CA2274893A1 - Excipient pour liberer de l'apomorphine dans la cavite buccale - Google Patents

Excipient pour liberer de l'apomorphine dans la cavite buccale Download PDF

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Publication number
CA2274893A1
CA2274893A1 CA002274893A CA2274893A CA2274893A1 CA 2274893 A1 CA2274893 A1 CA 2274893A1 CA 002274893 A CA002274893 A CA 002274893A CA 2274893 A CA2274893 A CA 2274893A CA 2274893 A1 CA2274893 A1 CA 2274893A1
Authority
CA
Canada
Prior art keywords
active substance
pharmaceutical preparation
apomorphine
preparation according
administration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002274893A
Other languages
English (en)
Inventor
Karsten Cremer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LTS Lohmann Therapie Systeme AG
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2274893A1 publication Critical patent/CA2274893A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne une préparation médicamenteuse à forme galénique plate, de type film, papier ou hostie, servant à administrer et à libérer des principes actifs dans la cavité buccale, qui se caractérise par une teneur en apomorphine ou en un de ses sels appropriés sur le plan thérapeutique.
CA002274893A 1996-12-16 1997-11-21 Excipient pour liberer de l'apomorphine dans la cavite buccale Abandoned CA2274893A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19652268.4 1996-12-16
DE19652268A DE19652268C2 (de) 1996-12-16 1996-12-16 Arzneizubereitung für die Freisetzung von Apomorphin in der Mundhöhle
PCT/EP1997/006529 WO1998026763A1 (fr) 1996-12-16 1997-11-21 Excipient pour liberer de l'apomorphine dans la cavite buccale

Publications (1)

Publication Number Publication Date
CA2274893A1 true CA2274893A1 (fr) 1998-06-25

Family

ID=7814859

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002274893A Abandoned CA2274893A1 (fr) 1996-12-16 1997-11-21 Excipient pour liberer de l'apomorphine dans la cavite buccale

Country Status (8)

Country Link
EP (1) EP0959875A1 (fr)
JP (1) JP2001506612A (fr)
KR (1) KR20000057627A (fr)
AU (1) AU746373B2 (fr)
CA (1) CA2274893A1 (fr)
DE (1) DE19652268C2 (fr)
NO (1) NO992944L (fr)
WO (1) WO1998026763A1 (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7910132B2 (en) 1998-09-24 2011-03-22 Orexo Ab Pharmaceutical composition for the treatment of acute disorders
CN101005824B (zh) * 2004-06-17 2012-05-30 高露洁-棕榄公司 口腔护理薄膜
US9044475B2 (en) 2009-06-12 2015-06-02 Cynapsus Therapeutics, Inc. Sublingual apomorphine
US9283219B2 (en) 2010-12-16 2016-03-15 Cynapsus Therapeutics, Inc. Sublingual films
US10449146B2 (en) 2015-04-21 2019-10-22 Sunovion Pharmaceuticals Inc. Methods of treating parkinson's disease by administration of apomorphine to an oral mucosa

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6596298B2 (en) 1998-09-25 2003-07-22 Warner-Lambert Company Fast dissolving orally comsumable films
US6291471B1 (en) 1998-12-17 2001-09-18 Abb Holdings, Inc. Use of apomorphine for the treatment of organic erectile dysfunction in males
WO2000038536A2 (fr) 1998-12-23 2000-07-06 Mount Sinai School Of Medicine Of New York University Inhibiteurs de la reaction a la saveur amere
US7314716B2 (en) 1999-11-19 2008-01-01 Mount Sinai School Of Medicine Gustducin γ subunit materials and methods
US7067116B1 (en) 2000-03-23 2006-06-27 Warner-Lambert Company Llc Fast dissolving orally consumable solid film containing a taste masking agent and pharmaceutically active agent at weight ratio of 1:3 to 3:1
USRE44145E1 (en) 2000-07-07 2013-04-09 A.V. Topchiev Institute Of Petrochemical Synthesis Preparation of hydrophilic pressure sensitive adhesives having optimized adhesive properties
US8206738B2 (en) 2001-05-01 2012-06-26 Corium International, Inc. Hydrogel compositions with an erodible backing member
US20050215727A1 (en) 2001-05-01 2005-09-29 Corium Water-absorbent adhesive compositions and associated methods of manufacture and use
ATE438418T1 (de) 2001-05-01 2009-08-15 Av Topchiev Inst Petrochemical Hydrogel-zusammensetzungen
US8541021B2 (en) 2001-05-01 2013-09-24 A.V. Topchiev Institute Of Petrochemical Synthesis Hydrogel compositions demonstrating phase separation on contact with aqueous media
US8840918B2 (en) 2001-05-01 2014-09-23 A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences Hydrogel compositions for tooth whitening
DE10252726B4 (de) * 2002-11-13 2008-05-08 Lts Lohmann Therapie-Systeme Ag Mehrschichtiges transmucosales therapeutisches System
AU2003277788A1 (en) * 2002-11-14 2004-06-03 Givaudan Sa Edible film containing food acid
KR100945741B1 (ko) * 2003-01-16 2010-03-05 부광약품 주식회사 염산아포모르핀을 함유하는 구강스프레이 제제
CN1929819B (zh) * 2004-01-30 2012-02-29 考里安国际公司 递送活性剂的快速溶解膜
WO2010083035A2 (fr) 2009-01-14 2010-07-22 Corium International, Inc. Administration transdermique de tamsulosine
US10806703B2 (en) * 2012-01-20 2020-10-20 Lts Lohmann Therapie-System Ag Transmucosal administration system for a pharmaceutical drug
MX2016006087A (es) * 2013-11-11 2016-08-12 Impax Laboratories Inc Formulaciones de desintegracion rapida y metodos de uso.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3972995A (en) * 1975-04-14 1976-08-03 American Home Products Corporation Dosage form
DE2746414A1 (de) * 1977-10-15 1979-04-26 Gerlach Eduard Chem Fab Mittel zum dosieren von stoffen und verfahren zu seiner herstellung
DE69514794T2 (de) * 1994-04-22 2000-07-27 Pentech Pharmaceuticals Inc Sublinguale dosierungsformen enthaltend apomorphin zur verwendung bei der behandlung von erektiler dysfunktion
FR2732896B1 (fr) * 1995-04-11 1997-06-13 Prographarm Lab Forme pharmaceutique transdermique pour l'administration percutanee de l'apomorphine

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7910132B2 (en) 1998-09-24 2011-03-22 Orexo Ab Pharmaceutical composition for the treatment of acute disorders
US8454996B2 (en) 1998-09-24 2013-06-04 Orexo Ab Pharmaceutical composition for the treatment of acute disorders
US8512747B2 (en) 1998-09-24 2013-08-20 Orexo Ab Pharmaceutical composition for the treatment of acute disorders
CN101005824B (zh) * 2004-06-17 2012-05-30 高露洁-棕榄公司 口腔护理薄膜
US9669018B2 (en) 2009-06-12 2017-06-06 Sunovion Pharmaceuticals Inc. Sublingual apomorphine
US9669020B2 (en) 2009-06-12 2017-06-06 Sunovion Pharmaceuticals Inc. Sublingual apomorphine
US9326981B2 (en) 2009-06-12 2016-05-03 Cynapsus Therapeutics, Inc. Sublingual apomorphine
US10420763B2 (en) 2009-06-12 2019-09-24 Sunovion Pharmaceuticals Inc. Sublingual apomorphine
US9044475B2 (en) 2009-06-12 2015-06-02 Cynapsus Therapeutics, Inc. Sublingual apomorphine
US9669021B2 (en) 2009-06-12 2017-06-06 Sunovion Pharmaceuticals Inc. Sublingual apomorphine
US9669019B2 (en) 2009-06-12 2017-06-06 Sunovion Pharmaceuticals Inc. Sublingual apomorphine
EP2952191B1 (fr) 2009-06-12 2018-08-22 Sunovion Pharmaceuticals Inc. Apomorphine sublinguale
US9283219B2 (en) 2010-12-16 2016-03-15 Cynapsus Therapeutics, Inc. Sublingual films
US10285953B2 (en) 2010-12-16 2019-05-14 Sunovion Pharmaceuticals Inc. Sublingual films
US9427412B2 (en) 2010-12-16 2016-08-30 Cynapsus Therapeutics, Inc. Sublingual films
US11419769B2 (en) 2010-12-16 2022-08-23 Sunovion Pharmaceuticals Inc. Sublingual films
US10449146B2 (en) 2015-04-21 2019-10-22 Sunovion Pharmaceuticals Inc. Methods of treating parkinson's disease by administration of apomorphine to an oral mucosa
US10959943B2 (en) 2015-04-21 2021-03-30 Sunovion Pharmaceuticals Inc. Methods of treating Parkinson's disease by administration of apomorphine to an oral mucosa

Also Published As

Publication number Publication date
NO992944D0 (no) 1999-06-16
AU746373B2 (en) 2002-04-18
DE19652268C2 (de) 2000-06-29
NO992944L (no) 1999-06-16
WO1998026763A1 (fr) 1998-06-25
DE19652268A1 (de) 1998-06-18
KR20000057627A (ko) 2000-09-25
AU5654798A (en) 1998-07-15
EP0959875A1 (fr) 1999-12-01
JP2001506612A (ja) 2001-05-22

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued
FZDE Discontinued

Effective date: 20031121