CA2271135A1 - Nucleosides - Google Patents
Nucleosides Download PDFInfo
- Publication number
- CA2271135A1 CA2271135A1 CA002271135A CA2271135A CA2271135A1 CA 2271135 A1 CA2271135 A1 CA 2271135A1 CA 002271135 A CA002271135 A CA 002271135A CA 2271135 A CA2271135 A CA 2271135A CA 2271135 A1 CA2271135 A1 CA 2271135A1
- Authority
- CA
- Canada
- Prior art keywords
- guanine
- mmole
- valyl
- butyl
- mmol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
Esters mélangés de nucléosides antiviraux, tels que des composés représentés par la formule (I) dans laquelle B représente une base de nucléotide naturelle ou non, X représente O ou CH¿2?, Y et Z représente chacun H ou constituent ensemble une liaison ou Y représente méthylène ou -CH(OH)- et Z représente une liaison avec ces dernières; n est 0 ou 1; un de R¿1? et de R¿2? représente le résidu acyle d'un acide amino aliphatique et l'autre représente alkyle -C(=O)C¿5?-C¿21?, et leurs sels acceptables sur le plan pharmaceutique, possédant des propriétés pharmacocinétiques et d'autres propriétés avantageuses.
Applications Claiming Priority (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9604154-6 | 1996-11-12 | ||
SE9604154A SE9604154D0 (sv) | 1996-11-12 | 1996-11-12 | Anticancer compounds |
SE9604165A SE9604165D0 (sv) | 1996-11-12 | 1996-11-12 | Antivirals |
SE9604165-2 | 1996-11-12 | ||
US79821897A | 1997-02-10 | 1997-02-10 | |
US08/798,218 | 1997-02-10 | ||
US91292797A | 1997-08-15 | 1997-08-15 | |
SE9702957A SE9702957D0 (sv) | 1997-08-15 | 1997-08-15 | Antivirals |
US08/912,927 | 1997-08-15 | ||
SE9702957-3 | 1997-08-15 | ||
PCT/SE1997/001903 WO1998021223A1 (fr) | 1996-11-12 | 1997-11-12 | Nucleosides |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2271135A1 true CA2271135A1 (fr) | 1998-05-22 |
Family
ID=27532793
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002271135A Abandoned CA2271135A1 (fr) | 1996-11-12 | 1997-11-12 | Nucleosides |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0942916A2 (fr) |
JP (1) | JP2001503767A (fr) |
KR (1) | KR20000053226A (fr) |
AU (1) | AU735438B2 (fr) |
CA (1) | CA2271135A1 (fr) |
WO (1) | WO1998021223A1 (fr) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6458772B1 (en) | 1909-10-07 | 2002-10-01 | Medivir Ab | Prodrugs |
ATE200900T1 (de) * | 1997-08-15 | 2001-05-15 | Medivir Ab | Analoge nukleoside, wie antivirale einschliesslich inhibitoren der retroviralen reverstranskriptase und der dna polymerase des hepatitis b virus |
WO1999051613A1 (fr) * | 1998-04-03 | 1999-10-14 | Medivir Ab | Promedicaments de produits pharmaceutiques contenant du phosphore |
US6277830B1 (en) * | 1998-10-16 | 2001-08-21 | Schering Corporation | 5′-amino acid esters of ribavirin and the use of same to treat hepatitis C with interferon |
AU762395B2 (en) * | 1998-10-16 | 2003-06-26 | Schering Corporation | Ribavirin-interferon alfa combination therapy for eradicating detectable HCV-RNA in patients having chronic hepatitis C infection |
US6403564B1 (en) | 1998-10-16 | 2002-06-11 | Schering Corporation | Ribavirin-interferon alfa combination therapy for eradicating detectable HCV-RNA in patients having chronic hepatitis C infection |
AU2001255495A1 (en) | 2000-04-20 | 2001-11-07 | Schering Corporation | Ribavirin-interferon alfa combination therapy for eradicating detectable hcv-rnain patients having chronic hepatitis c infection |
CA2649826A1 (fr) * | 2001-11-14 | 2003-05-22 | Teva Pharmaceutical Industries Ltd. | Synthese et purification de valacyclovir |
TW200500374A (en) * | 2002-06-28 | 2005-01-01 | Idenlx Cayman Ltd | 2' and 3' -nucleoside produrgs for treating flavivridae infections |
JP5087211B2 (ja) * | 2002-06-28 | 2012-12-05 | イデニクス(ケイマン)リミテツド | フラビウィルス感染治療のための2′および3′−ヌクレオシドプロドラッグ |
ZA200702234B (en) * | 2006-03-21 | 2008-07-30 | Cipla Ltd | Preparation of ester of purine derivatives |
DE102017219046A1 (de) | 2017-10-25 | 2019-04-25 | BSH Hausgeräte GmbH | Haushaltsgerät zur Pflege von Wäschestücken mit einer Unwuchtausgleichsvorrichtung mit verformbarer Bremseinheit und Verfahren zum Betreiben eines derartigen Haushaltsgeräts |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1321994C (fr) * | 1987-10-28 | 1993-09-07 | Reid Von Borstel | Uridine et cytidine acylee et ses utilisations |
DE68922903T2 (de) * | 1988-12-19 | 1995-11-23 | Wellcome Found | Antivirale Pyrimidin- und Purinverbindungen, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Präparate. |
GB9515279D0 (en) * | 1995-07-25 | 1995-09-20 | Norsk Hydro As | Improved therapeutic agents |
DE4311801A1 (de) * | 1993-04-09 | 1994-10-13 | Hoechst Ag | Neue Carbonsäureester von 2-Amino-7-(1,3-dihydroxy-2-propoxymethyl)purin, deren Herstellung sowie deren Verwendung |
US5840890A (en) * | 1996-01-26 | 1998-11-24 | Syntex (U.S.A.) Inc. | Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative |
US5869493A (en) * | 1996-02-16 | 1999-02-09 | Medivir Ab | Acyclic nucleoside derivatives |
-
1997
- 1997-11-12 WO PCT/SE1997/001903 patent/WO1998021223A1/fr not_active Application Discontinuation
- 1997-11-12 JP JP52248098A patent/JP2001503767A/ja active Pending
- 1997-11-12 KR KR1019990704201A patent/KR20000053226A/ko not_active Application Discontinuation
- 1997-11-12 CA CA002271135A patent/CA2271135A1/fr not_active Abandoned
- 1997-11-12 AU AU50759/98A patent/AU735438B2/en not_active Ceased
- 1997-11-12 EP EP97913620A patent/EP0942916A2/fr not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
EP0942916A2 (fr) | 1999-09-22 |
KR20000053226A (ko) | 2000-08-25 |
AU735438B2 (en) | 2001-07-05 |
AU5075998A (en) | 1998-06-03 |
JP2001503767A (ja) | 2001-03-21 |
WO1998021223A1 (fr) | 1998-05-22 |
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CA2271135A1 (fr) | Nucleosides | |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Dead |