CA2250167C - Cryogenic accumulator for spin-polarized xenon-129 - Google Patents
Cryogenic accumulator for spin-polarized xenon-129 Download PDFInfo
- Publication number
- CA2250167C CA2250167C CA002250167A CA2250167A CA2250167C CA 2250167 C CA2250167 C CA 2250167C CA 002250167 A CA002250167 A CA 002250167A CA 2250167 A CA2250167 A CA 2250167A CA 2250167 C CA2250167 C CA 2250167C
- Authority
- CA
- Canada
- Prior art keywords
- hyperpolarized
- gas
- accumulation
- accumulation reservoir
- reservoir
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- FHNFHKCVQCLJFQ-YPZZEJLDSA-N xenon-129 atom Chemical compound [129Xe] FHNFHKCVQCLJFQ-YPZZEJLDSA-N 0.000 title claims abstract 67
- 238000009825 accumulation Methods 0.000 claims abstract description 188
- 238000000034 method Methods 0.000 claims abstract description 99
- 230000002102 hyperpolarization Effects 0.000 claims abstract description 95
- 238000003860 storage Methods 0.000 claims abstract description 25
- 239000007789 gas Substances 0.000 claims description 265
- 230000010287 polarization Effects 0.000 claims description 91
- 229910052724 xenon Inorganic materials 0.000 claims description 81
- FHNFHKCVQCLJFQ-UHFFFAOYSA-N xenon atom Chemical compound [Xe] FHNFHKCVQCLJFQ-UHFFFAOYSA-N 0.000 claims description 78
- 150000001340 alkali metals Chemical class 0.000 claims description 59
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 54
- 229910052783 alkali metal Inorganic materials 0.000 claims description 54
- 230000005291 magnetic effect Effects 0.000 claims description 37
- 238000005057 refrigeration Methods 0.000 claims description 37
- 229910052757 nitrogen Inorganic materials 0.000 claims description 30
- 229910052734 helium Inorganic materials 0.000 claims description 29
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 claims description 26
- 239000001307 helium Substances 0.000 claims description 25
- 239000007788 liquid Substances 0.000 claims description 21
- 238000010791 quenching Methods 0.000 claims description 20
- 230000000171 quenching effect Effects 0.000 claims description 20
- 229910052739 hydrogen Inorganic materials 0.000 claims description 12
- 230000005415 magnetization Effects 0.000 claims description 12
- 239000001257 hydrogen Substances 0.000 claims description 11
- 230000005855 radiation Effects 0.000 claims description 10
- 238000009833 condensation Methods 0.000 claims description 8
- 230000005494 condensation Effects 0.000 claims description 8
- 230000028161 membrane depolarization Effects 0.000 claims description 7
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 6
- 230000008014 freezing Effects 0.000 claims description 6
- 238000007710 freezing Methods 0.000 claims description 6
- 150000002431 hydrogen Chemical class 0.000 claims description 5
- 238000010924 continuous production Methods 0.000 claims description 4
- 239000012530 fluid Substances 0.000 claims description 3
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- 238000002595 magnetic resonance imaging Methods 0.000 abstract description 10
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- 241001465754 Metazoa Species 0.000 abstract description 2
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- MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 abstract 1
- 238000005086 pumping Methods 0.000 description 73
- 210000004027 cell Anatomy 0.000 description 68
- 229910052756 noble gas Inorganic materials 0.000 description 48
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- 239000000203 mixture Substances 0.000 description 31
- 229910052701 rubidium Inorganic materials 0.000 description 27
- IGLNJRXAVVLDKE-UHFFFAOYSA-N rubidium atom Chemical compound [Rb] IGLNJRXAVVLDKE-UHFFFAOYSA-N 0.000 description 27
- 238000005481 NMR spectroscopy Methods 0.000 description 23
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- 150000002835 noble gases Chemical class 0.000 description 13
- 239000000463 material Substances 0.000 description 11
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- 230000008901 benefit Effects 0.000 description 8
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- 229910052792 caesium Inorganic materials 0.000 description 7
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- 230000003595 spectral effect Effects 0.000 description 7
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- TVFDJXOCXUVLDH-UHFFFAOYSA-N caesium atom Chemical compound [Cs] TVFDJXOCXUVLDH-UHFFFAOYSA-N 0.000 description 6
- 238000013459 approach Methods 0.000 description 5
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- -1 ferrous metals Chemical class 0.000 description 3
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- 229910052760 oxygen Inorganic materials 0.000 description 3
- 239000004033 plastic Substances 0.000 description 3
- 229920003023 plastic Polymers 0.000 description 3
- 238000010926 purge Methods 0.000 description 3
- 239000003507 refrigerant Substances 0.000 description 3
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 2
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 2
- 239000003513 alkali Substances 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 210000002421 cell wall Anatomy 0.000 description 2
- 239000000356 contaminant Substances 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 230000002999 depolarising effect Effects 0.000 description 2
- 230000001066 destructive effect Effects 0.000 description 2
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- WZFUQSJFWNHZHM-UHFFFAOYSA-N 2-[4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]piperazin-1-yl]-1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethanone Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)N1CCN(CC1)CC(=O)N1CC2=C(CC1)NN=N2 WZFUQSJFWNHZHM-UHFFFAOYSA-N 0.000 description 1
- XMTQQYYKAHVGBJ-UHFFFAOYSA-N 3-(3,4-DICHLOROPHENYL)-1,1-DIMETHYLUREA Chemical compound CN(C)C(=O)NC1=CC=C(Cl)C(Cl)=C1 XMTQQYYKAHVGBJ-UHFFFAOYSA-N 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 238000000862 absorption spectrum Methods 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 239000005354 aluminosilicate glass Substances 0.000 description 1
- 229910052786 argon Inorganic materials 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000005388 borosilicate glass Substances 0.000 description 1
- 244000309464 bull Species 0.000 description 1
- 230000008859 change Effects 0.000 description 1
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- 238000013270 controlled release Methods 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
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- 229910001873 dinitrogen Inorganic materials 0.000 description 1
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- 239000003302 ferromagnetic material Substances 0.000 description 1
- 239000007888 film coating Substances 0.000 description 1
- 238000009501 film coating Methods 0.000 description 1
- 239000007792 gaseous phase Substances 0.000 description 1
- 238000005247 gettering Methods 0.000 description 1
- 238000007511 glassblowing Methods 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
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- 208000014674 injury Diseases 0.000 description 1
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- 230000031700 light absorption Effects 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
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- 150000002739 metals Chemical class 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 238000013421 nuclear magnetic resonance imaging Methods 0.000 description 1
- 230000005298 paramagnetic effect Effects 0.000 description 1
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- 239000011148 porous material Substances 0.000 description 1
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- 238000009423 ventilation Methods 0.000 description 1
- 238000013022 venting Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
- G01R33/282—Means specially adapted for hyperpolarisation or for hyperpolarised contrast agents, e.g. for the generation of hyperpolarised gases using optical pumping cells, for storing hyperpolarised contrast agents or for the determination of the polarisation of a hyperpolarised contrast agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1806—Suspensions, emulsions, colloids, dispersions
- A61K49/1815—Suspensions, emulsions, colloids, dispersions compo-inhalant, e.g. breath tests
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B23/00—Noble gases; Compounds thereof
- C01B23/001—Purification or separation processes of noble gases
- C01B23/0036—Physical processing only
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25J—LIQUEFACTION, SOLIDIFICATION OR SEPARATION OF GASES OR GASEOUS OR LIQUEFIED GASEOUS MIXTURES BY PRESSURE AND COLD TREATMENT OR BY BRINGING THEM INTO THE SUPERCRITICAL STATE
- F25J3/00—Processes or apparatus for separating the constituents of gaseous or liquefied gaseous mixtures involving the use of liquefaction or solidification
- F25J3/06—Processes or apparatus for separating the constituents of gaseous or liquefied gaseous mixtures involving the use of liquefaction or solidification by partial condensation
- F25J3/063—Processes or apparatus for separating the constituents of gaseous or liquefied gaseous mixtures involving the use of liquefaction or solidification by partial condensation characterised by the separated product stream
- F25J3/0685—Processes or apparatus for separating the constituents of gaseous or liquefied gaseous mixtures involving the use of liquefaction or solidification by partial condensation characterised by the separated product stream separation of noble gases
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
- H05H3/00—Production or acceleration of neutral particle beams, e.g. molecular or atomic beams
- H05H3/02—Molecular or atomic-beam generation, e.g. resonant beam generation
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B2210/00—Purification or separation of specific gases
- C01B2210/0029—Obtaining noble gases
- C01B2210/0037—Xenon
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25J—LIQUEFACTION, SOLIDIFICATION OR SEPARATION OF GASES OR GASEOUS OR LIQUEFIED GASEOUS MIXTURES BY PRESSURE AND COLD TREATMENT OR BY BRINGING THEM INTO THE SUPERCRITICAL STATE
- F25J2205/00—Processes or apparatus using other separation and/or other processing means
- F25J2205/20—Processes or apparatus using other separation and/or other processing means using solidification of components
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25J—LIQUEFACTION, SOLIDIFICATION OR SEPARATION OF GASES OR GASEOUS OR LIQUEFIED GASEOUS MIXTURES BY PRESSURE AND COLD TREATMENT OR BY BRINGING THEM INTO THE SUPERCRITICAL STATE
- F25J2210/00—Processes characterised by the type or other details of the feed stream
- F25J2210/42—Nitrogen
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25J—LIQUEFACTION, SOLIDIFICATION OR SEPARATION OF GASES OR GASEOUS OR LIQUEFIED GASEOUS MIXTURES BY PRESSURE AND COLD TREATMENT OR BY BRINGING THEM INTO THE SUPERCRITICAL STATE
- F25J2215/00—Processes characterised by the type or other details of the product stream
- F25J2215/36—Xenon
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25J—LIQUEFACTION, SOLIDIFICATION OR SEPARATION OF GASES OR GASEOUS OR LIQUEFIED GASEOUS MIXTURES BY PRESSURE AND COLD TREATMENT OR BY BRINGING THEM INTO THE SUPERCRITICAL STATE
- F25J2270/00—Refrigeration techniques used
- F25J2270/60—Closed external refrigeration cycle with single component refrigerant [SCR], e.g. C1-, C2- or C3-hydrocarbons
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25J—LIQUEFACTION, SOLIDIFICATION OR SEPARATION OF GASES OR GASEOUS OR LIQUEFIED GASEOUS MIXTURES BY PRESSURE AND COLD TREATMENT OR BY BRINGING THEM INTO THE SUPERCRITICAL STATE
- F25J2270/00—Refrigeration techniques used
- F25J2270/90—External refrigeration, e.g. conventional closed-loop mechanical refrigeration unit using Freon or NH3, unspecified external refrigeration
- F25J2270/904—External refrigeration, e.g. conventional closed-loop mechanical refrigeration unit using Freon or NH3, unspecified external refrigeration by liquid or gaseous cryogen in an open loop
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25J—LIQUEFACTION, SOLIDIFICATION OR SEPARATION OF GASES OR GASEOUS OR LIQUEFIED GASEOUS MIXTURES BY PRESSURE AND COLD TREATMENT OR BY BRINGING THEM INTO THE SUPERCRITICAL STATE
- F25J2290/00—Other details not covered by groups F25J2200/00 - F25J2280/00
- F25J2290/62—Details of storing a fluid in a tank
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S62/00—Refrigeration
- Y10S62/919—Isotope
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S62/00—Refrigeration
- Y10S62/923—Inert gas
- Y10S62/925—Xenon or krypton
Landscapes
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Analytical Chemistry (AREA)
- Radiology & Medical Imaging (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Dispersion Chemistry (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- General Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Inorganic Chemistry (AREA)
- Plasma & Fusion (AREA)
- Mechanical Engineering (AREA)
- Thermal Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Separation By Low-Temperature Treatments (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Developing Agents For Electrophotography (AREA)
- Vaporization, Distillation, Condensation, Sublimation, And Cold Traps (AREA)
- Image Processing (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA002349069A CA2349069C (en) | 1996-03-29 | 1997-03-27 | Cryogenic accumulator for spin-polarized xenon-129 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/622,865 US5809801A (en) | 1996-03-29 | 1996-03-29 | Cryogenic accumulator for spin-polarized xenon-129 |
| US08/622,865 | 1996-03-29 | ||
| PCT/US1997/005004 WO1997037177A1 (en) | 1996-03-29 | 1997-03-27 | Cryogenic accumulator for spin-polarized xenon-129 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002349069A Division CA2349069C (en) | 1996-03-29 | 1997-03-27 | Cryogenic accumulator for spin-polarized xenon-129 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2250167A1 CA2250167A1 (en) | 1997-10-09 |
| CA2250167C true CA2250167C (en) | 2002-05-07 |
Family
ID=24495803
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002250167A Expired - Lifetime CA2250167C (en) | 1996-03-29 | 1997-03-27 | Cryogenic accumulator for spin-polarized xenon-129 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US5809801A (cg-RX-API-DMAC7.html) |
| EP (1) | EP0890066B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP2000507688A (cg-RX-API-DMAC7.html) |
| AT (1) | ATE235032T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU712530B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2250167C (cg-RX-API-DMAC7.html) |
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| DK (1) | DK0890066T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2195131T3 (cg-RX-API-DMAC7.html) |
| WO (1) | WO1997037177A1 (cg-RX-API-DMAC7.html) |
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| US7281393B2 (en) * | 2004-04-21 | 2007-10-16 | University Of New Hampshire | Method and apparatus for accumulating hyperpolarized xenon |
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| KR101095943B1 (ko) | 2006-02-21 | 2011-12-19 | 밀리켈빈 테크놀로지스 엘엘씨 | 과분극화 방법, 시스템 및 조성물 |
| US8456161B2 (en) * | 2006-09-05 | 2013-06-04 | The Trustees Of Princeton University | Polarizing nuclei solids via spin transfer from an optically-pumped alkali vapor |
| US8405022B2 (en) | 2006-09-20 | 2013-03-26 | University Of New Hampshire | Thermal management technology for polarizing xenon |
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| US8763410B2 (en) * | 2008-04-21 | 2014-07-01 | General Electric Company | Method and apparatus for the dissolution and filtration of a hyperpolarized agent with a neutral dissolution media |
| WO2009143368A2 (en) * | 2008-05-23 | 2009-11-26 | University Of Utah | Non-cryogenic storage cell for hyperpolarized 129xe |
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| US8329122B1 (en) * | 2009-07-01 | 2012-12-11 | The United States Of America, As Represented By The Department Of Energy | Method for production of an isotopically enriched compound |
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| US9080710B2 (en) | 2011-01-21 | 2015-07-14 | Hamilton Sundstrand Corporation | Accumulator reservoir venting |
| FR2988857B1 (fr) * | 2012-03-30 | 2015-02-20 | Commissariat Energie Atomique | Procede de determination de la resistance cellulaire aux medicaments. |
| EP3107583B1 (en) | 2014-02-21 | 2019-05-29 | Duke University | Hyperpolarized noble gas production systems with nanocluster suppression, detection and/or filtering and related methods and devices |
| US10126438B2 (en) | 2014-09-19 | 2018-11-13 | University Of Virginia Patent Foundation | Systems and methods for polarized nuclear imaging and spectroscopy |
| CN104921726B (zh) * | 2015-05-26 | 2017-12-19 | 中国科学院武汉物理与数学研究所 | 一种用于超极化氙收集的液氮液位控制和显示装置 |
| US11754652B2 (en) | 2016-09-15 | 2023-09-12 | University Of Virginia Patent Foundation | Systems and methods for polarized nuclear imaging and spectroscopy |
| US12178891B2 (en) | 2017-10-06 | 2024-12-31 | University Of Florida Research Foundation, Inc. | Methods and systems for producing, using, and administering hyperpolarized fluids |
| US11944424B2 (en) | 2018-05-18 | 2024-04-02 | Duke University | Dynamic 129Xe gas exchange spectroscopy |
| US11148833B1 (en) | 2018-05-21 | 2021-10-19 | Space Systems/Loral, Llc | Spacecraft propellant management system |
| CN114644322B (zh) * | 2022-04-15 | 2024-02-06 | 宁波诺丁汉大学 | 超极化稀有气体生产设备 |
| WO2025151298A1 (en) | 2024-01-10 | 2025-07-17 | Polarean, Inc. | Hyperpolarizers with a load-lock chamber for alkali metal |
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1996
- 1996-03-29 US US08/622,865 patent/US5809801A/en not_active Expired - Lifetime
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- 1997-03-27 EP EP97917656A patent/EP0890066B1/en not_active Expired - Lifetime
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- 1997-03-27 JP JP9535422A patent/JP2000507688A/ja active Pending
- 1997-03-27 AT AT97917656T patent/ATE235032T1/de active
- 1997-03-27 ES ES97917656T patent/ES2195131T3/es not_active Expired - Lifetime
- 1997-03-27 DK DK97917656T patent/DK0890066T3/da active
- 1997-03-27 CA CA002250167A patent/CA2250167C/en not_active Expired - Lifetime
- 1997-03-27 DE DE69719962T patent/DE69719962T2/de not_active Expired - Lifetime
- 1997-03-27 WO PCT/US1997/005004 patent/WO1997037177A1/en not_active Ceased
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Also Published As
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| JP2008036443A (ja) | 2008-02-21 |
| DK0890066T3 (da) | 2003-07-14 |
| CA2250167A1 (en) | 1997-10-09 |
| EP0890066A4 (en) | 2000-01-19 |
| DE69719962T2 (de) | 2003-12-18 |
| WO1997037177A1 (en) | 1997-10-09 |
| ES2195131T3 (es) | 2003-12-01 |
| JP2000507688A (ja) | 2000-06-20 |
| EP0890066B1 (en) | 2003-03-19 |
| US5809801A (en) | 1998-09-22 |
| JP4231533B2 (ja) | 2009-03-04 |
| AU712530B2 (en) | 1999-11-11 |
| ATE235032T1 (de) | 2003-04-15 |
| DE69719962D1 (de) | 2003-04-24 |
| EP0890066A1 (en) | 1999-01-13 |
| AU2592097A (en) | 1997-10-22 |
| US5860295A (en) | 1999-01-19 |
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