CA2267193A1 - Therapeutic compositions and methods for treating disease states with myeloid progenitor inhibitory factor-1 (mpif-1), monocyte colony inhibitory factor (m-cif), and macrophage inhibitory factor-4 (mip-4) - Google Patents

Info

Publication number

CA2267193A1

CA2267193A1 CA002267193A CA2267193A CA2267193A1 CA 2267193 A1 CA2267193 A1 CA 2267193A1 CA 002267193 A CA002267193 A CA 002267193A CA 2267193 A CA2267193 A CA 2267193A CA 2267193 A1 CA2267193 A1 CA 2267193A1

Authority

CA

Canada

Prior art keywords

amino acid

acid sequence

polypeptide

mpif

terminal

Prior art date

1996-09-30

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Abandoned

Links

• Espacenet
• Global Dossier
• CIPO
• Discuss

• 101000713081 Homo sapiens C-C motif chemokine 23 Proteins 0.000 title claims abstract description 297
• 102100036850 C-C motif chemokine 23 Human genes 0.000 title claims abstract description 276
• 238000000034 method Methods 0.000 title claims abstract description 180
• 230000002401 inhibitory effect Effects 0.000 title claims abstract description 21
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims description 67
• 210000001616 monocyte Anatomy 0.000 title claims description 25
• 239000000203 mixture Substances 0.000 title abstract description 25
• 210000002540 macrophage Anatomy 0.000 title abstract description 19
• 230000001225 therapeutic effect Effects 0.000 title abstract description 7
• 201000010099 disease Diseases 0.000 title description 34
• 108010030175 colony inhibiting factor Proteins 0.000 title description 2
• 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 473
• 102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 448
• 229920001184 polypeptide Polymers 0.000 claims abstract description 410
• 210000004027 cell Anatomy 0.000 claims abstract description 165
• 239000013598 vector Substances 0.000 claims abstract description 76
• 241000282414 Homo sapiens Species 0.000 claims abstract description 37
• 125000003275 alpha amino acid group Chemical group 0.000 claims description 239
• 238000012217 deletion Methods 0.000 claims description 154
• 230000037430 deletion Effects 0.000 claims description 154
• 239000002157 polynucleotide Substances 0.000 claims description 108
• 102000040430 polynucleotide Human genes 0.000 claims description 108
• 108091033319 polynucleotide Proteins 0.000 claims description 108
• 125000000729 N-terminal amino-acid group Chemical group 0.000 claims description 81
• 125000001433 C-terminal amino-acid group Chemical group 0.000 claims description 76
• 150000001413 amino acids Chemical class 0.000 claims description 73
• 125000000539 amino acid group Chemical group 0.000 claims description 68
• 238000006467 substitution reaction Methods 0.000 claims description 45
• CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims description 39
• 238000004519 manufacturing process Methods 0.000 claims description 33
• 208000035475 disorder Diseases 0.000 claims description 32
• 238000002560 therapeutic procedure Methods 0.000 claims description 24
• 210000004899 c-terminal region Anatomy 0.000 claims description 20
• 210000003714 granulocyte Anatomy 0.000 claims description 14
• 230000004069 differentiation Effects 0.000 claims description 12
• 238000011084 recovery Methods 0.000 claims description 12
• 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims description 11
• 206010003246 arthritis Diseases 0.000 claims description 11
• 230000035755 proliferation Effects 0.000 claims description 11
• 238000002512 chemotherapy Methods 0.000 claims description 9
• 210000003958 hematopoietic stem cell Anatomy 0.000 claims description 9
• 230000001332 colony forming effect Effects 0.000 claims description 8
• 206010040047 Sepsis Diseases 0.000 claims description 7
• 210000003643 myeloid progenitor cell Anatomy 0.000 claims description 7
• 230000002062 proliferating effect Effects 0.000 claims description 7
• 238000001959 radiotherapy Methods 0.000 claims description 7
• 241000588724 Escherichia coli Species 0.000 claims description 6
• 208000032027 Essential Thrombocythemia Diseases 0.000 claims description 6
• 208000017733 acquired polycythemia vera Diseases 0.000 claims description 6
• 230000012010 growth Effects 0.000 claims description 6
• 206010028537 myelofibrosis Diseases 0.000 claims description 6
• 208000037244 polycythemia vera Diseases 0.000 claims description 6
• 208000003476 primary myelofibrosis Diseases 0.000 claims description 6
• 108090000177 Interleukin-11 Proteins 0.000 claims description 5
• 230000001629 suppression Effects 0.000 claims description 5
• 238000012258 culturing Methods 0.000 claims description 4
• 239000003937 drug carrier Substances 0.000 claims description 4
• 206010043554 thrombocytopenia Diseases 0.000 claims description 4
• 208000018937 joint inflammation Diseases 0.000 claims description 3
• 239000000546 pharmaceutical excipient Substances 0.000 claims description 3
• 208000014767 Myeloproliferative disease Diseases 0.000 claims description 2
• 102000036693 Thrombopoietin Human genes 0.000 claims description 2
• 108010041111 Thrombopoietin Proteins 0.000 claims description 2
• 229940074383 interleukin-11 Drugs 0.000 claims description 2
• 208000004235 neutropenia Diseases 0.000 claims description 2
• 206010061481 Renal injury Diseases 0.000 claims 2
• 208000010227 enterocolitis Diseases 0.000 claims 2
• 206010025135 lupus erythematosus Diseases 0.000 claims 2
• 241000024188 Andala Species 0.000 claims 1
• 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 claims 1
• 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 claims 1
• 102000004457 Granulocyte-Macrophage Colony-Stimulating Factor Human genes 0.000 claims 1
• 102100030694 Interleukin-11 Human genes 0.000 claims 1
• 201000007224 Myeloproliferative neoplasm Diseases 0.000 claims 1
• 150000007523 nucleic acids Chemical class 0.000 abstract description 72
• 102000039446 nucleic acids Human genes 0.000 abstract description 51
• 108020004707 nucleic acids Proteins 0.000 abstract description 51
• 102000019034 Chemokines Human genes 0.000 abstract description 42
• 108010012236 Chemokines Proteins 0.000 abstract description 42
• 238000010188 recombinant method Methods 0.000 abstract description 8
• 101150002381 ckb-1 gene Proteins 0.000 abstract description 2
• 108090000623 proteins and genes Proteins 0.000 description 177
• 102000004169 proteins and genes Human genes 0.000 description 121
• 235000018102 proteins Nutrition 0.000 description 118
• 235000001014 amino acid Nutrition 0.000 description 89
• 239000002773 nucleotide Substances 0.000 description 85
• 125000003729 nucleotide group Chemical group 0.000 description 85
• 239000002299 complementary DNA Substances 0.000 description 80
• 229940024606 amino acid Drugs 0.000 description 74
• 230000000694 effects Effects 0.000 description 64
• 108010082155 Chemokine CCL18 Proteins 0.000 description 62
• 108020004414 DNA Proteins 0.000 description 59
• IPWKGIFRRBGCJO-IMJSIDKUSA-N Ala-Ser Chemical compound C[C@H]([NH3+])C(=O)N[C@@H](CO)C([O-])=O IPWKGIFRRBGCJO-IMJSIDKUSA-N 0.000 description 51
• 239000012634 fragment Substances 0.000 description 51
• 230000014509 gene expression Effects 0.000 description 51
• 241000699670 Mus sp. Species 0.000 description 43
• 101710151805 Mitochondrial intermediate peptidase 1 Proteins 0.000 description 38
• 238000011282 treatment Methods 0.000 description 36
• 108091026890 Coding region Proteins 0.000 description 34
• 239000000523 sample Substances 0.000 description 32
• 238000003556 assay Methods 0.000 description 30
• 239000002158 endotoxin Substances 0.000 description 30
• 108091028043 Nucleic acid sequence Proteins 0.000 description 29
• 108020004999 messenger RNA Proteins 0.000 description 29
• 239000005557 antagonist Substances 0.000 description 28
• 229920006008 lipopolysaccharide Polymers 0.000 description 28
• 108091032973 (ribonucleotides)n+m Proteins 0.000 description 26
• 210000000130 stem cell Anatomy 0.000 description 25
• 230000027455 binding Effects 0.000 description 24
• 230000035772 mutation Effects 0.000 description 22
• 238000000746 purification Methods 0.000 description 22
• 210000001744 T-lymphocyte Anatomy 0.000 description 21
• 125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 description 21
• 241001465754 Metazoa Species 0.000 description 20
• 206010028980 Neoplasm Diseases 0.000 description 20
• 230000000890 antigenic effect Effects 0.000 description 20
• 230000001580 bacterial effect Effects 0.000 description 19
• 239000002246 antineoplastic agent Substances 0.000 description 18
• 239000000872 buffer Substances 0.000 description 18
• 239000013604 expression vector Substances 0.000 description 17
• 102000005962 receptors Human genes 0.000 description 17
• 108020003175 receptors Proteins 0.000 description 17
• KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 16
• 239000000556 agonist Substances 0.000 description 16
• 210000000349 chromosome Anatomy 0.000 description 16
• 238000000338 in vitro Methods 0.000 description 16
• 238000003752 polymerase chain reaction Methods 0.000 description 16
• 210000001519 tissue Anatomy 0.000 description 16
• DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 description 15
• 210000001185 bone marrow Anatomy 0.000 description 15
• 208000029632 chronic intestinal failure Diseases 0.000 description 15
• 229940127089 cytotoxic agent Drugs 0.000 description 15
• WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 14
• 241000700605 Viruses Species 0.000 description 14
• 102000037865 fusion proteins Human genes 0.000 description 14
• 108020001507 fusion proteins Proteins 0.000 description 14
• -1 host cell Proteins 0.000 description 14
• 238000001727 in vivo Methods 0.000 description 14
• 230000003039 myelosuppressive effect Effects 0.000 description 14
• 230000008569 process Effects 0.000 description 14
• WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 13
• 239000000427 antigen Substances 0.000 description 13
• 210000000612 antigen-presenting cell Anatomy 0.000 description 13
• 108091007433 antigens Proteins 0.000 description 13
• 102000036639 antigens Human genes 0.000 description 13
• 239000012472 biological sample Substances 0.000 description 13
• 230000000295 complement effect Effects 0.000 description 13
• 239000003814 drug Substances 0.000 description 13
• 230000002163 immunogen Effects 0.000 description 13
• 230000001965 increasing effect Effects 0.000 description 13
• 210000000066 myeloid cell Anatomy 0.000 description 13
• 239000013615 primer Substances 0.000 description 13
• NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 12
• QTZXSYBVOSXBEJ-WDSKDSINSA-N Met-Asp Chemical compound CSCC[C@H](N)C(=O)N[C@H](C(O)=O)CC(O)=O QTZXSYBVOSXBEJ-WDSKDSINSA-N 0.000 description 12
• 238000004458 analytical method Methods 0.000 description 12
• 230000000692 anti-sense effect Effects 0.000 description 12
• 230000015572 biosynthetic process Effects 0.000 description 12
• 239000003795 chemical substances by application Substances 0.000 description 12
• 150000001875 compounds Chemical class 0.000 description 12
• 230000000875 corresponding effect Effects 0.000 description 12
• 230000006870 function Effects 0.000 description 12
• 230000002757 inflammatory effect Effects 0.000 description 12
• 239000003550 marker Substances 0.000 description 12
• 230000001404 mediated effect Effects 0.000 description 12
• 239000000047 product Substances 0.000 description 12
• 238000013518 transcription Methods 0.000 description 12
• 230000035897 transcription Effects 0.000 description 12
• 102000004190 Enzymes Human genes 0.000 description 11
• 108090000790 Enzymes Proteins 0.000 description 11
• 241000124008 Mammalia Species 0.000 description 11
• 230000001684 chronic effect Effects 0.000 description 11
• 229940088598 enzyme Drugs 0.000 description 11
• 238000009396 hybridization Methods 0.000 description 11
• 238000007912 intraperitoneal administration Methods 0.000 description 11
• 208000032839 leukemia Diseases 0.000 description 11
• 239000013612 plasmid Substances 0.000 description 11
• 230000004952 protein activity Effects 0.000 description 11
• 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 description 10
• 206010020751 Hypersensitivity Diseases 0.000 description 10
• ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 10
• FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 description 10
• 108091034117 Oligonucleotide Proteins 0.000 description 10
• 108700026244 Open Reading Frames Proteins 0.000 description 10
• 238000007792 addition Methods 0.000 description 10
• 210000001124 body fluid Anatomy 0.000 description 10
• 210000002798 bone marrow cell Anatomy 0.000 description 10
• 230000005757 colony formation Effects 0.000 description 10
• 229940079593 drug Drugs 0.000 description 10
• 230000002068 genetic effect Effects 0.000 description 10
• 210000004408 hybridoma Anatomy 0.000 description 10
• 208000015181 infectious disease Diseases 0.000 description 10
• 238000013507 mapping Methods 0.000 description 10
• 229960000485 methotrexate Drugs 0.000 description 10
• 230000004044 response Effects 0.000 description 10
• WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 9
• 102000004127 Cytokines Human genes 0.000 description 9
• 108090000695 Cytokines Proteins 0.000 description 9
• 230000001154 acute effect Effects 0.000 description 9
• 238000003745 diagnosis Methods 0.000 description 9
• 238000002474 experimental method Methods 0.000 description 9
• 239000000499 gel Substances 0.000 description 9
• 238000012163 sequencing technique Methods 0.000 description 9
• 239000007787 solid Substances 0.000 description 9
• 239000000126 substance Substances 0.000 description 9
• 108020005544 Antisense RNA Proteins 0.000 description 8
• 108020004635 Complementary DNA Proteins 0.000 description 8
• SCCPDJAQCXWPTF-VKHMYHEASA-N Gly-Asp Chemical compound NCC(=O)N[C@H](C(O)=O)CC(O)=O SCCPDJAQCXWPTF-VKHMYHEASA-N 0.000 description 8
• DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 8
• 102000004890 Interleukin-8 Human genes 0.000 description 8
• 108090001007 Interleukin-8 Proteins 0.000 description 8
• COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 8
• 102000004211 Platelet factor 4 Human genes 0.000 description 8
• 108090000778 Platelet factor 4 Proteins 0.000 description 8
• 240000004808 Saccharomyces cerevisiae Species 0.000 description 8
• 230000004071 biological effect Effects 0.000 description 8
• 239000010839 body fluid Substances 0.000 description 8
• 230000002759 chromosomal effect Effects 0.000 description 8
• 238000003776 cleavage reaction Methods 0.000 description 8
• 239000003184 complementary RNA Substances 0.000 description 8
• 238000005516 engineering process Methods 0.000 description 8
• 239000003112 inhibitor Substances 0.000 description 8
• 229940096397 interleukin-8 Drugs 0.000 description 8
• XKTZWUACRZHVAN-VADRZIEHSA-N interleukin-8 Chemical compound C([C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](NC(C)=O)CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N1[C@H](CCC1)C(=O)N1[C@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC(O)=CC=1)C(=O)N[C@H](CO)C(=O)N1[C@H](CCC1)C(N)=O)C1=CC=CC=C1 XKTZWUACRZHVAN-VADRZIEHSA-N 0.000 description 8
• 210000004698 lymphocyte Anatomy 0.000 description 8
• 230000004224 protection Effects 0.000 description 8
• 230000010076 replication Effects 0.000 description 8
• 230000007017 scission Effects 0.000 description 8
• 108020004491 Antisense DNA Proteins 0.000 description 7
• 206010065553 Bone marrow failure Diseases 0.000 description 7
• 108010021064 CTLA-4 Antigen Proteins 0.000 description 7
• 229940045513 CTLA4 antagonist Drugs 0.000 description 7
• 102100039498 Cytotoxic T-lymphocyte protein 4 Human genes 0.000 description 7
• 241000282412 Homo Species 0.000 description 7
• 102000007651 Macrophage Colony-Stimulating Factor Human genes 0.000 description 7
• 108010046938 Macrophage Colony-Stimulating Factor Proteins 0.000 description 7
• 241000699666 Mus <mouse, genus> Species 0.000 description 7
• 102100040247 Tumor necrosis factor Human genes 0.000 description 7
• 239000002253 acid Substances 0.000 description 7
• 230000002776 aggregation Effects 0.000 description 7
• 238000004220 aggregation Methods 0.000 description 7
• 230000002788 anti-peptide Effects 0.000 description 7
• 239000003816 antisense DNA Substances 0.000 description 7
• 210000004369 blood Anatomy 0.000 description 7
• 239000008280 blood Substances 0.000 description 7
• 210000001772 blood platelet Anatomy 0.000 description 7
• 230000000973 chemotherapeutic effect Effects 0.000 description 7
• 239000005547 deoxyribonucleotide Substances 0.000 description 7
• 239000003623 enhancer Substances 0.000 description 7
• 230000003394 haemopoietic effect Effects 0.000 description 7
• 230000001939 inductive effect Effects 0.000 description 7
• 238000002347 injection Methods 0.000 description 7
• 239000007924 injection Substances 0.000 description 7
• 238000003780 insertion Methods 0.000 description 7
• 230000037431 insertion Effects 0.000 description 7
• 210000003734 kidney Anatomy 0.000 description 7
• 210000004072 lung Anatomy 0.000 description 7
• 210000004962 mammalian cell Anatomy 0.000 description 7
• 230000007170 pathology Effects 0.000 description 7
• 238000002360 preparation method Methods 0.000 description 7
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 7
• 238000003786 synthesis reaction Methods 0.000 description 7
• 238000013519 translation Methods 0.000 description 7
• IIFDPDVJAHQFSR-WHFBIAKZSA-N Asn-Glu Chemical compound NC(=O)C[C@H](N)C(=O)N[C@H](C(O)=O)CCC(O)=O IIFDPDVJAHQFSR-WHFBIAKZSA-N 0.000 description 6
• 241000894006 Bacteria Species 0.000 description 6
• 102000053602 DNA Human genes 0.000 description 6
• ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 6
• 206010061218 Inflammation Diseases 0.000 description 6
• 102000000589 Interleukin-1 Human genes 0.000 description 6
• 108010002352 Interleukin-1 Proteins 0.000 description 6
• 108010002386 Interleukin-3 Proteins 0.000 description 6
• 102000000646 Interleukin-3 Human genes 0.000 description 6
• 108091092195 Intron Proteins 0.000 description 6
• 238000000636 Northern blotting Methods 0.000 description 6
• 102000015636 Oligopeptides Human genes 0.000 description 6
• 108010038807 Oligopeptides Proteins 0.000 description 6
• 230000004075 alteration Effects 0.000 description 6
• 208000006673 asthma Diseases 0.000 description 6
• 230000022131 cell cycle Effects 0.000 description 6
• 230000004663 cell proliferation Effects 0.000 description 6
• 230000036755 cellular response Effects 0.000 description 6
• 238000004587 chromatography analysis Methods 0.000 description 6
• 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 description 6
• 125000002637 deoxyribonucleotide group Chemical group 0.000 description 6
• 238000011156 evaluation Methods 0.000 description 6
• 229960001340 histamine Drugs 0.000 description 6
• 230000028993 immune response Effects 0.000 description 6
• CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 description 6
• 230000004054 inflammatory process Effects 0.000 description 6
• 239000008194 pharmaceutical composition Substances 0.000 description 6
• 230000001681 protective effect Effects 0.000 description 6
• 230000001105 regulatory effect Effects 0.000 description 6
• 230000028327 secretion Effects 0.000 description 6
• 230000029663 wound healing Effects 0.000 description 6
• QXRNAOYBCYVZCD-BQBZGAKWSA-N Ala-Lys Chemical compound C[C@H](N)C(=O)N[C@H](C(O)=O)CCCCN QXRNAOYBCYVZCD-BQBZGAKWSA-N 0.000 description 5
• UHDGCWIWMRVCDJ-CCXZUQQUSA-N Cytarabine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 UHDGCWIWMRVCDJ-CCXZUQQUSA-N 0.000 description 5
• 238000012286 ELISA Assay Methods 0.000 description 5
• UKKNTTCNGZLJEX-WHFBIAKZSA-N Gln-Ser Chemical compound NC(=O)CC[C@H](N)C(=O)N[C@@H](CO)C(O)=O UKKNTTCNGZLJEX-WHFBIAKZSA-N 0.000 description 5
• 101000611183 Homo sapiens Tumor necrosis factor Proteins 0.000 description 5
• 108010009474 Macrophage Inflammatory Proteins Proteins 0.000 description 5
• 102000009571 Macrophage Inflammatory Proteins Human genes 0.000 description 5
• LAFKUZYWNCHOHT-WHFBIAKZSA-N Ser-Glu Chemical compound OC[C@H](N)C(=O)N[C@H](C(O)=O)CCC(O)=O LAFKUZYWNCHOHT-WHFBIAKZSA-N 0.000 description 5
• 239000002671 adjuvant Substances 0.000 description 5
• 230000003321 amplification Effects 0.000 description 5
• 238000013459 approach Methods 0.000 description 5
• 230000008827 biological function Effects 0.000 description 5
• 230000037396 body weight Effects 0.000 description 5
• 239000003153 chemical reaction reagent Substances 0.000 description 5
• 238000010367 cloning Methods 0.000 description 5
• 239000013599 cloning vector Substances 0.000 description 5
• 230000003053 immunization Effects 0.000 description 5
• 230000006698 induction Effects 0.000 description 5
• 230000005764 inhibitory process Effects 0.000 description 5
• 230000003993 interaction Effects 0.000 description 5
• 231100000225 lethality Toxicity 0.000 description 5
• 239000000463 material Substances 0.000 description 5
• 239000002609 medium Substances 0.000 description 5
• 238000003199 nucleic acid amplification method Methods 0.000 description 5
• 239000012071 phase Substances 0.000 description 5
• 230000003248 secreting effect Effects 0.000 description 5
• 239000000243 solution Substances 0.000 description 5
• 238000001890 transfection Methods 0.000 description 5
• 230000009466 transformation Effects 0.000 description 5
• 210000002700 urine Anatomy 0.000 description 5
• 230000003612 virological effect Effects 0.000 description 5
• 208000032467 Aplastic anaemia Diseases 0.000 description 4
• 238000002965 ELISA Methods 0.000 description 4
• 241000196324 Embryophyta Species 0.000 description 4
• 102000003951 Erythropoietin Human genes 0.000 description 4
• 108090000394 Erythropoietin Proteins 0.000 description 4
• 108700039691 Genetic Promoter Regions Proteins 0.000 description 4
• IEFJWDNGDZAYNZ-BYPYZUCNSA-N Gly-Glu Chemical compound NCC(=O)N[C@H](C(O)=O)CCC(O)=O IEFJWDNGDZAYNZ-BYPYZUCNSA-N 0.000 description 4
• 101710154606 Hemagglutinin Proteins 0.000 description 4
• 241000238631 Hexapoda Species 0.000 description 4
• MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 4
• 102000003815 Interleukin-11 Human genes 0.000 description 4
• AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 4
• 101000946797 Mus musculus C-C motif chemokine 9 Proteins 0.000 description 4
• 241000283973 Oryctolagus cuniculus Species 0.000 description 4
• 101710093908 Outer capsid protein VP4 Proteins 0.000 description 4
• 101710135467 Outer capsid protein sigma-1 Proteins 0.000 description 4
• 208000037581 Persistent Infection Diseases 0.000 description 4
• 101710176177 Protein A56 Proteins 0.000 description 4
• 241000700159 Rattus Species 0.000 description 4
• 108091028664 Ribonucleotide Proteins 0.000 description 4
• 238000012300 Sequence Analysis Methods 0.000 description 4
• DSGIVWSDDRDJIO-ZXXMMSQZSA-N Thr-Thr Chemical compound C[C@@H](O)[C@H](N)C(=O)N[C@@H]([C@@H](C)O)C(O)=O DSGIVWSDDRDJIO-ZXXMMSQZSA-N 0.000 description 4
• 206010052428 Wound Diseases 0.000 description 4
• 208000027418 Wounds and injury Diseases 0.000 description 4
• JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 4
• 230000004913 activation Effects 0.000 description 4
• 230000007815 allergy Effects 0.000 description 4
• 230000006907 apoptotic process Effects 0.000 description 4
• 230000001363 autoimmune Effects 0.000 description 4
• 230000033228 biological regulation Effects 0.000 description 4
• 210000000988 bone and bone Anatomy 0.000 description 4
• 238000004113 cell culture Methods 0.000 description 4
• 230000008859 change Effects 0.000 description 4
• 230000003399 chemotactic effect Effects 0.000 description 4
• 230000035605 chemotaxis Effects 0.000 description 4
• 235000018417 cysteine Nutrition 0.000 description 4
• 231100000433 cytotoxic Toxicity 0.000 description 4
• 230000001472 cytotoxic effect Effects 0.000 description 4
• 238000001514 detection method Methods 0.000 description 4
• 229940105423 erythropoietin Drugs 0.000 description 4
• 210000003527 eukaryotic cell Anatomy 0.000 description 4
• 239000012530 fluid Substances 0.000 description 4
• 238000009472 formulation Methods 0.000 description 4
• 238000001415 gene therapy Methods 0.000 description 4
• KZNQNBZMBZJQJO-YFKPBYRVSA-N glyclproline Chemical compound NCC(=O)N1CCC[C@H]1C(O)=O KZNQNBZMBZJQJO-YFKPBYRVSA-N 0.000 description 4
• 239000003102 growth factor Substances 0.000 description 4
• 230000002209 hydrophobic effect Effects 0.000 description 4
• 210000002865 immune cell Anatomy 0.000 description 4
• 210000000987 immune system Anatomy 0.000 description 4
• 238000002649 immunization Methods 0.000 description 4
• 238000011534 incubation Methods 0.000 description 4
• 230000000977 initiatory effect Effects 0.000 description 4
• 229910052740 iodine Inorganic materials 0.000 description 4
• 201000006417 multiple sclerosis Diseases 0.000 description 4
• 230000007935 neutral effect Effects 0.000 description 4
• 210000000440 neutrophil Anatomy 0.000 description 4
• 210000003819 peripheral blood mononuclear cell Anatomy 0.000 description 4
• 210000002381 plasma Anatomy 0.000 description 4
• OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 description 4
• 238000011160 research Methods 0.000 description 4
• 108091008146 restriction endonucleases Proteins 0.000 description 4
• 230000001177 retroviral effect Effects 0.000 description 4
• 239000002336 ribonucleotide Substances 0.000 description 4
• 125000002652 ribonucleotide group Chemical group 0.000 description 4
• 201000000306 sarcoidosis Diseases 0.000 description 4
• 238000012216 screening Methods 0.000 description 4
• 210000002966 serum Anatomy 0.000 description 4
• 238000010254 subcutaneous injection Methods 0.000 description 4
• 239000000758 substrate Substances 0.000 description 4
• 239000003981 vehicle Substances 0.000 description 4
• 208000035143 Bacterial infection Diseases 0.000 description 3
• 241000283690 Bos taurus Species 0.000 description 3
• 101100289995 Caenorhabditis elegans mac-1 gene Proteins 0.000 description 3
• OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 3
• 108091033380 Coding strand Proteins 0.000 description 3
• 238000001712 DNA sequencing Methods 0.000 description 3
• 108700024394 Exon Proteins 0.000 description 3
• 206010016654 Fibrosis Diseases 0.000 description 3
• GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 description 3
• 108010093488 His-His-His-His-His-His Proteins 0.000 description 3
• 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 description 3
• 206010048643 Hypereosinophilic syndrome Diseases 0.000 description 3
• 108060003951 Immunoglobulin Proteins 0.000 description 3
• 206010062016 Immunosuppression Diseases 0.000 description 3
• 208000022559 Inflammatory bowel disease Diseases 0.000 description 3
• OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 3
• OTXBNHIUIHNGAO-UWVGGRQHSA-N Leu-Lys Chemical compound CC(C)C[C@H](N)C(=O)N[C@H](C(O)=O)CCCCN OTXBNHIUIHNGAO-UWVGGRQHSA-N 0.000 description 3
• 206010025323 Lymphomas Diseases 0.000 description 3
• 201000003793 Myelodysplastic syndrome Diseases 0.000 description 3
• 108020004711 Nucleic Acid Probes Proteins 0.000 description 3
• 206010035226 Plasma cell myeloma Diseases 0.000 description 3
• 206010037660 Pyrexia Diseases 0.000 description 3
• 108020004511 Recombinant DNA Proteins 0.000 description 3
• 108010083644 Ribonucleases Proteins 0.000 description 3
• 102000006382 Ribonucleases Human genes 0.000 description 3
• 241000293869 Salmonella enterica subsp. enterica serovar Typhimurium Species 0.000 description 3
• 206010040070 Septic Shock Diseases 0.000 description 3
• 201000010001 Silicosis Diseases 0.000 description 3
• 108091081024 Start codon Proteins 0.000 description 3
• 241000187747 Streptomyces Species 0.000 description 3
• 230000024932 T cell mediated immunity Effects 0.000 description 3
• 230000005867 T cell response Effects 0.000 description 3
• 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 description 3
• IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 description 3
• XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 3
• 150000007513 acids Chemical class 0.000 description 3
• 230000009471 action Effects 0.000 description 3
• 229960001694 anagrelide Drugs 0.000 description 3
• OTBXOEAOVRKTNQ-UHFFFAOYSA-N anagrelide Chemical compound N1=C2NC(=O)CN2CC2=C(Cl)C(Cl)=CC=C21 OTBXOEAOVRKTNQ-UHFFFAOYSA-N 0.000 description 3
• 210000004102 animal cell Anatomy 0.000 description 3
• 125000003118 aryl group Chemical group 0.000 description 3
• 230000005784 autoimmunity Effects 0.000 description 3
• 210000003719 b-lymphocyte Anatomy 0.000 description 3
• 208000022362 bacterial infectious disease Diseases 0.000 description 3
• 210000003651 basophil Anatomy 0.000 description 3
• 238000001574 biopsy Methods 0.000 description 3
• 238000010322 bone marrow transplantation Methods 0.000 description 3
• 239000011575 calcium Substances 0.000 description 3
• 229910052791 calcium Inorganic materials 0.000 description 3
• 238000004422 calculation algorithm Methods 0.000 description 3
• 229910052799 carbon Inorganic materials 0.000 description 3
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 3
• 230000003915 cell function Effects 0.000 description 3
• 238000006243 chemical reaction Methods 0.000 description 3
• 230000031902 chemoattractant activity Effects 0.000 description 3
• 229940044683 chemotherapy drug Drugs 0.000 description 3
• 208000037976 chronic inflammation Diseases 0.000 description 3
• 238000007796 conventional method Methods 0.000 description 3
• 150000001945 cysteines Chemical class 0.000 description 3
• 230000003013 cytotoxicity Effects 0.000 description 3
• 231100000135 cytotoxicity Toxicity 0.000 description 3
• 230000007423 decrease Effects 0.000 description 3
• 230000003247 decreasing effect Effects 0.000 description 3
• 230000007850 degeneration Effects 0.000 description 3
• 238000013461 design Methods 0.000 description 3
• 231100000673 dose–response relationship Toxicity 0.000 description 3
• 210000003979 eosinophil Anatomy 0.000 description 3
• 230000001747 exhibiting effect Effects 0.000 description 3
• 210000002950 fibroblast Anatomy 0.000 description 3
• 230000004761 fibrosis Effects 0.000 description 3
• 229960002949 fluorouracil Drugs 0.000 description 3
• 238000004128 high performance liquid chromatography Methods 0.000 description 3
• 210000003917 human chromosome Anatomy 0.000 description 3
• RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 3
• 102000018358 immunoglobulin Human genes 0.000 description 3
• 230000001506 immunosuppresive effect Effects 0.000 description 3
• 230000001976 improved effect Effects 0.000 description 3
• 238000007901 in situ hybridization Methods 0.000 description 3
• 229960000905 indomethacin Drugs 0.000 description 3
• 230000001524 infective effect Effects 0.000 description 3
• 230000008595 infiltration Effects 0.000 description 3
• 238000001764 infiltration Methods 0.000 description 3
• 229930027917 kanamycin Natural products 0.000 description 3
• 229960000318 kanamycin Drugs 0.000 description 3
• SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SBUJHOSQTJFQJX-NOAMYHISSA-N 0.000 description 3
• 229930182823 kanamycin A Natural products 0.000 description 3
• 230000002147 killing effect Effects 0.000 description 3
• 238000002372 labelling Methods 0.000 description 3
• 210000000265 leukocyte Anatomy 0.000 description 3
• 239000003446 ligand Substances 0.000 description 3
• 230000007246 mechanism Effects 0.000 description 3
• 201000001441 melanoma Diseases 0.000 description 3
• 238000002844 melting Methods 0.000 description 3
• 230000008018 melting Effects 0.000 description 3
• 239000012528 membrane Substances 0.000 description 3
• 230000005012 migration Effects 0.000 description 3
• 238000013508 migration Methods 0.000 description 3
• 201000000050 myeloid neoplasm Diseases 0.000 description 3
• 230000002410 myeloprotective effect Effects 0.000 description 3
• 239000002853 nucleic acid probe Substances 0.000 description 3
• 238000012261 overproduction Methods 0.000 description 3
• 230000008488 polyadenylation Effects 0.000 description 3
• 239000002243 precursor Substances 0.000 description 3
• 230000000770 proinflammatory effect Effects 0.000 description 3
• 230000005855 radiation Effects 0.000 description 3
• 238000003127 radioimmunoassay Methods 0.000 description 3
• 239000011541 reaction mixture Substances 0.000 description 3
• 230000027425 release of sequestered calcium ion into cytosol Effects 0.000 description 3
• 238000010839 reverse transcription Methods 0.000 description 3
• 206010039073 rheumatoid arthritis Diseases 0.000 description 3
• 230000035939 shock Effects 0.000 description 3
• 238000010532 solid phase synthesis reaction Methods 0.000 description 3
• 238000000527 sonication Methods 0.000 description 3
• 241000894007 species Species 0.000 description 3
• 238000003860 storage Methods 0.000 description 3
• 239000007929 subcutaneous injection Substances 0.000 description 3
• 210000001179 synovial fluid Anatomy 0.000 description 3
• 238000012360 testing method Methods 0.000 description 3
• 230000002103 transcriptional effect Effects 0.000 description 3
• 230000032258 transport Effects 0.000 description 3
• 238000011269 treatment regimen Methods 0.000 description 3
• 241000701161 unidentified adenovirus Species 0.000 description 3
• 238000011870 unpaired t-test Methods 0.000 description 3
• 238000005406 washing Methods 0.000 description 3
• 210000005253 yeast cell Anatomy 0.000 description 3
• YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
• LLXVXPPXELIDGQ-UHFFFAOYSA-N (2,5-dioxopyrrolidin-1-yl) 3-(2,5-dioxopyrrol-1-yl)benzoate Chemical compound C=1C=CC(N2C(C=CC2=O)=O)=CC=1C(=O)ON1C(=O)CCC1=O LLXVXPPXELIDGQ-UHFFFAOYSA-N 0.000 description 2
• 102000040650 (ribonucleotides)n+m Human genes 0.000 description 2
• VSNHCAURESNICA-NJFSPNSNSA-N 1-oxidanylurea Chemical compound N[14C](=O)NO VSNHCAURESNICA-NJFSPNSNSA-N 0.000 description 2
• 229920001817 Agar Polymers 0.000 description 2
• 208000024827 Alzheimer disease Diseases 0.000 description 2
• 206010003591 Ataxia Diseases 0.000 description 2
• 201000001320 Atherosclerosis Diseases 0.000 description 2
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
• 241000972773 Aulopiformes Species 0.000 description 2
• 208000023275 Autoimmune disease Diseases 0.000 description 2
• DWRXFEITVBNRMK-UHFFFAOYSA-N Beta-D-1-Arabinofuranosylthymine Natural products O=C1NC(=O)C(C)=CN1C1C(O)C(O)C(CO)O1 DWRXFEITVBNRMK-UHFFFAOYSA-N 0.000 description 2
• 208000018240 Bone Marrow Failure disease Diseases 0.000 description 2
• 102100023705 C-C motif chemokine 14 Human genes 0.000 description 2
• 102000014914 Carrier Proteins Human genes 0.000 description 2
• 108010078791 Carrier Proteins Proteins 0.000 description 2
• 241000282693 Cercopithecidae Species 0.000 description 2
• 208000015879 Cerebellar disease Diseases 0.000 description 2
• 241000701022 Cytomegalovirus Species 0.000 description 2
• 239000003155 DNA primer Substances 0.000 description 2
• IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
• 241000255581 Drosophila <fruit fly, genus> Species 0.000 description 2
• 102100031780 Endonuclease Human genes 0.000 description 2
• 206010014824 Endotoxic shock Diseases 0.000 description 2
• ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 2
• 208000009386 Experimental Arthritis Diseases 0.000 description 2
• 102100028071 Fibroblast growth factor 7 Human genes 0.000 description 2
• 241000700662 Fowlpox virus Species 0.000 description 2
• 108700028146 Genetic Enhancer Elements Proteins 0.000 description 2
• SSHIXEILTLPAQT-WHFBIAKZSA-N Gln-Asp Chemical compound NC(=O)CC[C@H](N)C(=O)N[C@@H](CC(O)=O)C(O)=O SSHIXEILTLPAQT-WHFBIAKZSA-N 0.000 description 2
• 108010015776 Glucose oxidase Proteins 0.000 description 2
• 239000004366 Glucose oxidase Substances 0.000 description 2
• SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 2
• HVLSXIKZNLPZJJ-TXZCQADKSA-N HA peptide Chemical compound C([C@@H](C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](C)C(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=C(O)C=C1 HVLSXIKZNLPZJJ-TXZCQADKSA-N 0.000 description 2
• 230000010556 Heparin Binding Activity Effects 0.000 description 2
• 101000978381 Homo sapiens C-C motif chemokine 14 Proteins 0.000 description 2
• 101001033279 Homo sapiens Interleukin-3 Proteins 0.000 description 2
• 108010001336 Horseradish Peroxidase Proteins 0.000 description 2
• 108090000144 Human Proteins Proteins 0.000 description 2
• 102000003839 Human Proteins Human genes 0.000 description 2
• 201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 description 2
• 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 description 2
• 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 description 2
• 102000008070 Interferon-gamma Human genes 0.000 description 2
• 108010074328 Interferon-gamma Proteins 0.000 description 2
• 102000014150 Interferons Human genes 0.000 description 2
• 108010050904 Interferons Proteins 0.000 description 2
• 102100039064 Interleukin-3 Human genes 0.000 description 2
• 108090001005 Interleukin-6 Proteins 0.000 description 2
• XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
• 102000004195 Isomerases Human genes 0.000 description 2
• 108090000769 Isomerases Proteins 0.000 description 2
• GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
• 108090001090 Lectins Proteins 0.000 description 2
• 102000004856 Lectins Human genes 0.000 description 2
• IMTUWVJPCQPJEE-IUCAKERBSA-N Met-Lys Chemical compound CSCC[C@H](N)C(=O)N[C@H](C(O)=O)CCCCN IMTUWVJPCQPJEE-IUCAKERBSA-N 0.000 description 2
• WEDDFMCSUNNZJR-WDSKDSINSA-N Met-Ser Chemical compound CSCC[C@H](N)C(=O)N[C@@H](CO)C(O)=O WEDDFMCSUNNZJR-WDSKDSINSA-N 0.000 description 2
• 208000016285 Movement disease Diseases 0.000 description 2
• 125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 description 2
• 101710163270 Nuclease Proteins 0.000 description 2
• 108020005187 Oligonucleotide Probes Proteins 0.000 description 2
• 102000004316 Oxidoreductases Human genes 0.000 description 2
• 108090000854 Oxidoreductases Proteins 0.000 description 2
• 102000003992 Peroxidases Human genes 0.000 description 2
• 108091000080 Phosphotransferase Proteins 0.000 description 2
• 239000004793 Polystyrene Substances 0.000 description 2
• 108010076504 Protein Sorting Signals Proteins 0.000 description 2
• 108091034057 RNA (poly(A)) Proteins 0.000 description 2
• 108020005091 Replication Origin Proteins 0.000 description 2
• 241000714474 Rous sarcoma virus Species 0.000 description 2
• 238000011579 SCID mouse model Methods 0.000 description 2
• 108091081021 Sense strand Proteins 0.000 description 2
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
• 208000003954 Spinal Muscular Atrophies of Childhood Diseases 0.000 description 2
• QOLYAJSZHIJCTO-VQVTYTSYSA-N Thr-Pro Chemical compound C[C@@H](O)[C@H](N)C(=O)N1CCC[C@H]1C(O)=O QOLYAJSZHIJCTO-VQVTYTSYSA-N 0.000 description 2
• 208000005485 Thrombocytosis Diseases 0.000 description 2
• 108060008682 Tumor Necrosis Factor Proteins 0.000 description 2
• 206010067584 Type 1 diabetes mellitus Diseases 0.000 description 2
• DRTQHJPVMGBUCF-XVFCMESISA-N Uridine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-XVFCMESISA-N 0.000 description 2
• 208000036142 Viral infection Diseases 0.000 description 2
• 230000002378 acidificating effect Effects 0.000 description 2
• 230000003213 activating effect Effects 0.000 description 2
• 208000038016 acute inflammation Diseases 0.000 description 2
• 230000006022 acute inflammation Effects 0.000 description 2
• 208000018254 acute transverse myelitis Diseases 0.000 description 2
• 238000001042 affinity chromatography Methods 0.000 description 2
• 239000008272 agar Substances 0.000 description 2
• 229940100198 alkylating agent Drugs 0.000 description 2
• 239000002168 alkylating agent Substances 0.000 description 2
• 208000026935 allergic disease Diseases 0.000 description 2
• BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 2
• 229910052921 ammonium sulfate Inorganic materials 0.000 description 2
• 238000012870 ammonium sulfate precipitation Methods 0.000 description 2
• 235000011130 ammonium sulphate Nutrition 0.000 description 2
• 229960000723 ampicillin Drugs 0.000 description 2
• AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 description 2
• 150000001450 anions Chemical class 0.000 description 2
• 230000003110 anti-inflammatory effect Effects 0.000 description 2
• 230000005875 antibody response Effects 0.000 description 2
• 230000030741 antigen processing and presentation Effects 0.000 description 2
• 208000018300 basal ganglia disease Diseases 0.000 description 2
• IQFYYKKMVGJFEH-UHFFFAOYSA-N beta-L-thymidine Natural products O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C1 IQFYYKKMVGJFEH-UHFFFAOYSA-N 0.000 description 2
• 238000004166 bioassay Methods 0.000 description 2
• 210000004204 blood vessel Anatomy 0.000 description 2
• 239000001506 calcium phosphate Substances 0.000 description 2
• 229910000389 calcium phosphate Inorganic materials 0.000 description 2
• 235000011010 calcium phosphates Nutrition 0.000 description 2
• 201000011510 cancer Diseases 0.000 description 2
• 239000004202 carbamide Substances 0.000 description 2
• 210000000845 cartilage Anatomy 0.000 description 2
• 230000030833 cell death Effects 0.000 description 2
• 239000002975 chemoattractant Substances 0.000 description 2
• 238000003200 chromosome mapping Methods 0.000 description 2
• 230000006020 chronic inflammation Effects 0.000 description 2
• 238000009643 clonogenic assay Methods 0.000 description 2
• 231100000096 clonogenic assay Toxicity 0.000 description 2
• 238000004590 computer program Methods 0.000 description 2
• 230000001276 controlling effect Effects 0.000 description 2
• 230000002596 correlated effect Effects 0.000 description 2
• 238000010168 coupling process Methods 0.000 description 2
• 230000006378 damage Effects 0.000 description 2
• 230000007123 defense Effects 0.000 description 2
• 230000002939 deleterious effect Effects 0.000 description 2
• 230000001419 dependent effect Effects 0.000 description 2
• 206010012601 diabetes mellitus Diseases 0.000 description 2
• 238000002405 diagnostic procedure Methods 0.000 description 2
• 238000004520 electroporation Methods 0.000 description 2
• 210000002889 endothelial cell Anatomy 0.000 description 2
• 230000002708 enhancing effect Effects 0.000 description 2
• 210000003743 erythrocyte Anatomy 0.000 description 2
• 238000012869 ethanol precipitation Methods 0.000 description 2
• 238000000605 extraction Methods 0.000 description 2
• GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 2
• 210000002683 foot Anatomy 0.000 description 2
• 230000037433 frameshift Effects 0.000 description 2
• 230000002538 fungal effect Effects 0.000 description 2
• 230000004927 fusion Effects 0.000 description 2
• 238000001502 gel electrophoresis Methods 0.000 description 2
• 238000007429 general method Methods 0.000 description 2
• 231100000853 glomerular lesion Toxicity 0.000 description 2
• 229940116332 glucose oxidase Drugs 0.000 description 2
• 235000019420 glucose oxidase Nutrition 0.000 description 2
• LEQAOMBKQFMDFZ-UHFFFAOYSA-N glyoxal Chemical compound O=CC=O LEQAOMBKQFMDFZ-UHFFFAOYSA-N 0.000 description 2
• 239000000185 hemagglutinin Substances 0.000 description 2
• 230000011132 hemopoiesis Effects 0.000 description 2
• 230000004727 humoral immunity Effects 0.000 description 2
• 210000004754 hybrid cell Anatomy 0.000 description 2
• 238000004191 hydrophobic interaction chromatography Methods 0.000 description 2
• 238000012872 hydroxylapatite chromatography Methods 0.000 description 2
• 208000024364 idiopathic hypereosinophilic syndrome Diseases 0.000 description 2
• 238000003384 imaging method Methods 0.000 description 2
• 208000026278 immune system disease Diseases 0.000 description 2
• 229940072221 immunoglobulins Drugs 0.000 description 2
• 206010022000 influenza Diseases 0.000 description 2
• 229960003130 interferon gamma Drugs 0.000 description 2
• 229940047124 interferons Drugs 0.000 description 2
• 208000036971 interstitial lung disease 2 Diseases 0.000 description 2
• 230000003834 intracellular effect Effects 0.000 description 2
• 238000010253 intravenous injection Methods 0.000 description 2
• 108010045069 keyhole-limpet hemocyanin Proteins 0.000 description 2
• 239000008101 lactose Substances 0.000 description 2
• 239000002523 lectin Substances 0.000 description 2
• 230000003902 lesion Effects 0.000 description 2
• 231100000518 lethal Toxicity 0.000 description 2
• 230000001665 lethal effect Effects 0.000 description 2
• 210000004185 liver Anatomy 0.000 description 2
• 210000004379 membrane Anatomy 0.000 description 2
• 229930182817 methionine Natural products 0.000 description 2
• 229920000609 methyl cellulose Polymers 0.000 description 2
• 239000001923 methylcellulose Substances 0.000 description 2
• 235000010981 methylcellulose Nutrition 0.000 description 2
• 230000037230 mobility Effects 0.000 description 2
• 238000010369 molecular cloning Methods 0.000 description 2
• 239000000178 monomer Substances 0.000 description 2
• 210000002864 mononuclear phagocyte Anatomy 0.000 description 2
• 230000001613 neoplastic effect Effects 0.000 description 2
• 230000004770 neurodegeneration Effects 0.000 description 2
• 208000015122 neurodegenerative disease Diseases 0.000 description 2
• 235000015097 nutrients Nutrition 0.000 description 2
• 229940046166 oligodeoxynucleotide Drugs 0.000 description 2
• 239000002751 oligonucleotide probe Substances 0.000 description 2
• 230000002018 overexpression Effects 0.000 description 2
• 230000001575 pathological effect Effects 0.000 description 2
• 238000010647 peptide synthesis reaction Methods 0.000 description 2
• 230000002093 peripheral effect Effects 0.000 description 2
• 210000001322 periplasm Anatomy 0.000 description 2
• 108040007629 peroxidase activity proteins Proteins 0.000 description 2
• 229940080469 phosphocellulose Drugs 0.000 description 2
• 102000020233 phosphotransferase Human genes 0.000 description 2
• 239000013600 plasmid vector Substances 0.000 description 2
• BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
• 229920002401 polyacrylamide Polymers 0.000 description 2
• 102000054765 polymorphisms of proteins Human genes 0.000 description 2
• 229920002223 polystyrene Polymers 0.000 description 2
• 239000011148 porous material Substances 0.000 description 2
• 230000003389 potentiating effect Effects 0.000 description 2
• 230000002265 prevention Effects 0.000 description 2
• 239000002987 primer (paints) Substances 0.000 description 2
• 238000012545 processing Methods 0.000 description 2
• 210000001236 prokaryotic cell Anatomy 0.000 description 2
• 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 2
• 150000003180 prostaglandins Chemical class 0.000 description 2
• 230000004853 protein function Effects 0.000 description 2
• 239000012264 purified product Substances 0.000 description 2
• 230000002285 radioactive effect Effects 0.000 description 2
• 230000002829 reductive effect Effects 0.000 description 2
• 238000007894 restriction fragment length polymorphism technique Methods 0.000 description 2
• 230000002441 reversible effect Effects 0.000 description 2
• 238000012552 review Methods 0.000 description 2
• PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 2
• 235000019515 salmon Nutrition 0.000 description 2
• 238000010008 shearing Methods 0.000 description 2
• 239000011780 sodium chloride Substances 0.000 description 2
• 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 2
• 239000012064 sodium phosphate buffer Substances 0.000 description 2
• 210000004988 splenocyte Anatomy 0.000 description 2
• 230000006641 stabilisation Effects 0.000 description 2
• 238000011105 stabilization Methods 0.000 description 2
• 238000010186 staining Methods 0.000 description 2
• 230000004936 stimulating effect Effects 0.000 description 2
• UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 2
• 229910052717 sulfur Inorganic materials 0.000 description 2
• 230000004083 survival effect Effects 0.000 description 2
• 230000009885 systemic effect Effects 0.000 description 2
• 201000000596 systemic lupus erythematosus Diseases 0.000 description 2
• 229940126585 therapeutic drug Drugs 0.000 description 2
• 229940104230 thymidine Drugs 0.000 description 2
• 238000010361 transduction Methods 0.000 description 2
• 230000026683 transduction Effects 0.000 description 2
• 238000012546 transfer Methods 0.000 description 2
• 230000014621 translational initiation Effects 0.000 description 2
• 208000009174 transverse myelitis Diseases 0.000 description 2
• QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 2
• 210000004881 tumor cell Anatomy 0.000 description 2
• 230000009452 underexpressoin Effects 0.000 description 2
• 241000701447 unidentified baculovirus Species 0.000 description 2
• 241001430294 unidentified retrovirus Species 0.000 description 2
• 238000001262 western blot Methods 0.000 description 2
• 238000001086 yeast two-hybrid system Methods 0.000 description 2
• DIGQNXIGRZPYDK-WKSCXVIASA-N (2R)-6-amino-2-[[2-[[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-[[(2R,3S)-2-[[2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S,3S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2R)-2-[[2-[[2-[[2-[(2-amino-1-hydroxyethylidene)amino]-3-carboxy-1-hydroxypropylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxypropylidene]amino]-1,3-dihydroxypropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxybutylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1-hydroxypropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxyethylidene]amino]-1,5-dihydroxy-5-iminopentylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxybutylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1-hydroxyethylidene]amino]hexanoic acid Chemical compound C[C@@H]([C@@H](C(=N[C@@H](CS)C(=N[C@@H](C)C(=N[C@@H](CO)C(=NCC(=N[C@@H](CCC(=N)O)C(=NC(CS)C(=N[C@H]([C@H](C)O)C(=N[C@H](CS)C(=N[C@H](CO)C(=NCC(=N[C@H](CS)C(=NCC(=N[C@H](CCCCN)C(=O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)N=C([C@H](CS)N=C([C@H](CO)N=C([C@H](CO)N=C([C@H](C)N=C(CN=C([C@H](CO)N=C([C@H](CS)N=C(CN=C(C(CS)N=C(C(CC(=O)O)N=C(CN)O)O)O)O)O)O)O)O)O)O)O)O DIGQNXIGRZPYDK-WKSCXVIASA-N 0.000 description 1
• KUHSEZKIEJYEHN-BXRBKJIMSA-N (2s)-2-amino-3-hydroxypropanoic acid;(2s)-2-aminopropanoic acid Chemical compound C[C@H](N)C(O)=O.OC[C@H](N)C(O)=O KUHSEZKIEJYEHN-BXRBKJIMSA-N 0.000 description 1
• PSLCKQYQNVNTQI-BHFSHLQUSA-N (2s)-2-aminobutanedioic acid;(2s)-2-aminopentanedioic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O.OC(=O)[C@@H](N)CCC(O)=O PSLCKQYQNVNTQI-BHFSHLQUSA-N 0.000 description 1
• RMBMWXHVTXYPQN-UHFFFAOYSA-N 1-[3-[(1-hydroxy-2,5-dioxopyrrolidin-3-yl)methyl]phenyl]pyrrole-2,5-dione Chemical compound O=C1N(O)C(=O)CC1CC1=CC=CC(N2C(C=CC2=O)=O)=C1 RMBMWXHVTXYPQN-UHFFFAOYSA-N 0.000 description 1
• GZCWLCBFPRFLKL-UHFFFAOYSA-N 1-prop-2-ynoxypropan-2-ol Chemical compound CC(O)COCC#C GZCWLCBFPRFLKL-UHFFFAOYSA-N 0.000 description 1
• CTRPRMNBTVRDFH-UHFFFAOYSA-N 2-n-methyl-1,3,5-triazine-2,4,6-triamine Chemical class CNC1=NC(N)=NC(N)=N1 CTRPRMNBTVRDFH-UHFFFAOYSA-N 0.000 description 1
• OSJPPGNTCRNQQC-UWTATZPHSA-N 3-phospho-D-glyceric acid Chemical compound OC(=O)[C@H](O)COP(O)(O)=O OSJPPGNTCRNQQC-UWTATZPHSA-N 0.000 description 1
• 102100031126 6-phosphogluconolactonase Human genes 0.000 description 1
• 108010029731 6-phosphogluconolactonase Proteins 0.000 description 1
• ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
• 206010065040 AIDS dementia complex Diseases 0.000 description 1
• 108010051457 Acid Phosphatase Proteins 0.000 description 1
• 102000013563 Acid Phosphatase Human genes 0.000 description 1
• 206010000830 Acute leukaemia Diseases 0.000 description 1
• 206010067484 Adverse reaction Diseases 0.000 description 1
• 108010000239 Aequorin Proteins 0.000 description 1
• 201000010000 Agranulocytosis Diseases 0.000 description 1
• 102100027211 Albumin Human genes 0.000 description 1
• 108010088751 Albumins Proteins 0.000 description 1
• 102000007698 Alcohol dehydrogenase Human genes 0.000 description 1
• 108010021809 Alcohol dehydrogenase Proteins 0.000 description 1
• 208000007848 Alcoholism Diseases 0.000 description 1
• 108020004774 Alkaline Phosphatase Proteins 0.000 description 1
• 102000002260 Alkaline Phosphatase Human genes 0.000 description 1
• 108700028369 Alleles Proteins 0.000 description 1
• 241000710929 Alphavirus Species 0.000 description 1
• 108091093088 Amplicon Proteins 0.000 description 1
• 108010032595 Antibody Binding Sites Proteins 0.000 description 1
• 206010002961 Aplasia Diseases 0.000 description 1
• 101100238293 Arabidopsis thaliana MOR1 gene Proteins 0.000 description 1
• 206010003210 Arteriosclerosis Diseases 0.000 description 1
• 208000036487 Arthropathies Diseases 0.000 description 1
• 206010003445 Ascites Diseases 0.000 description 1
• HZYFHQOWCFUSOV-IMJSIDKUSA-N Asn-Asp Chemical compound NC(=O)C[C@H](N)C(=O)N[C@@H](CC(O)=O)C(O)=O HZYFHQOWCFUSOV-IMJSIDKUSA-N 0.000 description 1
• QJMCHPGWFZZRID-BQBZGAKWSA-N Asn-Lys Chemical compound NCCCC[C@@H](C(O)=O)NC(=O)[C@@H](N)CC(N)=O QJMCHPGWFZZRID-BQBZGAKWSA-N 0.000 description 1
• SONUFGRSSMFHFN-IMJSIDKUSA-N Asn-Ser Chemical compound NC(=O)C[C@H](N)C(=O)N[C@@H](CO)C(O)=O SONUFGRSSMFHFN-IMJSIDKUSA-N 0.000 description 1
• 108010024976 Asparaginase Proteins 0.000 description 1
• 102000015790 Asparaginase Human genes 0.000 description 1
• DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 description 1
• NOWKCMXCCJGMRR-UHFFFAOYSA-N Aziridine Chemical class C1CN1 NOWKCMXCCJGMRR-UHFFFAOYSA-N 0.000 description 1
• 244000063299 Bacillus subtilis Species 0.000 description 1
• 235000014469 Bacillus subtilis Nutrition 0.000 description 1
• 102100026189 Beta-galactosidase Human genes 0.000 description 1
• 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
• COVZYZSDYWQREU-UHFFFAOYSA-N Busulfan Chemical compound CS(=O)(=O)OCCCCOS(C)(=O)=O COVZYZSDYWQREU-UHFFFAOYSA-N 0.000 description 1
• 102100034673 C-C motif chemokine 3-like 1 Human genes 0.000 description 1
• 210000001266 CD8-positive T-lymphocyte Anatomy 0.000 description 1
• 206010006895 Cachexia Diseases 0.000 description 1
• 101100230428 Caenorhabditis elegans hil-5 gene Proteins 0.000 description 1
• 241000282472 Canis lupus familiaris Species 0.000 description 1
• 101710132601 Capsid protein Proteins 0.000 description 1
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
• 102100035882 Catalase Human genes 0.000 description 1
• 108010053835 Catalase Proteins 0.000 description 1
• 206010057248 Cell death Diseases 0.000 description 1
• 241001227713 Chiron Species 0.000 description 1
• 108010049048 Cholera Toxin Proteins 0.000 description 1
• 102000009016 Cholera Toxin Human genes 0.000 description 1
• 206010008748 Chorea Diseases 0.000 description 1
• 206010009193 Circulatory collapse and shock Diseases 0.000 description 1
• 108091062157 Cis-regulatory element Proteins 0.000 description 1
• 101710094648 Coat protein Proteins 0.000 description 1
• 102000008186 Collagen Human genes 0.000 description 1
• 108010035532 Collagen Proteins 0.000 description 1
• 102000000503 Collagen Type II Human genes 0.000 description 1
• 108010041390 Collagen Type II Proteins 0.000 description 1
• 208000035473 Communicable disease Diseases 0.000 description 1
• 102000000989 Complement System Proteins Human genes 0.000 description 1
• 108010069112 Complement System Proteins Proteins 0.000 description 1
• 208000020406 Creutzfeldt Jacob disease Diseases 0.000 description 1
• 208000003407 Creutzfeldt-Jakob Syndrome Diseases 0.000 description 1
• 208000010859 Creutzfeldt-Jakob disease Diseases 0.000 description 1
• 208000011231 Crohn disease Diseases 0.000 description 1
• IGXWBGJHJZYPQS-SSDOTTSWSA-N D-Luciferin Chemical compound OC(=O)[C@H]1CSC(C=2SC3=CC=C(O)C=C3N=2)=N1 IGXWBGJHJZYPQS-SSDOTTSWSA-N 0.000 description 1
• WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 1
• 239000003298 DNA probe Substances 0.000 description 1
• 102000004163 DNA-directed RNA polymerases Human genes 0.000 description 1
• 108090000626 DNA-directed RNA polymerases Proteins 0.000 description 1
• 206010011878 Deafness Diseases 0.000 description 1
• CYCGRDQQIOGCKX-UHFFFAOYSA-N Dehydro-luciferin Natural products OC(=O)C1=CSC(C=2SC3=CC(O)=CC=C3N=2)=N1 CYCGRDQQIOGCKX-UHFFFAOYSA-N 0.000 description 1
• 208000016192 Demyelinating disease Diseases 0.000 description 1
• 206010012434 Dermatitis allergic Diseases 0.000 description 1
• 206010012438 Dermatitis atopic Diseases 0.000 description 1
• 229920002307 Dextran Polymers 0.000 description 1
• BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 description 1
• 108010053187 Diphtheria Toxin Proteins 0.000 description 1
• 102000016607 Diphtheria Toxin Human genes 0.000 description 1
• 102000015554 Dopamine receptor Human genes 0.000 description 1
• 108050004812 Dopamine receptor Proteins 0.000 description 1
• 201000010374 Down Syndrome Diseases 0.000 description 1
• 101100456896 Drosophila melanogaster metl gene Proteins 0.000 description 1
• 108010042407 Endonucleases Proteins 0.000 description 1
• 241000283086 Equidae Species 0.000 description 1
• 241000701959 Escherichia virus Lambda Species 0.000 description 1
• 108090000371 Esterases Proteins 0.000 description 1
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
• 241000206602 Eukaryota Species 0.000 description 1
• 241000282326 Felis catus Species 0.000 description 1
• BJGNCJDXODQBOB-UHFFFAOYSA-N Fivefly Luciferin Natural products OC(=O)C1CSC(C=2SC3=CC(O)=CC=C3N=2)=N1 BJGNCJDXODQBOB-UHFFFAOYSA-N 0.000 description 1
• 241000710198 Foot-and-mouth disease virus Species 0.000 description 1
• 208000024412 Friedreich ataxia Diseases 0.000 description 1
• 206010017533 Fungal infection Diseases 0.000 description 1
• 229910052688 Gadolinium Inorganic materials 0.000 description 1
• CLSDNFWKGFJIBZ-YUMQZZPRSA-N Gln-Lys Chemical compound NCCCC[C@@H](C(O)=O)NC(=O)[C@@H](N)CCC(N)=O CLSDNFWKGFJIBZ-YUMQZZPRSA-N 0.000 description 1
• KOSRFJWDECSPRO-WDSKDSINSA-N Glu-Glu Chemical compound OC(=O)CC[C@H](N)C(=O)N[C@@H](CCC(O)=O)C(O)=O KOSRFJWDECSPRO-WDSKDSINSA-N 0.000 description 1
• 108010073178 Glucan 1,4-alpha-Glucosidase Proteins 0.000 description 1
• 102100022624 Glucoamylase Human genes 0.000 description 1
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
• 108010018962 Glucosephosphate Dehydrogenase Proteins 0.000 description 1
• PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 1
• 239000004471 Glycine Substances 0.000 description 1
• 102000003886 Glycoproteins Human genes 0.000 description 1
• 108090000288 Glycoproteins Proteins 0.000 description 1
• 102100021181 Golgi phosphoprotein 3 Human genes 0.000 description 1
• 102000002812 Heat-Shock Proteins Human genes 0.000 description 1
• 108010004889 Heat-Shock Proteins Proteins 0.000 description 1
• 241001272567 Hominoidea Species 0.000 description 1
• 101000777387 Homo sapiens C-C motif chemokine 3 Proteins 0.000 description 1
• 101000946370 Homo sapiens C-C motif chemokine 3-like 1 Proteins 0.000 description 1
• 101100220044 Homo sapiens CD34 gene Proteins 0.000 description 1
• 208000023105 Huntington disease Diseases 0.000 description 1
• 208000000269 Hyperkinesis Diseases 0.000 description 1
• 206010020880 Hypertrophy Diseases 0.000 description 1
• 102000018071 Immunoglobulin Fc Fragments Human genes 0.000 description 1
• 108010091135 Immunoglobulin Fc Fragments Proteins 0.000 description 1
• 108010021625 Immunoglobulin Fragments Proteins 0.000 description 1
• 102000008394 Immunoglobulin Fragments Human genes 0.000 description 1
• 208000012659 Joint disease Diseases 0.000 description 1
• 208000006264 Korsakoff syndrome Diseases 0.000 description 1
• FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
• QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 1
• ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
• 108060001084 Luciferase Proteins 0.000 description 1
• 239000005089 Luciferase Substances 0.000 description 1
• DDWFXDSYGUXRAY-UHFFFAOYSA-N Luciferin Natural products CCc1c(C)c(CC2NC(=O)C(=C2C=C)C)[nH]c1Cc3[nH]c4C(=C5/NC(CC(=O)O)C(C)C5CC(=O)O)CC(=O)c4c3C DDWFXDSYGUXRAY-UHFFFAOYSA-N 0.000 description 1
• 208000019693 Lung disease Diseases 0.000 description 1
• 101710125418 Major capsid protein Proteins 0.000 description 1
• 102000013460 Malate Dehydrogenase Human genes 0.000 description 1
• 108010026217 Malate Dehydrogenase Proteins 0.000 description 1
• 102000003792 Metallothionein Human genes 0.000 description 1
• 108090000157 Metallothionein Proteins 0.000 description 1
• 108010059724 Micrococcal Nuclease Proteins 0.000 description 1
• 101000969137 Mus musculus Metallothionein-1 Proteins 0.000 description 1
• 108010021466 Mutant Proteins Proteins 0.000 description 1
• 102000008300 Mutant Proteins Human genes 0.000 description 1
• 241000186359 Mycobacterium Species 0.000 description 1
• 208000031888 Mycoses Diseases 0.000 description 1
• KZNQNBZMBZJQJO-UHFFFAOYSA-N N-glycyl-L-proline Natural products NCC(=O)N1CCCC1C(O)=O KZNQNBZMBZJQJO-UHFFFAOYSA-N 0.000 description 1
• 108010002311 N-glycylglutamic acid Proteins 0.000 description 1
• 238000005481 NMR spectroscopy Methods 0.000 description 1
• 229930193140 Neomycin Natural products 0.000 description 1
• 239000000020 Nitrocellulose Substances 0.000 description 1
• 101710141454 Nucleoprotein Proteins 0.000 description 1
• 239000004677 Nylon Substances 0.000 description 1
• 206010030113 Oedema Diseases 0.000 description 1
• 238000012408 PCR amplification Methods 0.000 description 1
• 229930012538 Paclitaxel Natural products 0.000 description 1
• 108020002230 Pancreatic Ribonuclease Proteins 0.000 description 1
• 102000005891 Pancreatic ribonuclease Human genes 0.000 description 1
• 241001111421 Pannus Species 0.000 description 1
• 108090000526 Papain Proteins 0.000 description 1
• 206010033799 Paralysis Diseases 0.000 description 1
• 208000018737 Parkinson disease Diseases 0.000 description 1
• 229930182555 Penicillin Natural products 0.000 description 1
• JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
• 102000057297 Pepsin A Human genes 0.000 description 1
• 108090000284 Pepsin A Proteins 0.000 description 1
• 108010033276 Peptide Fragments Proteins 0.000 description 1
• 102000007079 Peptide Fragments Human genes 0.000 description 1
• OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
• 108010053210 Phycocyanin Proteins 0.000 description 1
• 108010004729 Phycoerythrin Proteins 0.000 description 1
• 241000276498 Pollachius virens Species 0.000 description 1
• 239000002202 Polyethylene glycol Substances 0.000 description 1
• 101710083689 Probable capsid protein Proteins 0.000 description 1
• 239000004365 Protease Substances 0.000 description 1
• 229940096437 Protein S Drugs 0.000 description 1
• 108010066124 Protein S Proteins 0.000 description 1
• 102000029301 Protein S Human genes 0.000 description 1
• 208000032225 Proximal spinal muscular atrophy type 1 Diseases 0.000 description 1
• 208000033526 Proximal spinal muscular atrophy type 3 Diseases 0.000 description 1
• 241000589516 Pseudomonas Species 0.000 description 1
• 241000667869 Psix Species 0.000 description 1
• 201000004681 Psoriasis Diseases 0.000 description 1
• 108020005067 RNA Splice Sites Proteins 0.000 description 1
• 108010092799 RNA-directed DNA polymerase Proteins 0.000 description 1
• 206010037742 Rabies Diseases 0.000 description 1
• 102000007056 Recombinant Fusion Proteins Human genes 0.000 description 1
• 108010008281 Recombinant Fusion Proteins Proteins 0.000 description 1
• 208000005587 Refsum Disease Diseases 0.000 description 1
• 108010034634 Repressor Proteins Proteins 0.000 description 1
• 102000009661 Repressor Proteins Human genes 0.000 description 1
• 206010039085 Rhinitis allergic Diseases 0.000 description 1
• 108010039491 Ricin Proteins 0.000 description 1
• BFDMCHRDSYTOLE-UHFFFAOYSA-N SC#N.NC(N)=N.ClC(Cl)Cl.OC1=CC=CC=C1 Chemical compound SC#N.NC(N)=N.ClC(Cl)Cl.OC1=CC=CC=C1 BFDMCHRDSYTOLE-UHFFFAOYSA-N 0.000 description 1
• 206010039491 Sarcoma Diseases 0.000 description 1
• 206010039966 Senile dementia Diseases 0.000 description 1
• 206010053879 Sepsis syndrome Diseases 0.000 description 1
• 241000700584 Simplexvirus Species 0.000 description 1
• 108020004682 Single-Stranded DNA Proteins 0.000 description 1
• VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
• 238000002105 Southern blotting Methods 0.000 description 1
• 208000010112 Spinocerebellar Degenerations Diseases 0.000 description 1
• 241000256248 Spodoptera Species 0.000 description 1
• 241000191940 Staphylococcus Species 0.000 description 1
• 208000037065 Subacute sclerosing leukoencephalitis Diseases 0.000 description 1
• 206010042297 Subacute sclerosing panencephalitis Diseases 0.000 description 1
• 241000701093 Suid alphaherpesvirus 1 Species 0.000 description 1
• 241000282887 Suidae Species 0.000 description 1
• NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
• 239000005864 Sulphur Substances 0.000 description 1
• 206010042674 Swelling Diseases 0.000 description 1
• 206010051379 Systemic Inflammatory Response Syndrome Diseases 0.000 description 1
• 230000006044 T cell activation Effects 0.000 description 1
• 101150076211 TH gene Proteins 0.000 description 1
• 108700012920 TNF Proteins 0.000 description 1
• 101150006914 TRP1 gene Proteins 0.000 description 1
• 206010043189 Telangiectasia Diseases 0.000 description 1
• 108020005038 Terminator Codon Proteins 0.000 description 1
• 239000004098 Tetracycline Substances 0.000 description 1
• IOWJRKAVLALBQB-IWGUZYHVSA-N Thr-Asp Chemical compound C[C@@H](O)[C@H](N)C(=O)N[C@H](C(O)=O)CC(O)=O IOWJRKAVLALBQB-IWGUZYHVSA-N 0.000 description 1
• YKRQRPFODDJQTC-CSMHCCOUSA-N Thr-Lys Chemical compound C[C@@H](O)[C@H](N)C(=O)N[C@H](C(O)=O)CCCCN YKRQRPFODDJQTC-CSMHCCOUSA-N 0.000 description 1
• AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 1
• 239000004473 Threonine Substances 0.000 description 1
• 108010022394 Threonine synthase Proteins 0.000 description 1
• 102000006601 Thymidine Kinase Human genes 0.000 description 1
• 108020004440 Thymidine kinase Proteins 0.000 description 1
• 206010044688 Trisomy 21 Diseases 0.000 description 1
• YZCKVEUIGOORGS-NJFSPNSNSA-N Tritium Chemical compound [3H] YZCKVEUIGOORGS-NJFSPNSNSA-N 0.000 description 1
• QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 1
• 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 description 1
• 229910052770 Uranium Inorganic materials 0.000 description 1
• 108010046334 Urease Proteins 0.000 description 1
• 206010052568 Urticaria chronic Diseases 0.000 description 1
• 241000700618 Vaccinia virus Species 0.000 description 1
• 206010046865 Vaccinia virus infection Diseases 0.000 description 1
• KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Chemical compound CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 1
• 229940122803 Vinca alkaloid Drugs 0.000 description 1
• 201000008485 Wernicke-Korsakoff syndrome Diseases 0.000 description 1
• 230000002159 abnormal effect Effects 0.000 description 1
• 238000009825 accumulation Methods 0.000 description 1
• OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical compound CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 description 1
• 229960004373 acetylcholine Drugs 0.000 description 1
• DZBUGLKDJFMEHC-UHFFFAOYSA-N acridine Chemical class C1=CC=CC2=CC3=CC=CC=C3N=C21 DZBUGLKDJFMEHC-UHFFFAOYSA-N 0.000 description 1
• 239000000654 additive Substances 0.000 description 1
• 230000000996 additive effect Effects 0.000 description 1
• 238000005377 adsorption chromatography Methods 0.000 description 1
• 208000030597 adult Refsum disease Diseases 0.000 description 1
• 230000002411 adverse Effects 0.000 description 1
• 230000006838 adverse reaction Effects 0.000 description 1
• 239000011543 agarose gel Substances 0.000 description 1
• 238000000246 agarose gel electrophoresis Methods 0.000 description 1
• 108010005233 alanylglutamic acid Proteins 0.000 description 1
• 229940045714 alkyl sulfonate alkylating agent Drugs 0.000 description 1
• 150000008052 alkyl sulfonates Chemical class 0.000 description 1
• 201000009961 allergic asthma Diseases 0.000 description 1
• 201000010105 allergic rhinitis Diseases 0.000 description 1
• 108010004469 allophycocyanin Proteins 0.000 description 1
• KOSRFJWDECSPRO-UHFFFAOYSA-N alpha-L-glutamyl-L-glutamic acid Natural products OC(=O)CCC(N)C(=O)NC(CCC(O)=O)C(O)=O KOSRFJWDECSPRO-UHFFFAOYSA-N 0.000 description 1
• 210000001132 alveolar macrophage Anatomy 0.000 description 1
• 150000001408 amides Chemical group 0.000 description 1
• 206010002026 amyotrophic lateral sclerosis Diseases 0.000 description 1
• 238000010171 animal model Methods 0.000 description 1
• 238000005571 anion exchange chromatography Methods 0.000 description 1
• 238000000137 annealing Methods 0.000 description 1
• 210000002226 anterior horn cell Anatomy 0.000 description 1
• RGHILYZRVFRRNK-UHFFFAOYSA-N anthracene-1,2-dione Chemical compound C1=CC=C2C=C(C(C(=O)C=C3)=O)C3=CC2=C1 RGHILYZRVFRRNK-UHFFFAOYSA-N 0.000 description 1
• 239000003242 anti bacterial agent Substances 0.000 description 1
• 229940121363 anti-inflammatory agent Drugs 0.000 description 1
• 239000002260 anti-inflammatory agent Substances 0.000 description 1
• 230000000340 anti-metabolite Effects 0.000 description 1
• 230000001028 anti-proliverative effect Effects 0.000 description 1
• 230000000259 anti-tumor effect Effects 0.000 description 1
• 229940088710 antibiotic agent Drugs 0.000 description 1
• 230000009830 antibody antigen interaction Effects 0.000 description 1
• 229940100197 antimetabolite Drugs 0.000 description 1
• 239000002256 antimetabolite Substances 0.000 description 1
• 229940045687 antimetabolites folic acid analogs Drugs 0.000 description 1
• 239000002787 antisense oligonuctleotide Substances 0.000 description 1
• 239000003443 antiviral agent Substances 0.000 description 1
• 239000003125 aqueous solvent Substances 0.000 description 1
• 108010062796 arginyllysine Proteins 0.000 description 1
• 208000011775 arteriosclerosis disease Diseases 0.000 description 1
• 210000001367 artery Anatomy 0.000 description 1
• 229960003272 asparaginase Drugs 0.000 description 1
• DCXYFEDJOCDNAF-UHFFFAOYSA-M asparaginate Chemical compound [O-]C(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-M 0.000 description 1
• 235000009582 asparagine Nutrition 0.000 description 1
• 229960001230 asparagine Drugs 0.000 description 1
• 201000008937 atopic dermatitis Diseases 0.000 description 1
• 230000003305 autocrine Effects 0.000 description 1
• 238000011888 autopsy Methods 0.000 description 1
• 210000003578 bacterial chromosome Anatomy 0.000 description 1
• 210000004227 basal ganglia Anatomy 0.000 description 1
• 210000002469 basement membrane Anatomy 0.000 description 1
• 230000008721 basement membrane thickening Effects 0.000 description 1
• 230000008901 benefit Effects 0.000 description 1
• 108010005774 beta-Galactosidase Proteins 0.000 description 1
• DRTQHJPVMGBUCF-PSQAKQOGSA-N beta-L-uridine Natural products O[C@H]1[C@@H](O)[C@H](CO)O[C@@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-PSQAKQOGSA-N 0.000 description 1
• 229960002685 biotin Drugs 0.000 description 1
• 235000020958 biotin Nutrition 0.000 description 1
• 239000011616 biotin Substances 0.000 description 1
• 210000000601 blood cell Anatomy 0.000 description 1
• 210000000481 breast Anatomy 0.000 description 1
• 229960002092 busulfan Drugs 0.000 description 1
• 150000001720 carbohydrates Chemical class 0.000 description 1
• 235000014633 carbohydrates Nutrition 0.000 description 1
• 238000005277 cation exchange chromatography Methods 0.000 description 1
• 125000002091 cationic group Chemical group 0.000 description 1
• 230000005779 cell damage Effects 0.000 description 1
• 230000010261 cell growth Effects 0.000 description 1
• 208000037887 cell injury Diseases 0.000 description 1
• 210000000170 cell membrane Anatomy 0.000 description 1
• 108091092328 cellular RNA Proteins 0.000 description 1
• 210000003169 central nervous system Anatomy 0.000 description 1
• 238000005119 centrifugation Methods 0.000 description 1
• 210000001638 cerebellum Anatomy 0.000 description 1
• 230000002490 cerebral effect Effects 0.000 description 1
• 210000001175 cerebrospinal fluid Anatomy 0.000 description 1
• 239000002559 chemokine receptor antagonist Substances 0.000 description 1
• 230000001767 chemoprotection Effects 0.000 description 1
• 229940124444 chemoprotective agent Drugs 0.000 description 1
• 229960004630 chlorambucil Drugs 0.000 description 1
• JCKYGMPEJWAADB-UHFFFAOYSA-N chlorambucil Chemical compound OC(=O)CCCC1=CC=C(N(CCCl)CCCl)C=C1 JCKYGMPEJWAADB-UHFFFAOYSA-N 0.000 description 1
• 229910052804 chromium Inorganic materials 0.000 description 1
• 208000037893 chronic inflammatory disorder Diseases 0.000 description 1
• 230000007665 chronic toxicity Effects 0.000 description 1
• 231100000160 chronic toxicity Toxicity 0.000 description 1
• 208000024376 chronic urticaria Diseases 0.000 description 1
• 229920001436 collagen Polymers 0.000 description 1
• 238000010293 colony formation assay Methods 0.000 description 1
• 230000009137 competitive binding Effects 0.000 description 1
• 102000006834 complement receptors Human genes 0.000 description 1
• 108010047295 complement receptors Proteins 0.000 description 1
• 239000000356 contaminant Substances 0.000 description 1
• 230000001054 cortical effect Effects 0.000 description 1
• 230000002594 corticospinal effect Effects 0.000 description 1
• 230000004940 costimulation Effects 0.000 description 1
• 230000000139 costimulatory effect Effects 0.000 description 1
• 230000008878 coupling Effects 0.000 description 1
• 238000005859 coupling reaction Methods 0.000 description 1
• 239000011243 crosslinked material Substances 0.000 description 1
• 239000000287 crude extract Substances 0.000 description 1
• 230000001186 cumulative effect Effects 0.000 description 1
• 230000001351 cycling effect Effects 0.000 description 1
• XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
• 230000016396 cytokine production Effects 0.000 description 1
• 210000001151 cytotoxic T lymphocyte Anatomy 0.000 description 1
• 231100000599 cytotoxic agent Toxicity 0.000 description 1
• 239000002619 cytotoxin Substances 0.000 description 1
• 230000034994 death Effects 0.000 description 1
• 231100000517 death Toxicity 0.000 description 1
• 230000002950 deficient Effects 0.000 description 1
• 230000003412 degenerative effect Effects 0.000 description 1
• 238000005695 dehalogenation reaction Methods 0.000 description 1
• 230000003210 demyelinating effect Effects 0.000 description 1
• 239000003599 detergent Substances 0.000 description 1
• 238000011161 development Methods 0.000 description 1
• 230000018109 developmental process Effects 0.000 description 1
• 229960002086 dextran Drugs 0.000 description 1
• 229960000633 dextran sulfate Drugs 0.000 description 1
• 238000010586 diagram Methods 0.000 description 1
• 230000029087 digestion Effects 0.000 description 1
• 102000004419 dihydrofolate reductase Human genes 0.000 description 1
• 230000010339 dilation Effects 0.000 description 1
• 238000010790 dilution Methods 0.000 description 1
• 239000012895 dilution Substances 0.000 description 1
• 231100000676 disease causative agent Toxicity 0.000 description 1
• 208000009190 disseminated intravascular coagulation Diseases 0.000 description 1
• 230000003828 downregulation Effects 0.000 description 1
• 238000007876 drug discovery Methods 0.000 description 1
• 238000001035 drying Methods 0.000 description 1
• 238000010828 elution Methods 0.000 description 1
• 239000000839 emulsion Substances 0.000 description 1
• 210000003038 endothelium Anatomy 0.000 description 1
• 230000007613 environmental effect Effects 0.000 description 1
• 230000003628 erosive effect Effects 0.000 description 1
• 229960003276 erythromycin Drugs 0.000 description 1
• 230000029142 excretion Effects 0.000 description 1
• 238000013401 experimental design Methods 0.000 description 1
• 238000001400 expression cloning Methods 0.000 description 1
• 239000000284 extract Substances 0.000 description 1
• 230000002349 favourable effect Effects 0.000 description 1
• 210000003608 fece Anatomy 0.000 description 1
• 230000012953 feeding on blood of other organism Effects 0.000 description 1
• 238000000855 fermentation Methods 0.000 description 1
• 230000004151 fermentation Effects 0.000 description 1
• 239000012091 fetal bovine serum Substances 0.000 description 1
• 239000012847 fine chemical Substances 0.000 description 1
• 235000019688 fish Nutrition 0.000 description 1
• ZFKJVJIDPQDDFY-UHFFFAOYSA-N fluorescamine Chemical compound C12=CC=CC=C2C(=O)OC1(C1=O)OC=C1C1=CC=CC=C1 ZFKJVJIDPQDDFY-UHFFFAOYSA-N 0.000 description 1
• 238000001943 fluorescence-activated cell sorting Methods 0.000 description 1
• 150000002224 folic acids Chemical class 0.000 description 1
• 230000005714 functional activity Effects 0.000 description 1
• 239000007789 gas Substances 0.000 description 1
• 238000002523 gelfiltration Methods 0.000 description 1
• 101150056310 gem1 gene Proteins 0.000 description 1
• 238000010353 genetic engineering Methods 0.000 description 1
• 230000000762 glandular Effects 0.000 description 1
• 239000011521 glass Substances 0.000 description 1
• 239000008103 glucose Substances 0.000 description 1
• ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
• 108010055341 glutamyl-glutamic acid Proteins 0.000 description 1
• 108020004445 glyceraldehyde-3-phosphate dehydrogenase Proteins 0.000 description 1
• 102000006602 glyceraldehyde-3-phosphate dehydrogenase Human genes 0.000 description 1
• 230000002414 glycolytic effect Effects 0.000 description 1
• 108010077515 glycylproline Proteins 0.000 description 1
• 229940015043 glyoxal Drugs 0.000 description 1
• 239000011544 gradient gel Substances 0.000 description 1
• 244000144993 groups of animals Species 0.000 description 1
• 239000001963 growth medium Substances 0.000 description 1
• 210000002216 heart Anatomy 0.000 description 1
• 229910001385 heavy metal Inorganic materials 0.000 description 1
• 230000002607 hemopoietic effect Effects 0.000 description 1
• 208000006454 hepatitis Diseases 0.000 description 1
• 231100000283 hepatitis Toxicity 0.000 description 1
• 238000012188 high-throughput screening assay Methods 0.000 description 1
• 210000003630 histaminocyte Anatomy 0.000 description 1
• HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
• 238000007489 histopathology method Methods 0.000 description 1
• 102000044532 human CCL23 Human genes 0.000 description 1
• 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
• 230000003463 hyperproliferative effect Effects 0.000 description 1
• 230000003483 hypokinetic effect Effects 0.000 description 1
• 230000036039 immunity Effects 0.000 description 1
• 238000003018 immunoassay Methods 0.000 description 1
• 239000000367 immunologic factor Substances 0.000 description 1
• 238000001114 immunoprecipitation Methods 0.000 description 1
• 230000004957 immunoregulator effect Effects 0.000 description 1
• 238000011503 in vivo imaging Methods 0.000 description 1
• 238000010249 in-situ analysis Methods 0.000 description 1
• 238000011065 in-situ storage Methods 0.000 description 1
• 229910052738 indium Inorganic materials 0.000 description 1
• APFVFJFRJDLVQX-UHFFFAOYSA-N indium atom Chemical compound [In] APFVFJFRJDLVQX-UHFFFAOYSA-N 0.000 description 1
• PNDZEEPOYCVIIY-UHFFFAOYSA-N indo-1 Chemical compound CC1=CC=C(N(CC(O)=O)CC(O)=O)C(OCCOC=2C(=CC=C(C=2)C=2N=C3[CH]C(=CC=C3C=2)C(O)=O)N(CC(O)=O)CC(O)=O)=C1 PNDZEEPOYCVIIY-UHFFFAOYSA-N 0.000 description 1
• 239000000411 inducer Substances 0.000 description 1
• 230000002458 infectious effect Effects 0.000 description 1
• 208000027866 inflammatory disease Diseases 0.000 description 1
• 230000004941 influx Effects 0.000 description 1
• 239000004615 ingredient Substances 0.000 description 1
• 239000000543 intermediate Substances 0.000 description 1
• 230000016507 interphase Effects 0.000 description 1
• 230000037041 intracellular level Effects 0.000 description 1
• 238000001990 intravenous administration Methods 0.000 description 1
• 230000009545 invasion Effects 0.000 description 1
• 230000026045 iodination Effects 0.000 description 1
• 238000006192 iodination reaction Methods 0.000 description 1
• 239000011630 iodine Substances 0.000 description 1
• 229910052742 iron Inorganic materials 0.000 description 1
• 238000002955 isolation Methods 0.000 description 1
• 229960000310 isoleucine Drugs 0.000 description 1
• AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 1
• 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
• 150000002540 isothiocyanates Chemical class 0.000 description 1
• 230000000155 isotopic effect Effects 0.000 description 1
• 210000001503 joint Anatomy 0.000 description 1
• 201000004815 juvenile spinal muscular atrophy Diseases 0.000 description 1
• 210000002510 keratinocyte Anatomy 0.000 description 1
• 238000011813 knockout mouse model Methods 0.000 description 1
• 108010034529 leucyl-lysine Proteins 0.000 description 1
• 206010024378 leukocytosis Diseases 0.000 description 1
• 150000002617 leukotrienes Chemical class 0.000 description 1
• 238000011694 lewis rat Methods 0.000 description 1
• 210000004558 lewy body Anatomy 0.000 description 1
• 238000007834 ligase chain reaction Methods 0.000 description 1
• 230000000670 limiting effect Effects 0.000 description 1
• 238000012417 linear regression Methods 0.000 description 1
• 150000002632 lipids Chemical class 0.000 description 1
• 239000007788 liquid Substances 0.000 description 1
• 239000010871 livestock manure Substances 0.000 description 1
• 210000003141 lower extremity Anatomy 0.000 description 1
• 230000002934 lysing effect Effects 0.000 description 1
• 230000002132 lysosomal effect Effects 0.000 description 1
• 238000012423 maintenance Methods 0.000 description 1
• 230000003211 malignant effect Effects 0.000 description 1
• 229910052748 manganese Inorganic materials 0.000 description 1
• 238000005259 measurement Methods 0.000 description 1
• 210000003593 megakaryocyte Anatomy 0.000 description 1
• 230000031864 metaphase Effects 0.000 description 1
• 108091047102 miR-4 stem-loop Proteins 0.000 description 1
• 108091049748 miR-4-1 stem-loop Proteins 0.000 description 1
• 108091058497 miR-4-2 stem-loop Proteins 0.000 description 1
• 230000000813 microbial effect Effects 0.000 description 1
• 244000005700 microbiome Species 0.000 description 1
• 230000003278 mimic effect Effects 0.000 description 1
• 210000003470 mitochondria Anatomy 0.000 description 1
• 239000002808 molecular sieve Substances 0.000 description 1
• 238000010172 mouse model Methods 0.000 description 1
• 210000002894 multi-fate stem cell Anatomy 0.000 description 1
• 210000003205 muscle Anatomy 0.000 description 1
• 201000000585 muscular atrophy Diseases 0.000 description 1
• 238000002703 mutagenesis Methods 0.000 description 1
• 231100000350 mutagenesis Toxicity 0.000 description 1
• 229930014626 natural product Natural products 0.000 description 1
• 229960004927 neomycin Drugs 0.000 description 1
• 201000009925 nephrosclerosis Diseases 0.000 description 1
• 230000003472 neutralizing effect Effects 0.000 description 1
• 229920001220 nitrocellulos Polymers 0.000 description 1
• 229910052757 nitrogen Inorganic materials 0.000 description 1
• 210000004940 nucleus Anatomy 0.000 description 1
• 229920001778 nylon Polymers 0.000 description 1
• 238000011275 oncology therapy Methods 0.000 description 1
• 230000002611 ovarian Effects 0.000 description 1
• 238000004806 packaging method and process Methods 0.000 description 1
• 229960001592 paclitaxel Drugs 0.000 description 1
• 208000021090 palsy Diseases 0.000 description 1
• 210000000496 pancreas Anatomy 0.000 description 1
• 238000004091 panning Methods 0.000 description 1
• 229940055729 papain Drugs 0.000 description 1
• 235000019834 papain Nutrition 0.000 description 1
• 230000003071 parasitic effect Effects 0.000 description 1
• 238000007911 parenteral administration Methods 0.000 description 1
• 230000036961 partial effect Effects 0.000 description 1
• 239000002245 particle Substances 0.000 description 1
• 230000008506 pathogenesis Effects 0.000 description 1
• 230000007310 pathophysiology Effects 0.000 description 1
• 239000013610 patient sample Substances 0.000 description 1
• 229940049954 penicillin Drugs 0.000 description 1
• 229940111202 pepsin Drugs 0.000 description 1
• 125000001151 peptidyl group Chemical group 0.000 description 1
• KHIWWQKSHDUIBK-UHFFFAOYSA-N periodic acid Chemical compound OI(=O)(=O)=O KHIWWQKSHDUIBK-UHFFFAOYSA-N 0.000 description 1
• 210000005259 peripheral blood Anatomy 0.000 description 1
• 239000011886 peripheral blood Substances 0.000 description 1
• 210000003200 peritoneal cavity Anatomy 0.000 description 1
• 230000002688 persistence Effects 0.000 description 1
• 238000002205 phenol-chloroform extraction Methods 0.000 description 1
• RXNXLAHQOVLMIE-UHFFFAOYSA-N phenyl 10-methylacridin-10-ium-9-carboxylate Chemical compound C12=CC=CC=C2[N+](C)=C2C=CC=CC2=C1C(=O)OC1=CC=CC=C1 RXNXLAHQOVLMIE-UHFFFAOYSA-N 0.000 description 1
• COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
• 229910052698 phosphorus Inorganic materials 0.000 description 1
• 239000011574 phosphorus Substances 0.000 description 1
• ZWLUXSQADUDCSB-UHFFFAOYSA-N phthalaldehyde Chemical compound O=CC1=CC=CC=C1C=O ZWLUXSQADUDCSB-UHFFFAOYSA-N 0.000 description 1
• 210000002826 placenta Anatomy 0.000 description 1
• 238000007747 plating Methods 0.000 description 1
• 229910052697 platinum Inorganic materials 0.000 description 1
• 238000002264 polyacrylamide gel electrophoresis Methods 0.000 description 1
• 229920001223 polyethylene glycol Polymers 0.000 description 1
• 238000011176 pooling Methods 0.000 description 1
• 230000001323 posttranslational effect Effects 0.000 description 1
• 238000011533 pre-incubation Methods 0.000 description 1
• 239000002244 precipitate Substances 0.000 description 1
• 238000002203 pretreatment Methods 0.000 description 1
• 238000004393 prognosis Methods 0.000 description 1
• 230000000750 progressive effect Effects 0.000 description 1
• 230000002035 prolonged effect Effects 0.000 description 1
• 210000002307 prostate Anatomy 0.000 description 1
• 102000021127 protein binding proteins Human genes 0.000 description 1
• 230000030788 protein refolding Effects 0.000 description 1
• 230000006337 proteolytic cleavage Effects 0.000 description 1
• 208000009305 pseudorabies Diseases 0.000 description 1
• 150000003212 purines Chemical class 0.000 description 1
• 150000003230 pyrimidines Chemical class 0.000 description 1
• 238000012205 qualitative assay Methods 0.000 description 1
• 238000012207 quantitative assay Methods 0.000 description 1
• 238000003259 recombinant expression Methods 0.000 description 1
• 230000007115 recruitment Effects 0.000 description 1
• 230000009467 reduction Effects 0.000 description 1
• 230000014493 regulation of gene expression Effects 0.000 description 1
• 230000003252 repetitive effect Effects 0.000 description 1
• 229920005989 resin Polymers 0.000 description 1
• 239000011347 resin Substances 0.000 description 1
• 230000019254 respiratory burst Effects 0.000 description 1
• 230000000717 retained effect Effects 0.000 description 1
• 210000003660 reticulum Anatomy 0.000 description 1
• 239000003161 ribonuclease inhibitor Substances 0.000 description 1
• 210000003705 ribosome Anatomy 0.000 description 1
• 210000003296 saliva Anatomy 0.000 description 1
• 230000037390 scarring Effects 0.000 description 1
• 238000009094 second-line therapy Methods 0.000 description 1
• 230000036303 septic shock Effects 0.000 description 1
• 238000002864 sequence alignment Methods 0.000 description 1
• 230000009919 sequestration Effects 0.000 description 1
• 230000011664 signaling Effects 0.000 description 1
• 210000003491 skin Anatomy 0.000 description 1
• 150000003384 small molecules Chemical class 0.000 description 1
• 239000001632 sodium acetate Substances 0.000 description 1
• 235000017281 sodium acetate Nutrition 0.000 description 1
• URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 1
• 239000001509 sodium citrate Substances 0.000 description 1
• 239000001488 sodium phosphate Substances 0.000 description 1
• 229910000162 sodium phosphate Inorganic materials 0.000 description 1
• 239000007790 solid phase Substances 0.000 description 1
• 238000001179 sorption measurement Methods 0.000 description 1
• 210000000952 spleen Anatomy 0.000 description 1
• 210000004989 spleen cell Anatomy 0.000 description 1
• 239000007858 starting material Substances 0.000 description 1
• 230000000638 stimulation Effects 0.000 description 1
• 229960005322 streptomycin Drugs 0.000 description 1
• 238000012916 structural analysis Methods 0.000 description 1
• 125000001424 substituent group Chemical group 0.000 description 1
• 230000008961 swelling Effects 0.000 description 1
• 238000010189 synthetic method Methods 0.000 description 1
• RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 1
• 229910052713 technetium Inorganic materials 0.000 description 1
• GKLVYJBZJHMRIY-UHFFFAOYSA-N technetium atom Chemical compound [Tc] GKLVYJBZJHMRIY-UHFFFAOYSA-N 0.000 description 1
• 208000009056 telangiectasis Diseases 0.000 description 1
• 229960000814 tetanus toxoid Drugs 0.000 description 1
• 229960002180 tetracycline Drugs 0.000 description 1
• 229930101283 tetracycline Natural products 0.000 description 1
• 235000019364 tetracycline Nutrition 0.000 description 1
• 150000003522 tetracyclines Chemical class 0.000 description 1
• 239000003104 tissue culture media Substances 0.000 description 1
• 239000003053 toxin Substances 0.000 description 1
• 231100000765 toxin Toxicity 0.000 description 1
• 108700012359 toxins Proteins 0.000 description 1
• 230000005026 transcription initiation Effects 0.000 description 1
• 230000005030 transcription termination Effects 0.000 description 1
• 230000005945 translocation Effects 0.000 description 1
• 150000004654 triazenes Chemical class 0.000 description 1
• HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 1
• 229940038773 trisodium citrate Drugs 0.000 description 1
• RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
• 229910052722 tritium Inorganic materials 0.000 description 1
• 102000003298 tumor necrosis factor receptor Human genes 0.000 description 1
• 230000002476 tumorcidal effect Effects 0.000 description 1
• OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
• 241000712461 unidentified influenza virus Species 0.000 description 1
• 241001515965 unidentified phage Species 0.000 description 1
• DRTQHJPVMGBUCF-UHFFFAOYSA-N uracil arabinoside Natural products OC1C(O)C(CO)OC1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-UHFFFAOYSA-N 0.000 description 1
• 150000003672 ureas Chemical class 0.000 description 1
• 229940045145 uridine Drugs 0.000 description 1
• 208000007089 vaccinia Diseases 0.000 description 1
• 230000002792 vascular Effects 0.000 description 1
• 230000009385 viral infection Effects 0.000 description 1
• 239000013603 viral vector Substances 0.000 description 1
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1