CA2271952A1 - Variants de recepteur il-9, utilises pour le traitement et le diagnostic des allergies atopique, y compris l'asthme et les troubles apparentes - Google Patents
Variants de recepteur il-9, utilises pour le traitement et le diagnostic des allergies atopique, y compris l'asthme et les troubles apparentes Download PDFInfo
- Publication number
- CA2271952A1 CA2271952A1 CA002271952A CA2271952A CA2271952A1 CA 2271952 A1 CA2271952 A1 CA 2271952A1 CA 002271952 A CA002271952 A CA 002271952A CA 2271952 A CA2271952 A CA 2271952A CA 2271952 A1 CA2271952 A1 CA 2271952A1
- Authority
- CA
- Canada
- Prior art keywords
- dna
- seq
- receptor
- asthma
- human
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims abstract 22
- 208000006673 asthma Diseases 0.000 title claims abstract 14
- 108010038414 Interleukin-9 Receptors Proteins 0.000 title claims 10
- 102000010682 Interleukin-9 Receptors Human genes 0.000 title claims 10
- 206010003645 Atopy Diseases 0.000 title abstract 2
- 206010020751 Hypersensitivity Diseases 0.000 title 1
- 230000007815 allergy Effects 0.000 title 1
- 238000000034 method Methods 0.000 claims abstract 34
- 102000004169 proteins and genes Human genes 0.000 claims abstract 15
- 108090000623 proteins and genes Proteins 0.000 claims abstract 15
- 238000011282 treatment Methods 0.000 claims abstract 6
- 108020004705 Codon Proteins 0.000 claims abstract 4
- 150000001413 amino acids Chemical class 0.000 claims abstract 4
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims abstract 4
- 108020004414 DNA Proteins 0.000 claims 38
- 102000039446 nucleic acids Human genes 0.000 claims 25
- 108020004707 nucleic acids Proteins 0.000 claims 25
- 150000007523 nucleic acids Chemical class 0.000 claims 25
- 101001055219 Homo sapiens Interleukin-9 receptor Proteins 0.000 claims 21
- 239000012634 fragment Substances 0.000 claims 20
- 208000030603 inherited susceptibility to asthma Diseases 0.000 claims 16
- 208000013931 susceptibility to asthma Diseases 0.000 claims 16
- 210000004027 cell Anatomy 0.000 claims 14
- 239000000203 mixture Substances 0.000 claims 11
- 102000053602 DNA Human genes 0.000 claims 10
- 230000003321 amplification Effects 0.000 claims 10
- 238000003199 nucleic acid amplification method Methods 0.000 claims 10
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 7
- 102000000585 Interleukin-9 Human genes 0.000 claims 7
- 108010002335 Interleukin-9 Proteins 0.000 claims 7
- 239000005557 antagonist Substances 0.000 claims 6
- 241001529936 Murinae Species 0.000 claims 3
- 210000003979 eosinophil Anatomy 0.000 claims 3
- 102000051950 human IL9R Human genes 0.000 claims 3
- 239000002773 nucleotide Substances 0.000 claims 3
- 125000003729 nucleotide group Chemical group 0.000 claims 3
- 230000006907 apoptotic process Effects 0.000 claims 2
- 210000001072 colon Anatomy 0.000 claims 2
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims 2
- 229960003957 dexamethasone Drugs 0.000 claims 2
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 2
- 125000000487 histidyl group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C([H])=N1 0.000 claims 2
- 210000003593 megakaryocyte Anatomy 0.000 claims 2
- 210000000440 neutrophil Anatomy 0.000 claims 2
- 230000037361 pathway Effects 0.000 claims 2
- 230000026731 phosphorylation Effects 0.000 claims 2
- 238000006366 phosphorylation reaction Methods 0.000 claims 2
- 230000004163 JAK-STAT signaling pathway Effects 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 238000011144 upstream manufacturing Methods 0.000 claims 1
- 208000024711 extrinsic asthma Diseases 0.000 abstract 3
- 238000003745 diagnosis Methods 0.000 abstract 2
- 238000012217 deletion Methods 0.000 abstract 1
- 230000037430 deletion Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Analytical Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- General Engineering & Computer Science (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
L'invention porte sur le diagnostic, le traitement et des procédés visant à rechercher de nouvelles thérapies pour l'asthme atopique et les pathologies apparentées sur la base de variantes du facteur 2 associé à l'asthme (AAF2). Selon une réalisation, l'invention porte sur une variante de l'AAF2 dans laquelle est supprimé le codon à la position 173, ce qui entraîne la perte de la glutamine à la position 173 issue du précurseur de la protéine mature. Cette suppression des acides aminés génère une protéine non fonctionnelle de l'AAF2 et, par conséquent, la présence de phénotype devrait être manifestement moins associée à l'asthme atopique. Donc, le manque de sensibilité à un phénotype atopique, asthmatique est caractérisé par la perte de glutamine à la position 173 du codon. Cette invention porte également sur des molécules d'ADN isolées qui sont des variantes de la séquence du phénotype sauvage, ainsi que sur des protéines codées par cet ADN, et sur l'utilisation des molécules d'ADN et de la protéine exprimée, dans le diagnostic et le traitement de l'asthme atopique.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA002689842A CA2689842A1 (fr) | 1996-12-02 | 1997-12-02 | Variants de recepteur il-9, utilises pour le traitement et le diagnostic des allergies atopique, y compris l'asthme et les troubles apparentes |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3222496P | 1996-12-02 | 1996-12-02 | |
| US60/032,224 | 1996-12-02 | ||
| US98087297A | 1997-12-01 | 1997-12-01 | |
| US08/980,872 | 1997-12-01 | ||
| PCT/US1997/021992 WO1998024904A2 (fr) | 1996-12-02 | 1997-12-02 | Variants de recepteur il-9, utilises pour le traitement et le diagnostic des allergies atopique, y compris l'asthme et les troubles apparentes |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002689842A Division CA2689842A1 (fr) | 1996-12-02 | 1997-12-02 | Variants de recepteur il-9, utilises pour le traitement et le diagnostic des allergies atopique, y compris l'asthme et les troubles apparentes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2271952A1 true CA2271952A1 (fr) | 1998-06-11 |
| CA2271952C CA2271952C (fr) | 2010-04-06 |
Family
ID=26708147
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2271952A Expired - Fee Related CA2271952C (fr) | 1996-12-02 | 1997-12-02 | Variants de recepteur il-9, utilises pour le traitement et le diagnostic des allergies atopique, y compris l'asthme et les troubles apparentes |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0942979A2 (fr) |
| JP (2) | JP4552076B2 (fr) |
| AT (1) | ATE471982T1 (fr) |
| AU (1) | AU746595B2 (fr) |
| CA (1) | CA2271952C (fr) |
| DE (1) | DE69739920D1 (fr) |
| ES (1) | ES2347962T3 (fr) |
| PT (1) | PT1471144E (fr) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1632248T3 (da) * | 1995-08-24 | 2011-01-24 | Ligand Pharm Inc | Anti-interleukin-9-antistof eller anti-interleukin-9-receptor-antistof til behandling af bronkial overfølsomhed |
-
1997
- 1997-12-02 AU AU56891/98A patent/AU746595B2/en not_active Ceased
- 1997-12-02 ES ES04013403T patent/ES2347962T3/es not_active Expired - Lifetime
- 1997-12-02 CA CA2271952A patent/CA2271952C/fr not_active Expired - Fee Related
- 1997-12-02 DE DE69739920T patent/DE69739920D1/de not_active Expired - Lifetime
- 1997-12-02 JP JP52573798A patent/JP4552076B2/ja not_active Expired - Fee Related
- 1997-12-02 AT AT04013403T patent/ATE471982T1/de not_active IP Right Cessation
- 1997-12-02 EP EP97953072A patent/EP0942979A2/fr not_active Withdrawn
- 1997-12-02 PT PT04013403T patent/PT1471144E/pt unknown
-
2009
- 2009-03-02 JP JP2009048597A patent/JP2009159976A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP4552076B2 (ja) | 2010-09-29 |
| JP2002514911A (ja) | 2002-05-21 |
| ATE471982T1 (de) | 2010-07-15 |
| PT1471144E (pt) | 2010-08-17 |
| CA2271952C (fr) | 2010-04-06 |
| AU746595B2 (en) | 2002-05-02 |
| JP2009159976A (ja) | 2009-07-23 |
| EP0942979A2 (fr) | 1999-09-22 |
| AU5689198A (en) | 1998-06-29 |
| ES2347962T3 (es) | 2010-11-26 |
| DE69739920D1 (de) | 2010-08-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Kapur et al. | A118g polymorphism in mu opioid receptor gene (oprm1): association with opiate addiction in subjects of Indian origin | |
| CA2337491A1 (fr) | Mutations geniques mink humaines associees a l'arythmie | |
| Chanock et al. | Genomic structure of the human p47-phox (NCF1) gene | |
| Dianzani et al. | Mutations in the erythropoietin receptor gene are not a common cause of Diamond-Blackfan anemia | |
| Caggana et al. | Population-based studies reveal differences in the allelic frequencies of two functionally significant human interleukin-4 receptor polymorphisms in several ethnic groups | |
| CA2271952A1 (fr) | Variants de recepteur il-9, utilises pour le traitement et le diagnostic des allergies atopique, y compris l'asthme et les troubles apparentes | |
| CN113943795B (zh) | 一种用于检测噪音相关性耳聋基因的探针组及其试剂盒 | |
| Qin et al. | Association between CXCL12 and CXCR4 polymorphisms and inflammatory bowel disease risk in a Guangxi Zhuang population. | |
| WO2001090169A1 (fr) | Nouveau polypeptide, antigene nucleaire de proliferation cellulaire (pcna) 13, et polynucleotide codant ce polypeptide | |
| WO2001068689A1 (fr) | Nouveau polypeptide, 1alpha sous-unite 13 humaine du facteur adaptatif de l'hypoxie, et polynucleotide codant pour ce polypeptide | |
| WO2001098502A1 (fr) | Nouveau polypeptide, arginase humaine 9, et polynucleotide codant ce polypeptide | |
| WO2001098505A1 (fr) | Nouveau polypeptide, proteine 11 de liaison d'une udp-glycosyltransferase (ugt) et d'une cobalamine, et polynucleotide codant ce polypeptide | |
| WO2001074888A1 (fr) | Nouveau polypeptide, $g(b)-preprotachykinine humaine 9, et polynucleotide codant pour ce polypeptide | |
| WO2001066707A1 (fr) | Nouveau polypeptide, serine protease humaine atp-dependante 11, et polynucleotide codant pour ce polypeptide | |
| Julies | Molecular-genetic analysis of Hirschsprung's disease in South Africa | |
| WO2001064745A1 (fr) | Nouveau polypeptide, beta-preprotachykinine 12, et polynucleotide codant pour ce polypeptide | |
| WO2001049858A1 (fr) | NOUVEAU POLYPEPTIDE, η-GLUTAMYL TRANSPEPTIDASE 9, ET POLYNUCLEOTIDE CODANT POUR CE POLYPEPTIDE | |
| WO2001049733A1 (fr) | Nouveau polypeptide, glycosyl hydrolase 12, et polynucleotide codant pour ce polypeptide | |
| WO2001075040A2 (fr) | Nouveau polypeptide, pterine-molybdene oxydoreductase humaine 12, et polynucleotide codant pour ce polypeptide | |
| WO2002004633A1 (fr) | Nouveau polypeptide, proteine humaine de fasciculation et d'extension 12.87, et polynucleotide codant ce polypeptide | |
| WO2001087965A1 (fr) | Nouveau polypeptide, proteine humaine 15 associee a la voie de transmission synaptique, et polynucleotide codant pour ce polypeptide | |
| WO2002012303A1 (fr) | Nouveau polypeptide, proteine humaine de regulation 10.23 d'une ribonucleoside-diphosphate reductase, et polynucleotide codant ce polypeptide | |
| WO2002020781A1 (fr) | Nouveau polypeptide, proteine associee au gene de translocation de la moelle osseuse 12.32, et polynucleotide codant ce polypeptide | |
| WO2002006336A1 (fr) | Nouveau polypeptide, proteine humaine drim 13.09, et polynucleotide codant ce polypeptide | |
| WO2002012512A1 (fr) | Nouveau polypeptide, 6-pyruvoyl-tetrahydropterine synthase 11 humaine (ptps), et polynucleotide codant ce polypeptide |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20131203 |