CA2271088C - Dispositif d'ionophorese comportant au moins un ensemble electrode a membrane, pour l'administration transcutanee de principes actifs a un sujet - Google Patents
Dispositif d'ionophorese comportant au moins un ensemble electrode a membrane, pour l'administration transcutanee de principes actifs a un sujet Download PDFInfo
- Publication number
- CA2271088C CA2271088C CA002271088A CA2271088A CA2271088C CA 2271088 C CA2271088 C CA 2271088C CA 002271088 A CA002271088 A CA 002271088A CA 2271088 A CA2271088 A CA 2271088A CA 2271088 C CA2271088 C CA 2271088C
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- Prior art keywords
- electrode
- polyamide
- membrane
- primary
- assembly
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- LLPOLZWFYMWNKH-CMKMFDCUSA-N hydrocodone Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)CC(=O)[C@@H]1OC1=C2C3=CC=C1OC LLPOLZWFYMWNKH-CMKMFDCUSA-N 0.000 description 1
- 229960000240 hydrocodone Drugs 0.000 description 1
- OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 description 1
- 238000000099 in vitro assay Methods 0.000 description 1
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- 229940102223 injectable solution Drugs 0.000 description 1
- 238000009413 insulation Methods 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000003055 low molecular weight heparin Substances 0.000 description 1
- 229940127215 low-molecular weight heparin Drugs 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 238000001465 metallisation Methods 0.000 description 1
- IUBSYMUCCVWXPE-UHFFFAOYSA-N metoprolol Chemical compound COCCC1=CC=C(OCC(O)CNC(C)C)C=C1 IUBSYMUCCVWXPE-UHFFFAOYSA-N 0.000 description 1
- 229960002237 metoprolol Drugs 0.000 description 1
- 244000309715 mini pig Species 0.000 description 1
- 150000002823 nitrates Chemical class 0.000 description 1
- 206010033675 panniculitis Diseases 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 229920002492 poly(sulfone) Polymers 0.000 description 1
- 229920002480 polybenzimidazole Polymers 0.000 description 1
- 229920006146 polyetheresteramide block copolymer Polymers 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 229920002689 polyvinyl acetate Polymers 0.000 description 1
- 239000011118 polyvinyl acetate Substances 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- DOKHEARVIDLSFF-UHFFFAOYSA-N prop-1-en-1-ol Chemical group CC=CO DOKHEARVIDLSFF-UHFFFAOYSA-N 0.000 description 1
- 239000001294 propane Substances 0.000 description 1
- AQHHHDLHHXJYJD-UHFFFAOYSA-N propranolol Chemical compound C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 AQHHHDLHHXJYJD-UHFFFAOYSA-N 0.000 description 1
- 230000001012 protector Effects 0.000 description 1
- 238000012797 qualification Methods 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 229960002052 salbutamol Drugs 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000004544 sputter deposition Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000012086 standard solution Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 210000004304 subcutaneous tissue Anatomy 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 229910052715 tantalum Inorganic materials 0.000 description 1
- GUVRBAGPIYLISA-UHFFFAOYSA-N tantalum atom Chemical compound [Ta] GUVRBAGPIYLISA-UHFFFAOYSA-N 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- 229940040944 tetracyclines Drugs 0.000 description 1
- HQHCYKULIHKCEB-UHFFFAOYSA-N tetradecanedioic acid Natural products OC(=O)CCCCCCCCCCCCC(O)=O HQHCYKULIHKCEB-UHFFFAOYSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 229920001169 thermoplastic Polymers 0.000 description 1
- 239000004416 thermosoftening plastic Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- LLPOLZWFYMWNKH-UHFFFAOYSA-N trans-dihydrocodeinone Natural products C1C(N(CCC234)C)C2CCC(=O)C3OC2=C4C1=CC=C2OC LLPOLZWFYMWNKH-UHFFFAOYSA-N 0.000 description 1
- 230000026683 transduction Effects 0.000 description 1
- 238000010361 transduction Methods 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- MSRILKIQRXUYCT-UHFFFAOYSA-M valproate semisodium Chemical compound [Na+].CCCC(C(O)=O)CCC.CCCC(C([O-])=O)CCC MSRILKIQRXUYCT-UHFFFAOYSA-M 0.000 description 1
- 229960000604 valproic acid Drugs 0.000 description 1
- 229910052720 vanadium Inorganic materials 0.000 description 1
- GPPXJZIENCGNKB-UHFFFAOYSA-N vanadium Chemical compound [V]#[V] GPPXJZIENCGNKB-UHFFFAOYSA-N 0.000 description 1
- 239000003071 vasodilator agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/20—Applying electric currents by contact electrodes continuous direct currents
- A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Electrotherapy Devices (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR96/13583 | 1996-11-07 | ||
| FR9613583A FR2755372B1 (fr) | 1996-11-07 | 1996-11-07 | Dispositif d'ionophorese comportant au moins un ensemble electrode a membrane, pour l'administration transcutanee de principes actifs a un sujet |
| PCT/FR1997/001997 WO1998019735A1 (fr) | 1996-11-07 | 1997-11-06 | Dispositif d'ionophorese comportant au moins un ensemble electrode a membrane, pour l'administration transcutanee de principes actifs a un sujet |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2271088A1 CA2271088A1 (fr) | 1998-05-14 |
| CA2271088C true CA2271088C (fr) | 2006-08-08 |
Family
ID=9497416
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002271088A Expired - Lifetime CA2271088C (fr) | 1996-11-07 | 1997-11-06 | Dispositif d'ionophorese comportant au moins un ensemble electrode a membrane, pour l'administration transcutanee de principes actifs a un sujet |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6064908A (https=) |
| EP (1) | EP1011790A1 (https=) |
| JP (1) | JP4215118B2 (https=) |
| AU (1) | AU5058198A (https=) |
| CA (1) | CA2271088C (https=) |
| FR (1) | FR2755372B1 (https=) |
| WO (1) | WO1998019735A1 (https=) |
Families Citing this family (71)
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| US6629968B1 (en) * | 2000-06-30 | 2003-10-07 | Vyteris, Inc. | Shelf storage stable iontophoresis reservoir-electrode and iontophoretic system incorporating the reservoir-electrode |
| US20020087390A1 (en) * | 2000-10-04 | 2002-07-04 | Weathersby Robert G. | Method and system of using collective human intelligence to logically group related items |
| US20020169851A1 (en) * | 2000-10-04 | 2002-11-14 | Robert Weathersby | Internet-based system for dynamically creating and delivering customized content within remote web pages |
| CA2324431A1 (fr) * | 2000-10-25 | 2002-04-25 | Hydro-Quebec | Nouveau procede d'obtention de particule du graphite naturel sous forme spherique: modelisation et application |
| DE10141254C1 (de) * | 2001-08-23 | 2003-04-03 | Susann Edel | Iontophorese-Kaltkontaktelektrodensystem zur gleichzeitigen Anwendung der Kühlung und der Iontophorese |
| EE200400090A (et) * | 2001-10-31 | 2004-10-15 | R&R Ventures Incorporation | Ionoforeesiseade |
| US6913594B2 (en) * | 2001-12-31 | 2005-07-05 | Biosense Webster, Inc. | Dual-function catheter handle |
| DE10205373B4 (de) * | 2002-02-09 | 2007-07-19 | Aloys Wobben | Brandschutz |
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| JP2006334164A (ja) * | 2005-06-02 | 2006-12-14 | Transcutaneous Technologies Inc | イオントフォレーシス装置及びその制御方法 |
| JP2007000342A (ja) * | 2005-06-23 | 2007-01-11 | Transcutaneous Technologies Inc | 複数薬剤の投与量および投与時期を制御するイオントフォレーシス装置 |
| US20070027426A1 (en) * | 2005-06-24 | 2007-02-01 | Transcutaneous Technologies Inc. | Iontophoresis device to deliver active agents to biological interfaces |
| US8295922B2 (en) | 2005-08-08 | 2012-10-23 | Tti Ellebeau, Inc. | Iontophoresis device |
| US8386030B2 (en) | 2005-08-08 | 2013-02-26 | Tti Ellebeau, Inc. | Iontophoresis device |
| US20070088331A1 (en) * | 2005-08-18 | 2007-04-19 | Transcutaneous Technologies Inc. | Method and apparatus for managing active agent usage, and active agent injecting device |
| US20070088332A1 (en) * | 2005-08-22 | 2007-04-19 | Transcutaneous Technologies Inc. | Iontophoresis device |
| US20090254018A1 (en) * | 2005-08-24 | 2009-10-08 | Mizuo Nakayama | Electrode assembly for freezing-type iontophoresis device |
| WO2007029611A1 (ja) * | 2005-09-06 | 2007-03-15 | Tti Ellebeau, Inc. | イオントフォレーシス装置 |
| US20070112294A1 (en) * | 2005-09-14 | 2007-05-17 | Transcutaneous Technologies Inc. | Iontophoresis device |
| KR20080047600A (ko) | 2005-09-15 | 2008-05-29 | 티티아이 엘뷰 가부시키가이샤 | 로드형 이온토포레시스 장치 |
| US20070073212A1 (en) * | 2005-09-28 | 2007-03-29 | Takehiko Matsumura | Iontophoresis apparatus and method to deliver active agents to biological interfaces |
| US20070071807A1 (en) * | 2005-09-28 | 2007-03-29 | Hidero Akiyama | Capsule-type drug-releasing device and capsule-type drug-releasing device system |
| JPWO2007037324A1 (ja) * | 2005-09-28 | 2009-04-09 | Ｔｔｉ・エルビュー株式会社 | 乾燥型イオントフォレーシス用電極構造体 |
| US20070078445A1 (en) * | 2005-09-30 | 2007-04-05 | Curt Malloy | Synchronization apparatus and method for iontophoresis device to deliver active agents to biological interfaces |
| EP1928542A1 (en) * | 2005-09-30 | 2008-06-11 | Tti Ellebeau, Inc. | Method and system to detect malfunctions in an iontophoresis device that delivers active agents to biological interfaces |
| WO2007041118A1 (en) * | 2005-09-30 | 2007-04-12 | Tti Ellebeau, Inc. | Iontophoretic device and method of delivery of active agents to biological interface |
| WO2007041526A2 (en) * | 2005-09-30 | 2007-04-12 | Transcutaneous Technologies Inc. | Iontophoresis apparatus and method to deliver antibiotics to biological interfaces |
| US20090299265A1 (en) * | 2005-09-30 | 2009-12-03 | Tti Ellebeau, Inc. | Electrode Assembly for Iontophoresis Having Shape-Memory Separator and Iontophoresis Device Using the Same |
| KR20080066712A (ko) * | 2005-09-30 | 2008-07-16 | 티티아이 엘뷰 가부시키가이샤 | 관능화된 미세바늘 경피 약물 전달 시스템, 장치 및 방법 |
| US20070135754A1 (en) * | 2005-09-30 | 2007-06-14 | Hidero Akiyama | Electrode assembly for iontophoresis for administering active agent enclosed in nanoparticle and iontophoresis device using the same |
| EP1944057A4 (en) * | 2005-09-30 | 2009-02-18 | Tti Ellebeau Inc | IONTOPHORESIS DEVICE FOR MONITORING THE DOSE AND TIME OF ADMINISTRATION OF A SLEEP-INDUCING AND ANALYTICAL AGENT |
| US20080033398A1 (en) * | 2005-12-29 | 2008-02-07 | Transcutaneous Technologies Inc. | Device and method for enhancing immune response by electrical stimulation |
| EP1965858A2 (en) * | 2005-12-30 | 2008-09-10 | Tti Ellebeau, Inc. | System and method for remote based control of an iontophoresis device |
| WO2007079193A2 (en) * | 2005-12-30 | 2007-07-12 | Tti Ellebeau, Inc. | Iontophoretic systems, devices, and methods of delivery of active agents to biological interface |
| JP2007229003A (ja) * | 2006-02-27 | 2007-09-13 | Transcutaneous Technologies Inc | イオントフォレーシス装置 |
| JP2007244699A (ja) * | 2006-03-16 | 2007-09-27 | Transcutaneous Technologies Inc | イオントフォレーシス装置 |
| US20080004564A1 (en) * | 2006-03-30 | 2008-01-03 | Transcutaneous Technologies Inc. | Controlled release membrane and methods of use |
| JP2009542685A (ja) * | 2006-07-05 | 2009-12-03 | Ｔｔｉ・エルビュー株式会社 | 自己組織性樹脂状高分子を有する送達装置及びその使用方法 |
| KR20090106492A (ko) | 2006-12-01 | 2009-10-09 | 티티아이 엘뷰 가부시키가이샤 | 경피성 전달 장치와 같은 장치에 전력을 제공하거나 제어하기 위한 시스템, 장치, 및 방법 |
| AU2008254748A1 (en) * | 2007-05-18 | 2008-11-27 | Tti Ellebeau, Inc. | Transdermal delivery devices assuring an improved release of an active principle through a biological interface |
| US8197844B2 (en) | 2007-06-08 | 2012-06-12 | Activatek, Inc. | Active electrode for transdermal medicament administration |
| US8123745B2 (en) * | 2007-06-29 | 2012-02-28 | Biosense Webster, Inc. | Ablation catheter with optically transparent, electrically conductive tip |
| US8862223B2 (en) | 2008-01-18 | 2014-10-14 | Activatek, Inc. | Active transdermal medicament patch and circuit board for same |
| WO2009158032A1 (en) * | 2008-06-25 | 2009-12-30 | Fe2, Inc. | Patches and methods for the transdermal delivery of a therapeutically effective amount of iron |
| US20100069877A1 (en) * | 2008-09-10 | 2010-03-18 | Smith Gregory A | Apparatus and method to dispense hpc-based viscous liquids into porous substrates, e.g., continuous web-based process |
| US9008765B2 (en) | 2009-02-12 | 2015-04-14 | Incube Labs, Llc | System and method for biphasic transdermal iontophoretic delivery of therapeutic agents for the control of addictive cravings |
| US8348922B2 (en) * | 2009-02-12 | 2013-01-08 | Incube Labs, Llc | Method and apparatus for oscillatory iontophoretic transdermal delivery of a therapeutic agent |
| US8190252B2 (en) | 2009-02-12 | 2012-05-29 | Incube Labs, Llc | Iontophoretic system for transdermal delivery of active agents for therapeutic and medicinal purposes |
| US8961492B2 (en) | 2009-02-12 | 2015-02-24 | Incube Labs, Llc | System and method for controlling the iontophoretic delivery of therapeutic agents based on user inhalation |
| KR101674904B1 (ko) | 2009-02-26 | 2016-11-10 | 더 유니버시티 오브 노쓰 캐롤라이나 엣 채플 힐 | 중재형 약물전달 시스템과 그 방법 |
| US8821945B2 (en) * | 2009-04-25 | 2014-09-02 | Fe3 Medical, Inc. | Method for transdermal iontophoretic delivery of chelated agents |
| TW201121604A (en) * | 2009-06-09 | 2011-07-01 | Tti Ellebeau Inc | Long life high capacity electrode, device, and method of manufacture |
| WO2010144266A2 (en) * | 2009-06-10 | 2010-12-16 | Boston Scientific Scimed, Inc. | Electrochemical therapeutic agent delivery device |
| US8417330B2 (en) * | 2009-06-26 | 2013-04-09 | Incube Labs, Llc | Corrosion resistant electrodes for iontophoretic transdermal delivery devices and methods of use |
| US20100331812A1 (en) * | 2009-06-29 | 2010-12-30 | Nitric Biotherapeutics, Inc. | Pharmaceutical Formulations for Iontophoretic Delivery of an Immunomodulator |
| US8903485B2 (en) | 2009-08-06 | 2014-12-02 | Incube Labs, Llc | Patch and patch assembly for iontophoretic transdermal delivery of active agents for therapeutic and medicinal purposes |
| US9101733B2 (en) * | 2009-09-29 | 2015-08-11 | Biosense Webster, Inc. | Catheter with biased planar deflection |
| US8685038B2 (en) | 2009-12-07 | 2014-04-01 | Incube Labs, Llc | Iontophoretic apparatus and method for marking of the skin |
| US8747383B2 (en) * | 2009-12-18 | 2014-06-10 | University Medical Pharmaceuticals Corp. | Process and system for iontophoretic wrinkle reduction |
| WO2011100376A2 (en) | 2010-02-10 | 2011-08-18 | Incube Labs, Llc | Methods and architecture for power optimization of iontophoretic transdermal drug delivery |
| EP3626304A1 (en) | 2011-03-24 | 2020-03-25 | Incube Labs, Llc | System and method for biphasic transdermal iontophoretic delivery of therapeutic agents |
| BR112017013606A2 (en) * | 2014-12-22 | 2018-03-06 | 3M Innovative Properties Company | biomedical electrode comprising discontinuous primer layer |
| US11672487B2 (en) * | 2017-10-06 | 2023-06-13 | Medtronic Xomed, Inc. | Pledget stimulation and recording electrode assemblies |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3163166A (en) | 1961-04-28 | 1964-12-29 | Colgate Palmolive Co | Iontophoresis apparatus |
| FR2273021B1 (https=) | 1974-05-31 | 1977-03-11 | Ato Chimie | |
| US4325367A (en) | 1977-06-13 | 1982-04-20 | Robert Tapper | Iontophoretic treatment apparatus |
| FR2401947A1 (fr) * | 1977-09-02 | 1979-03-30 | Ato Chimie | Procede de preparation de polyether-ester-amides sequences utilisables, entre autres, comme produits a mouler, a extruder ou a filer |
| EP0060452B1 (en) | 1981-03-05 | 1985-10-23 | Medtronic, Inc. | Iontophoretic device |
| JPS5810066A (ja) | 1981-07-10 | 1983-01-20 | 株式会社アドバンス | イオントフオレ−ゼ用プラスタ−構造体 |
| US4766164A (en) | 1983-12-01 | 1988-08-23 | Golder Michael D | Stabilized thermoplastic elastomer |
| CA1260461A (fr) | 1984-10-18 | 1989-09-26 | Jean-Claude Lormeau | Procede de preparation de compositions de mucopolysaccharides dotes d'une activite antithrombotique elevee |
| US5080646A (en) * | 1988-10-03 | 1992-01-14 | Alza Corporation | Membrane for electrotransport transdermal drug delivery |
| US4927408A (en) * | 1988-10-03 | 1990-05-22 | Alza Corporation | Electrotransport transdermal system |
| MX9101782A (es) * | 1990-10-29 | 1992-06-05 | Alza Corp | Dispositivo de suministro iontoforetico y metodo para hidratar el mismo |
| FR2722993B1 (fr) | 1994-07-26 | 1996-09-27 | Elf Aquitaine | Dispositif d'ionophorese comportant au moins un ensemble electrode a electrode composite reversible |
| DE4429251C2 (de) * | 1994-08-18 | 1996-10-31 | Tex A Med Gmbh Entwicklung Pro | Wiederverwendbarer absorbierender Hygieneartikel, wie Inkontinenzvorlage, Erwachsenenwindel od. dgl. |
| FR2724115B1 (fr) | 1994-09-02 | 1996-10-25 | Elf Aquitaine | Dispositif d'ionophorese pour l'administration transcutanee d'un principe actif a un sujet assurant un controle precis de la posologie |
| EP0793517B1 (en) * | 1994-11-17 | 1999-09-08 | Alza Corporation | Device for enhancing electrotransport agent delivery |
| FR2729575B1 (fr) | 1995-01-24 | 1997-07-04 | Elf Aquitaine | Dispositif d'ionophorese pour l'administration transcutanee d'un principe actif de type glycosaminoglycane anionique de basse masse moleculaire |
-
1996
- 1996-11-07 FR FR9613583A patent/FR2755372B1/fr not_active Expired - Lifetime
-
1997
- 1997-11-06 CA CA002271088A patent/CA2271088C/fr not_active Expired - Lifetime
- 1997-11-06 AU AU50581/98A patent/AU5058198A/en not_active Abandoned
- 1997-11-06 US US09/284,971 patent/US6064908A/en not_active Expired - Lifetime
- 1997-11-06 EP EP97913269A patent/EP1011790A1/fr not_active Withdrawn
- 1997-11-06 JP JP52110998A patent/JP4215118B2/ja not_active Expired - Lifetime
- 1997-11-06 WO PCT/FR1997/001997 patent/WO1998019735A1/fr not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AU5058198A (en) | 1998-05-29 |
| US6064908A (en) | 2000-05-16 |
| JP4215118B2 (ja) | 2009-01-28 |
| CA2271088A1 (fr) | 1998-05-14 |
| FR2755372B1 (fr) | 1998-12-24 |
| FR2755372A1 (fr) | 1998-05-07 |
| JP2001505091A (ja) | 2001-04-17 |
| EP1011790A1 (fr) | 2000-06-28 |
| WO1998019735A1 (fr) | 1998-05-14 |
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