CA2294344A1 - Antagonistes du recepteur adrenergique alpha 1a - Google Patents
Antagonistes du recepteur adrenergique alpha 1a Download PDFInfo
- Publication number
- CA2294344A1 CA2294344A1 CA002294344A CA2294344A CA2294344A1 CA 2294344 A1 CA2294344 A1 CA 2294344A1 CA 002294344 A CA002294344 A CA 002294344A CA 2294344 A CA2294344 A CA 2294344A CA 2294344 A1 CA2294344 A1 CA 2294344A1
- Authority
- CA
- Canada
- Prior art keywords
- alkyl
- hydrogen
- cycloalkyl
- alpha
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
On décrit certains nouveaux composés et des dérivés de ces derniers ainsi que leur synthèse et leur utilisation en tant qu'antagonistes du récepteur adrénergique alpha 1a. Une application des ces composés se situe dans le cadre du traitement de l'hyperplasie prostatique bénigne. Ces composés sont sélectifs dans leur capacité à détendre les tissus des muscles lisses enrichis en sous-type du récepteur alpha 1a sans induire parallèlement d'hypotension. On trouve un tissu de ce type autour du revêtement urétral. Par conséquent, on peut utiliser ces nouveaux composés pour soulager fortement les hommes souffrant d'hyperplasie prostatique bénigne du fait que l'écoulement de l'urine se fait plus librement. Ces composés sont également utiles en combinaison avec un composé inhibiteur de réductase 5-alpha humaine, pour soulager de manière ponctuelle et chronique les effets de l'hyperplasie prostatique bénigne.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5012697P | 1997-06-18 | 1997-06-18 | |
US60/050,126 | 1997-06-18 | ||
GBGB9800234.8A GB9800234D0 (en) | 1998-01-06 | 1998-01-06 | Alpha 1a adrenergic receptor antagonists |
GB9800234.8 | 1998-01-06 | ||
PCT/US1998/012678 WO1998057642A1 (fr) | 1997-06-18 | 1998-06-17 | Antagonistes du recepteur adrenergique alpha 1a |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2294344A1 true CA2294344A1 (fr) | 1998-12-23 |
Family
ID=26312905
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002294344A Abandoned CA2294344A1 (fr) | 1997-06-18 | 1998-06-17 | Antagonistes du recepteur adrenergique alpha 1a |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1003512A1 (fr) |
JP (1) | JP2002505685A (fr) |
AU (1) | AU7976698A (fr) |
CA (1) | CA2294344A1 (fr) |
WO (1) | WO1998057642A1 (fr) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH1017566A (ja) * | 1996-07-05 | 1998-01-20 | Nippon Bayeragrochem Kk | 1,2,3−ベンゾチアジアゾール誘導体及び植物病害防除剤 |
US6207444B1 (en) | 1997-08-05 | 2001-03-27 | Merck & Co., Inc. | Enzymatic process of making alpha 1a adrenergic receptor antagonists using protease |
AU5234899A (en) | 1998-07-30 | 2000-02-21 | Merck & Co., Inc. | Alpha 1a adrenergic receptor antagonists |
US6319932B1 (en) | 1998-11-10 | 2001-11-20 | Merck & Co., Inc. | Oxazolidinones useful as alpha 1A adrenoceptor antagonists |
US6228870B1 (en) | 1998-11-10 | 2001-05-08 | Merck & Co., Inc. | Oxazolidinones useful as alpha 1a adrenoceptor antagonists |
US6358959B1 (en) | 1999-01-26 | 2002-03-19 | Merck & Co., Inc. | Polyazanaphthalenone derivatives useful as alpha 1a adrenoceptor antagonists |
GB2355263A (en) | 1999-09-30 | 2001-04-18 | Merck & Co Inc | Lactam and cyclic urea derivatives useful as alpha 1a adrenoceptor antagonists |
GB2355457A (en) | 1999-09-30 | 2001-04-25 | Merck & Co Inc | Novel spirotricyclic substituted azacycloalkane derivatives useful as alpha 1a adrenoceptor antagonists |
GB2355456A (en) | 1999-09-30 | 2001-04-25 | Merck & Co Inc | Novel arylhydantoin derivatives useful as alpha 1a adrenoceptor antagonists |
GB2355264A (en) | 1999-09-30 | 2001-04-18 | Merck & Co Inc | Spirohydantoin derivatives useful as alpha 1a adrenoceptor antagonists |
KR20080025190A (ko) * | 2005-06-30 | 2008-03-19 | 프로시디온 리미티드 | G-단백질 결합된 수용체 효능제 |
WO2010080864A1 (fr) * | 2009-01-12 | 2010-07-15 | Array Biopharma Inc. | Composés contenant de la pipéridine et leurs utilisations |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9206989D0 (en) * | 1992-03-31 | 1992-05-13 | Glaxo Group Ltd | Chemical compounds |
US5574044A (en) * | 1994-10-27 | 1996-11-12 | Merck & Co., Inc. | Muscarine antagonists |
-
1998
- 1998-06-17 WO PCT/US1998/012678 patent/WO1998057642A1/fr not_active Application Discontinuation
- 1998-06-17 EP EP98930359A patent/EP1003512A1/fr not_active Withdrawn
- 1998-06-17 CA CA002294344A patent/CA2294344A1/fr not_active Abandoned
- 1998-06-17 AU AU79766/98A patent/AU7976698A/en not_active Abandoned
- 1998-06-17 JP JP50478399A patent/JP2002505685A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
WO1998057642A1 (fr) | 1998-12-23 |
EP1003512A1 (fr) | 2000-05-31 |
JP2002505685A (ja) | 2002-02-19 |
AU7976698A (en) | 1999-01-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Dead |