CA2293426C - Method and apparatus for detecting microparticles in fluid samples - Google Patents

Method and apparatus for detecting microparticles in fluid samples Download PDF

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Publication number
CA2293426C
CA2293426C CA002293426A CA2293426A CA2293426C CA 2293426 C CA2293426 C CA 2293426C CA 002293426 A CA002293426 A CA 002293426A CA 2293426 A CA2293426 A CA 2293426A CA 2293426 C CA2293426 C CA 2293426C
Authority
CA
Canada
Prior art keywords
microparticle
fluorescent substance
electromagnetic radiation
sample tube
source
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA002293426A
Other languages
English (en)
French (fr)
Other versions
CA2293426A1 (en
Inventor
Philippe Goix
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EMD Millipore Corp
Original Assignee
Guava Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guava Technologies Inc filed Critical Guava Technologies Inc
Publication of CA2293426A1 publication Critical patent/CA2293426A1/en
Application granted granted Critical
Publication of CA2293426C publication Critical patent/CA2293426C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1484—Optical investigation techniques, e.g. flow cytometry microstructural devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N2021/0346—Capillary cells; Microcells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence

Landscapes

  • Chemical & Material Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Farming Of Fish And Shellfish (AREA)
CA002293426A 1997-06-09 1998-06-09 Method and apparatus for detecting microparticles in fluid samples Expired - Lifetime CA2293426C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4901297P 1997-06-09 1997-06-09
US60/049,012 1997-06-09
PCT/US1998/011958 WO1998057152A1 (en) 1997-06-09 1998-06-09 Method and apparatus for detecting microparticles in fluid samples

Publications (2)

Publication Number Publication Date
CA2293426A1 CA2293426A1 (en) 1998-12-17
CA2293426C true CA2293426C (en) 2007-05-15

Family

ID=21957617

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002293426A Expired - Lifetime CA2293426C (en) 1997-06-09 1998-06-09 Method and apparatus for detecting microparticles in fluid samples

Country Status (6)

Country Link
EP (2) EP2302368B1 (enExample)
JP (2) JP4754661B2 (enExample)
AU (1) AU7831798A (enExample)
CA (1) CA2293426C (enExample)
ES (1) ES2626646T3 (enExample)
WO (1) WO1998057152A1 (enExample)

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JP4323571B2 (ja) 1997-01-31 2009-09-02 エックスワイ， インコーポレイテッド 光学装置
US6149867A (en) 1997-12-31 2000-11-21 Xy, Inc. Sheath fluids and collection systems for sex-specific cytometer sorting of sperm
US6071689A (en) 1997-12-31 2000-06-06 Xy, Inc. System for improving yield of sexed embryos in mammals
US7208265B1 (en) 1999-11-24 2007-04-24 Xy, Inc. Method of cryopreserving selected sperm cells
US20020028434A1 (en) * 2000-09-06 2002-03-07 Guava Technologies, Inc. Particle or cell analyzer and method
JP4685229B2 (ja) * 2000-10-31 2011-05-18 オリンパス株式会社 レーザ顕微鏡
WO2002043574A2 (en) 2000-11-29 2002-06-06 Xy, Inc. System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations
US7713687B2 (en) 2000-11-29 2010-05-11 Xy, Inc. System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations
DE60126775T2 (de) * 2001-10-10 2007-10-31 Borealis Technology Oy Teilchendatenanalyse
US8211629B2 (en) 2002-08-01 2012-07-03 Xy, Llc Low pressure sperm cell separation system
US8486618B2 (en) 2002-08-01 2013-07-16 Xy, Llc Heterogeneous inseminate system
CA2534394C (en) 2002-08-15 2013-01-08 Xy, Inc. High resolution flow cytometer
US7169548B2 (en) 2002-09-13 2007-01-30 Xy, Inc. Sperm cell processing and preservation systems
DK2308419T3 (da) 2003-03-28 2016-06-06 Inguran Llc Fremgangsmåde til bedømmelse af farvningstilstandene for dyresperm, som skal sorteres.
EP1625203B1 (en) 2003-05-15 2015-04-08 Xy, Llc Efficient haploid cell sorting for flow cytometer systems
WO2005095590A2 (en) 2004-03-29 2005-10-13 Monsanto Technology Llc Sperm suspensions for sorting into x or y chromosome-bearing enriched populations
AR049732A1 (es) 2004-07-22 2006-08-30 Monsanto Co Proceso para enriquecer una poblacion de celulas de esperma
EP2085762B1 (en) * 2008-01-30 2018-07-04 Palo Alto Research Center Incorporated Transmitting/reflecting emanating light with time variation
CN101672841B (zh) * 2008-09-09 2013-05-08 北京万德高科技发展有限公司 用于生物样品的检测仪器和检测方法
WO2012061155A2 (en) * 2010-10-25 2012-05-10 Accuri Cytometers, Inc. Systems and user interface for collecting a data set in a flow cytometer
EP2594334A1 (en) 2011-11-21 2013-05-22 Drive O2 Sample vial for digital holographic analysis of a liquid cell sample
KR20160103175A (ko) 2011-07-19 2016-08-31 오비지오 이미징 시스템스 엔.브이. 세포 샘플에서의 암 세포들의 검출 및/또는 분류를 위한 방법 및 시스템
EP2626686A1 (en) 2012-02-13 2013-08-14 Ovizio Imaging Systems NV/SA Flow cytometer with digital holographic microscope
US9904248B2 (en) 2012-09-20 2018-02-27 Ovizio Imaging Systems NV/SA Digital holographic microscope with fluid systems
EP3196631A1 (en) 2016-01-19 2017-07-26 Ovizio Imaging Systems NV/SA Digital holographic microscope with electro-fluidic system, said electro-fluidic system and methods of use
CN109270032B (zh) * 2018-08-20 2021-08-20 杭州腾海科技有限公司 一种水体藻类在线监测装置

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US4172227A (en) 1978-07-21 1979-10-23 Becton, Dickinson And Company Flow microfluorometer
DE3266669D1 (en) * 1981-06-24 1985-11-07 Becton Dickinson Co Analyzer for simultaneously determining volume and light emission characteristics of particles
DE3574617D1 (de) * 1984-09-11 1990-01-11 Partec Ag Verfahren und vorrichtung zur sortierung von mikroskopischen partikeln.
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DE3718407A1 (de) * 1987-06-02 1988-12-22 Hund Helmut Gmbh Anordnung fuer die optische analyse von partikelpopulationen in gasen und fluessigkeiten
US4838688A (en) * 1987-10-16 1989-06-13 Robert Rhoads High sensitivity chromatography detector
JPH02145941A (ja) * 1988-11-28 1990-06-05 Hitachi Ltd 細胞分析装置
US4979824A (en) * 1989-05-26 1990-12-25 Board Of Trustees Of The Leland Stanford Junior University High sensitivity fluorescent single particle and single molecule detection apparatus and method
DK111990D0 (da) 1990-05-04 1990-05-04 Biometic Aps Apparat og fremgangsmaade til analyse af en vaeskesuspension
JPH04102062A (ja) * 1990-08-22 1992-04-03 Hitachi Ltd 粒子免疫側定法
JP3102938B2 (ja) * 1991-12-30 2000-10-23 シスメックス株式会社 粒子画像分析装置
JP2756397B2 (ja) * 1992-02-20 1998-05-25 キヤノン株式会社 粒子操作方法及び装置、並びにこれを用いた測定装置
JP3076144B2 (ja) * 1992-05-01 2000-08-14 キヤノン株式会社 生体微量成分検査装置
US5430541A (en) * 1993-01-12 1995-07-04 Applied Biosystems Inc. High efficiency fluorescence flow cell for capillary liquid chromatography or capillary electrophoresis
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JPH07286953A (ja) * 1994-04-19 1995-10-31 Toa Medical Electronics Co Ltd イメージングフローサイトメータ
JPH08163996A (ja) * 1994-12-13 1996-06-25 Sumitomo Bakelite Co Ltd 動物細胞毒性試験方法
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DE19520298A1 (de) * 1995-06-02 1996-12-05 Bayer Ag Sortiervorrichtung für biologische Zellen oder Viren
US5726751A (en) * 1995-09-27 1998-03-10 University Of Washington Silicon microchannel optical flow cytometer

Also Published As

Publication number Publication date
EP2302368B1 (en) 2017-04-05
CA2293426A1 (en) 1998-12-17
JP4754661B2 (ja) 2011-08-24
JP2010017188A (ja) 2010-01-28
ES2626646T3 (es) 2017-07-25
EP2302368A1 (en) 2011-03-30
JP4999900B2 (ja) 2012-08-15
JP2002506522A (ja) 2002-02-26
EP0988523B1 (en) 2013-08-14
WO1998057152A1 (en) 1998-12-17
AU7831798A (en) 1998-12-30
EP0988523A1 (en) 2000-03-29

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Effective date: 20180611