CA2262676A1 - Reaction de desoxygenation stereoselective - Google Patents
Reaction de desoxygenation stereoselective Download PDFInfo
- Publication number
- CA2262676A1 CA2262676A1 CA002262676A CA2262676A CA2262676A1 CA 2262676 A1 CA2262676 A1 CA 2262676A1 CA 002262676 A CA002262676 A CA 002262676A CA 2262676 A CA2262676 A CA 2262676A CA 2262676 A1 CA2262676 A1 CA 2262676A1
- Authority
- CA
- Canada
- Prior art keywords
- alkyl
- group
- cycloalkyl
- alkenyl
- alkynyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
L'invention concerne un intermédiaire clé dans la synthèse d'un antagoniste de l'endothéline, la synthèse dudit intermédiaire clé et la synthèse d'un antagoniste de l'endothéline réalisées par l'emploi dudit intermédiaire dans une réaction de désoxygénation stéréosélective.
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2361496P | 1996-08-09 | 1996-08-09 | |
US60/023,614 | 1996-08-09 | ||
GBGB9617900.7A GB9617900D0 (en) | 1996-08-28 | 1996-08-28 | Stereoselective deoxygenation reaction |
GB9617900.7 | 1996-08-28 | ||
US2843896P | 1996-10-10 | 1996-10-10 | |
US60/028,438 | 1996-10-10 | ||
GB9625806.6 | 1996-12-12 | ||
GBGB9625806.6A GB9625806D0 (en) | 1996-12-12 | 1996-12-12 | Stereoselective deoxygenation reaction |
PCT/US1997/014045 WO1998006700A1 (fr) | 1996-08-09 | 1997-08-08 | Reaction de desoxygenation stereoselective |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2262676A1 true CA2262676A1 (fr) | 1998-02-19 |
Family
ID=27451511
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002262676A Abandoned CA2262676A1 (fr) | 1996-08-09 | 1997-08-08 | Reaction de desoxygenation stereoselective |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0923557A4 (fr) |
JP (1) | JPH11514676A (fr) |
AU (1) | AU711936B2 (fr) |
CA (1) | CA2262676A1 (fr) |
WO (1) | WO1998006700A1 (fr) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3262805B2 (ja) * | 1996-08-09 | 2002-03-04 | メルク エンド カンパニー インコーポレーテッド | 非対称性共役付加反応 |
US6172235B1 (en) | 1996-08-09 | 2001-01-09 | Merck & Co., Inc. | Asymmetric conjugate addition reaction |
ATE259800T1 (de) * | 1998-01-21 | 2004-03-15 | Banyu Pharma Co Ltd | Substituierte 5-(2,2difluor-1,3-benzodioxol-5-yl) cyclopentenopyridinderivate |
WO1999052900A1 (fr) * | 1998-04-09 | 1999-10-21 | Merck & Co., Inc. | Procede d'oxydation au moyen de tempo |
US6031101A (en) * | 1998-04-09 | 2000-02-29 | Merck & Co., Inc. | Oxidation process using tempo |
EP1070041B1 (fr) * | 1998-04-09 | 2003-07-02 | Merck & Co., Inc. (a New Jersey corp.) | Cyclisation par l'intermediaire d'un phosphate |
CA2327926A1 (fr) * | 1998-04-09 | 1999-10-21 | Merck & Co., Inc. | Procede d'oxydation au moyen d'acide periodique |
US6046327A (en) * | 1998-04-09 | 2000-04-04 | Merck & Co., Inc. | Phosphate-mediated cyclization |
AR029289A1 (es) * | 2000-07-05 | 2003-06-18 | Ishihara Sangyo Kaisha | Derivado de benzoilpiridina o su sal, fungicida que lo contiene como un ingrediente activo, su proceso de produccion e intermediario para producirlo |
JP4608140B2 (ja) * | 2000-07-05 | 2011-01-05 | 石原産業株式会社 | ベンゾイルピリジン誘導体またはその塩、それらを有効成分として含有する殺菌剤、それらの製造方法ならびにそれらを製造するための中間体 |
AP1286A (en) * | 2000-07-05 | 2004-06-26 | Ishihara Sangyo Kaisha | Benzoylpyridine derivative or its salt, Fungicide containing it as an active ingredient, its production process and intermediate for producing it. |
IL153504A0 (en) | 2001-03-09 | 2003-07-06 | Nugen Technologies Inc | Methods and compositions for amplification of rna sequences |
US20060281788A1 (en) | 2005-06-10 | 2006-12-14 | Baumann Christian A | Synergistic modulation of flt3 kinase using a flt3 inhibitor and a farnesyl transferase inhibitor |
CA2649924C (fr) | 2006-04-20 | 2014-08-19 | Janssen Pharmaceutica N.V. | Inhibiteurs de la c-fms kinase |
US8697716B2 (en) | 2006-04-20 | 2014-04-15 | Janssen Pharmaceutica Nv | Method of inhibiting C-KIT kinase |
MX2008013533A (es) | 2006-04-20 | 2009-01-15 | Janssen Pharmaceutica Nv | Compuestos heterociclicos como inhibidores de c-fms cinasa. |
JO3240B1 (ar) | 2007-10-17 | 2018-03-08 | Janssen Pharmaceutica Nv | c-fms مثبطات كيناز |
CN102131772B (zh) | 2008-07-30 | 2015-03-11 | 英特威国际有限公司 | 用作氟苯尼考的中间体的*唑啉-保护的氨基二醇化合物的制备方法 |
AU2013299922B2 (en) | 2012-08-07 | 2018-06-21 | Janssen Pharmaceutica Nv | Process for the preparation of heterocyclic ester derivatives |
JOP20180012A1 (ar) | 2012-08-07 | 2019-01-30 | Janssen Pharmaceutica Nv | عملية السلفنة باستخدام نونافلوروبوتانيسولفونيل فلوريد |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2086544C1 (ru) * | 1991-06-13 | 1997-08-10 | Хоффманн-Ля Рош АГ | Бензолсульфонамидные производные пиримидина или их соли, фармацевтическая композиция для лечения заболеваний, связанных с активностью эндотелина |
RO117847B1 (ro) * | 1991-11-05 | 2002-08-30 | Smithkline Beecham Corp | Derivati de indan, procedeu de preparare, compozitie farmaceutica care ii contine si metoda de tratament |
US5389620A (en) * | 1993-08-18 | 1995-02-14 | Banyu Pharmaceutical Co., Ltd. | Endothelin antagonistic heteroaromatic ring-fused cyclopentene derivatives |
CN1049219C (zh) * | 1993-08-18 | 2000-02-09 | 万有制药株式会社 | 具有内皮素拮抗活性的芳香杂环并环戊烯衍生物 |
WO1997017342A1 (fr) * | 1995-11-08 | 1997-05-15 | Smithkline Beecham Corporation | Procede pour la production de derives d'acide 3-phenyl-1-methylenedioxyphenyl-indane-2-carboxylique |
IL126175A (en) * | 1996-04-04 | 2003-05-29 | Banyu Pharma Co Ltd | Pharmaceutical compositions containing endothelin antagonists and novel endothelin antagonists |
-
1997
- 1997-08-08 WO PCT/US1997/014045 patent/WO1998006700A1/fr not_active Application Discontinuation
- 1997-08-08 EP EP97937187A patent/EP0923557A4/fr not_active Withdrawn
- 1997-08-08 JP JP10509915A patent/JPH11514676A/ja active Pending
- 1997-08-08 AU AU39757/97A patent/AU711936B2/en not_active Ceased
- 1997-08-08 CA CA002262676A patent/CA2262676A1/fr not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU711936B2 (en) | 1999-10-28 |
AU3975797A (en) | 1998-03-06 |
EP0923557A4 (fr) | 1999-12-08 |
WO1998006700A1 (fr) | 1998-02-19 |
EP0923557A1 (fr) | 1999-06-23 |
JPH11514676A (ja) | 1999-12-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2262676A1 (fr) | Reaction de desoxygenation stereoselective | |
AU728441B2 (en) | Endothelin intermediates by asymmetric conjugate addition reaction using a chiral additive | |
US5962688A (en) | Stereoselective deoxygenation reaction | |
US6353110B1 (en) | Asymmetric conjugate addition reaction | |
CA2262837C (fr) | Reaction d'addition par conjugue asymetrique | |
WO1999007367A1 (fr) | Reaction d'addition conjuguee asymetrique | |
US6172231B1 (en) | Oxidation process using periodic acid | |
US6172235B1 (en) | Asymmetric conjugate addition reaction | |
US5998625A (en) | Asymmetric conjugate addition reaction using a chiral additive | |
AU747645B2 (en) | Phosphate-mediated cyclization | |
US6046327A (en) | Phosphate-mediated cyclization | |
AU748208B2 (en) | Oxidation process using tempo | |
MXPA99006544A (en) | Endothelin intermediates by asymmetric conjugate addition reaction using a chiral additive | |
CA2327926A1 (fr) | Procede d'oxydation au moyen d'acide periodique |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Dead |