CA2271088C - Dispositif d'ionophorese comportant au moins un ensemble electrode a membrane, pour l'administration transcutanee de principes actifs a un sujet - Google Patents
Dispositif d'ionophorese comportant au moins un ensemble electrode a membrane, pour l'administration transcutanee de principes actifs a un sujet Download PDFInfo
- Publication number
- CA2271088C CA2271088C CA002271088A CA2271088A CA2271088C CA 2271088 C CA2271088 C CA 2271088C CA 002271088 A CA002271088 A CA 002271088A CA 2271088 A CA2271088 A CA 2271088A CA 2271088 C CA2271088 C CA 2271088C
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- Prior art keywords
- electrode
- polyamide
- membrane
- primary
- assembly
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- LLPOLZWFYMWNKH-CMKMFDCUSA-N hydrocodone Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)CC(=O)[C@@H]1OC1=C2C3=CC=C1OC LLPOLZWFYMWNKH-CMKMFDCUSA-N 0.000 description 1
- 229960000240 hydrocodone Drugs 0.000 description 1
- OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 description 1
- 238000000099 in vitro assay Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 229940102223 injectable solution Drugs 0.000 description 1
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- 229940125396 insulin Drugs 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000003055 low molecular weight heparin Substances 0.000 description 1
- 229940127215 low-molecular weight heparin Drugs 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 238000001465 metallisation Methods 0.000 description 1
- IUBSYMUCCVWXPE-UHFFFAOYSA-N metoprolol Chemical compound COCCC1=CC=C(OCC(O)CNC(C)C)C=C1 IUBSYMUCCVWXPE-UHFFFAOYSA-N 0.000 description 1
- 229960002237 metoprolol Drugs 0.000 description 1
- 244000309715 mini pig Species 0.000 description 1
- 150000002823 nitrates Chemical class 0.000 description 1
- 206010033675 panniculitis Diseases 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 229920002492 poly(sulfone) Polymers 0.000 description 1
- 229920002480 polybenzimidazole Polymers 0.000 description 1
- 229920006146 polyetheresteramide block copolymer Polymers 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 229920002689 polyvinyl acetate Polymers 0.000 description 1
- 239000011118 polyvinyl acetate Substances 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- DOKHEARVIDLSFF-UHFFFAOYSA-N prop-1-en-1-ol Chemical group CC=CO DOKHEARVIDLSFF-UHFFFAOYSA-N 0.000 description 1
- 239000001294 propane Substances 0.000 description 1
- AQHHHDLHHXJYJD-UHFFFAOYSA-N propranolol Chemical compound C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 AQHHHDLHHXJYJD-UHFFFAOYSA-N 0.000 description 1
- 230000001012 protector Effects 0.000 description 1
- 238000012797 qualification Methods 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 229960002052 salbutamol Drugs 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000004544 sputter deposition Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000012086 standard solution Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 210000004304 subcutaneous tissue Anatomy 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 229910052715 tantalum Inorganic materials 0.000 description 1
- GUVRBAGPIYLISA-UHFFFAOYSA-N tantalum atom Chemical compound [Ta] GUVRBAGPIYLISA-UHFFFAOYSA-N 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- 229940040944 tetracyclines Drugs 0.000 description 1
- HQHCYKULIHKCEB-UHFFFAOYSA-N tetradecanedioic acid Natural products OC(=O)CCCCCCCCCCCCC(O)=O HQHCYKULIHKCEB-UHFFFAOYSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 229920001169 thermoplastic Polymers 0.000 description 1
- 239000004416 thermosoftening plastic Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- LLPOLZWFYMWNKH-UHFFFAOYSA-N trans-dihydrocodeinone Natural products C1C(N(CCC234)C)C2CCC(=O)C3OC2=C4C1=CC=C2OC LLPOLZWFYMWNKH-UHFFFAOYSA-N 0.000 description 1
- 230000026683 transduction Effects 0.000 description 1
- 238000010361 transduction Methods 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- MSRILKIQRXUYCT-UHFFFAOYSA-M valproate semisodium Chemical compound [Na+].CCCC(C(O)=O)CCC.CCCC(C([O-])=O)CCC MSRILKIQRXUYCT-UHFFFAOYSA-M 0.000 description 1
- 229960000604 valproic acid Drugs 0.000 description 1
- 229910052720 vanadium Inorganic materials 0.000 description 1
- GPPXJZIENCGNKB-UHFFFAOYSA-N vanadium Chemical compound [V]#[V] GPPXJZIENCGNKB-UHFFFAOYSA-N 0.000 description 1
- 239000003071 vasodilator agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/20—Applying electric currents by contact electrodes continuous direct currents
- A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Electrotherapy Devices (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9613583A FR2755372B1 (fr) | 1996-11-07 | 1996-11-07 | Dispositif d'ionophorese comportant au moins un ensemble electrode a membrane, pour l'administration transcutanee de principes actifs a un sujet |
| FR96/13583 | 1996-11-07 | ||
| PCT/FR1997/001997 WO1998019735A1 (fr) | 1996-11-07 | 1997-11-06 | Dispositif d'ionophorese comportant au moins un ensemble electrode a membrane, pour l'administration transcutanee de principes actifs a un sujet |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2271088A1 CA2271088A1 (fr) | 1998-05-14 |
| CA2271088C true CA2271088C (fr) | 2006-08-08 |
Family
ID=9497416
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002271088A Expired - Lifetime CA2271088C (fr) | 1996-11-07 | 1997-11-06 | Dispositif d'ionophorese comportant au moins un ensemble electrode a membrane, pour l'administration transcutanee de principes actifs a un sujet |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6064908A (enExample) |
| EP (1) | EP1011790A1 (enExample) |
| JP (1) | JP4215118B2 (enExample) |
| AU (1) | AU5058198A (enExample) |
| CA (1) | CA2271088C (enExample) |
| FR (1) | FR2755372B1 (enExample) |
| WO (1) | WO1998019735A1 (enExample) |
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| US6629968B1 (en) * | 2000-06-30 | 2003-10-07 | Vyteris, Inc. | Shelf storage stable iontophoresis reservoir-electrode and iontophoretic system incorporating the reservoir-electrode |
| US20020087390A1 (en) * | 2000-10-04 | 2002-07-04 | Weathersby Robert G. | Method and system of using collective human intelligence to logically group related items |
| US20020169851A1 (en) * | 2000-10-04 | 2002-11-14 | Robert Weathersby | Internet-based system for dynamically creating and delivering customized content within remote web pages |
| CA2324431A1 (fr) | 2000-10-25 | 2002-04-25 | Hydro-Quebec | Nouveau procede d'obtention de particule du graphite naturel sous forme spherique: modelisation et application |
| DE10141254C1 (de) * | 2001-08-23 | 2003-04-03 | Susann Edel | Iontophorese-Kaltkontaktelektrodensystem zur gleichzeitigen Anwendung der Kühlung und der Iontophorese |
| IL161529A0 (en) * | 2001-10-31 | 2004-09-27 | R & R Ventures Inc | Iontophoresis device |
| US6913594B2 (en) * | 2001-12-31 | 2005-07-05 | Biosense Webster, Inc. | Dual-function catheter handle |
| DE10205373B4 (de) * | 2002-02-09 | 2007-07-19 | Aloys Wobben | Brandschutz |
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| US20060135906A1 (en) * | 2004-11-16 | 2006-06-22 | Akihiko Matsumura | Iontophoretic device and method for administering immune response-enhancing agents and compositions |
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| JP2006296511A (ja) * | 2005-04-15 | 2006-11-02 | Transcutaneous Technologies Inc | 外用剤、外用剤の塗布方法、イオントフォレーシス装置及び経皮パッチ |
| JP2006334164A (ja) * | 2005-06-02 | 2006-12-14 | Transcutaneous Technologies Inc | イオントフォレーシス装置及びその制御方法 |
| JP2007000342A (ja) * | 2005-06-23 | 2007-01-11 | Transcutaneous Technologies Inc | 複数薬剤の投与量および投与時期を制御するイオントフォレーシス装置 |
| US20070027426A1 (en) * | 2005-06-24 | 2007-02-01 | Transcutaneous Technologies Inc. | Iontophoresis device to deliver active agents to biological interfaces |
| US8295922B2 (en) | 2005-08-08 | 2012-10-23 | Tti Ellebeau, Inc. | Iontophoresis device |
| US8386030B2 (en) | 2005-08-08 | 2013-02-26 | Tti Ellebeau, Inc. | Iontophoresis device |
| US20070088331A1 (en) * | 2005-08-18 | 2007-04-19 | Transcutaneous Technologies Inc. | Method and apparatus for managing active agent usage, and active agent injecting device |
| US20070088332A1 (en) * | 2005-08-22 | 2007-04-19 | Transcutaneous Technologies Inc. | Iontophoresis device |
| WO2007023907A1 (ja) * | 2005-08-24 | 2007-03-01 | Transcu Ltd. | 冷凍型イオントフォレーシス用電極構造体 |
| US20100030128A1 (en) * | 2005-09-06 | 2010-02-04 | Kazuma Mitsuguchi | Iontophoresis device |
| US20070112294A1 (en) * | 2005-09-14 | 2007-05-17 | Transcutaneous Technologies Inc. | Iontophoresis device |
| KR20080047600A (ko) | 2005-09-15 | 2008-05-29 | 티티아이 엘뷰 가부시키가이샤 | 로드형 이온토포레시스 장치 |
| US20070071807A1 (en) * | 2005-09-28 | 2007-03-29 | Hidero Akiyama | Capsule-type drug-releasing device and capsule-type drug-releasing device system |
| US20070073212A1 (en) * | 2005-09-28 | 2007-03-29 | Takehiko Matsumura | Iontophoresis apparatus and method to deliver active agents to biological interfaces |
| WO2007037324A1 (ja) * | 2005-09-28 | 2007-04-05 | Transcu Ltd. | 乾燥型イオントフォレーシス用電極構造体 |
| US20070078445A1 (en) * | 2005-09-30 | 2007-04-05 | Curt Malloy | Synchronization apparatus and method for iontophoresis device to deliver active agents to biological interfaces |
| US20070135754A1 (en) * | 2005-09-30 | 2007-06-14 | Hidero Akiyama | Electrode assembly for iontophoresis for administering active agent enclosed in nanoparticle and iontophoresis device using the same |
| WO2007041526A2 (en) * | 2005-09-30 | 2007-04-12 | Transcutaneous Technologies Inc. | Iontophoresis apparatus and method to deliver antibiotics to biological interfaces |
| EP1928542A1 (en) * | 2005-09-30 | 2008-06-11 | Tti Ellebeau, Inc. | Method and system to detect malfunctions in an iontophoresis device that delivers active agents to biological interfaces |
| JP2009509657A (ja) * | 2005-09-30 | 2009-03-12 | Ｔｔｉ・エルビュー株式会社 | 生体界面への活性物質の送達のイオントフォレーシス装置及び方法 |
| US20090299265A1 (en) * | 2005-09-30 | 2009-12-03 | Tti Ellebeau, Inc. | Electrode Assembly for Iontophoresis Having Shape-Memory Separator and Iontophoresis Device Using the Same |
| KR20080066712A (ko) * | 2005-09-30 | 2008-07-16 | 티티아이 엘뷰 가부시키가이샤 | 관능화된 미세바늘 경피 약물 전달 시스템, 장치 및 방법 |
| JPWO2007037476A1 (ja) * | 2005-09-30 | 2009-04-16 | Ｔｔｉ・エルビュー株式会社 | 睡眠導入剤と興奮剤の投与量および投与時期を制御するイオントフォレーシス装置 |
| WO2007079190A2 (en) * | 2005-12-29 | 2007-07-12 | Tti Ellebeau, Inc. | Device and method for enhancing immune response by electrical stimulation |
| EP1965856A2 (en) * | 2005-12-30 | 2008-09-10 | Tti Ellebeau, Inc. | Iontophoretic systems, devices, and methods of delivery of active agents to biological interface |
| EP1965858A2 (en) * | 2005-12-30 | 2008-09-10 | Tti Ellebeau, Inc. | System and method for remote based control of an iontophoresis device |
| JP2007229003A (ja) * | 2006-02-27 | 2007-09-13 | Transcutaneous Technologies Inc | イオントフォレーシス装置 |
| JP2007244699A (ja) * | 2006-03-16 | 2007-09-27 | Transcutaneous Technologies Inc | イオントフォレーシス装置 |
| WO2007123707A1 (en) * | 2006-03-30 | 2007-11-01 | Tti Ellebeau, Inc. | Controlled release membrane and methods of use |
| US20080058701A1 (en) * | 2006-07-05 | 2008-03-06 | Transcutaneous Technologies Inc. | Delivery device having self-assembling dendritic polymers and method of use thereof |
| TW200838576A (en) | 2006-12-01 | 2008-10-01 | Transcu Ltd | Systems, devices and methods for powering and/or controlling transdermal delivery devices |
| NZ582049A (en) * | 2007-05-18 | 2012-12-21 | Tti Ellebeau Inc | Transdermal delivery devices assuring an improved release of an active principle through a biological interface |
| US8197844B2 (en) | 2007-06-08 | 2012-06-12 | Activatek, Inc. | Active electrode for transdermal medicament administration |
| US8123745B2 (en) * | 2007-06-29 | 2012-02-28 | Biosense Webster, Inc. | Ablation catheter with optically transparent, electrically conductive tip |
| US8862223B2 (en) | 2008-01-18 | 2014-10-14 | Activatek, Inc. | Active transdermal medicament patch and circuit board for same |
| CN102159205A (zh) * | 2008-06-25 | 2011-08-17 | Fe3医学有限公司 | 用于经皮递送治疗有效量的铁的贴片和方法 |
| JP2012501801A (ja) * | 2008-09-10 | 2012-01-26 | トランスキュー リミテッド | ヒドロキシプロピルセルロース（ｈｐｃ）をベースにした粘性液体を多孔質基材に薬剤投与する装置および方法、例えば連続ウェブをベースにしたプロセス |
| US8348922B2 (en) * | 2009-02-12 | 2013-01-08 | Incube Labs, Llc | Method and apparatus for oscillatory iontophoretic transdermal delivery of a therapeutic agent |
| US8190252B2 (en) | 2009-02-12 | 2012-05-29 | Incube Labs, Llc | Iontophoretic system for transdermal delivery of active agents for therapeutic and medicinal purposes |
| US8961492B2 (en) | 2009-02-12 | 2015-02-24 | Incube Labs, Llc | System and method for controlling the iontophoretic delivery of therapeutic agents based on user inhalation |
| KR101674904B1 (ko) | 2009-02-26 | 2016-11-10 | 더 유니버시티 오브 노쓰 캐롤라이나 엣 채플 힐 | 중재형 약물전달 시스템과 그 방법 |
| US8821945B2 (en) * | 2009-04-25 | 2014-09-02 | Fe3 Medical, Inc. | Method for transdermal iontophoretic delivery of chelated agents |
| EP2440694A4 (en) * | 2009-06-09 | 2012-12-19 | Tti Ellebeau Inc | DURABLE HIGH-CAPACITY ELECTRODE AND METHOD OF MANUFACTURING THEREOF |
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| WO2010151845A2 (en) * | 2009-06-26 | 2010-12-29 | Incube Labs, Llc | Corrosion resistant electrodes for iontophoretic transdermal delivery devices and methods of use |
| WO2011002776A1 (en) * | 2009-06-29 | 2011-01-06 | Nitric Biotherapeutics, Inc. | Pharmaceutical formulations for iontophoretic delivery of an immunomodulator |
| US8903485B2 (en) * | 2009-08-06 | 2014-12-02 | Incube Labs, Llc | Patch and patch assembly for iontophoretic transdermal delivery of active agents for therapeutic and medicinal purposes |
| US9101733B2 (en) | 2009-09-29 | 2015-08-11 | Biosense Webster, Inc. | Catheter with biased planar deflection |
| US8685038B2 (en) | 2009-12-07 | 2014-04-01 | Incube Labs, Llc | Iontophoretic apparatus and method for marking of the skin |
| US8747383B2 (en) * | 2009-12-18 | 2014-06-10 | University Medical Pharmaceuticals Corp. | Process and system for iontophoretic wrinkle reduction |
| WO2011100376A2 (en) | 2010-02-10 | 2011-08-18 | Incube Labs, Llc | Methods and architecture for power optimization of iontophoretic transdermal drug delivery |
| AU2012230701B2 (en) | 2011-03-24 | 2016-09-29 | Incube Labs, Llc | System and method for biphasic transdermal iontophoretic delivery of therapeutic agents |
| WO2012154704A2 (en) | 2011-05-06 | 2012-11-15 | Incube Labs, Llc | System and method for biphasic transdermal iontophoretic delivery of therapeutic agents for the control of addictive cravings |
| JP2018501061A (ja) | 2014-12-22 | 2018-01-18 | スリーエム イノベイティブ プロパティズ カンパニー | 不連続なプライマー層を含む生体用電極 |
| CN111093493A (zh) * | 2017-10-06 | 2020-05-01 | 美敦力施美德公司 | 脱脂棉刺激和记录电极组合件 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3163166A (en) | 1961-04-28 | 1964-12-29 | Colgate Palmolive Co | Iontophoresis apparatus |
| FR2273021B1 (enExample) | 1974-05-31 | 1977-03-11 | Ato Chimie | |
| US4325367A (en) | 1977-06-13 | 1982-04-20 | Robert Tapper | Iontophoretic treatment apparatus |
| FR2401947A1 (fr) * | 1977-09-02 | 1979-03-30 | Ato Chimie | Procede de preparation de polyether-ester-amides sequences utilisables, entre autres, comme produits a mouler, a extruder ou a filer |
| EP0060452B1 (en) | 1981-03-05 | 1985-10-23 | Medtronic, Inc. | Iontophoretic device |
| JPS5810066A (ja) | 1981-07-10 | 1983-01-20 | 株式会社アドバンス | イオントフオレ−ゼ用プラスタ−構造体 |
| US4766164A (en) | 1983-12-01 | 1988-08-23 | Golder Michael D | Stabilized thermoplastic elastomer |
| CA1260461A (fr) | 1984-10-18 | 1989-09-26 | Jean-Claude Lormeau | Procede de preparation de compositions de mucopolysaccharides dotes d'une activite antithrombotique elevee |
| US5080646A (en) * | 1988-10-03 | 1992-01-14 | Alza Corporation | Membrane for electrotransport transdermal drug delivery |
| US4927408A (en) * | 1988-10-03 | 1990-05-22 | Alza Corporation | Electrotransport transdermal system |
| WO1992007618A1 (en) * | 1990-10-29 | 1992-05-14 | Alza Corporation | Iontophoretic drug delivery electrode and method of hydrating the same |
| FR2722993B1 (fr) | 1994-07-26 | 1996-09-27 | Elf Aquitaine | Dispositif d'ionophorese comportant au moins un ensemble electrode a electrode composite reversible |
| DE4429251C2 (de) * | 1994-08-18 | 1996-10-31 | Tex A Med Gmbh Entwicklung Pro | Wiederverwendbarer absorbierender Hygieneartikel, wie Inkontinenzvorlage, Erwachsenenwindel od. dgl. |
| FR2724115B1 (fr) | 1994-09-02 | 1996-10-25 | Elf Aquitaine | Dispositif d'ionophorese pour l'administration transcutanee d'un principe actif a un sujet assurant un controle precis de la posologie |
| DE69512083T2 (de) * | 1994-11-17 | 2000-03-30 | Alza Corp., Palo Alto | Vorrichtung zur erhöhung der wirkstoffsverabreichung durch elektrotransport |
| FR2729575B1 (fr) | 1995-01-24 | 1997-07-04 | Elf Aquitaine | Dispositif d'ionophorese pour l'administration transcutanee d'un principe actif de type glycosaminoglycane anionique de basse masse moleculaire |
-
1996
- 1996-11-07 FR FR9613583A patent/FR2755372B1/fr not_active Expired - Lifetime
-
1997
- 1997-11-06 AU AU50581/98A patent/AU5058198A/en not_active Abandoned
- 1997-11-06 CA CA002271088A patent/CA2271088C/fr not_active Expired - Lifetime
- 1997-11-06 JP JP52110998A patent/JP4215118B2/ja not_active Expired - Lifetime
- 1997-11-06 WO PCT/FR1997/001997 patent/WO1998019735A1/fr not_active Ceased
- 1997-11-06 US US09/284,971 patent/US6064908A/en not_active Expired - Lifetime
- 1997-11-06 EP EP97913269A patent/EP1011790A1/fr not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| JP4215118B2 (ja) | 2009-01-28 |
| AU5058198A (en) | 1998-05-29 |
| CA2271088A1 (fr) | 1998-05-14 |
| EP1011790A1 (fr) | 2000-06-28 |
| FR2755372B1 (fr) | 1998-12-24 |
| FR2755372A1 (fr) | 1998-05-07 |
| JP2001505091A (ja) | 2001-04-17 |
| WO1998019735A1 (fr) | 1998-05-14 |
| US6064908A (en) | 2000-05-16 |
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Effective date: 20171106 |