CA2257559A1 - Complex preparations characterised by a betain content - Google Patents
Complex preparations characterised by a betain content Download PDFInfo
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- CA2257559A1 CA2257559A1 CA002257559A CA2257559A CA2257559A1 CA 2257559 A1 CA2257559 A1 CA 2257559A1 CA 002257559 A CA002257559 A CA 002257559A CA 2257559 A CA2257559 A CA 2257559A CA 2257559 A1 CA2257559 A1 CA 2257559A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/42—Phosphorus; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Preparations, especially for topical use, containing a) ion-containing compounds, b) astringent, bonding and adhesive agents, c) possibly lipotropic compounds, antimycotic, anti-inflammatory and plant components, having a betaine content.
Description
CA 022~7~9 1998-12-04 WO 97/46Z46 PCT/EP97/028q9 COMPLEX PREPARATIONS CHARACTERIZED BY A aETAINE CONTENT
The invention relates to complex preparations for topical, intracorporal, or oral treatment, affecting, maintaining, and improvinq cellular function, cellular metabolism, physiological processes, microcirculation, immunity, homeostasis, and/or prevention, healing, care of various tissue damaging manifestations, changes in and deformation of tissue, caused by/arising due to exogenic and/or endogenic factors in humans and animals.
It is known that agents and preparations for treating and/or improving cellular function, physiological processes, or immunity already exist. It is also known that there are topical agents for surface stimulation of blood circulation or for healing and care of the human or animal body. The bases of these agents, especially where dermatics are concerned, are as a rule antibiotics, cortisones, antimycotics, and other often very dangerous materials. 8ecause of their side effects, they are often contraindicated, for example during pregnancy or for infants. These agents are also associated with other disadvantages because, if they are effective at all, they are therapeutically effective only after extended use or when used in conjunction with other agents, or with a special diet. None of these known agents contain ionic preparations, which, under high osmotic pressure, can introduce the physiologically necessary materials such as amino acid-containing substances, enzymes, mineral substances, vitamins, etc. into the cell interior and blood plasma by its effect on the cell membrane.
CA 022~7~9 1998-12-04 WO 97/46246 ~ PCT/EP97/02849 It is an object of this invention to provide preparations with natural materials on a phytobiological basis, especially for topical use for fast, effective treatment, affecting, and maintaining of cellular function, cellular metabolism, physiological processes, microcirculation, immunity, resistance~
homeostasis, and/or prevention, healing, care of various tissue damaging manifestations, changes in and deformation of tissue, caused by/arising due to exogenic and/or endogenic influences in humans and animals, which, under high osmotic pressure, bring the ions and active ingredients to the cellular layer, selectively make the cell membrane porous, and introduce themselves into the cell interior and blood plasma and, with the necessary substances, mineral materials, amino acids, enzymes, vitamins, proteins, acid, and/or other components, provide for and significantly contribute to supporting and encouraging physiological processes and to reestablishing the equilibrium in the organism.
This object is achieved according to the principles of the invention. A
topical agent for treatment of mycotic, microbic tissue damage is known in the prior art (Patent DE 3816442 C2). [handwritten: INSERT PA OE 2a]
The invention is based on special compositions of the preparations. The preparations according to the invention comprise ion-containing compounds, salts, astringent components, amphoterics, [stamp:l CHANGED PAGE
CA 022~7~9 1998-12-04 NO 97/46246 2a pcT/Ee97/o2849 In addition, UK patent application no. 2 106 386 relates to a preparation for scalp and hair treatment that contains a mixture of metals ~especially iron salts, magnesium salts, manganese salts, calcium salts, zinc salts, and copper salts), phosphates, carbohydrates, amino acids, vitamins, and oils.
[stamp:] CHANGED PAGE
CA 022~7~9 1998-12-04 ~O 9?/46246 PCT/EP97/02849 moisturizing agents, bonding and adhesive agents, etheric oils, to which, if necessary, one or more appropriate materials such as enzymes, vitamins, proteins, and auxiliary components can be added. The preparations according to the invention are characterized not only by the presence of ion-containing compounds, but also by the presence of lipotropic active agents, preferably betaine. Ion-containing compounds and salts with Na, Cl, K, Mg, Ca, and phosphate are preferred; preferred astringents are tannin, aspartic acid, and/or sandalwood oil; a preferred moisturizing agent is qlycerin and a preferred etheric oil is peppermint oil. Preferred bonding agents include preferably pectin and/or a hydrogel such as agar gel.
The preparations according to the invention have a comparatively low to physiologically normal pH value and a comparatively high osmotic pressure. The components combined according to the invention have a surprisingly effective synergistic effect, whereby cellular function, metabolism, physiological processes, and microcirculation are promoted while all tissues are simultaneously supplied and provided with important substances such as mineral substances, amino acids, dextrose, enzymes, vitamins, and proteins, which is especially advantageous in the case of physical stress and disturbed physiological equilibrium.
If necessary, the preparations according to the invention can also contain, among other ingredients, plant extracts, emulsifiers, amino acids, lanolin, glycine, choline, eucerin, _ . . . ~
CA 022~7~9 1998-12-04 .
dyes, waxes, bacteriostatics, oils, starches, tin, iron, fats, gelatins, preservatives, vaseline, camphor, carbamide, tensides, paraffins. The amount for the components is variable and can be 0.01% for one component and 20% or more for another.
The examples provided explain this further.
In their consistency or administration, the preparations according to the invention can be an infundible and/or topical solution, salve, cream, gel, lotion, powder, spray, foam, emulsion, tablets, capsules, textile wound bandages, bandages, or can be mixed partially/completely with other agents or other materials. In the preparations according to the invention, the quantities provided can increase or decrease and/or components can be omitted and/or exchanged.
The preparations according to the invention vary in their composition and the resulting principle and effect of its function, period of effect, methods of use, interaction, and affordability based upon other comparable prior art agents, especially agents which are for topical use for affecting, encouraging, maintaining, and/or restoring cell function, physiological processes, microcirculation, immunity in human or animal tissue.
As a lipotropic active ingredient, betaine is known as a component in pro~ucing soothing, surface-active, infection-inhibiting body cleansing agents.
CA 022~7~9 1998-12-04 .
WO 97/46246 PCT/EP97/02~99 Put it is to be regarded as highly surprising that betaine reaches the deep cellular layer as a lipotropic, amino acid-containing substance in the ion-containing preparations according to the invention by way of the ions and under high osmotic pressure and brings about an unexpectedly high cell and nutrient exchange, an improved microcirculation, and extensive physiological processes.
It is to be regarded as highly surprising that only in the indicated preparations according to the invention does the betaine reach the deep tissue and display an effective influence on the cellular and physiological processes.
It is to be regarded as surprisinq that effective substances such as betaine, but also enzymes, vitamins, and other essential materials and elements can be quickly and accurately administered in topical form by way of the ion-contai ni ng preparations according to the invention and under high osmotic pressure.
The clinical results confirm these surprising effects and show a significantly improved microcirculation and improved, increased physiological processes, which especially manifest themselves in skin and muscle tissues, fibers, joints, and healing processes. These surprising results can also open up new advantages and opportunities in the immunological, hematological, and metabolic fields.
The surprising effect of the betaine-containing c ,,u..ds according to the invention was confirmed by the following clinical tests:
. . . _ , , CA 022~7~9 l998-l2-04 WO 97/462q6 PCT/Ee97/02849 ~ ifteen female subjects ages 20-58 were divided into three groups of five each ~A, 8, and C). All subjects exhibited a characteristic manifestation of cellulitis in the second or third stage on the thigh: pincer test positive, mattress-shaped bulges visible to the naked eye when standing ~second stage) or when lying down as well as when standing (third stage), slack skin tone. These symptoms are the result of deficient, interrupted cellular function and microcirculation, which leads to a collection of water and fat in the tissue.
During the text period, the subjects were required to change nothing about their lifestyle and not to begin any diets or aerobics/sport activities.
Group A applied the ion-containing preparation according to the invention to the affected skin area (right thigh) once a day for 14 days, applying it in a thin layer and massaging it into the skin until completely absorbed. The circumference of the thigh was measured at a marked location on the first and last day of treatment. A tightening and smoothing of the skin was already visible after four days. After eight days of treatment, a clearly visible reduction of the protrusion on the skin surface could be observed. After fourteen days, the treated skin surface was smooth, supply, elastic, and tight. A reduction in thigh circumference of up to three centimeters was measured in all five subjects.
Group B went through the same treatment with an ion-cont~i ni ng preparation as group A, but without CA 022~7~9 1998-12-04 the inclusion of betaine. After approximately ten days, a liqht smoothing and tightening of the skin was ascertained in four of the five subjects. However, after the fourteen-day treatment, there were no further changes or improvements in the manifestation of cellulitis.
Group C went through the same treatment with a betaine-containing body cleansing agent. After fourteen days, none of the subjects displayed an improvement or a positive change, either in the condition of the skin or in the circumference of the thigh.
Example 1 Component Content in grams Approx. content in %
~etaine 1.0 0.1 Hamamelis 1.0 0.1 Glycerin 20.0 2.0 NaCl 10.0 1.0 MgCl 0.8 0.08 KCl 0.8 0.08 Na~HPO~12H2O 6.0 0.6 Agar 2.0 0.2 Tannin 10.2 1.0 Peppermint oil 0.5 O.OS
Calendula 1.0 0.1 H2O ad 100.0 W0 97/46246 PCT/EP97/028qg Example 2 Component Content in grams Approx. content in %
Petaine 3.0 o 3 Lanolin S0 S.S
Eucerin S0 5.5 Almond oil 100 10.0 Paraffin 100 10.0 NaCl 10.2 1.0 MgCl 0.8 0.08 KCl 0.8 0.08 Tannin 10.0 1.0 Glycerin 20.0 2.0 Vitamins A ~ D 0.13 0.01 H2O ad 100.0 CA 02257559 l998-l2-04 .
.
Example 3 Component - Content in grams Approx. content in Betaine lO.0 1.0 Carbamide 3.0 0.3 Ca3(P0~)2 80.0 8.0 Glycerin 80.0 8.0 Na~HPO~ 12H20 NaCl 6.5 0.6 MgCl 0.2 0.02 ~Cl 0.2 0.02 Tannin 12.0 1.2 MgO2 2.5 0.25 Pectin 80.0 8.0 Peppermint oil 1.0 0.1 Benzalkonium chloride 0.002 0.0002 H2O ad 100.0 .
WO 97/46246 . PCT/Ee97/02849 Example q Component Content in grams Approx. content in %
Betaine 20.0 2.0 Calendula 0.5 0.05 Hamamelis 0-5 0-05 Pectin 30.0 3.0 Tannin 10.0 1.0 Glycerin 20.0 2.0 Na,HPO~12H2O 6.0 0.6 MgC~ 1.0 0.1 KCl 1.0 0.1 NaCl 10.0 1.0 Peppermint oil 0.5 0.05 H2O ad 100.0 .
Example 5 Component Content in grams Approx. content in %
Betaine 20.0 2.0 Avena sativa 1.0 0.7 Echinacea angustifolia 1.0 0.1 Urtica dioica 1.0 0.1 Pectin 1.5 0.15 NaCl 0.3 0.03 KCl 0 3 MgCl 0.3 0.03 Peppermint oil ~ 2.0 0.2 CaHPO~ 2H20 Tannin 0.2 0.02 FeSO, . 0.02 0.002 H2O ad 100.0 Example 6 Component Content in grams Approx. content in %
Betaine 60.0 6.0 Pectin 110.0 11.0 Tannin 15.0 1.5 CaH(PO~)2 100.0 10.0 Glycerin 115.0 11.5 NaCl 14.0 1.4 MgCl 1.0 0.1 KCl 1.0 0.1 Na~HP0~12HzO 12.0 1.2 MgO2 2.0 0.2 Peppermint oil 1.0 0.1 Benzalkonium chloride 0.002 0.0002 H2O ad 100.0 , _
The invention relates to complex preparations for topical, intracorporal, or oral treatment, affecting, maintaining, and improvinq cellular function, cellular metabolism, physiological processes, microcirculation, immunity, homeostasis, and/or prevention, healing, care of various tissue damaging manifestations, changes in and deformation of tissue, caused by/arising due to exogenic and/or endogenic factors in humans and animals.
It is known that agents and preparations for treating and/or improving cellular function, physiological processes, or immunity already exist. It is also known that there are topical agents for surface stimulation of blood circulation or for healing and care of the human or animal body. The bases of these agents, especially where dermatics are concerned, are as a rule antibiotics, cortisones, antimycotics, and other often very dangerous materials. 8ecause of their side effects, they are often contraindicated, for example during pregnancy or for infants. These agents are also associated with other disadvantages because, if they are effective at all, they are therapeutically effective only after extended use or when used in conjunction with other agents, or with a special diet. None of these known agents contain ionic preparations, which, under high osmotic pressure, can introduce the physiologically necessary materials such as amino acid-containing substances, enzymes, mineral substances, vitamins, etc. into the cell interior and blood plasma by its effect on the cell membrane.
CA 022~7~9 1998-12-04 WO 97/46246 ~ PCT/EP97/02849 It is an object of this invention to provide preparations with natural materials on a phytobiological basis, especially for topical use for fast, effective treatment, affecting, and maintaining of cellular function, cellular metabolism, physiological processes, microcirculation, immunity, resistance~
homeostasis, and/or prevention, healing, care of various tissue damaging manifestations, changes in and deformation of tissue, caused by/arising due to exogenic and/or endogenic influences in humans and animals, which, under high osmotic pressure, bring the ions and active ingredients to the cellular layer, selectively make the cell membrane porous, and introduce themselves into the cell interior and blood plasma and, with the necessary substances, mineral materials, amino acids, enzymes, vitamins, proteins, acid, and/or other components, provide for and significantly contribute to supporting and encouraging physiological processes and to reestablishing the equilibrium in the organism.
This object is achieved according to the principles of the invention. A
topical agent for treatment of mycotic, microbic tissue damage is known in the prior art (Patent DE 3816442 C2). [handwritten: INSERT PA OE 2a]
The invention is based on special compositions of the preparations. The preparations according to the invention comprise ion-containing compounds, salts, astringent components, amphoterics, [stamp:l CHANGED PAGE
CA 022~7~9 1998-12-04 NO 97/46246 2a pcT/Ee97/o2849 In addition, UK patent application no. 2 106 386 relates to a preparation for scalp and hair treatment that contains a mixture of metals ~especially iron salts, magnesium salts, manganese salts, calcium salts, zinc salts, and copper salts), phosphates, carbohydrates, amino acids, vitamins, and oils.
[stamp:] CHANGED PAGE
CA 022~7~9 1998-12-04 ~O 9?/46246 PCT/EP97/02849 moisturizing agents, bonding and adhesive agents, etheric oils, to which, if necessary, one or more appropriate materials such as enzymes, vitamins, proteins, and auxiliary components can be added. The preparations according to the invention are characterized not only by the presence of ion-containing compounds, but also by the presence of lipotropic active agents, preferably betaine. Ion-containing compounds and salts with Na, Cl, K, Mg, Ca, and phosphate are preferred; preferred astringents are tannin, aspartic acid, and/or sandalwood oil; a preferred moisturizing agent is qlycerin and a preferred etheric oil is peppermint oil. Preferred bonding agents include preferably pectin and/or a hydrogel such as agar gel.
The preparations according to the invention have a comparatively low to physiologically normal pH value and a comparatively high osmotic pressure. The components combined according to the invention have a surprisingly effective synergistic effect, whereby cellular function, metabolism, physiological processes, and microcirculation are promoted while all tissues are simultaneously supplied and provided with important substances such as mineral substances, amino acids, dextrose, enzymes, vitamins, and proteins, which is especially advantageous in the case of physical stress and disturbed physiological equilibrium.
If necessary, the preparations according to the invention can also contain, among other ingredients, plant extracts, emulsifiers, amino acids, lanolin, glycine, choline, eucerin, _ . . . ~
CA 022~7~9 1998-12-04 .
dyes, waxes, bacteriostatics, oils, starches, tin, iron, fats, gelatins, preservatives, vaseline, camphor, carbamide, tensides, paraffins. The amount for the components is variable and can be 0.01% for one component and 20% or more for another.
The examples provided explain this further.
In their consistency or administration, the preparations according to the invention can be an infundible and/or topical solution, salve, cream, gel, lotion, powder, spray, foam, emulsion, tablets, capsules, textile wound bandages, bandages, or can be mixed partially/completely with other agents or other materials. In the preparations according to the invention, the quantities provided can increase or decrease and/or components can be omitted and/or exchanged.
The preparations according to the invention vary in their composition and the resulting principle and effect of its function, period of effect, methods of use, interaction, and affordability based upon other comparable prior art agents, especially agents which are for topical use for affecting, encouraging, maintaining, and/or restoring cell function, physiological processes, microcirculation, immunity in human or animal tissue.
As a lipotropic active ingredient, betaine is known as a component in pro~ucing soothing, surface-active, infection-inhibiting body cleansing agents.
CA 022~7~9 1998-12-04 .
WO 97/46246 PCT/EP97/02~99 Put it is to be regarded as highly surprising that betaine reaches the deep cellular layer as a lipotropic, amino acid-containing substance in the ion-containing preparations according to the invention by way of the ions and under high osmotic pressure and brings about an unexpectedly high cell and nutrient exchange, an improved microcirculation, and extensive physiological processes.
It is to be regarded as highly surprising that only in the indicated preparations according to the invention does the betaine reach the deep tissue and display an effective influence on the cellular and physiological processes.
It is to be regarded as surprisinq that effective substances such as betaine, but also enzymes, vitamins, and other essential materials and elements can be quickly and accurately administered in topical form by way of the ion-contai ni ng preparations according to the invention and under high osmotic pressure.
The clinical results confirm these surprising effects and show a significantly improved microcirculation and improved, increased physiological processes, which especially manifest themselves in skin and muscle tissues, fibers, joints, and healing processes. These surprising results can also open up new advantages and opportunities in the immunological, hematological, and metabolic fields.
The surprising effect of the betaine-containing c ,,u..ds according to the invention was confirmed by the following clinical tests:
. . . _ , , CA 022~7~9 l998-l2-04 WO 97/462q6 PCT/Ee97/02849 ~ ifteen female subjects ages 20-58 were divided into three groups of five each ~A, 8, and C). All subjects exhibited a characteristic manifestation of cellulitis in the second or third stage on the thigh: pincer test positive, mattress-shaped bulges visible to the naked eye when standing ~second stage) or when lying down as well as when standing (third stage), slack skin tone. These symptoms are the result of deficient, interrupted cellular function and microcirculation, which leads to a collection of water and fat in the tissue.
During the text period, the subjects were required to change nothing about their lifestyle and not to begin any diets or aerobics/sport activities.
Group A applied the ion-containing preparation according to the invention to the affected skin area (right thigh) once a day for 14 days, applying it in a thin layer and massaging it into the skin until completely absorbed. The circumference of the thigh was measured at a marked location on the first and last day of treatment. A tightening and smoothing of the skin was already visible after four days. After eight days of treatment, a clearly visible reduction of the protrusion on the skin surface could be observed. After fourteen days, the treated skin surface was smooth, supply, elastic, and tight. A reduction in thigh circumference of up to three centimeters was measured in all five subjects.
Group B went through the same treatment with an ion-cont~i ni ng preparation as group A, but without CA 022~7~9 1998-12-04 the inclusion of betaine. After approximately ten days, a liqht smoothing and tightening of the skin was ascertained in four of the five subjects. However, after the fourteen-day treatment, there were no further changes or improvements in the manifestation of cellulitis.
Group C went through the same treatment with a betaine-containing body cleansing agent. After fourteen days, none of the subjects displayed an improvement or a positive change, either in the condition of the skin or in the circumference of the thigh.
Example 1 Component Content in grams Approx. content in %
~etaine 1.0 0.1 Hamamelis 1.0 0.1 Glycerin 20.0 2.0 NaCl 10.0 1.0 MgCl 0.8 0.08 KCl 0.8 0.08 Na~HPO~12H2O 6.0 0.6 Agar 2.0 0.2 Tannin 10.2 1.0 Peppermint oil 0.5 O.OS
Calendula 1.0 0.1 H2O ad 100.0 W0 97/46246 PCT/EP97/028qg Example 2 Component Content in grams Approx. content in %
Petaine 3.0 o 3 Lanolin S0 S.S
Eucerin S0 5.5 Almond oil 100 10.0 Paraffin 100 10.0 NaCl 10.2 1.0 MgCl 0.8 0.08 KCl 0.8 0.08 Tannin 10.0 1.0 Glycerin 20.0 2.0 Vitamins A ~ D 0.13 0.01 H2O ad 100.0 CA 02257559 l998-l2-04 .
.
Example 3 Component - Content in grams Approx. content in Betaine lO.0 1.0 Carbamide 3.0 0.3 Ca3(P0~)2 80.0 8.0 Glycerin 80.0 8.0 Na~HPO~ 12H20 NaCl 6.5 0.6 MgCl 0.2 0.02 ~Cl 0.2 0.02 Tannin 12.0 1.2 MgO2 2.5 0.25 Pectin 80.0 8.0 Peppermint oil 1.0 0.1 Benzalkonium chloride 0.002 0.0002 H2O ad 100.0 .
WO 97/46246 . PCT/Ee97/02849 Example q Component Content in grams Approx. content in %
Betaine 20.0 2.0 Calendula 0.5 0.05 Hamamelis 0-5 0-05 Pectin 30.0 3.0 Tannin 10.0 1.0 Glycerin 20.0 2.0 Na,HPO~12H2O 6.0 0.6 MgC~ 1.0 0.1 KCl 1.0 0.1 NaCl 10.0 1.0 Peppermint oil 0.5 0.05 H2O ad 100.0 .
Example 5 Component Content in grams Approx. content in %
Betaine 20.0 2.0 Avena sativa 1.0 0.7 Echinacea angustifolia 1.0 0.1 Urtica dioica 1.0 0.1 Pectin 1.5 0.15 NaCl 0.3 0.03 KCl 0 3 MgCl 0.3 0.03 Peppermint oil ~ 2.0 0.2 CaHPO~ 2H20 Tannin 0.2 0.02 FeSO, . 0.02 0.002 H2O ad 100.0 Example 6 Component Content in grams Approx. content in %
Betaine 60.0 6.0 Pectin 110.0 11.0 Tannin 15.0 1.5 CaH(PO~)2 100.0 10.0 Glycerin 115.0 11.5 NaCl 14.0 1.4 MgCl 1.0 0.1 KCl 1.0 0.1 Na~HP0~12HzO 12.0 1.2 MgO2 2.0 0.2 Peppermint oil 1.0 0.1 Benzalkonium chloride 0.002 0.0002 H2O ad 100.0 , _
Claims (8)
1. Complex preparations containing the following components:
a) one or more ion-containing compounds and lipotropic substances b) an astringent agent, a bonding and adhesive agent, a moisturizing agent and one or more etheric oils c) if necessary, amino acids, proteins, antimycotic, anti-inflammatory, plant, and other components necessary for the purpose of the invention, characterized by a betaine content.
a) one or more ion-containing compounds and lipotropic substances b) an astringent agent, a bonding and adhesive agent, a moisturizing agent and one or more etheric oils c) if necessary, amino acids, proteins, antimycotic, anti-inflammatory, plant, and other components necessary for the purpose of the invention, characterized by a betaine content.
2. Preparations as in claim 1, wherein component a) contains Na-, K-, Cl-, Mg-, Ca, and phosphate compounds, or at least one of these compounds.
3. Preparations as in claims 1 and 2, wherein component b) contains tannin or an acidic compound as an astringent, pectin or a gel as a bonding and adhesive agent, peppermint oil as an etheric oil, or at least one of these components.
4. Preparations as in claims 1, 2, and 3, wherein component c) contains, if necessary, amino acid-containing substances, acid-containing substances, lipotropic substances, bacteriostatics, lanolin, eucerin, plant extracts, waxes, dyes, oils, starches, tin, iron, sulphate compounds, gelatins, fats, carbamide, tensides, paraffins, vaseline, sandalwood oil, camphor, or preservatives.
[stamp:] CHANGED PAGE
[stamp:] CHANGED PAGE
5. Preparations according to claims 1 and 2, characteristic in that they contain at least 1.0 - 10 percent betaine; 0.6 - 2.0 percent NaCl; 0.02 - 0.5 percent KCl; 0.02 - 0.5 percent MgCl; 0.2 - 0.5 percent MgO; 0.5 - 2.0 percent tannin;
2.0 - 20 percent glycerine; 3.0 - 20 percent pectin; 0.6 - 2.0 Na2HPO4~12H2O; 3.0 - 20 percent Ca3(PO4)2; 0.1 - 0.6 percent peppermint oil.
2.0 - 20 percent glycerine; 3.0 - 20 percent pectin; 0.6 - 2.0 Na2HPO4~12H2O; 3.0 - 20 percent Ca3(PO4)2; 0.1 - 0.6 percent peppermint oil.
6. Preparations according to claims 1 through 5, wherein the pH value is between 2.5 and 7.8 and the osmotic pressure is greater than 10 Atm.
7. Preparations according to claims 1 through 6, for treating, influencing, maintaining, and improving of microcirculation, cellular function, physiological processes, especially in skin and muscle tissues, fibers, joints, and for healing, care, and prevention of tissue-damaging processes, tissue and body deformation, strengthening of immunity, and delivery of necessary mineral materials, vitamins, enzymes, and other materials.
8. Preparations according to claims 1 through 7, in the form of a solution, paste, cream, emulsion, gel, salve, powder, spray, foam, gelatine, tablets, capsules, textile wound bandages, bandage material, also partially or entirely mixed with other agents, for topical, intracorporeal, or oral use.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19622708.9 | 1996-06-05 | ||
| DE1996122708 DE19622708A1 (en) | 1996-06-05 | 1996-06-05 | Aqueous compositions containing betaine |
| DE1996148232 DE19648232A1 (en) | 1996-11-21 | 1996-11-21 | Aqueous compositions containing betaine |
| DE19648232.1 | 1996-11-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2257559A1 true CA2257559A1 (en) | 1997-12-11 |
Family
ID=26026360
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002257559A Abandoned CA2257559A1 (en) | 1996-06-05 | 1997-06-02 | Complex preparations characterised by a betain content |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0914138B1 (en) |
| JP (1) | JP2000514414A (en) |
| AT (1) | ATE234105T1 (en) |
| AU (1) | AU3170997A (en) |
| BR (1) | BR9709539A (en) |
| CA (1) | CA2257559A1 (en) |
| DE (2) | DE19780509D2 (en) |
| WO (1) | WO1997046246A1 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8557228B2 (en) | 2009-12-23 | 2013-10-15 | Colgate-Palmolive Company | Aqueous antiperspirant composition |
| AU2020272040B2 (en) * | 2019-04-10 | 2023-09-14 | The Regents Of The University Of Colorado, A Body Corporate | Compositions and methods for treating homocystinuria and other conditions |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPO821097A0 (en) * | 1997-07-25 | 1997-08-14 | Cultor Ltd. | A prophylactic |
| DE19855934A1 (en) * | 1998-12-04 | 2000-06-08 | Beiersdorf Ag | Use of betaines as antiperspirants |
| JP3503884B2 (en) * | 2000-01-28 | 2004-03-08 | 花王株式会社 | Cosmetics |
| WO2004011032A1 (en) * | 2002-07-26 | 2004-02-05 | Mikasa Seiyaku Co., Ltd. | External preparation |
| EP1675559B1 (en) | 2003-04-04 | 2009-11-11 | Colgate-Palmolive Company | Glycine-free antiperspirant salts with betaine for enhanced cosmetic products |
| US7204976B2 (en) | 2003-05-30 | 2007-04-17 | Colgate-Palmolive Company | High efficacy gel with low glycol content |
| US7105691B2 (en) | 2003-06-26 | 2006-09-12 | Colgate-Palmolive Company | Aluminum / zirconium / glycine antiperspirant actives stabilized with Betaine |
| US9789038B2 (en) | 2007-02-02 | 2017-10-17 | Colgate-Palmolive Company | Antiperspirant/deodorant compositions |
| US7976828B2 (en) | 2007-02-02 | 2011-07-12 | Colgate-Palmolive Company | Antiperspirant/deodorant composition |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2106386A (en) * | 1981-05-27 | 1983-04-13 | Ralph Brooke | A composition for the treatment of scalp and hair to retard loss and maintain and enhance the growth of hair |
| DE3816442A1 (en) * | 1988-05-13 | 1989-11-23 | Tomic Dobrivoje | AGENTS FOR TREATING MYCOTIC, MICROBIC AND OTHER TISSUE-DAMAGING AND PATHOLOGICAL MANIFESTATIONS AND TISSUE INFORMATION |
-
1997
- 1997-06-02 AU AU31709/97A patent/AU3170997A/en not_active Abandoned
- 1997-06-02 BR BR9709539A patent/BR9709539A/en not_active Application Discontinuation
- 1997-06-02 DE DE19780509T patent/DE19780509D2/en not_active Ceased
- 1997-06-02 DE DE59709512T patent/DE59709512D1/en not_active Expired - Fee Related
- 1997-06-02 AT AT97927099T patent/ATE234105T1/en not_active IP Right Cessation
- 1997-06-02 WO PCT/EP1997/002849 patent/WO1997046246A1/en active IP Right Grant
- 1997-06-02 CA CA002257559A patent/CA2257559A1/en not_active Abandoned
- 1997-06-02 JP JP10500213A patent/JP2000514414A/en active Pending
- 1997-06-02 EP EP97927099A patent/EP0914138B1/en not_active Expired - Lifetime
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8557228B2 (en) | 2009-12-23 | 2013-10-15 | Colgate-Palmolive Company | Aqueous antiperspirant composition |
| US8663610B2 (en) | 2009-12-23 | 2014-03-04 | Colgate-Palmolive Company | Method of making an anhydrous liquid antiperspirant composition |
| US8815222B2 (en) | 2009-12-23 | 2014-08-26 | Colgate—Palmolive Company | Anhydrous liquid antiperspirant composition |
| US9585825B2 (en) | 2009-12-23 | 2017-03-07 | Colgate-Palmolive Company | Method of making an anhydrous liquid antiperspirant composition |
| AU2020272040B2 (en) * | 2019-04-10 | 2023-09-14 | The Regents Of The University Of Colorado, A Body Corporate | Compositions and methods for treating homocystinuria and other conditions |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2000514414A (en) | 2000-10-31 |
| DE59709512D1 (en) | 2003-04-17 |
| AU3170997A (en) | 1998-01-05 |
| ATE234105T1 (en) | 2003-03-15 |
| BR9709539A (en) | 1999-08-10 |
| EP0914138A1 (en) | 1999-05-12 |
| EP0914138B1 (en) | 2003-03-12 |
| DE19780509D2 (en) | 1999-08-05 |
| WO1997046246A1 (en) | 1997-12-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |