CA2288430C - Crsp protein (cysteine-rich secreted proteins), nucleic acid molecules encoding them and uses therefor - Google Patents
Crsp protein (cysteine-rich secreted proteins), nucleic acid molecules encoding them and uses therefor Download PDFInfo
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- CA2288430C CA2288430C CA2288430A CA2288430A CA2288430C CA 2288430 C CA2288430 C CA 2288430C CA 2288430 A CA2288430 A CA 2288430A CA 2288430 A CA2288430 A CA 2288430A CA 2288430 C CA2288430 C CA 2288430C
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- crsp
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Classifications
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- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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- C07—ORGANIC CHEMISTRY
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Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84370497A | 1997-04-16 | 1997-04-16 | |
| US08/843,704 | 1997-04-16 | ||
| US84289897A | 1997-04-17 | 1997-04-17 | |
| US08/842,898 | 1997-04-17 | ||
| US7158998P | 1998-01-15 | 1998-01-15 | |
| US60/071,589 | 1998-01-15 | ||
| US980298A | 1998-01-20 | 1998-01-20 | |
| US09/009,802 | 1998-01-20 | ||
| PCT/US1998/007894 WO1998046755A1 (en) | 1997-04-16 | 1998-04-16 | Crsp protein (cysteine-rich secreted proteins), nucleic acid molecules encoding them and uses therefor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2288430A1 CA2288430A1 (en) | 1998-10-22 |
| CA2288430C true CA2288430C (en) | 2013-04-09 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2288430A Expired - Lifetime CA2288430C (en) | 1997-04-16 | 1998-04-16 | Crsp protein (cysteine-rich secreted proteins), nucleic acid molecules encoding them and uses therefor |
Country Status (11)
| Country | Link |
|---|---|
| EP (3) | EP0975755B2 (https=) |
| JP (4) | JP2001524824A (https=) |
| AT (2) | ATE505543T1 (https=) |
| AU (2) | AU7137398A (https=) |
| CA (1) | CA2288430C (https=) |
| CY (1) | CY1107629T1 (https=) |
| DE (2) | DE69842225D1 (https=) |
| DK (1) | DK0975755T3 (https=) |
| ES (1) | ES2285768T5 (https=) |
| PT (1) | PT975755E (https=) |
| WO (1) | WO1998046755A1 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US7057017B2 (en) | 1997-04-16 | 2006-06-06 | Millennium Pharmaceuticals, Inc. | Human dickkopf-related protein and nucleic acid molecules and uses therefor |
| JP2001512012A (ja) * | 1997-08-01 | 2001-08-21 | ジェンセット | 精巣およびその他の組織で発現する分泌タンパク質の５’ｅｓｔ |
| DE19747418C1 (de) | 1997-10-27 | 1999-07-15 | Deutsches Krebsforsch | Inhibitor-Protein des wnt-Signalwegs |
| US7446181B2 (en) | 1998-01-15 | 2008-11-04 | Millennium Pharmaceuticals, Inc. | Antibodies that bind human Dickkopf-1 proteins |
| US6344541B1 (en) * | 1998-09-25 | 2002-02-05 | Amgen Inc. | DKR polypeptides |
| DK1124949T3 (da) * | 1998-10-26 | 2006-11-06 | Novozymes As | Konstruktion og screening af et DNA-bibliotek af interesse i trådformede svampeceller |
| AU3510200A (en) * | 1999-03-05 | 2000-09-21 | Millennium Pharmaceuticals, Inc. | Human dickkopf-related protein and nucleic acid molecules and uses therefor |
| US7115665B1 (en) | 2000-11-16 | 2006-10-03 | Onocozyme Pharma, Inc. | Inhibitors of endo-exonuclease activity for treating cancer |
| EP1234877B1 (en) * | 1999-11-19 | 2010-06-02 | Kumon, Hiromi | Cell proliferation inhibitory protein, polynucleotide, antisense polynucleotide to the polynucleotide, and cell proliferation inhibitors, cancer diagnostics, cancer remedies and compositions for gene therapy by using the same |
| AU3589101A (en) * | 2000-02-24 | 2001-09-03 | Oxford Glycosciences (Uk) Limited | Dpi-6, a putative therapeutic target and biomarker in neuropsychiatric and neurological disorders |
| US7927597B2 (en) | 2001-04-10 | 2011-04-19 | Agensys, Inc. | Methods to inhibit cell growth |
| US7736654B2 (en) | 2001-04-10 | 2010-06-15 | Agensys, Inc. | Nucleic acids and corresponding proteins useful in the detection and treatment of various cancers |
| US7682607B2 (en) | 2001-05-01 | 2010-03-23 | The Regents Of The University Of California | Wnt and frizzled receptors as targets for immunotherapy in head and neck squamous cell carcinomas |
| US20040038860A1 (en) | 2002-05-17 | 2004-02-26 | Allen Kristina M. | Reagents and methods for modulating dkk-mediated interactions |
| WO2005049797A2 (en) | 2003-11-17 | 2005-06-02 | Merck & Co., Inc. | Cynomolgus monkey dickkopf-4, nucleotides encoding same, and uses thereof |
| WO2005049640A2 (en) | 2003-11-17 | 2005-06-02 | Merck & Co., Inc. | Rhesus monkey dickkopf-1, nucleotides encoding same, and uses thereof |
| US7867699B2 (en) | 2004-03-23 | 2011-01-11 | Wyeth | Method of synthesizing and purifying Dkk proteins and Dkk proteins obtained thereby |
| MX2007001221A (es) | 2004-08-04 | 2007-03-23 | Amgen Inc | Anticuerpos para proteina dickkopf-1 (dkk-1). |
| AR060017A1 (es) | 2006-01-13 | 2008-05-21 | Novartis Ag | Composiciones y metodos de uso para anticuerpos de dickkopf -1 |
| US7465585B1 (en) * | 2006-04-10 | 2008-12-16 | The Burnham Institute | Compositions and methods for inhibiting cell migration |
| AR075989A1 (es) | 2009-04-10 | 2011-05-11 | Lilly Co Eli | Anticuerpo dkk -1 (dickkopf-1) humano disenado por ingenieria |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4873191A (en) | 1981-06-12 | 1989-10-10 | Ohio University | Genetic transformation of zygotes |
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US4870009A (en) | 1982-11-22 | 1989-09-26 | The Salk Institute For Biological Studies | Method of obtaining gene product through the generation of transgenic animals |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4736866B1 (en) | 1984-06-22 | 1988-04-12 | Transgenic non-human mammals | |
| JPS6147500A (ja) | 1984-08-15 | 1986-03-07 | Res Dev Corp Of Japan | キメラモノクロ−ナル抗体及びその製造法 |
| EP0173494A3 (en) | 1984-08-27 | 1987-11-25 | The Board Of Trustees Of The Leland Stanford Junior University | Chimeric receptors by dna splicing and expression |
| GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
| JPS61134325A (ja) | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| DE122007000007I1 (de) | 1986-04-09 | 2007-05-16 | Genzyme Corp | Genetisch transformierte Tiere, die ein gewünschtes Protein in Milch absondern |
| US4902505A (en) | 1986-07-30 | 1990-02-20 | Alkermes | Chimeric peptides for neuropeptide delivery through the blood-brain barrier |
| US5116742A (en) | 1986-12-03 | 1992-05-26 | University Patents, Inc. | RNA ribozyme restriction endoribonucleases and methods |
| US4987071A (en) | 1986-12-03 | 1991-01-22 | University Patents, Inc. | RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods |
| US4904582A (en) | 1987-06-11 | 1990-02-27 | Synthetic Genetics | Novel amphiphilic nucleic acid conjugates |
| US4873316A (en) | 1987-06-23 | 1989-10-10 | Biogen, Inc. | Isolation of exogenous recombinant proteins from the milk of transgenic mammals |
| US5080891A (en) | 1987-08-03 | 1992-01-14 | Ddi Pharmaceuticals, Inc. | Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols |
| EP0436597B1 (en) | 1988-09-02 | 1997-04-02 | Protein Engineering Corporation | Generation and selection of recombinant varied binding proteins |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US5272057A (en) | 1988-10-14 | 1993-12-21 | Georgetown University | Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase |
| US5225538A (en) | 1989-02-23 | 1993-07-06 | Genentech, Inc. | Lymphocyte homing receptor/immunoglobulin fusion proteins |
| US5116964A (en) | 1989-02-23 | 1992-05-26 | Genentech, Inc. | Hybrid immunoglobulins |
| FR2646438B1 (fr) | 1989-03-20 | 2007-11-02 | Pasteur Institut | Procede de remplacement specifique d'une copie d'un gene present dans le genome receveur par l'integration d'un gene different de celui ou se fait l'integration |
| US5328470A (en) | 1989-03-31 | 1994-07-12 | The Regents Of The University Of Michigan | Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor |
| US5459039A (en) | 1989-05-12 | 1995-10-17 | Duke University | Methods for mapping genetic mutations |
| AU633958B2 (en) | 1989-07-25 | 1993-02-11 | Cell Genesys, Inc. | Homologous recombination for universal donor cells and chimeric mammalian hosts |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| US5393788A (en) | 1990-07-10 | 1995-02-28 | Smithkline Beecham Corporation | Phenylalkyl oxamides |
| EP0585287B1 (en) | 1990-07-10 | 1999-10-13 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
| WO1992009688A1 (en) | 1990-11-21 | 1992-06-11 | Massachusetts Institute Of Technology | MICE HAVING β2 MICROGLOBULIN GENE DISRUPTION |
| CA2405246A1 (en) | 1990-12-03 | 1992-06-11 | Genentech, Inc. | Enrichment method for variant proteins with alterred binding properties |
| EP0575485A1 (en) | 1991-03-01 | 1993-12-29 | Dyax Corp. | Process for the development of binding mini-proteins |
| DK0580737T3 (da) | 1991-04-10 | 2004-11-01 | Scripps Research Inst | Heterodimere receptorbiblioteker ved anvendelse af phagemider |
| DE69226871T3 (de) | 1991-06-27 | 2009-09-24 | Bristol-Myers Squibb Co. | CTL4A-Rezeptor, ihn enthaltenden Fusionsproteine und deren Verwendung |
| DE4122599C2 (de) | 1991-07-08 | 1993-11-11 | Deutsches Krebsforsch | Phagemid zum Screenen von Antikörpern |
| WO1993004169A1 (en) | 1991-08-20 | 1993-03-04 | Genpharm International, Inc. | Gene targeting in animal cells using isogenic dna constructs |
| EP1362913B1 (en) | 1992-10-30 | 2006-01-25 | The General Hospital Corporation | Interaction trap system for isolating proteins |
| CA2153387A1 (en) | 1993-01-07 | 1994-07-21 | Hubert Koester | Dna sequencing by mass spectrometry |
| JP2879303B2 (ja) * | 1993-01-14 | 1999-04-05 | 佑 本庶 | ｃＤＮＡライブラリーの作製方法、および新規なポリペプチドとそれをコードするＤＮＡ |
| US5498531A (en) | 1993-09-10 | 1996-03-12 | President And Fellows Of Harvard College | Intron-mediated recombinant techniques and reagents |
| EP0954575A2 (en) * | 1996-12-20 | 1999-11-10 | Human Genome Sciences, Inc. | Cerebellum and embryo specific protein |
| DE19747418C1 (de) * | 1997-10-27 | 1999-07-15 | Deutsches Krebsforsch | Inhibitor-Protein des wnt-Signalwegs |
| IT1395574B1 (it) | 2009-09-14 | 2012-10-16 | Guala Dispensing Spa | Dispositivo di erogazione |
-
1998
- 1998-04-16 AU AU71373/98A patent/AU7137398A/en not_active Abandoned
- 1998-04-16 DE DE69842225T patent/DE69842225D1/de not_active Expired - Lifetime
- 1998-04-16 DE DE69837085T patent/DE69837085T3/de not_active Expired - Lifetime
- 1998-04-16 ES ES98918453T patent/ES2285768T5/es not_active Expired - Lifetime
- 1998-04-16 AT AT06021943T patent/ATE505543T1/de not_active IP Right Cessation
- 1998-04-16 DK DK98918453T patent/DK0975755T3/da active
- 1998-04-16 EP EP98918453A patent/EP0975755B2/en not_active Expired - Lifetime
- 1998-04-16 EP EP10010403A patent/EP2298899A3/en not_active Withdrawn
- 1998-04-16 CA CA2288430A patent/CA2288430C/en not_active Expired - Lifetime
- 1998-04-16 WO PCT/US1998/007894 patent/WO1998046755A1/en not_active Ceased
- 1998-04-16 JP JP54436198A patent/JP2001524824A/ja active Pending
- 1998-04-16 AT AT98918453T patent/ATE353964T1/de active
- 1998-04-16 EP EP06021943A patent/EP1852507B1/en not_active Expired - Lifetime
- 1998-04-16 PT PT98918453T patent/PT975755E/pt unknown
-
2005
- 2005-12-22 JP JP2005370262A patent/JP2006166917A/ja active Pending
-
2007
- 2007-05-14 CY CY20071100650T patent/CY1107629T1/el unknown
-
2009
- 2009-08-17 JP JP2009188614A patent/JP2010011853A/ja active Pending
- 2009-10-22 AU AU2009227915A patent/AU2009227915A1/en not_active Abandoned
-
2010
- 2010-05-13 JP JP2010111163A patent/JP2010227110A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| ES2285768T3 (es) | 2007-11-16 |
| EP2298899A3 (en) | 2011-08-24 |
| DE69837085D1 (de) | 2007-03-29 |
| JP2001524824A (ja) | 2001-12-04 |
| EP0975755B1 (en) | 2007-02-14 |
| ATE505543T1 (de) | 2011-04-15 |
| CA2288430A1 (en) | 1998-10-22 |
| PT975755E (pt) | 2007-06-26 |
| JP2010227110A (ja) | 2010-10-14 |
| DK0975755T3 (da) | 2007-06-11 |
| DE69842225D1 (de) | 2011-05-26 |
| EP0975755A1 (en) | 2000-02-02 |
| EP1852507A1 (en) | 2007-11-07 |
| JP2010011853A (ja) | 2010-01-21 |
| DE69837085T3 (de) | 2012-01-12 |
| JP2006166917A (ja) | 2006-06-29 |
| EP0975755B9 (en) | 2007-08-29 |
| WO1998046755A1 (en) | 1998-10-22 |
| ES2285768T5 (es) | 2011-12-22 |
| DE69837085T2 (de) | 2007-11-22 |
| EP1852507B1 (en) | 2011-04-13 |
| AU2009227915A1 (en) | 2009-11-12 |
| AU7137398A (en) | 1998-11-11 |
| EP2298899A2 (en) | 2011-03-23 |
| EP0975755B2 (en) | 2011-08-03 |
| CY1107629T1 (el) | 2013-06-19 |
| ATE353964T1 (de) | 2007-03-15 |
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