CA2286232A1 - Dna-binding pyrrole and imidazole polyamide derivatives - Google Patents

Dna-binding pyrrole and imidazole polyamide derivatives Download PDF

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Publication number
CA2286232A1
CA2286232A1 CA002286232A CA2286232A CA2286232A1 CA 2286232 A1 CA2286232 A1 CA 2286232A1 CA 002286232 A CA002286232 A CA 002286232A CA 2286232 A CA2286232 A CA 2286232A CA 2286232 A1 CA2286232 A1 CA 2286232A1
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CA
Canada
Prior art keywords
polyamide
beta
gamma
dna
alanine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002286232A
Other languages
English (en)
French (fr)
Inventor
Peter B. Dervan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
California Institute of Technology CalTech
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/837,524 external-priority patent/US6143901A/en
Priority claimed from US08/853,522 external-priority patent/US6635417B1/en
Application filed by Individual filed Critical Individual
Publication of CA2286232A1 publication Critical patent/CA2286232A1/en
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06182—Dipeptides with the first amino acid being heterocyclic and Pristinamycin II; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6839—Triple helix formation or other higher order conformations in hybridisation assays

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA002286232A 1997-04-06 1998-04-08 Dna-binding pyrrole and imidazole polyamide derivatives Abandoned CA2286232A1 (en)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US4202297P 1997-04-06 1997-04-06
US4344497P 1997-04-08 1997-04-08
US4344697P 1997-04-08 1997-04-08
US60/043,444 1997-04-08
US60/043,446 1997-04-08
US60/042,022 1997-04-16
US08/837,524 1997-04-21
US08/837,524 US6143901A (en) 1996-07-31 1997-04-21 Complex formation between dsDNA and pyrrole imidazole polyamides
US08/853,522 1997-05-08
US08/853,522 US6635417B1 (en) 1996-07-31 1997-05-08 Complex formation between DSDNA and oligomer of cyclic heterocycles
PCT/US1997/012722 WO1998050582A1 (en) 1997-05-08 1997-07-21 COMPLEX FORMATION BETWEEN dsDNA AND OLIGOMER OF HETEROCYCLES
WOPCT/US97/12722 1997-07-21
PCT/US1998/006997 WO1998049142A1 (en) 1997-04-06 1998-04-08 Dna-binding pyrrole and imidazole polyamide derivatives

Publications (1)

Publication Number Publication Date
CA2286232A1 true CA2286232A1 (en) 1998-11-05

Family

ID=27556422

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002286232A Abandoned CA2286232A1 (en) 1997-04-06 1998-04-08 Dna-binding pyrrole and imidazole polyamide derivatives

Country Status (4)

Country Link
EP (1) EP0986539A1 (de)
JP (1) JP2002515063A (de)
CA (1) CA2286232A1 (de)
WO (1) WO1998049142A1 (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5801155A (en) 1995-04-03 1998-09-01 Epoch Pharmaceuticals, Inc. Covalently linked oligonucleotide minor grove binder conjugates
EP1112267A2 (de) * 1998-09-11 2001-07-04 California Institute Of Technology Hemmung der onkogentranskription durch synthetische polyamide
WO2000040605A2 (en) * 1999-01-08 2000-07-13 California Institute Of Technology Compositions and methods relating to cyclic compounds that undergo nucleotide base pair-specific interactions with double-stranded nucleic acids
JP2001136974A (ja) * 1999-11-16 2001-05-22 Japan Science & Technology Corp 生理活性ピロールイミダゾール誘導体のスクリーニング方法
US6559125B1 (en) 2000-01-28 2003-05-06 California Institute Of Technology Polyamide-alkylator conjugates and related products and method
DE60128551D1 (de) * 2000-03-16 2007-07-05 Genesoft Inc Geladene verbindungen mit einer nukleinsäure-bindenden einheit sowie deren verwendungen
US7078536B2 (en) 2001-03-14 2006-07-18 Genesoft Pharmaceuticals, Inc. Charged compounds comprising a nucleic acid binding moiety and uses therefor
GB0011938D0 (en) * 2000-05-17 2000-07-05 Angeletti P Ist Richerche Bio Improvements relating to gene delivery systems
US20020169296A1 (en) * 2000-07-11 2002-11-14 Ulrich Laemmli Linked, sequence-specific DNA-binding molecules
US7122626B2 (en) 2001-04-26 2006-10-17 Genesoft Pharmceuticals, Inc. Halogen-substitued thienyl compounds
WO2002095022A2 (en) * 2001-05-21 2002-11-28 Universite De Geneve Sequence-specific dna binding compounds and their use in targeting telomeres and other dna sequences
EP1470119A4 (de) 2001-06-13 2005-10-19 Genesoft Pharmaceuticals Inc Benzothiophenverbindungen mit antiinfektiver wirkung
WO2002101007A2 (en) 2001-06-13 2002-12-19 Genesoft Pharmaceuticals, Inc Antipathogenic benzamide compounds
WO2002101073A2 (en) 2001-06-13 2002-12-19 Genesoft Pharmaceuticals, Inc. Aryl-benzimidazole compounds having antiinfective activity
WO2002100832A1 (en) 2001-06-13 2002-12-19 Genesoft Pharmaceuticals, Inc. Isoquinoline compounds having antiinfective activity
WO2003000683A1 (en) * 2001-06-25 2003-01-03 Japan Science And Technology Agency Method of the solid phase synhesis of pyrrole-imidazole polyamide
EP1442022A4 (de) * 2001-11-07 2005-05-04 Pharmacia Corp Polyamidmodulatoren der transkription von cox2
WO2004012736A1 (en) 2002-08-02 2004-02-12 Genesoft Pharmaceuticals, Inc. Biaryl compounds having anti-infective activity
WO2004039318A2 (en) 2002-10-25 2004-05-13 Genesoft Pharmaceuticals, Inc. Anti-infective biaryl compounds
EP1587529A4 (de) 2002-12-10 2009-08-12 Oscient Pharmaceuticals Corp Antibakterielle verbindungen mit(pyrrolcarboxamid)-(benzamid)-(imidazolcarboxamid)-motiv
EP1678133A4 (de) 2003-10-07 2008-06-18 Univ Western Sydney Sequenzselektive pyrrol- und imidazolpolyamidmetallkomplexe
WO2005120582A2 (en) * 2004-06-07 2005-12-22 California Institute Of Technology Compositions and methods for inhibiting expression of hypoxia-inducible genes
JP2007176795A (ja) 2004-08-18 2007-07-12 Univ Nihon ＴＧＦ−β遺伝子発現抑制剤
WO2007034784A1 (ja) * 2005-09-20 2007-03-29 Nihon University Ｃｔｇｆ遺伝子発現抑制剤
WO2007060860A1 (ja) * 2005-11-22 2007-05-31 Nihon University ピロールイミダゾールポリアミドの固相自動合成
ES2387249T3 (es) * 2006-05-04 2012-09-19 Nanovir, Llc Poliamidas para el tratamiento del virus del papiloma humano
WO2008066890A2 (en) 2006-11-29 2008-06-05 California Institute Of Technology Polyamides with tail structures
WO2008133877A1 (en) 2007-04-23 2008-11-06 California Institute Of Technology Inhibitors for steroid response elements and related methods
US9630950B2 (en) 2007-04-23 2017-04-25 California Institute Of Technology Inhibitors for steroid response elements and RNA polymerase II and related methods
CN101980725B (zh) * 2008-02-01 2013-06-12 阿森迪斯药物股份有限公司 包含可自裂解的连接体的前药
US20110046070A1 (en) 2008-04-17 2011-02-24 Hiroki Nagase Gene expression inhibitor selective for matrix metalloproteinase-9 gene
EP3257527A4 (de) * 2015-02-12 2018-07-25 Kyoto University Ctb-pi-polyamid-konjugat zur aktivierung der expression eines spezifischen gens
EP3503898A1 (de) 2016-08-29 2019-07-03 California Institute of Technology Zusammensetzungen und verfahren zur behandlung von prostatakrebs
JPWO2022019303A1 (de) * 2020-07-20 2022-01-27
WO2022215622A1 (ja) * 2021-04-09 2022-10-13 学校法人川崎学園 ピロールイミダゾールポリアミド化合物を有効成分とするがん転移阻害剤
WO2023200009A1 (ja) * 2022-04-15 2023-10-19 国立大学法人 東京大学 原虫転写因子阻害剤

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6090947A (en) * 1996-02-26 2000-07-18 California Institute Of Technology Method for the synthesis of pyrrole and imidazole carboxamides on a solid support

Also Published As

Publication number Publication date
WO1998049142A1 (en) 1998-11-05
EP0986539A1 (de) 2000-03-22
JP2002515063A (ja) 2002-05-21

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