CA2272089A1 - 17.alpha.-dihydroequilenin for use as a medical antioxidant - Google Patents

17.alpha.-dihydroequilenin for use as a medical antioxidant Download PDF

Info

Publication number
CA2272089A1
CA2272089A1 CA002272089A CA2272089A CA2272089A1 CA 2272089 A1 CA2272089 A1 CA 2272089A1 CA 002272089 A CA002272089 A CA 002272089A CA 2272089 A CA2272089 A CA 2272089A CA 2272089 A1 CA2272089 A1 CA 2272089A1
Authority
CA
Canada
Prior art keywords
dihydroequilenin
alpha
free radical
pharmaceutically acceptable
sulfate ester
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002272089A
Other languages
English (en)
French (fr)
Inventor
Steven Jay Adelman
Dorothy Helen Prozialeck
Donald Eugene Clark
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2272089A1 publication Critical patent/CA2272089A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/5685—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone having an oxo group in position 17, e.g. androsterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Biochemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Toxicology (AREA)
  • Psychiatry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA002272089A 1996-12-09 1997-12-05 17.alpha.-dihydroequilenin for use as a medical antioxidant Abandoned CA2272089A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US76263496A 1996-12-09 1996-12-09
US08/762,634 1996-12-09
PCT/US1997/022155 WO1998025627A1 (en) 1996-12-09 1997-12-05 17α-DIHYDROEQUILENIN FOR USE AS A MEDICAL ANTIOXIDANT

Publications (1)

Publication Number Publication Date
CA2272089A1 true CA2272089A1 (en) 1998-06-18

Family

ID=25065657

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002272089A Abandoned CA2272089A1 (en) 1996-12-09 1997-12-05 17.alpha.-dihydroequilenin for use as a medical antioxidant

Country Status (13)

Country Link
EP (1) EP0946182A1 (es)
JP (1) JP2001506629A (es)
KR (1) KR20000069346A (es)
CN (1) CN1239890A (es)
AR (1) AR010336A1 (es)
AU (1) AU743519B2 (es)
BR (1) BR9714382A (es)
CA (1) CA2272089A1 (es)
HU (1) HUP0000570A3 (es)
IL (1) IL130069A0 (es)
NZ (1) NZ336341A (es)
WO (1) WO1998025627A1 (es)
ZA (1) ZA9711053B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6271221B1 (en) * 1996-12-10 2001-08-07 American Home Products Corporation Use of equilenin as an antioxidant
DE10154221A1 (de) * 2001-11-07 2003-05-15 Max Delbrueck Centrum Mittel zur Behandlung von Läsionen des Nervensystems

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4338314C1 (de) * 1993-11-10 1995-03-30 Jenapharm Gmbh Pharmazeutische Präparate zur Prophylaxe und Therapie radikalvermittelter Zellschädigungen

Also Published As

Publication number Publication date
HUP0000570A2 (hu) 2000-10-28
WO1998025627A1 (en) 1998-06-18
AU743519B2 (en) 2002-01-31
CN1239890A (zh) 1999-12-29
AR010336A1 (es) 2000-06-07
EP0946182A1 (en) 1999-10-06
IL130069A0 (en) 2000-02-29
BR9714382A (pt) 2000-05-16
ZA9711053B (en) 1999-06-09
HUP0000570A3 (en) 2000-12-28
NZ336341A (en) 2002-02-01
KR20000069346A (ko) 2000-11-25
AU5464498A (en) 1998-07-03
JP2001506629A (ja) 2001-05-22

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued