WO1998057642A1 - ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS - Google Patents

ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS Download PDF

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Publication number
WO1998057642A1
WO1998057642A1 PCT/US1998/012678 US9812678W WO9857642A1 WO 1998057642 A1 WO1998057642 A1 WO 1998057642A1 US 9812678 W US9812678 W US 9812678W WO 9857642 A1 WO9857642 A1 WO 9857642A1
Authority
WO
WIPO (PCT)
Prior art keywords
alkyl
hydrogen
cycloalkyl
alpha
compound
Prior art date
Application number
PCT/US1998/012678
Other languages
English (en)
French (fr)
Inventor
Michael A. Patane
Mark G. Bock
Original Assignee
Merck & Co., Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9800234.8A external-priority patent/GB9800234D0/en
Application filed by Merck & Co., Inc. filed Critical Merck & Co., Inc.
Priority to CA002294344A priority Critical patent/CA2294344A1/en
Priority to AU79766/98A priority patent/AU7976698A/en
Priority to EP98930359A priority patent/EP1003512A1/en
Priority to JP50478399A priority patent/JP2002505685A/ja
Publication of WO1998057642A1 publication Critical patent/WO1998057642A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
PCT/US1998/012678 1997-06-18 1998-06-17 ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS WO1998057642A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002294344A CA2294344A1 (en) 1997-06-18 1998-06-17 Alpha 1a adrenergic receptor antagonists
AU79766/98A AU7976698A (en) 1997-06-18 1998-06-17 Alpha 1a adrenergic receptor antagonists
EP98930359A EP1003512A1 (en) 1997-06-18 1998-06-17 ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS
JP50478399A JP2002505685A (ja) 1997-06-18 1998-06-17 α１ａアドレナリン受容体拮抗薬

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US5012697P 1997-06-18 1997-06-18
US60/050,126 1997-06-18
GB9800234.8 1998-01-06
GBGB9800234.8A GB9800234D0 (en) 1998-01-06 1998-01-06 Alpha 1a adrenergic receptor antagonists

Publications (1)

Publication Number Publication Date
WO1998057642A1 true WO1998057642A1 (en) 1998-12-23

Family

ID=26312905

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/012678 WO1998057642A1 (en) 1997-06-18 1998-06-17 ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS

Country Status (5)

Country Link
EP (1) EP1003512A1 (ja)
JP (1) JP2002505685A (ja)
AU (1) AU7976698A (ja)
CA (1) CA2294344A1 (ja)
WO (1) WO1998057642A1 (ja)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000043374A1 (en) * 1999-01-26 2000-07-27 Merck & Co., Inc. Polyazanaphthalenone derivatives useful as alpha 1a adrenoceptor antagonists
US6228870B1 (en) 1998-11-10 2001-05-08 Merck & Co., Inc. Oxazolidinones useful as alpha 1a adrenoceptor antagonists
US6316437B1 (en) 1999-09-30 2001-11-13 Merck & Co., Inc. Spirohydantoin compounds and uses thereof
US6319932B1 (en) 1998-11-10 2001-11-20 Merck & Co., Inc. Oxazolidinones useful as alpha 1A adrenoceptor antagonists
US6320049B1 (en) 1997-08-05 2001-11-20 Merck & Co., Inc. Alpha 1a adrenergic receptor antagonists
US6326372B1 (en) 1999-09-30 2001-12-04 Merck & Co., Inc. Lactam and cyclic urea derivatives useful as alpha 1a adrenoceptor antagonists
US6339090B1 (en) 1998-07-30 2002-01-15 Merck & Co., Inc. Alpha 1A adrenergic receptor antagonists
US6387893B1 (en) 1999-09-30 2002-05-14 Merck & Co., Inc. Spirotricyclic substituted azacycloalkane derivatives and uses thereof
US6436962B1 (en) 1999-09-30 2002-08-20 Merck & Co., Inc. Arylhydantoin derivatives and uses thereof

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH1017566A (ja) * 1996-07-05 1998-01-20 Nippon Bayeragrochem Kk １，２，３−ベンゾチアジアゾール誘導体及び植物病害防除剤
MX2007016545A (es) * 2005-06-30 2008-02-21 Prosidion Ltd Agonistas del receptor acoplado a la proteina g.
EP2375899B1 (en) * 2009-01-12 2015-02-25 Array Biopharma Inc. Piperidine-containing compounds and use thereof in the treatment of diabetes

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5574044A (en) * 1994-10-27 1996-11-12 Merck & Co., Inc. Muscarine antagonists
US5618827A (en) * 1992-03-31 1997-04-08 Glaxo Group Limited Substituted phenylcarbamates and phenylureas, their preparation and their use as 5-HT antagonists

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5618827A (en) * 1992-03-31 1997-04-08 Glaxo Group Limited Substituted phenylcarbamates and phenylureas, their preparation and their use as 5-HT antagonists
US5574044A (en) * 1994-10-27 1996-11-12 Merck & Co., Inc. Muscarine antagonists

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6320049B1 (en) 1997-08-05 2001-11-20 Merck & Co., Inc. Alpha 1a adrenergic receptor antagonists
US6339090B1 (en) 1998-07-30 2002-01-15 Merck & Co., Inc. Alpha 1A adrenergic receptor antagonists
US6228870B1 (en) 1998-11-10 2001-05-08 Merck & Co., Inc. Oxazolidinones useful as alpha 1a adrenoceptor antagonists
US6319932B1 (en) 1998-11-10 2001-11-20 Merck & Co., Inc. Oxazolidinones useful as alpha 1A adrenoceptor antagonists
WO2000043374A1 (en) * 1999-01-26 2000-07-27 Merck & Co., Inc. Polyazanaphthalenone derivatives useful as alpha 1a adrenoceptor antagonists
US6358959B1 (en) 1999-01-26 2002-03-19 Merck & Co., Inc. Polyazanaphthalenone derivatives useful as alpha 1a adrenoceptor antagonists
US6316437B1 (en) 1999-09-30 2001-11-13 Merck & Co., Inc. Spirohydantoin compounds and uses thereof
US6326372B1 (en) 1999-09-30 2001-12-04 Merck & Co., Inc. Lactam and cyclic urea derivatives useful as alpha 1a adrenoceptor antagonists
US6387893B1 (en) 1999-09-30 2002-05-14 Merck & Co., Inc. Spirotricyclic substituted azacycloalkane derivatives and uses thereof
US6436962B1 (en) 1999-09-30 2002-08-20 Merck & Co., Inc. Arylhydantoin derivatives and uses thereof

Also Published As

Publication number Publication date
EP1003512A1 (en) 2000-05-31
AU7976698A (en) 1999-01-04
CA2294344A1 (en) 1998-12-23
JP2002505685A (ja) 2002-02-19

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