HUP0000570A2 - 17 Alfa-dihidroekvilenin alkalmazása szabadgyökök által indukált betegségek elleni gyógyszerkészítmények előállítására - Google Patents
17 Alfa-dihidroekvilenin alkalmazása szabadgyökök által indukált betegségek elleni gyógyszerkészítmények előállításáraInfo
- Publication number
- HUP0000570A2 HUP0000570A2 HU0000570A HUP0000570A HUP0000570A2 HU P0000570 A2 HUP0000570 A2 HU P0000570A2 HU 0000570 A HU0000570 A HU 0000570A HU P0000570 A HUP0000570 A HU P0000570A HU P0000570 A2 HUP0000570 A2 HU P0000570A2
- Authority
- HU
- Hungary
- Prior art keywords
- disease
- disease states
- dihydroequilenin
- alpha
- treatment
- Prior art date
Links
- 201000010099 disease Diseases 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
- RYWZPRVUQHMJFF-KSZLIROESA-N 17alpha-Dihydroequilenin Chemical compound OC1=CC=C2C(CC[C@]3([C@H]4CC[C@H]3O)C)=C4C=CC2=C1 RYWZPRVUQHMJFF-KSZLIROESA-N 0.000 title 1
- RYWZPRVUQHMJFF-UHFFFAOYSA-N 17alpha-Dihydroequilenin Natural products OC1=CC=C2C(CCC3(C4CCC3O)C)=C4C=CC2=C1 RYWZPRVUQHMJFF-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000003254 radicals Chemical class 0.000 title 1
- 208000004756 Respiratory Insufficiency Diseases 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- 201000004193 respiratory failure Diseases 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 208000020084 Bone disease Diseases 0.000 abstract 1
- 206010008909 Chronic Hepatitis Diseases 0.000 abstract 1
- 206010014561 Emphysema Diseases 0.000 abstract 1
- 206010019755 Hepatitis chronic active Diseases 0.000 abstract 1
- 206010019799 Hepatitis viral Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000001738 Nervous System Trauma Diseases 0.000 abstract 1
- 208000018262 Peripheral vascular disease Diseases 0.000 abstract 1
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- 206010063837 Reperfusion injury Diseases 0.000 abstract 1
- 208000027418 Wounds and injury Diseases 0.000 abstract 1
- 230000032683 aging Effects 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 230000006378 damage Effects 0.000 abstract 1
- 230000018109 developmental process Effects 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 208000014674 injury Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000010410 reperfusion Effects 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 abstract 1
- 201000008827 tuberculosis Diseases 0.000 abstract 1
- 201000001862 viral hepatitis Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
- A61K31/5685—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone having an oxo group in position 17, e.g. androsterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Biochemistry (AREA)
- Hospice & Palliative Care (AREA)
- Toxicology (AREA)
- Psychiatry (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A találmány 17a-dihidroekvilenin vagy 17a-dihidroekvilenin-3-szulfát-észter gyógyszerészetileg elfogadható sójának az alkalmazásáravonatkozik szabadgyökök által indukált betegségi állapotok enyhítésérevagy kezelésére alkalmas gyógyszer előállításában, közelebbrőlrákfélék, központi idegrendszeri rendellenességek, Alzheimer-kór,csontbetegség, öregedés, gyulladásos rendellenességek, perifériálisvaszkuláris betegség, reumatoid arthritis, autoimmun betegségek,légzőszervi elégtelenség, emphysema, reperfúzióssérülés-megelőzés,virális hepatitisz, krónikus aktív hepatitisz, tuberkolózis,pszoriázis, szisztémiás lupus eriythematosus, felnőttkori légzőszervielégtelenségi szindróma, központi idegrendszeri trauma és stroke vagyreperfúziós eljárások alatti sérüléseknek a kialakulásában szerepetjátszó endogén szabadgyökök gátlására alkalmas gyógyszerelőállításában. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US76263496A | 1996-12-09 | 1996-12-09 | |
| PCT/US1997/022155 WO1998025627A1 (en) | 1996-12-09 | 1997-12-05 | 17α-DIHYDROEQUILENIN FOR USE AS A MEDICAL ANTIOXIDANT |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0000570A2 true HUP0000570A2 (hu) | 2000-10-28 |
| HUP0000570A3 HUP0000570A3 (en) | 2000-12-28 |
Family
ID=25065657
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0000570A HUP0000570A3 (en) | 1996-12-09 | 1997-12-05 | Use of 17 alpha-dihydroequilenin for producing pharmaceutical compositions for the treatment of free radical induced disease states |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0946182A1 (hu) |
| JP (1) | JP2001506629A (hu) |
| KR (1) | KR20000069346A (hu) |
| CN (1) | CN1239890A (hu) |
| AR (1) | AR010336A1 (hu) |
| AU (1) | AU743519B2 (hu) |
| BR (1) | BR9714382A (hu) |
| CA (1) | CA2272089A1 (hu) |
| HU (1) | HUP0000570A3 (hu) |
| IL (1) | IL130069A0 (hu) |
| NZ (1) | NZ336341A (hu) |
| WO (1) | WO1998025627A1 (hu) |
| ZA (1) | ZA9711053B (hu) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6271221B1 (en) * | 1996-12-10 | 2001-08-07 | American Home Products Corporation | Use of equilenin as an antioxidant |
| DE10154221A1 (de) * | 2001-11-07 | 2003-05-15 | Max Delbrueck Centrum | Mittel zur Behandlung von Läsionen des Nervensystems |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4338314C1 (de) * | 1993-11-10 | 1995-03-30 | Jenapharm Gmbh | Pharmazeutische Präparate zur Prophylaxe und Therapie radikalvermittelter Zellschädigungen |
-
1997
- 1997-12-05 BR BR9714382-0A patent/BR9714382A/pt not_active IP Right Cessation
- 1997-12-05 HU HU0000570A patent/HUP0000570A3/hu unknown
- 1997-12-05 WO PCT/US1997/022155 patent/WO1998025627A1/en not_active Application Discontinuation
- 1997-12-05 IL IL13006997A patent/IL130069A0/xx unknown
- 1997-12-05 KR KR1019997005048A patent/KR20000069346A/ko not_active Application Discontinuation
- 1997-12-05 AR ARP970105739A patent/AR010336A1/es unknown
- 1997-12-05 JP JP52680598A patent/JP2001506629A/ja active Pending
- 1997-12-05 CA CA002272089A patent/CA2272089A1/en not_active Abandoned
- 1997-12-05 CN CN97180446A patent/CN1239890A/zh active Pending
- 1997-12-05 EP EP97948610A patent/EP0946182A1/en not_active Ceased
- 1997-12-05 AU AU54644/98A patent/AU743519B2/en not_active Ceased
- 1997-12-05 NZ NZ336341A patent/NZ336341A/en unknown
- 1997-12-09 ZA ZA9711053A patent/ZA9711053B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU5464498A (en) | 1998-07-03 |
| CN1239890A (zh) | 1999-12-29 |
| KR20000069346A (ko) | 2000-11-25 |
| ZA9711053B (en) | 1999-06-09 |
| AU743519B2 (en) | 2002-01-31 |
| NZ336341A (en) | 2002-02-01 |
| BR9714382A (pt) | 2000-05-16 |
| EP0946182A1 (en) | 1999-10-06 |
| WO1998025627A1 (en) | 1998-06-18 |
| CA2272089A1 (en) | 1998-06-18 |
| IL130069A0 (en) | 2000-02-29 |
| JP2001506629A (ja) | 2001-05-22 |
| HUP0000570A3 (en) | 2000-12-28 |
| AR010336A1 (es) | 2000-06-07 |
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