CA2271728A1 - Substituted tetrahydro-1,3,5-triazin-2[1h]-thiones as anti-atherosclerotic agents - Google Patents

Substituted tetrahydro-1,3,5-triazin-2[1h]-thiones as anti-atherosclerotic agents Download PDF

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Publication number
CA2271728A1
CA2271728A1 CA002271728A CA2271728A CA2271728A1 CA 2271728 A1 CA2271728 A1 CA 2271728A1 CA 002271728 A CA002271728 A CA 002271728A CA 2271728 A CA2271728 A CA 2271728A CA 2271728 A1 CA2271728 A1 CA 2271728A1
Authority
CA
Canada
Prior art keywords
methyl
carbon atoms
triazin
tetrahydro
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002271728A
Other languages
English (en)
French (fr)
Inventor
Robert John Steffan
Kevin Anthony Memoli
Donald Peter Strike
Amedeo Arturo Failli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2271728A1 publication Critical patent/CA2271728A1/en
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/08—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA002271728A 1996-11-14 1997-11-10 Substituted tetrahydro-1,3,5-triazin-2[1h]-thiones as anti-atherosclerotic agents Abandoned CA2271728A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US74887696A 1996-11-14 1996-11-14
US08/748,876 1996-11-14
PCT/US1997/020233 WO1998021190A1 (en) 1996-11-14 1997-11-10 Substituted tetrahydro-1,3,5-triazin-2[1h]-thiones as anti-atherosclerotic agents

Publications (1)

Publication Number Publication Date
CA2271728A1 true CA2271728A1 (en) 1998-05-22

Family

ID=25011313

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002271728A Abandoned CA2271728A1 (en) 1996-11-14 1997-11-10 Substituted tetrahydro-1,3,5-triazin-2[1h]-thiones as anti-atherosclerotic agents

Country Status (7)

Country Link
EP (1) EP0938480A1 (ja)
JP (1) JP2001503769A (ja)
AR (1) AR010068A1 (ja)
AU (1) AU5170698A (ja)
CA (1) CA2271728A1 (ja)
WO (1) WO1998021190A1 (ja)
ZA (1) ZA9710265B (ja)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6562814B2 (en) 2000-10-02 2003-05-13 Wyeth 3-thioxo-[1,2,4]-oxadiazinan-5-one derivatives
CA2454059A1 (en) * 2001-07-19 2003-01-30 Cv Therapeutics, Inc. Substituted piperazine compounds and their use as fatty acid oxidation inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK236878A (da) * 1977-07-22 1979-01-23 Pfizer Tetrahydro-s-triazin-2(1h)-thioner
HUT62558A (en) * 1991-07-01 1993-05-28 Sandoz Ag Process for producing n-phenylthiourea derivaties and pharmaceutical compositions comprising same
US5554607A (en) * 1995-11-28 1996-09-10 American Home Products Corporation Use of 2-thioxo-imidazolin-4-one derivatives in the treatment of atherosclerosis
HUP9901968A3 (en) * 1996-03-07 2000-01-28 American Home Products Corp Ma 2-thioxotetrahydropyrimidin-4-one derivatives and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
AU5170698A (en) 1998-06-03
EP0938480A1 (en) 1999-09-01
WO1998021190A1 (en) 1998-05-22
AR010068A1 (es) 2000-05-17
JP2001503769A (ja) 2001-03-21
ZA9710265B (en) 1999-08-13

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