CA2262676A1 - Reaction de desoxygenation stereoselective - Google Patents

Reaction de desoxygenation stereoselective Download PDF

Info

Publication number
CA2262676A1
CA2262676A1 CA002262676A CA2262676A CA2262676A1 CA 2262676 A1 CA2262676 A1 CA 2262676A1 CA 002262676 A CA002262676 A CA 002262676A CA 2262676 A CA2262676 A CA 2262676A CA 2262676 A1 CA2262676 A1 CA 2262676A1
Authority
CA
Canada
Prior art keywords
alkyl
group
cycloalkyl
alkenyl
alkynyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002262676A
Other languages
English (en)
Inventor
Paul N. Devine
Ulf H. Dolling
Lisa Frey
Richard D. Tillyer
David M. Tschaen
Yoshiaki Kato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MSD KK
Merck and Co Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9617900.7A external-priority patent/GB9617900D0/en
Priority claimed from GBGB9625806.6A external-priority patent/GB9625806D0/en
Application filed by Individual filed Critical Individual
Publication of CA2262676A1 publication Critical patent/CA2262676A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

L'invention concerne un intermédiaire clé dans la synthèse d'un antagoniste de l'endothéline, la synthèse dudit intermédiaire clé et la synthèse d'un antagoniste de l'endothéline réalisées par l'emploi dudit intermédiaire dans une réaction de désoxygénation stéréosélective.
CA002262676A 1996-08-09 1997-08-08 Reaction de desoxygenation stereoselective Abandoned CA2262676A1 (fr)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US2361496P 1996-08-09 1996-08-09
US60/023,614 1996-08-09
GBGB9617900.7A GB9617900D0 (en) 1996-08-28 1996-08-28 Stereoselective deoxygenation reaction
US2843896P 1996-10-10 1996-10-10
US60/028,438 1996-10-10
GB9625806.6 1996-12-12
GBGB9625806.6A GB9625806D0 (en) 1996-12-12 1996-12-12 Stereoselective deoxygenation reaction
GB9617900.7 1996-12-12
PCT/US1997/014045 WO1998006700A1 (fr) 1996-08-09 1997-08-08 Reaction de desoxygenation stereoselective

Publications (1)

Publication Number Publication Date
CA2262676A1 true CA2262676A1 (fr) 1998-02-19

Family

ID=27451511

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002262676A Abandoned CA2262676A1 (fr) 1996-08-09 1997-08-08 Reaction de desoxygenation stereoselective

Country Status (5)

Country Link
EP (1) EP0923557A4 (fr)
JP (1) JPH11514676A (fr)
AU (1) AU711936B2 (fr)
CA (1) CA2262676A1 (fr)
WO (1) WO1998006700A1 (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6172235B1 (en) 1996-08-09 2001-01-09 Merck & Co., Inc. Asymmetric conjugate addition reaction
EP0923556B1 (fr) * 1996-08-09 2003-10-08 Merck & Co., Inc. Reaction d'addition par conjugue asymetrique
DE69914880T2 (de) * 1998-01-21 2004-08-05 Banyu Pharmaceutical Co., Ltd. Substituierte 5-(2,2difluor-1,3-benzodioxol-5-yl) cyclopentenopyridinderivate
AU748208B2 (en) * 1998-04-09 2002-05-30 Banyu Pharmaceutical Co., Ltd. Oxidation process using tempo
AU3383399A (en) * 1998-04-09 1999-11-01 Merck & Co., Inc. Oxidation process using periodic acid
US6031101A (en) * 1998-04-09 2000-02-29 Merck & Co., Inc. Oxidation process using tempo
US6046327A (en) * 1998-04-09 2000-04-04 Merck & Co., Inc. Phosphate-mediated cyclization
CA2327928A1 (fr) * 1998-04-09 1999-10-21 Merck & Co., Inc. Cyclisation par l'intermediaire d'un phosphate
JP4608140B2 (ja) * 2000-07-05 2011-01-05 石原産業株式会社 ベンゾイルピリジン誘導体またはその塩、それらを有効成分として含有する殺菌剤、それらの製造方法ならびにそれらを製造するための中間体
AR029289A1 (es) * 2000-07-05 2003-06-18 Ishihara Sangyo Kaisha Derivado de benzoilpiridina o su sal, fungicida que lo contiene como un ingrediente activo, su proceso de produccion e intermediario para producirlo
AP1286A (en) * 2000-07-05 2004-06-26 Ishihara Sangyo Kaisha Benzoylpyridine derivative or its salt, Fungicide containing it as an active ingredient, its production process and intermediate for producing it.
CA2416963C (fr) 2001-03-09 2012-01-10 Nugen Technologies, Inc. Procedes et compositions permettant l'amplification de sequences d'arn
US20060281788A1 (en) 2005-06-10 2006-12-14 Baumann Christian A Synergistic modulation of flt3 kinase using a flt3 inhibitor and a farnesyl transferase inhibitor
EP2016074B1 (fr) 2006-04-20 2016-01-13 Janssen Pharmaceutica N.V. Inhibiteurs de la c-fms kinase
US8697716B2 (en) 2006-04-20 2014-04-15 Janssen Pharmaceutica Nv Method of inhibiting C-KIT kinase
SI2021335T1 (sl) 2006-04-20 2011-09-30 Janssen Pharmaceutica Nv Heterocikliäśne spojine kot zaviralci c-fms kinaze
JO3240B1 (ar) 2007-10-17 2018-03-08 Janssen Pharmaceutica Nv c-fms مثبطات كيناز
KR20110038723A (ko) 2008-07-30 2011-04-14 인터벳 인터내셔널 비.브이. 플로르페니콜에 대한 중간체로서 유용한 옥사졸린-보호된 아미노디올 화합물의 제조 방법
IN2015DN00659A (fr) 2012-08-07 2015-06-26 Janssen Pharmaceutica Nv
JOP20180012A1 (ar) 2012-08-07 2019-01-30 Janssen Pharmaceutica Nv عملية السلفنة باستخدام نونافلوروبوتانيسولفونيل فلوريد

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2086544C1 (ru) * 1991-06-13 1997-08-10 Хоффманн-Ля Рош АГ Бензолсульфонамидные производные пиримидина или их соли, фармацевтическая композиция для лечения заболеваний, связанных с активностью эндотелина
DE69232072T2 (de) * 1991-11-05 2002-06-20 Smithkline Beecham Corp Endothelin-rezeptor-antagonisten
CN1049219C (zh) * 1993-08-18 2000-02-09 万有制药株式会社 具有内皮素拮抗活性的芳香杂环并环戊烯衍生物
US5389620A (en) * 1993-08-18 1995-02-14 Banyu Pharmaceutical Co., Ltd. Endothelin antagonistic heteroaromatic ring-fused cyclopentene derivatives
AR005237A1 (es) * 1995-11-08 1999-04-28 Smithkline Beecham Corp Procedimiento para la preparacion de derivados de ciclopenteno condensados con anillos aromaticos, intermediarios y procedimientos para su preparacion, yderivados de ciclopenteno.
WO1997037665A1 (fr) * 1996-04-04 1997-10-16 Banyu Pharmaceutical Co., Ltd. Procede de traitement de l'insuffisance cardiaque par des antagonistes de l'endotheline

Also Published As

Publication number Publication date
AU3975797A (en) 1998-03-06
AU711936B2 (en) 1999-10-28
EP0923557A4 (fr) 1999-12-08
WO1998006700A1 (fr) 1998-02-19
EP0923557A1 (fr) 1999-06-23
JPH11514676A (ja) 1999-12-14

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CA2262676A1 (fr) Reaction de desoxygenation stereoselective
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CA2262837C (fr) Reaction d'addition par conjugue asymetrique
WO1999007367A1 (fr) Reaction d'addition conjuguee asymetrique
US6172231B1 (en) Oxidation process using periodic acid
US6172235B1 (en) Asymmetric conjugate addition reaction
US5998625A (en) Asymmetric conjugate addition reaction using a chiral additive
AU747645B2 (en) Phosphate-mediated cyclization
US6046327A (en) Phosphate-mediated cyclization
AU748208B2 (en) Oxidation process using tempo
MXPA99006544A (en) Endothelin intermediates by asymmetric conjugate addition reaction using a chiral additive
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Legal Events

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FZDE Dead