CA2279977A1 - Derives de la quinoline substituee en 4- et bibliotheques combinatoires les contenant - Google Patents

Derives de la quinoline substituee en 4- et bibliotheques combinatoires les contenant Download PDF

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Publication number
CA2279977A1
CA2279977A1 CA002279977A CA2279977A CA2279977A1 CA 2279977 A1 CA2279977 A1 CA 2279977A1 CA 002279977 A CA002279977 A CA 002279977A CA 2279977 A CA2279977 A CA 2279977A CA 2279977 A1 CA2279977 A1 CA 2279977A1
Authority
CA
Canada
Prior art keywords
substituted
alpha
phenyl
group
acetyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002279977A
Other languages
English (en)
Inventor
John S. Kiely
Behrouz Forood
Thomas K. Hayes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Trega Biosciences Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2279977A1 publication Critical patent/CA2279977A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D215/14—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention porte sur de nouveaux composés de la quinoline substituée en 4- de formule (I), sur des bibliothèques desdits composés, et sur la création desdites bibliothèques. Dans la formule (I): R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿, R?7¿, R?9¿ et Y sont tels que définis dans la description.
CA002279977A 1997-02-04 1997-12-05 Derives de la quinoline substituee en 4- et bibliotheques combinatoires les contenant Abandoned CA2279977A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US79539297A 1997-02-04 1997-02-04
US08/795,392 1997-02-04
PCT/US1997/022391 WO1998034115A1 (fr) 1997-02-04 1997-12-05 Derives de la quinoline substituee en 4- et bibliotheques combinatoires les contenant

Publications (1)

Publication Number Publication Date
CA2279977A1 true CA2279977A1 (fr) 1998-08-06

Family

ID=25165399

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002279977A Abandoned CA2279977A1 (fr) 1997-02-04 1997-12-05 Derives de la quinoline substituee en 4- et bibliotheques combinatoires les contenant

Country Status (4)

Country Link
EP (1) EP0977989A1 (fr)
AU (1) AU8191998A (fr)
CA (1) CA2279977A1 (fr)
WO (1) WO1998034115A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023077218A1 (fr) * 2021-11-08 2023-05-11 The Royal Institution For The Advancement Of Learning / Mcgill University Photocatalyseurs, leur préparation et leur utilisation

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6034256A (en) 1997-04-21 2000-03-07 G.D. Searle & Co. Substituted benzopyran derivatives for the treatment of inflammation
US6077850A (en) 1997-04-21 2000-06-20 G.D. Searle & Co. Substituted benzopyran analogs for the treatment of inflammation
US6417195B1 (en) 1999-02-22 2002-07-09 Lion Bioscience Ag Isoquinoline derivatives and isoquinoline combinatorial libraries
DE10137488A1 (de) * 2001-08-03 2003-02-20 Gruenenthal Gmbh Salze substituierter 1,2,3,4-Tetrahydrochinolin-2-carbonsäurederivate
CN101200450A (zh) 2002-04-30 2008-06-18 Ucb公司 2,6-喹啉基和2,6-萘基衍生物、用于制备它们的方法和它们作为vla-4抑制剂的用途
DE10236910A1 (de) * 2002-08-12 2004-03-11 Grünenthal GmbH Substituierte 1,2,3,4-Tetrahydrochinolinderivate
US7138412B2 (en) 2003-03-11 2006-11-21 Bristol-Myers Squibb Company Tetrahydroquinoline derivatives useful as serine protease inhibitors
CN1832941A (zh) 2003-08-08 2006-09-13 尤利塞斯药品公司 作为抗菌剂的卤代喹唑啉基硝基呋喃类化合物
US7511065B2 (en) 2003-11-12 2009-03-31 Eli Lilly And Company Mixed lineage kinase modulators
PA8619901A1 (es) 2003-12-12 2005-11-25 Wyeth Corp Quinolinas utiles en el tratamiento de enfermedades cardiovasculares
KR101156393B1 (ko) 2004-08-03 2012-06-13 키에시 파르마슈티시 엣스. 피. 에이. 신경퇴행성 질환 치료를 위한 1-페닐알캐인카복실산 유도체
CN101267813A (zh) * 2005-07-19 2008-09-17 第一三共株式会社 取代丙酰胺衍生物和含有其的药物组合物
EP1917245A1 (fr) 2005-08-21 2008-05-07 Abbott GmbH & Co. KG Composes heterocycliques et leur utilisation en tant que partenaires de liaison des recepteurs 5-ht5
US9844218B2 (en) 2013-06-13 2017-12-19 Monsanto Technology Llc Acetyl-CoA carboxylase modulators
AR096613A1 (es) 2013-06-13 2016-01-20 Monsanto Technology Llc Moduladores de la acetil-coa carboxilasa

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE188377T1 (de) * 1993-06-29 2000-01-15 Takeda Chemical Industries Ltd Chinoline oder chinazolin-derivate und deren verwendung zur herstellung eines medikaments für die behandlung von osteoporose
HUP9801628A2 (hu) * 1995-04-28 1999-01-28 Takeda Chemical Industries, Ltd. Artritisz elleni gyógyászati készítmények

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023077218A1 (fr) * 2021-11-08 2023-05-11 The Royal Institution For The Advancement Of Learning / Mcgill University Photocatalyseurs, leur préparation et leur utilisation

Also Published As

Publication number Publication date
AU8191998A (en) 1998-08-25
EP0977989A1 (fr) 2000-02-09
WO1998034115A1 (fr) 1998-08-06

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Legal Events

Date Code Title Description
FZDE Discontinued