CA2268448A1 - Ameliorations concernant les sources d'ions a pression atmospherique - Google Patents

Ameliorations concernant les sources d'ions a pression atmospherique

Info

Publication number
CA2268448A1
CA2268448A1 CA002268448A CA2268448A CA2268448A1 CA 2268448 A1 CA2268448 A1 CA 2268448A1 CA 002268448 A CA002268448 A CA 002268448A CA 2268448 A CA2268448 A CA 2268448A CA 2268448 A1 CA2268448 A1 CA 2268448A1
Authority
CA
Canada
Prior art keywords
atmospheric pressure
api
capillary
pressure ion
source
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002268448A
Other languages
English (en)
Other versions
CA2268448C (fr
Inventor
Craig M. Whitehouse
Bruce A. Andrien, Jr.
Michael A. Sansone
Clement Catalano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Revvity Health Sciences Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2268448A1 publication Critical patent/CA2268448A1/fr
Application granted granted Critical
Publication of CA2268448C publication Critical patent/CA2268448C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0468—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components with means for heating or cooling the sample
    • H01J49/0477—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components with means for heating or cooling the sample using a hot fluid
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0404—Capillaries used for transferring samples or ions
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0431—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for liquid samples
    • H01J49/044—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for liquid samples with means for preventing droplets from entering the analyzer; Desolvation of droplets

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Electron Tubes For Measurement (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Treatments Of Macromolecular Shaped Articles (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA002268448A 1996-09-10 1997-09-10 Ameliorations concernant les sources d'ions a pression atmospherique Expired - Lifetime CA2268448C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2586696P 1996-09-10 1996-09-10
US60/025,866 1996-09-10
PCT/US1997/015968 WO1998011595A1 (fr) 1996-09-10 1997-09-10 Ameliorations concernant les sources d'ions a pression atmospherique

Publications (2)

Publication Number Publication Date
CA2268448A1 true CA2268448A1 (fr) 1998-03-19
CA2268448C CA2268448C (fr) 2006-08-22

Family

ID=21828477

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002268448A Expired - Lifetime CA2268448C (fr) 1996-09-10 1997-09-10 Ameliorations concernant les sources d'ions a pression atmospherique

Country Status (7)

Country Link
US (1) US6593568B1 (fr)
EP (1) EP0925601B1 (fr)
AT (1) ATE488025T1 (fr)
AU (1) AU4338997A (fr)
CA (1) CA2268448C (fr)
DE (1) DE69740050D1 (fr)
WO (1) WO1998011595A1 (fr)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2328074B (en) * 1997-08-06 2001-11-07 Masslab Ltd Ion source for a mass analyser and method of cleaning an ion source
CA2275140C (fr) 1998-06-18 2008-04-29 Micromass Limited Spectrometre de masse a admission multiple
JP3876554B2 (ja) * 1998-11-25 2007-01-31 株式会社日立製作所 化学物質のモニタ方法及びモニタ装置並びにそれを用いた燃焼炉
JP5073168B2 (ja) * 2002-05-31 2012-11-14 ウオーターズ・テクノロジーズ・コーポレイシヨン 質量分析計用の高速組合せマルチモードイオン源
US7208727B2 (en) * 2003-01-14 2007-04-24 Georgia Tech Research Corporation Electrospray systems and methods
US7312440B2 (en) * 2003-01-14 2007-12-25 Georgia Tech Research Corporation Integrated micro fuel processor and flow delivery infrastructure
US7427750B2 (en) * 2003-01-17 2008-09-23 Griffin Analytical Technologies, L.L.C. Mass spectrometer assemblies, mass spectrometry vacuum chamber lid assemblies, and mass spectrometer operational methods
US7199364B2 (en) * 2004-05-21 2007-04-03 Thermo Finnigan Llc Electrospray ion source apparatus
WO2006002027A2 (fr) 2004-06-15 2006-01-05 Griffin Analytical Technologies, Inc. Instruments analytiques, assemblages et methodes associees
US7145136B2 (en) * 2004-12-17 2006-12-05 Varian, Inc. Atmospheric pressure ionization with optimized drying gas flow
GB2439261B (en) 2005-04-25 2011-02-23 Griffin Analytical Technologies Llc Analytical apparatuses and methods
US7335877B1 (en) * 2005-12-30 2008-02-26 Metara, Inc. Inline automated chemical analysis signal optimization
CN1901137B (zh) * 2006-06-20 2010-05-12 周振 大气压离子源接口及其实现方法与应用
US7992424B1 (en) 2006-09-14 2011-08-09 Griffin Analytical Technologies, L.L.C. Analytical instrumentation and sample analysis methods
US7547891B2 (en) * 2007-02-16 2009-06-16 Agilent Technologies, Inc. Ion sampling apparatuses in fast polarity-switching ion sources
US7564029B2 (en) * 2007-08-15 2009-07-21 Varian, Inc. Sample ionization at above-vacuum pressures
US8084736B2 (en) * 2008-05-30 2011-12-27 Mds Analytical Technologies, A Business Unit Of Mds Inc. Method and system for vacuum driven differential mobility spectrometer/mass spectrometer interface with adjustable resolution and selectivity
US20100282966A1 (en) * 2008-05-30 2010-11-11 DH Technologies Development Pte Ltd. Method and system for vacuum driven mass spectrometer interface with adjustable resolution and selectivity
US20100154568A1 (en) * 2008-11-19 2010-06-24 Roth Michael J Analytical Instruments, Assemblies, and Methods
US7939798B2 (en) * 2009-01-30 2011-05-10 Agilent Technologies, Inc. Tandem ionizer ion source for mass spectrometer and method of use
CN102347199B (zh) * 2010-08-04 2014-07-02 江苏天瑞仪器股份有限公司 Esi源质谱中金属毛细管伸出长度的微调机构
CN102903596B (zh) * 2012-09-18 2015-08-12 清华大学 一种离子源温控加热装置
JP6231219B2 (ja) * 2013-12-24 2017-11-15 ウオーターズ・テクノロジーズ・コーポレイシヨン 電気的に接地された電気スプレーための大気インターフェース
DE102014113482B4 (de) * 2014-09-18 2019-01-03 Bruker Daltonik Gmbh Ionisierungskammer mit temperierter Gaszufuhr
CN106298429B (zh) * 2016-09-20 2018-03-06 中国科学技术大学 一种电喷雾离子源装置
CN110211863B (zh) * 2019-06-14 2021-04-23 清华大学深圳研究生院 一种微量液体样品定量进样装置及方法
WO2023021424A1 (fr) * 2021-08-18 2023-02-23 Dh Technologies Development Pte. Ltd. Interface d'étanchéité pour chambre rideau

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4023398A (en) * 1975-03-03 1977-05-17 John Barry French Apparatus for analyzing trace components
US4542293A (en) * 1983-04-20 1985-09-17 Yale University Process and apparatus for changing the energy of charged particles contained in a gaseous medium
US4531056A (en) * 1983-04-20 1985-07-23 Yale University Method and apparatus for the mass spectrometric analysis of solutions
US4960992A (en) * 1983-08-30 1990-10-02 Research Corporation Technologies Method and means for vaporizing liquids by means of heating a sample capillary tube for detection or analysis
JP2834136B2 (ja) * 1988-04-27 1998-12-09 株式会社日立製作所 質量分析計
JPH0675390B2 (ja) * 1990-11-30 1994-09-21 株式会社島津製作所 質量分析計イオン源装置
US5171990A (en) * 1991-05-17 1992-12-15 Finnigan Corporation Electrospray ion source with reduced neutral noise and method
JP2902197B2 (ja) * 1992-02-04 1999-06-07 株式会社日立製作所 大気圧イオン化質量分析装置
US5304798A (en) * 1992-04-10 1994-04-19 Millipore Corporation Housing for converting an electrospray to an ion stream
US5352892A (en) * 1992-05-29 1994-10-04 Cornell Research Foundation, Inc. Atmospheric pressure ion interface for a mass analyzer
US5349186A (en) * 1993-06-25 1994-09-20 The Governors Of The University Of Alberta Electrospray interface for mass spectrometer and method of supplying analyte to a mass spectrometer
WO1995024259A1 (fr) * 1994-03-08 1995-09-14 Analytica Of Branford, Inc. Ameliorations apportees a des sources d'ionisation chimique sous pression atmospherique et par electropulverisation
US5495108A (en) * 1994-07-11 1996-02-27 Hewlett-Packard Company Orthogonal ion sampling for electrospray LC/MS
JP3415682B2 (ja) * 1994-08-10 2003-06-09 株式会社日立製作所 キャピラリー電気泳動・質量分析計
US5545304A (en) * 1995-05-15 1996-08-13 Battelle Memorial Institute Ion current detector for high pressure ion sources for monitoring separations
US5672868A (en) * 1996-02-16 1997-09-30 Varian Associates, Inc. Mass spectrometer system and method for transporting and analyzing ions

Also Published As

Publication number Publication date
CA2268448C (fr) 2006-08-22
WO1998011595A1 (fr) 1998-03-19
EP0925601A1 (fr) 1999-06-30
EP0925601A4 (fr) 2006-08-09
AU4338997A (en) 1998-04-02
US6593568B1 (en) 2003-07-15
EP0925601B1 (fr) 2010-11-10
DE69740050D1 (de) 2010-12-23
ATE488025T1 (de) 2010-11-15

Similar Documents

Publication Publication Date Title
CA2268448A1 (fr) Ameliorations concernant les sources d'ions a pression atmospherique
GB2308227B8 (en) Electrospray and atmospheric pressure chemical ionization mass spectrometer and ion source
CA2333031A1 (fr) Desorption laser assistee par matrice a la pression atmospherique
EP0954008A3 (fr) Vaporisateur de décaborane pour source d'ions
CA2359954A1 (fr) Ensemble a tube capillaire avec tube capillaire remplacable
EP1166327A1 (fr) Source d'ions pour spectrometre de masse
GB2391701A (en) Thermal regulation of an ion implantation system
CA2250415A1 (fr) Tube echangeur de chaleur et procede permettant de le produire
EP0846916A3 (fr) Dispositif de mélange air-gaz notamment pour brûleurs à air soufflé
US5030826A (en) Single port thermospray ion source with coaxial vapor flow
EP0723154A3 (fr) Détecteur à ionisation de flamme avec le bout de la flamme sur le diffuseur
EP1278258A3 (fr) Unité de pile à combustible et assemblage d'un empilage de piles à combustible
AU2924584A (en) Mass spectrometer pyrolysis inlet system
EP1255081A3 (fr) Brûleur radiant à gaz de type atmosphérique
AU2001282292A1 (en) Analyte detection system
EP1139099A3 (fr) Detecteur d'alcool et procede d'utilisation
CA2282784A1 (fr) Assemblage permettant d'associer une source d'ions un analyseur de masse
CA2245892A1 (fr) Laser a vapeur metallique
EP1290380B8 (fr) Unite de chauffage de fluide caloporteur pour installation de chauffage central
CN219040407U (zh) 一种雾化器组件及离子源装置和质谱仪
CA2285240A1 (fr) Bruleur a combustion pour chauffe-eau
CA2245022A1 (fr) Source d'ions
WO1999065281A3 (fr) Generateur de plasma a arc
HU9701790D0 (en) Exhaust chamber for ventilation
EP1005005A3 (fr) Détecteur de fumée à ionisation

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20170911