CA2258679C - Solution solide d'un agent antifongique avec biodisponibilite amelioree - Google Patents

Solution solide d'un agent antifongique avec biodisponibilite amelioree Download PDF

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Publication number
CA2258679C
CA2258679C CA002258679A CA2258679A CA2258679C CA 2258679 C CA2258679 C CA 2258679C CA 002258679 A CA002258679 A CA 002258679A CA 2258679 A CA2258679 A CA 2258679A CA 2258679 C CA2258679 C CA 2258679C
Authority
CA
Canada
Prior art keywords
solid solution
compound
composition
povidone
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002258679A
Other languages
English (en)
Other versions
CA2258679A1 (fr
Inventor
Surendra A. Sangekar
Ping I. Lee
Winston A. Vadino
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme Corp
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Priority claimed from PCT/US1997/010120 external-priority patent/WO1998000113A1/fr
Publication of CA2258679A1 publication Critical patent/CA2258679A1/fr
Application granted granted Critical
Publication of CA2258679C publication Critical patent/CA2258679C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4866Organic macromolecular compounds
CA002258679A 1996-06-28 1997-06-25 Solution solide d'un agent antifongique avec biodisponibilite amelioree Expired - Fee Related CA2258679C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US67270696A 1996-06-28 1996-06-28
US08/672,706 1996-06-28
PCT/US1997/010120 WO1998000113A1 (fr) 1996-06-28 1997-06-25 Solution solide d'un agent antifongique avec biodisponibilite amelioree

Publications (2)

Publication Number Publication Date
CA2258679A1 CA2258679A1 (fr) 1998-01-08
CA2258679C true CA2258679C (fr) 2007-05-29

Family

ID=38151061

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002258679A Expired - Fee Related CA2258679C (fr) 1996-06-28 1997-06-25 Solution solide d'un agent antifongique avec biodisponibilite amelioree

Country Status (1)

Country Link
CA (1) CA2258679C (fr)

Also Published As

Publication number Publication date
CA2258679A1 (fr) 1998-01-08

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