CA2263951A1 - Utilisation d'une proteine de fixation de macrolide mutee pour prevenir la reaction du greffon contre l'hote - Google Patents
Utilisation d'une proteine de fixation de macrolide mutee pour prevenir la reaction du greffon contre l'hote Download PDFInfo
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- CA2263951A1 CA2263951A1 CA002263951A CA2263951A CA2263951A1 CA 2263951 A1 CA2263951 A1 CA 2263951A1 CA 002263951 A CA002263951 A CA 002263951A CA 2263951 A CA2263951 A CA 2263951A CA 2263951 A1 CA2263951 A1 CA 2263951A1
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- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/90—Isomerases (5.)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Environmental Sciences (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Diabetes (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Hematology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Cette invention se rapporte à une cyclosporine A modifiée et à une version modifiée par génie génétique de son récepteur, la cyclophiline. Cette invention se rapporte en outre à un procédé pour traiter la réaction du greffon contre l'hôte après une greffe de moelle osseuse par transfection de cellules souches, pour que, après introduction dans le corps d'un patient, les cellules souches expriment la cyclophiline modifiée et, si nécessaire, administrent la cyclosporine A modifiée dans le corps du patient.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2466696P | 1996-08-27 | 1996-08-27 | |
US60/024,666 | 1996-08-27 | ||
PCT/US1997/015153 WO1998008956A2 (fr) | 1996-08-27 | 1997-08-27 | Utilisation d'une proteine de fixation de macrolide mutee pour prevenir la reaction du greffon contre l'hote |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2263951A1 true CA2263951A1 (fr) | 1998-03-05 |
Family
ID=21821767
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002263951A Abandoned CA2263951A1 (fr) | 1996-08-27 | 1997-08-27 | Utilisation d'une proteine de fixation de macrolide mutee pour prevenir la reaction du greffon contre l'hote |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0939822A2 (fr) |
JP (1) | JP2001527384A (fr) |
AU (1) | AU4167297A (fr) |
CA (1) | CA2263951A1 (fr) |
WO (1) | WO1998008956A2 (fr) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9812675D0 (en) * | 1998-06-11 | 1998-08-12 | Univ Edinburgh | Peptides |
WO2008132494A1 (fr) * | 2007-05-01 | 2008-11-06 | Ludwig Institute Of Cancer Research | Variante tronquée de la mtor (cible de la rapamycine chez les mammifères) |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69534300T2 (de) * | 1994-08-18 | 2006-05-18 | Ariad Gene Therapeutics, Inc., Cambridge | Neues multimerisierendes reagenz |
US5723436A (en) * | 1994-10-24 | 1998-03-03 | The Board Of Trustees Of The Leland Stanford Junior University | Calcineurin interacting protein compositions and methods |
-
1997
- 1997-08-27 AU AU41672/97A patent/AU4167297A/en not_active Abandoned
- 1997-08-27 WO PCT/US1997/015153 patent/WO1998008956A2/fr not_active Application Discontinuation
- 1997-08-27 CA CA002263951A patent/CA2263951A1/fr not_active Abandoned
- 1997-08-27 JP JP51190498A patent/JP2001527384A/ja active Pending
- 1997-08-27 EP EP97939629A patent/EP0939822A2/fr not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
EP0939822A2 (fr) | 1999-09-08 |
WO1998008956A2 (fr) | 1998-03-05 |
WO1998008956A3 (fr) | 1998-06-18 |
AU4167297A (en) | 1998-03-19 |
JP2001527384A (ja) | 2001-12-25 |
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