Agonistas del receptor acoplado a la proteina g.
EP2375899B1 (en) * 2009-01-12 2015-02-25 Array Biopharma Inc. Piperidine-containing compounds and use thereof in the treatment of diabetes

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9206989D0 (en) * 1992-03-31 1992-05-13 Glaxo Group Ltd Chemical compounds
US5574044A (en) * 1994-10-27 1996-11-12 Merck & Co., Inc. Muscarine antagonists

Also Published As

Publication number Publication date
EP1003512A1 (en) 2000-05-31
AU7976698A (en) 1999-01-04
JP2002505685A (ja) 2002-02-19
WO1998057642A1 (en) 1998-12-23

Similar Documents

Publication Publication Date Title
AU734892B2 (en) Alpha 1a adrenergic receptor antagonists
US5977115A (en) Alpha 1a adrenergic receptor antagonists
US5620993A (en) Alpha-1a adrenergic receptor antagonists
CA2294344A1 (en) Alpha 1a adrenergic receptor antagonists
US6358959B1 (en) Polyazanaphthalenone derivatives useful as alpha 1a adrenoceptor antagonists
WO1999025345A1 (en) Alpha-1a adrenergic receptor antagonists
CA2294346A1 (en) Alpha 1a adrenergic receptor antagonists
AU7972698A (en) Alpha 1a adrenergic receptor antagonists
AU7975998A (en) Alpha 1aadrenergic receptor antagonists
US6255315B1 (en) Alpha 1a adrenergic receptor antagonists
AU8147498A (en) Alpha 1a adrenergic receptor antagonists
US6080760A (en) Alpha 1A adrenergic receptor antagonists
US5807856A (en) Alpha 1a adrenergic receptor antagonist
US6143750A (en) Alpha 1a adrenergic receptor antagonists
US6376503B1 (en) Alpha 1a adrenergic receptor antagonists
US6387893B1 (en) Spirotricyclic substituted azacycloalkane derivatives and uses thereof
US6057350A (en) Alpha 1a adrenergic receptor antagonists
US6326372B1 (en) Lactam and cyclic urea derivatives useful as alpha 1a adrenoceptor antagonists
US6319932B1 (en) Oxazolidinones useful as alpha 1A adrenoceptor antagonists
US6214832B1 (en) Bis-piperidinyl-pyrimidin-2-ones as alpha 1a adrenergic receptor antagonists
WO1997011698A1 (en) ALPHA 1b ADRENERGIC RECEPTOR ANTAGONISTS
US5747490A (en) Alpha 1b adrenergic receptor antagonists
US5922722A (en) Alpha 1a adrenergic receptor antagonists
US6235759B1 (en) Dihydropyridinones and pyrrolinones useful as alpha 1A adrenoceptor antagonists
WO1997018209A1 (en) ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS

Legal Events

Date Code Title Description
FZDE Dead