CA2294344A1 - Antagonistes du recepteur adrenergique alpha 1a - Google Patents

Antagonistes du recepteur adrenergique alpha 1a Download PDF

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Publication number
CA2294344A1
CA2294344A1 CA002294344A CA2294344A CA2294344A1 CA 2294344 A1 CA2294344 A1 CA 2294344A1 CA 002294344 A CA002294344 A CA 002294344A CA 2294344 A CA2294344 A CA 2294344A CA 2294344 A1 CA2294344 A1 CA 2294344A1
Authority
CA
Canada
Prior art keywords
alkyl
hydrogen
cycloalkyl
alpha
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002294344A
Other languages
English (en)
Inventor
Michael A. Patane
Mark G. Bock
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9800234.8A external-priority patent/GB9800234D0/en
Application filed by Individual filed Critical Individual
Publication of CA2294344A1 publication Critical patent/CA2294344A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

On décrit certains nouveaux composés et des dérivés de ces derniers ainsi que leur synthèse et leur utilisation en tant qu'antagonistes du récepteur adrénergique alpha 1a. Une application des ces composés se situe dans le cadre du traitement de l'hyperplasie prostatique bénigne. Ces composés sont sélectifs dans leur capacité à détendre les tissus des muscles lisses enrichis en sous-type du récepteur alpha 1a sans induire parallèlement d'hypotension. On trouve un tissu de ce type autour du revêtement urétral. Par conséquent, on peut utiliser ces nouveaux composés pour soulager fortement les hommes souffrant d'hyperplasie prostatique bénigne du fait que l'écoulement de l'urine se fait plus librement. Ces composés sont également utiles en combinaison avec un composé inhibiteur de réductase 5-alpha humaine, pour soulager de manière ponctuelle et chronique les effets de l'hyperplasie prostatique bénigne.
CA002294344A 1997-06-18 1998-06-17 Antagonistes du recepteur adrenergique alpha 1a Abandoned CA2294344A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US5012697P 1997-06-18 1997-06-18
US60/050,126 1997-06-18
GBGB9800234.8A GB9800234D0 (en) 1998-01-06 1998-01-06 Alpha 1a adrenergic receptor antagonists
GB9800234.8 1998-01-06
PCT/US1998/012678 WO1998057642A1 (fr) 1997-06-18 1998-06-17 Antagonistes du recepteur adrenergique alpha 1a

Publications (1)

Publication Number Publication Date
CA2294344A1 true CA2294344A1 (fr) 1998-12-23

Family

ID=26312905

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002294344A Abandoned CA2294344A1 (fr) 1997-06-18 1998-06-17 Antagonistes du recepteur adrenergique alpha 1a

Country Status (5)

Country Link
EP (1) EP1003512A1 (fr)
JP (1) JP2002505685A (fr)
AU (1) AU7976698A (fr)
CA (1) CA2294344A1 (fr)
WO (1) WO1998057642A1 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH1017566A (ja) * 1996-07-05 1998-01-20 Nippon Bayeragrochem Kk １，２，３−ベンゾチアジアゾール誘導体及び植物病害防除剤
US6207444B1 (en) 1997-08-05 2001-03-27 Merck & Co., Inc. Enzymatic process of making alpha 1a adrenergic receptor antagonists using protease
AU5234899A (en) 1998-07-30 2000-02-21 Merck & Co., Inc. Alpha 1a adrenergic receptor antagonists
US6319932B1 (en) 1998-11-10 2001-11-20 Merck & Co., Inc. Oxazolidinones useful as alpha 1A adrenoceptor antagonists
US6228870B1 (en) 1998-11-10 2001-05-08 Merck & Co., Inc. Oxazolidinones useful as alpha 1a adrenoceptor antagonists
US6358959B1 (en) 1999-01-26 2002-03-19 Merck & Co., Inc. Polyazanaphthalenone derivatives useful as alpha 1a adrenoceptor antagonists
GB2355263A (en) 1999-09-30 2001-04-18 Merck & Co Inc Lactam and cyclic urea derivatives useful as alpha 1a adrenoceptor antagonists
GB2355457A (en) 1999-09-30 2001-04-25 Merck & Co Inc Novel spirotricyclic substituted azacycloalkane derivatives useful as alpha 1a adrenoceptor antagonists
GB2355456A (en) 1999-09-30 2001-04-25 Merck & Co Inc Novel arylhydantoin derivatives useful as alpha 1a adrenoceptor antagonists
GB2355264A (en) 1999-09-30 2001-04-18 Merck & Co Inc Spirohydantoin derivatives useful as alpha 1a adrenoceptor antagonists
KR20080025190A (ko) * 2005-06-30 2008-03-19 프로시디온 리미티드 Ｇ-단백질 결합된 수용체 효능제
WO2010080864A1 (fr) * 2009-01-12 2010-07-15 Array Biopharma Inc. Composés contenant de la pipéridine et leurs utilisations

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9206989D0 (en) * 1992-03-31 1992-05-13 Glaxo Group Ltd Chemical compounds
US5574044A (en) * 1994-10-27 1996-11-12 Merck & Co., Inc. Muscarine antagonists

Also Published As

Publication number Publication date
WO1998057642A1 (fr) 1998-12-23
EP1003512A1 (fr) 2000-05-31
JP2002505685A (ja) 2002-02-19
AU7976698A (en) 1999-01-04

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Legal Events

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FZDE Dead