CA2252783A1 - Method for improved selectivity in photo-activation of molecular agents - Google Patents

Method for improved selectivity in photo-activation of molecular agents Download PDF

Info

Publication number
CA2252783A1
CA2252783A1 CA002252783A CA2252783A CA2252783A1 CA 2252783 A1 CA2252783 A1 CA 2252783A1 CA 002252783 A CA002252783 A CA 002252783A CA 2252783 A CA2252783 A CA 2252783A CA 2252783 A1 CA2252783 A1 CA 2252783A1
Authority
CA
Canada
Prior art keywords
coumarin
photo
tissue
light
molecular agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002252783A
Other languages
English (en)
French (fr)
Inventor
Walter G. Fisher
Eric A. Wachter
H. Craig Dees
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Photogen Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24973830&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2252783(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Individual filed Critical Individual
Publication of CA2252783A1 publication Critical patent/CA2252783A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/008—Two-Photon or Multi-Photon PDT, e.g. with upconverting dyes or photosensitisers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B2017/00017—Electrical control of surgical instruments
    • A61B2017/00022—Sensing or detecting at the treatment site
    • A61B2017/00057—Light
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/062—Photodynamic therapy, i.e. excitation of an agent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nanotechnology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Radiation-Therapy Devices (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA002252783A 1996-10-30 1997-10-28 Method for improved selectivity in photo-activation of molecular agents Abandoned CA2252783A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/739,801 US5829448A (en) 1996-10-30 1996-10-30 Method for improved selectivity in photo-activation of molecular agents
US08/739,801 1996-10-30

Publications (1)

Publication Number Publication Date
CA2252783A1 true CA2252783A1 (en) 1998-05-07

Family

ID=24973830

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002252783A Abandoned CA2252783A1 (en) 1996-10-30 1997-10-28 Method for improved selectivity in photo-activation of molecular agents

Country Status (14)

Country Link
US (3) US5829448A (forum.php)
EP (1) EP0977592A4 (forum.php)
JP (1) JP2000511929A (forum.php)
KR (1) KR20000035893A (forum.php)
CN (1) CN1226148A (forum.php)
AU (1) AU716507B2 (forum.php)
BR (1) BR9712599A (forum.php)
CA (1) CA2252783A1 (forum.php)
IL (1) IL128355A (forum.php)
IN (1) IN186854B (forum.php)
IS (1) IS5006A (forum.php)
NO (1) NO991492L (forum.php)
NZ (1) NZ334190A (forum.php)
WO (1) WO1998018399A1 (forum.php)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006015493A1 (en) * 2004-08-13 2006-02-16 Derma Laser Inc Method for the treatment of mammalian skin tissues via pulse irradiation in the presence of a photoactive compound

Families Citing this family (137)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5912257A (en) 1995-09-06 1999-06-15 The Research Foundation Of State University Of New York Two-photon upconverting dyes and applications
US6493570B1 (en) * 1998-11-02 2002-12-10 Photogen, Inc. Method for improved imaging and photodynamic therapy
US7353829B1 (en) * 1996-10-30 2008-04-08 Provectus Devicetech, Inc. Methods and apparatus for multi-photon photo-activation of therapeutic agents
US7036516B1 (en) * 1996-10-30 2006-05-02 Xantech Pharmaceuticals, Inc. Treatment of pigmented tissues using optical energy
US6525862B2 (en) 1996-10-30 2003-02-25 Photogen, Inc. Methods and apparatus for optical imaging
US20060095097A1 (en) * 1996-10-30 2006-05-04 Provectus Devicetech, Inc. Treatment of pigmented tissue using optical energy
US6331286B1 (en) 1998-12-21 2001-12-18 Photogen, Inc. Methods for high energy phototherapeutics
US7390668B2 (en) * 1996-10-30 2008-06-24 Provectus Pharmatech, Inc. Intracorporeal medicaments for photodynamic treatment of disease
AU6569198A (en) * 1997-03-19 1998-10-12 Lucid Technologies, Inc. Cellular surgery utilizing confocal microscopy
US8974363B2 (en) 1997-12-11 2015-03-10 Provectus Pharmatech, Inc. Topical medicaments and methods for photodynamic treatment of disease
EP2133725B1 (en) * 1998-04-21 2018-06-06 University of Connecticut Fabrication method for nanofabrication using multi-photon excitation
US6223071B1 (en) 1998-05-01 2001-04-24 Dusa Pharmaceuticals Inc. Illuminator for photodynamic therapy and diagnosis which produces substantially uniform intensity visible light
US20090117199A1 (en) * 1998-08-06 2009-05-07 Scott Timothy C Method of treatment of cancer
US8557298B2 (en) 1998-08-06 2013-10-15 Provectus Pharmatech, Inc. Medicaments for chemotherapeutic treatment of disease
IL141273A0 (en) 1998-08-06 2002-03-10 Photogen Inc Improved method for targeted topical treatment of disease
US6986740B2 (en) * 1998-11-02 2006-01-17 Xantech Pharmaceuticals, Inc. Ultrasound contrast using halogenated xanthenes
US6936044B2 (en) * 1998-11-30 2005-08-30 Light Bioscience, Llc Method and apparatus for the stimulation of hair growth
US6887260B1 (en) * 1998-11-30 2005-05-03 Light Bioscience, Llc Method and apparatus for acne treatment
US9192780B2 (en) 1998-11-30 2015-11-24 L'oreal Low intensity light therapy for treatment of retinal, macular, and visual pathway disorders
US6283956B1 (en) * 1998-11-30 2001-09-04 David H. McDaniels Reduction, elimination, or stimulation of hair growth
US20060212025A1 (en) 1998-11-30 2006-09-21 Light Bioscience, Llc Method and apparatus for acne treatment
US7384623B1 (en) 1998-12-21 2008-06-10 Provectus Pharmatech, Inc. High energy phototherapeutic agents
US8470296B2 (en) * 1998-12-21 2013-06-25 Provectus Pharmatech, Inc. Intracorporeal medicaments for high energy phototherapeutic treatment of disease
US20020001567A1 (en) * 1998-12-21 2002-01-03 Photogen, Inc. Intracorporeal medicaments for high energy phototherapeutic treatment of disease
AU2504900A (en) * 1999-01-15 2000-08-01 Light Sciences Corporation Therapeutic compositions for metabolic bone disorders or bone metastases
US6454789B1 (en) 1999-01-15 2002-09-24 Light Science Corporation Patient portable device for photodynamic therapy
CA2356532A1 (en) 1999-01-15 2000-07-20 Light Sciences Corporation Noninvasive vascular therapy
US6602274B1 (en) 1999-01-15 2003-08-05 Light Sciences Corporation Targeted transcutaneous cancer therapy
US6584342B1 (en) * 1999-02-12 2003-06-24 Alexei I. Trushin Method for diagnosing proliferation regions and device for realizing the same
WO2001006505A1 (en) * 1999-07-15 2001-01-25 Trid Store Ip, L.L.C. Multilayer fluorescent optical disc with photosensitive fluorescent material
AU775373B2 (en) 1999-10-01 2004-07-29 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
US7167615B1 (en) 1999-11-05 2007-01-23 Board Of Regents, The University Of Texas System Resonant waveguide-grating filters and sensors and methods for making and using same
US6319273B1 (en) * 1999-12-16 2001-11-20 Light Sciences Corporation Illuminating device for treating eye disease
US7897140B2 (en) 1999-12-23 2011-03-01 Health Research, Inc. Multi DTPA conjugated tetrapyrollic compounds for phototherapeutic contrast agents
AU2001227837A1 (en) * 2000-01-12 2001-07-24 Light Sciences Corporation Novel treatment for eye disease
US8215314B2 (en) * 2000-02-11 2012-07-10 The General Hospital Corporation Photochemical tissue bonding
CA2399414A1 (en) * 2000-02-11 2001-08-16 The General Hospital Corporation Photochemical tissue bonding
US7073510B2 (en) * 2000-02-11 2006-07-11 The General Hospital Corporation Photochemical tissue bonding
WO2002019594A2 (en) 2000-08-02 2002-03-07 Arizona Board Of Regents, Acting On Behalf Of Arizona State University Scanning fluorescence lifetime microscope: directed evolution
JP4659300B2 (ja) * 2000-09-13 2011-03-30 浜松ホトニクス株式会社 レーザ加工方法及び半導体チップの製造方法
US7973936B2 (en) * 2001-01-30 2011-07-05 Board Of Trustees Of Michigan State University Control system and apparatus for use with ultra-fast laser
US8208505B2 (en) * 2001-01-30 2012-06-26 Board Of Trustees Of Michigan State University Laser system employing harmonic generation
US7450618B2 (en) * 2001-01-30 2008-11-11 Board Of Trustees Operating Michigan State University Laser system using ultrashort laser pulses
US7567596B2 (en) * 2001-01-30 2009-07-28 Board Of Trustees Of Michigan State University Control system and apparatus for use with ultra-fast laser
US7609731B2 (en) * 2001-01-30 2009-10-27 Board Of Trustees Operating Michigan State University Laser system using ultra-short laser pulses
AU2002245345A1 (en) 2001-01-30 2002-08-12 Board Of Trustees Operating Michigan State University Control system and apparatus for use with laser excitation or ionization
US7583710B2 (en) * 2001-01-30 2009-09-01 Board Of Trustees Operating Michigan State University Laser and environmental monitoring system
US20040102765A1 (en) * 2001-03-27 2004-05-27 Karsten Koenig Method for the minimal-to non-invase optical treatment of tissues of the eye and for diagnosis thereof and device for carrying out said method
US6894161B2 (en) * 2001-03-27 2005-05-17 The University Of British Columbia Methods and compositions for photo-cross linking photoactive compounds to target tissue
WO2002084271A2 (en) * 2001-04-16 2002-10-24 The Regents Of The University Of California Methods and sensors for luminescent and optoelectronic detection and analysis of polynucleotides
EP1401479B1 (en) * 2001-06-04 2007-04-18 The General Hospital Corporation Detection and therapy of vulnerable plaque with photodynamic compounds
EP1312353A1 (en) * 2001-11-16 2003-05-21 Ecole Polytechnique Federale De Lausanne (Epfl) Method for hair removal
US6960201B2 (en) * 2002-02-11 2005-11-01 Quanticum, Llc Method for the prevention and treatment of skin and nail infections
US7494502B2 (en) 2002-02-11 2009-02-24 Keraderm, Llc Alteration of the skin and nail for the prevention and treatment of skin and nail infections
US20030191458A1 (en) * 2002-04-03 2003-10-09 Cornelius Diamond Light-activated drug delivery method and device
DE60328496D1 (en) 2002-06-27 2009-09-03 Health Research Inc Fluorinierte chlorin und bacteriochlorin photosensitizer für fotodynamische therapie
AU2003249742A1 (en) 2002-07-02 2004-01-23 Health Research, Inc. Efficient synthesis of pyropheophorbide a and its derivatives
US8506979B2 (en) * 2002-08-28 2013-08-13 Nomir Medical Technologies, Inc. Near-infrared electromagnetic modification of cellular steady-state membrane potentials
US20080131968A1 (en) * 2002-08-28 2008-06-05 Nomir Medical Technologies, Inc. Near-infrared electromagnetic modification of cellular steady-state membrane potentials
US7713294B2 (en) 2002-08-28 2010-05-11 Nomir Medical Technologies, Inc. Near infrared microbial elimination laser systems (NIMEL)
US20040156743A1 (en) * 2002-08-28 2004-08-12 Eric Bornstein Near infrared microbial elimination laser system
AU2002347689A1 (en) * 2002-09-27 2004-04-19 Wilson O. Garcia Two-color (two-photon) excitation with focused excitation beams and a raman shifter
EP2221810B1 (en) * 2002-10-10 2014-09-24 Landauer, Inc. Method of erasing information stored on a luminescent data storage medium comprising aluminium oxide base material
WO2004092335A2 (en) 2003-04-10 2004-10-28 Light Bioscience, Inc. Photomodulation methods and devices for regulating cell proliferation and gene expression
ATE498426T1 (de) * 2003-06-20 2011-03-15 Univ Keio Photodynamisches therapiegerät
JP4739202B2 (ja) * 2003-07-31 2011-08-03 ジェントルウェイブス エルエルシー 熱傷、創傷、および関連皮膚疾患の光力学治療のためのシステムおよび方法
US7890157B2 (en) * 2003-08-19 2011-02-15 Cedars-Sinai Medical Center Method for fluorescence lifetime imaging microscopy and spectroscopy
US20050053895A1 (en) 2003-09-09 2005-03-10 The Procter & Gamble Company Attention: Chief Patent Counsel Illuminated electric toothbrushes emitting high luminous intensity toothbrush
US20050085455A1 (en) * 2003-10-16 2005-04-21 Light Sciences Corporation Photodynamic therapy for local adipocyte reduction
WO2006049132A1 (ja) * 2004-11-02 2006-05-11 Keio University 光線力学的治療装置
CA2526327C (en) * 2004-11-09 2014-01-07 Institut National D'optique Device for transmitting multiple optically-encoded stimulation signals to multiple cell locations
JP2008522492A (ja) * 2004-11-20 2008-06-26 センテラ インコーポレイテッド 高周波信号放出装置
US7280078B2 (en) 2004-11-20 2007-10-09 Scenterra, Inc. Sensor for detecting high frequency signals
WO2006088841A1 (en) * 2005-02-14 2006-08-24 Board Of Trustees Of Michigan State University Ultra-fast laser system
JP5619351B2 (ja) * 2005-05-31 2014-11-05 ダブリュ・オー・エム・ワールド・オブ・メディスン・アー・ゲーＷ．Ｏ．Ｍ． Ｗｏｒｌｄ Ｏｆｍｅｄｉｃｉｎｅ Ａｇ 組織を視覚的に特徴づけるための方法および装置
JP2009502258A (ja) * 2005-07-21 2009-01-29 ノミール・メディカル・テクノロジーズ・インコーポレーテッド 標的部位の生物学的汚染物質のレベルを下げる方法
WO2007064703A2 (en) 2005-11-30 2007-06-07 Board Of Trustees Of Michigan State University Laser based identification of molecular characteristics
RU2314023C2 (ru) * 2006-01-30 2008-01-10 Михаил Витальевич Мошнин Способ определения момента появления псораленов в коже пациента
WO2007145702A2 (en) * 2006-04-10 2007-12-21 Board Of Trustees Of Michigan State University Laser material processing systems and methods with, in particular, use of a hollow waveguide for broadening the bandwidth of the pulse above 20 nm
US20090203991A1 (en) * 2006-04-21 2009-08-13 Cedars-Sinai Medical Center Multiple imaging and/or spectroscopic modality probe
US20080275432A1 (en) * 2006-05-11 2008-11-06 Ceramoptec Industries, Inc. Photodynamic foam composition and sclerosis treatment
CA2670711A1 (en) * 2006-12-12 2008-06-19 Nomir Medical Technologies, Inc. Near-infrared electromagnetic modification of cellular steady-state membrane potentials
US20080208295A1 (en) * 2007-02-28 2008-08-28 Cumbie William E Phototherapy Treatment and Device to Improve the Appearance of Nails and skin
WO2015195896A1 (en) 2014-06-19 2015-12-23 Immunolight, Llc Methods and systems for treating cell proliferation disorders with psoralen derivatives
US9358292B2 (en) * 2007-04-08 2016-06-07 Immunolight, Llc Methods and systems for treating cell proliferation disorders
AU2016210665B2 (en) * 2007-04-08 2017-12-07 Immunolight, Llc Methods and systems for treating cell proliferation disorders
US8376013B2 (en) 2008-03-11 2013-02-19 Duke University Plasmonic assisted systems and methods for interior energy-activation from an exterior source
US20140324138A1 (en) * 2007-05-09 2014-10-30 Massachusetts Institute Of Technology Wirelessly-powered illumination of biological tissue
US20090104212A1 (en) * 2007-08-06 2009-04-23 Immunolight Methods and systems for treating cell proliferation disorders using two-photon simultaneous absorption
JP2010540900A (ja) 2007-09-18 2010-12-24 アプライド バイオシステムズ インコーポレイテッド 集光機構のための方法、システムおよび装置
WO2009052187A2 (en) * 2007-10-15 2009-04-23 Stokes John P Convergent well irradiating plaque for choroidal melanoma
US8168958B2 (en) * 2007-10-18 2012-05-01 The Invention Science Fund I, Llc Ionizing-radiation-responsive compositions, methods, and systems
US20090104113A1 (en) * 2007-10-18 2009-04-23 Searete Llc Ionizing-radiation-responsive compositions, methods, and systems
US8529426B2 (en) 2007-10-18 2013-09-10 The Invention Science Fund I Llc Ionizing-radiation-responsive compositions, methods, and systems
US8684898B2 (en) * 2007-10-18 2014-04-01 The Invention Science Fund I Llc Ionizing-radiation-responsive compositions, methods, and systems
US8227204B2 (en) * 2007-10-18 2012-07-24 The Invention Science Fund I, Llc Ionizing-radiation-responsive compositions, methods, and systems
US9557635B2 (en) * 2007-10-18 2017-01-31 Gearbox, Llc Ionizing-radiation-responsive compositions, methods, and systems
US8164074B2 (en) * 2007-10-18 2012-04-24 The Invention Science Fund I, Llc Ionizing-radiation-responsive compositions, methods, and systems
US9439897B2 (en) 2007-11-06 2016-09-13 Immunolight, Llc Use of psoralen derivatives and combination therapy for treatment of cell proliferation disorders
EP2232653B1 (en) 2007-12-21 2013-03-27 Board of Trustees of Michigan State University Phase control in ultrashort pulse lasers by a deformable mirror in the pulse stretcher
TWI574712B (zh) * 2008-02-21 2017-03-21 伊穆諾萊特公司 利用電漿子增強之光譜療法（ｐｅｐｓｔ）及激子-電漿增強之光療法（ｅｐｅｐ）治療細胞增生病症之組合物及產生自體疫苗之系統
DE102008011811B3 (de) * 2008-02-29 2009-10-15 Anton Dr. Kasenbacher Dentales Laserbearbeitungsgerät zur Bearbeitung von Zahnmaterial
WO2013009688A1 (en) 2011-07-08 2013-01-17 Bourke Frederic A Phosphors and scintillators for light stimulation within a medium
CA3095369C (en) * 2008-04-04 2023-09-26 Immunolight, Llc Non-invasive systems and methods for in-situ photobiomodulation
WO2010009106A1 (en) 2008-07-14 2010-01-21 Bourke Frederic A Jr Advanced methods and systems for treating cell proliferation disorders
DE102009005194B4 (de) * 2009-01-20 2016-09-08 Anton Kasenbacher Laserbearbeitungsgerät zur Bearbeitung eines Materials
EP2211430A3 (en) * 2009-01-23 2015-05-27 Board of Trustees of Michigan State University Laser autocorrelation system
WO2010141128A2 (en) 2009-03-05 2010-12-09 Board Of Trustees Of Michigan State University Laser amplification system
TWI511756B (zh) 2009-04-21 2015-12-11 伊穆諾萊特公司 用以修飾介導生物活性或與生物活性有關之標靶結構之醫藥組合物或套組
US20110054305A1 (en) * 2009-08-30 2011-03-03 Stephen Eliot Zweig Photon upconverting implantable medical devices
US20110275686A1 (en) * 2009-12-11 2011-11-10 Biolitec, Inc. Nanoparticle carrier systems based on poly(dl-lactic-co-glycolic acid) (plga) for photodynamic therapy (pdt)
US8630322B2 (en) * 2010-03-01 2014-01-14 Board Of Trustees Of Michigan State University Laser system for output manipulation
US9642687B2 (en) 2010-06-15 2017-05-09 The Procter & Gamble Company Methods for whitening teeth
US9095414B2 (en) * 2011-06-24 2015-08-04 The Regents Of The University Of California Nonlinear optical photodynamic therapy (NLO-PDT) of the cornea
EP2786380A1 (en) * 2011-12-02 2014-10-08 The Charles Stark Draper Laboratory, Inc. Adiabatic rapid passage atomic beamsplitter using frequency-swept coherent laser beam pairs
US10549112B2 (en) 2012-07-20 2020-02-04 The General Hospital Corporation Apparatus for tissue irradiation and methods and kits utilizing the same
WO2014015274A1 (en) 2012-07-20 2014-01-23 The General Hospital Corporation Methods for tissue passivation
WO2014055960A1 (en) 2012-10-05 2014-04-10 Genelux Corporation Energy absorbing-based diagnostic and therapeutic methods employing nucleic acid molecules encoding chromophore-producing enzymes
WO2014168734A1 (en) 2013-03-15 2014-10-16 Cedars-Sinai Medical Center Time-resolved laser-induced fluorescence spectroscopy systems and uses thereof
WO2014174010A1 (en) * 2013-04-25 2014-10-30 Koninklijke Philips N.V. Non-invasive device for treatment of the skin using laser light
AU2014290513B2 (en) 2013-07-18 2017-07-27 The General Hospital Corporation Vessel treatment systems, methods, and kits
WO2015108991A2 (en) 2014-01-17 2015-07-23 Imra America, Inc. Laser-based modification of transparent materials
EP3137165A4 (en) * 2014-04-29 2018-02-14 Theralase Technologies Inc. Apparatus and method for multiwavelength photodynamic therapy
EP3183037B1 (en) * 2014-08-18 2022-03-16 Immunolight, Llc. Compositions for selective activation of photoreactive responses
US20160088804A1 (en) * 2014-09-29 2016-03-31 King Abdullah University Of Science And Technology Laser-based agriculture system
US9897448B2 (en) 2014-10-31 2018-02-20 The Charles Stark Draper Laboratory, Inc. Systems and methods for multiple species atom interferometry
US10331087B2 (en) 2014-12-03 2019-06-25 The Charles Stark Draper Laboratory, Inc. Atom interferometry in dynamic environments
US11123366B1 (en) 2014-12-15 2021-09-21 Children's Hospital Of Orange County Methods, materials, and systems for treating injuries to the central nervous system using light emitting nanoparticles
CA2973200C (en) 2015-01-14 2023-09-26 Immunolight, Llc Non-invasive systems and methods for treatment of a host carrying a virus with photoactivatable drugs
CN115561211A (zh) 2016-04-01 2023-01-03 黑光外科公司 用于时间分辨荧光光谱法的系统、装置和方法
ES2983061T3 (es) 2017-11-29 2024-10-21 Univ Rockefeller Combinación de terapias locales y sistémicas para mejorar el tratamiento de afecciones dermatológicas
EP3773548B1 (en) 2018-05-16 2023-08-09 Provectus Pharmatech, Inc. In vitro and xenograft anti-tumor activity of a halogenated-xanthene against refractory pediatric solid tumors
US12064507B2 (en) 2019-11-19 2024-08-20 Provectus Pharmatech, Inc. Composition and method for oral treatment of leukemia
US11419844B2 (en) 2019-11-19 2022-08-23 Provectus Pharmatech, Inc. Halogenated xanthene composition and method for treating hematologic cancers
WO2021195400A1 (en) 2020-03-26 2021-09-30 Provectus Pharmatech, Inc. Novel uses of halogenated xanthenes in oncology and virology
US11938182B2 (en) 2020-03-26 2024-03-26 Provectus Pharmatech, Inc. Halogenated xanthenes as vaccine adjuvants
CN111592920A (zh) * 2020-05-21 2020-08-28 新沂百川畅银新能源有限公司 一种沼气脱硫净化工艺

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4589881A (en) * 1982-08-04 1986-05-20 La Jolla Cancer Research Foundation Polypeptide
US4578079A (en) * 1982-08-04 1986-03-25 La Jolla Cancer Research Foundation Tetrapeptide
JPS63111886A (ja) * 1986-10-29 1988-05-17 呉羽化学工業株式会社 光ダイオ−ドを用いた癌治療装置
US5053006A (en) * 1988-04-19 1991-10-01 Watson Brant D Method for the permanent occlusion of arteries
US4925736A (en) * 1988-07-06 1990-05-15 Long Island Jewish Medical Center Topical hematoporphyrin
US5654267A (en) * 1988-12-20 1997-08-05 La Jolla Cancer Research Center Cooperative combinations of ligands contained within a matrix
US5498694A (en) * 1989-05-25 1996-03-12 La Jolla Cancer Research Foundation Peptides of the cytoplasmic domain of integrin
US4973848A (en) * 1989-07-28 1990-11-27 J. Mccaughan Laser apparatus for concurrent analysis and treatment
US5121398A (en) * 1989-09-26 1992-06-09 Excel Technology, Inc. Broadly tunable, high repetition rate solid state lasers and uses thereof
US5034613A (en) * 1989-11-14 1991-07-23 Cornell Research Foundation, Inc. Two-photon laser microscopy
EP0505355A4 (en) * 1989-12-11 1992-12-30 Lasb Laser, Corp. Laser therapeutic apparatus and method
US5629291A (en) * 1992-01-31 1997-05-13 La Jolla Cancer Research Foundation Methods of modulating fibronectin extracellular matrix assembly
US5627263A (en) * 1993-11-24 1997-05-06 La Jolla Cancer Research Foundation Integrin-binding peptides
US5558666A (en) * 1994-01-14 1996-09-24 Coherent, Inc. Handpiece for producing highly collimated laser beam for dermatological procedures
US5586981A (en) * 1994-08-25 1996-12-24 Xin-Hua Hu Treatment of cutaneous vascular and pigmented lesions
US5643334A (en) * 1995-02-07 1997-07-01 Esc Medical Systems Ltd. Method and apparatus for the diagnostic and composite pulsed heating and photodynamic therapy treatment
US5576013A (en) * 1995-03-21 1996-11-19 Eastern Virginia Medical School Treating vascular and neoplastic tissues
US5912257A (en) * 1995-09-06 1999-06-15 The Research Foundation Of State University Of New York Two-photon upconverting dyes and applications
US5622699A (en) * 1995-09-11 1997-04-22 La Jolla Cancer Research Foundation Method of identifying molecules that home to a selected organ in vivo
US5759767A (en) * 1996-10-11 1998-06-02 Joseph R. Lakowicz Two-photon and multi-photon measurement of analytes in animal and human tissues and fluids
US5832931A (en) * 1996-10-30 1998-11-10 Photogen, Inc. Method for improved selectivity in photo-activation and detection of molecular diagnostic agents

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006015493A1 (en) * 2004-08-13 2006-02-16 Derma Laser Inc Method for the treatment of mammalian skin tissues via pulse irradiation in the presence of a photoactive compound

Also Published As

Publication number Publication date
EP0977592A1 (en) 2000-02-09
JP2000511929A (ja) 2000-09-12
IL128355A0 (en) 2000-01-31
KR20000035893A (ko) 2000-06-26
IL128355A (en) 2002-11-10
EP0977592A4 (en) 2001-01-10
WO1998018399A1 (en) 1998-05-07
AU5152898A (en) 1998-05-22
US5829448A (en) 1998-11-03
US5998597A (en) 1999-12-07
IS5006A (is) 1999-03-19
NO991492D0 (no) 1999-03-26
NZ334190A (en) 2000-10-27
BR9712599A (pt) 1999-12-21
NO991492L (no) 1999-05-31
IN186854B (forum.php) 2001-11-24
AU716507B2 (en) 2000-02-24
US6042603A (en) 2000-03-28
CN1226148A (zh) 1999-08-18

Similar Documents

Publication Publication Date Title
US5829448A (en) Method for improved selectivity in photo-activation of molecular agents
US7353829B1 (en) Methods and apparatus for multi-photon photo-activation of therapeutic agents
US7346387B1 (en) Methods for improved selectivity in photo-activation and detection of molecular diagnostic agents
KR20010080932A (ko) 개선된 조영 방법 및 광역학 요법
CN113274496A (zh) 用于原位光生物调节的非侵入性系统和方法
BENSON Jr Laser photodynamic therapy for bladder cancer
Bonneau et al. Tetrapyrrole photosensitisers, determinants of subcellular localisation and mechanisms of photodynamic processes in therapeutic approaches
Lassalle et al. Fluorescence imaging of Foscan® and Foslip in the plasma membrane and in whole cells
Atif et al. Role of sensitivity of zinc oxide nanorods (ZnO-NRs) based photosensitizers in hepatocellular site of biological tissue
EP1187555A1 (en) Improved methods and apparatus for multi-photon photo-activation and detection of molecular agents
Kamalov et al. Selective effect of laser radiation on cancer cells and laser spectroscopyof the cell
Wilson et al. Photodynamic therapy
Wachter et al. Photodynamic therapy with ultrafast lasers
HK1020853A (en) Method for improved selectivity in photo-activation of molecular agents
Wilson et al. Photodynamic therapy
Duarte Tunable organic lasers, light sheet illumination, and organic molecules for biology and medicine
Almughathawi et al. Photoluminescence-Based Phototherapy
Gupta et al. Multifunctional ORMOSIL and PAA nanoparticles
Misra Phase transition in laser irradiated dye-liposome complexes with implications for photodynamic therapy
Schlager Immunophototherapy for the treatment of AIDS and AIDS-related infections
MXPA99004045A (en) Method for improved selectivity in photo-activation and detection of molecular diagnostic agents

Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued