EP0871672A4 - Human chemokine beta-8, chemokine beta-1 and macrophage inflammatory protein-4 - Google Patents

Human chemokine beta-8, chemokine beta-1 and macrophage inflammatory protein-4

Info

Publication number
EP0871672A4
EP0871672A4 EP95927260A EP95927260A EP0871672A4 EP 0871672 A4 EP0871672 A4 EP 0871672A4 EP 95927260 A EP95927260 A EP 95927260A EP 95927260 A EP95927260 A EP 95927260A EP 0871672 A4 EP0871672 A4 EP 0871672A4
Authority
EP
European Patent Office
Prior art keywords
chemokine beta
inflammatory protein
macrophage inflammatory
beta
human
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP95927260A
Other languages
German (de)
French (fr)
Other versions
EP0871672A1 (en
Inventor
Craig A Rosen
Steven M Ruben
Haodong Li
Mark D Adams
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Human Genome Sciences Inc
Original Assignee
Human Genome Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Human Genome Sciences Inc filed Critical Human Genome Sciences Inc
Publication of EP0871672A1 publication Critical patent/EP0871672A1/en
Publication of EP0871672A4 publication Critical patent/EP0871672A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/521—Chemokines
    • C07K14/523—Beta-chemokines, e.g. RANTES, I-309/TCA-3, MIP-1alpha, MIP-1beta/ACT-2/LD78/SCIF, MCP-1/MCAF, MCP-2, MCP-3, LDCF-1, LDCF-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Toxicology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Communicable Diseases (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP95927260A 1995-05-05 1995-06-23 Human chemokine beta-8, chemokine beta-1 and macrophage inflammatory protein-4 Withdrawn EP0871672A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US446881 1982-12-06
US44688195A 1995-05-05 1995-05-05
PCT/US1995/009058 WO1996034891A1 (en) 1995-05-05 1995-06-23 Human chemokine beta-8, chemokine beta-1 and macrophage inflammatory protein-4

Publications (2)

Publication Number Publication Date
EP0871672A1 EP0871672A1 (en) 1998-10-21
EP0871672A4 true EP0871672A4 (en) 1999-05-12

Family

ID=23774170

Family Applications (1)

Application Number Title Priority Date Filing Date
EP95927260A Withdrawn EP0871672A4 (en) 1995-05-05 1995-06-23 Human chemokine beta-8, chemokine beta-1 and macrophage inflammatory protein-4

Country Status (8)

Country Link
EP (1) EP0871672A4 (en)
JP (2) JPH11505417A (en)
KR (1) KR19990008335A (en)
CN (2) CN1125082C (en)
AU (1) AU3134695A (en)
CA (1) CA2220123A1 (en)
MX (1) MX9708537A (en)
WO (1) WO1996034891A1 (en)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6811773B1 (en) 1993-12-22 2004-11-02 Human Genome Sciences, Inc. Human monocyte colony inhibitory factor (M-CIF) polypeptides
US6488925B2 (en) 1993-12-22 2002-12-03 Human Genome Sciences, Inc. Macrophage inflammatory protein-4 (MIP-4) polypeptides
US6001606A (en) * 1994-03-08 1999-12-14 Human Genome Sciences, Inc. Polynucleotides encoding myeloid progenitor inhibitory factor-1 (MPIF-1) and polypeptides encoded thereby
US6623942B2 (en) 1994-03-08 2003-09-23 Human Genome Sciences, Inc. Macrophage inflammatory protein-4 (MIP-4) polynucleotides
US6495129B1 (en) 1994-03-08 2002-12-17 Human Genome Sciences, Inc. Methods of inhibiting hematopoietic stem cells using human myeloid progenitor inhibitory factor-1 (MPIF-1) (Ckbeta-8/MIP-3)
US6180773B1 (en) 1994-04-30 2001-01-30 Wolf-Georg Forssmann Tandem cDNAs encoding chemokines CC-1, CC-2, and CC-3
EA199800352A1 (en) * 1995-09-29 1998-12-24 Смитклайн Бичам Корпорейшн POLYPEPTIDE chemokine β-8 (VARIANTS) AND A METHOD FOR ITS PREPARATION, COMPOSITIONS polypeptide vector, host cell, agonists and antagonists, ALL - of said polypeptides and methods IDENTIFYING LAST, METHOD FOR TREATING A PATIENT, feels the need for Xk-β-8 (VARIANTS ), A METHOD OF TREATING A PATIENT, TESTING THE NEED TO SUPPRESS XK-β-8, A METHOD FOR DIAGNOSTIC DISEASE OR PREDISPOSITION TO THE DISEASE, INCIDENTALLY INSUFFICIENT EXPRESSION OF AIDS TO THE DISEASE, FOR A DISEASE
US6512103B1 (en) 1995-12-08 2003-01-28 Schering Corporation Mammalian chemokine reagents
US7888466B2 (en) 1996-01-11 2011-02-15 Human Genome Sciences, Inc. Human G-protein chemokine receptor HSATU68
JP2001500382A (en) * 1996-09-30 2001-01-16 ヒューマン ジノーム サイエンシーズ，インコーポレイテッド Therapeutic compositions and methods for treating disease states with bone marrow precursor inhibitor-1 (MPIF-1), monocyte colony inhibitor (M-CIF), and macrophage inhibitor-4 (MIP-4)
US5912327A (en) * 1996-09-30 1999-06-15 Human Genome Sciences, Inc. Method of purifying chemokines from inclusion bodies
US6632425B1 (en) 1997-03-20 2003-10-14 Human Genome Sciences, Inc. Chemokine compositions
EP2332975A1 (en) 1997-05-30 2011-06-15 Human Genome Sciences, Inc. Human proteins
ATE384732T1 (en) 1997-11-03 2008-02-15 Human Genome Sciences Inc VEGI, AN INHIBITOR OF ANGIOGENESIS AND TUMOR GROWTH
KR19990042713A (en) * 1997-11-27 1999-06-15 허일섭 Method for preparing CDNA and recombinant LKN-1 of C 6 beta-chemokine LKN-1 isolated from human
DE69943022D1 (en) 1998-03-19 2011-01-20 Human Genome Sciences Rockville THE COMMON GAMMA CHAIN SIMILAR CYTOKINE RECEPTOR
EP1093516A2 (en) * 1998-07-06 2001-04-25 Schering Corporation Mammalian genes; dendritic cell prostaglandin-like transporter (dc-pgt), hdtea84, hsljd37r and rankl, hcc5 chemokine, deubiquitinating 11 and 12 (dub11, dub12), md-1, md2 and cyclin e2, related reagents and methods
EP0974357A1 (en) * 1998-07-16 2000-01-26 Schering-Plough Chemokines as adjuvants of immune response
WO2000028035A1 (en) 1998-11-10 2000-05-18 Human Genome Sciences Inc. CHEMOKINE β-7
WO2001026676A1 (en) * 1999-10-14 2001-04-19 Human Genome Sciences, Inc. Methods of treating or preventing cell, tissue, and organ damage using human myeloid progenitor inhibitory factor-1 (mpif-1)
EP1167527A1 (en) * 2000-06-22 2002-01-02 Euroscreen S.A. Processed human chemokines PHC-1 and PHC-2
JP2003512843A (en) * 1999-10-25 2003-04-08 オーロスクレーン エス． エー． Processed human chemokines PHC-1 and PHC-2
JP2003530838A (en) 2000-04-12 2003-10-21 ヒューマン ゲノム サイエンシズ インコーポレイテッド Albumin fusion protein
EP1294949A4 (en) 2000-06-15 2004-08-25 Human Genome Sciences Inc Human tumor necrosis factor delta and epsilon
EP1176200A3 (en) 2000-06-20 2005-01-12 Switch Biotech Aktiengesellschaft Use of polyeptides or their encoding nucleic acids for the diagnosis or treatment of skin diseases or wound healing and their use in indentifying pharmacologically acitve substances
US6774223B2 (en) 2000-06-28 2004-08-10 Diadexus, Inc. Method of diagnosing, monitoring, staging, imaging and treating colon cancer
CA2420325A1 (en) 2000-08-25 2002-02-28 Basf Plant Science Gmbh Plant polynucleotides encoding novel prenyl proteases
US6989247B2 (en) 2000-11-28 2006-01-24 Celltech R & D, Inc. Compositions and methods for diagnosing or treating psoriasis
WO2005057220A2 (en) * 2003-12-05 2005-06-23 Oxagen Limited Agents modulating the activity of ccrl2 and methods of using the same
US7572618B2 (en) 2006-06-30 2009-08-11 Bristol-Myers Squibb Company Polynucleotides encoding novel PCSK9 variants
JP5256199B2 (en) 2006-08-07 2013-08-07 テヴァ バイオファーマシューティカルズ ユーエスエー，インコーポレーティッド Albumin-insulin fusion protein
AU2012222833B2 (en) 2011-03-03 2017-03-16 Zymeworks Inc. Multivalent heteromultimer scaffold design and constructs
JP6498601B2 (en) 2012-07-13 2019-04-10 ザイムワークス，インコーポレイテッド Multivalent heteromultimeric scaffold designs and constructs

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992005198A1 (en) * 1990-09-14 1992-04-02 Chiron Corporation EXPRESSION OF MACROPHAGE INDUCIBLE PROTEINS (MIPs) IN YEAST CELLS
WO1995017092A1 (en) * 1993-12-22 1995-06-29 Human Genome Sciences, Inc. MACROPHAGE INFLAMMATORY PROTEINS-3, -4 AND -1¿η?
WO1995018228A1 (en) * 1993-12-24 1995-07-06 Forssmann Wolf Georg Human circulating cytokine cc-1
WO1996016979A1 (en) * 1994-11-29 1996-06-06 Incyte Pharmaceuticals, Inc. Expressed chemokines, their production and uses
WO1996032481A1 (en) * 1995-04-13 1996-10-17 Incyte Pharmaceuticals, Inc. New chemokine expressed in eosinophils

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0290455A4 (en) * 1986-01-08 1989-01-18 Rhone Poulenc Agrochimie Haloarylnitrile degrading gene, its use, and cells containing the same.

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992005198A1 (en) * 1990-09-14 1992-04-02 Chiron Corporation EXPRESSION OF MACROPHAGE INDUCIBLE PROTEINS (MIPs) IN YEAST CELLS
WO1995017092A1 (en) * 1993-12-22 1995-06-29 Human Genome Sciences, Inc. MACROPHAGE INFLAMMATORY PROTEINS-3, -4 AND -1¿η?
WO1995018228A1 (en) * 1993-12-24 1995-07-06 Forssmann Wolf Georg Human circulating cytokine cc-1
WO1996016979A1 (en) * 1994-11-29 1996-06-06 Incyte Pharmaceuticals, Inc. Expressed chemokines, their production and uses
WO1996032481A1 (en) * 1995-04-13 1996-10-17 Incyte Pharmaceuticals, Inc. New chemokine expressed in eosinophils

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9634891A1 *

Also Published As

Publication number Publication date
CN1186501A (en) 1998-07-01
EP0871672A1 (en) 1998-10-21
WO1996034891A1 (en) 1996-11-07
MX9708537A (en) 1998-02-28
CN1515672A (en) 2004-07-28
JP2003102486A (en) 2003-04-08
AU3134695A (en) 1996-11-21
CN1125082C (en) 2003-10-22
KR19990008335A (en) 1999-01-25
CA2220123A1 (en) 1996-11-07
JPH11505417A (en) 1999-05-21

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