CA2248985A1 - Acide nucleique et sequence d'acides amines pour lutter contre helicobacter pylori et compositions de vaccins - Google Patents
Acide nucleique et sequence d'acides amines pour lutter contre helicobacter pylori et compositions de vaccins Download PDFInfo
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- CA2248985A1 CA2248985A1 CA002248985A CA2248985A CA2248985A1 CA 2248985 A1 CA2248985 A1 CA 2248985A1 CA 002248985 A CA002248985 A CA 002248985A CA 2248985 A CA2248985 A CA 2248985A CA 2248985 A1 CA2248985 A1 CA 2248985A1
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- GWUSZQUVEVMBPI-UHFFFAOYSA-N nimetazepam Chemical class N=1CC(=O)N(C)C2=CC=C([N+]([O-])=O)C=C2C=1C1=CC=CC=C1 GWUSZQUVEVMBPI-UHFFFAOYSA-N 0.000 description 1
- JPXMTWWFLBLUCD-UHFFFAOYSA-N nitro blue tetrazolium(2+) Chemical compound COC1=CC(C=2C=C(OC)C(=CC=2)[N+]=2N(N=C(N=2)C=2C=CC=CC=2)C=2C=CC(=CC=2)[N+]([O-])=O)=CC=C1[N+]1=NC(C=2C=CC=CC=2)=NN1C1=CC=C([N+]([O-])=O)C=C1 JPXMTWWFLBLUCD-UHFFFAOYSA-N 0.000 description 1
- 230000009871 nonspecific binding Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 238000007899 nucleic acid hybridization Methods 0.000 description 1
- 239000002853 nucleic acid probe Substances 0.000 description 1
- 239000002751 oligonucleotide probe Substances 0.000 description 1
- 238000002515 oligonucleotide synthesis Methods 0.000 description 1
- 101150016099 omcA gene Proteins 0.000 description 1
- 229940126578 oral vaccine Drugs 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 229940092253 ovalbumin Drugs 0.000 description 1
- 230000002018 overexpression Effects 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 229940111202 pepsin Drugs 0.000 description 1
- 108010091212 pepstatin Proteins 0.000 description 1
- 229950000964 pepstatin Drugs 0.000 description 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 description 1
- 210000001322 periplasm Anatomy 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 150000004633 phorbol derivatives Chemical class 0.000 description 1
- 239000002644 phorbol ester Substances 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 239000013600 plasmid vector Substances 0.000 description 1
- 108010054442 polyalanine Proteins 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 229920002704 polyhistidine Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 102000054765 polymorphisms of proteins Human genes 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 238000011176 pooling Methods 0.000 description 1
- 230000001124 posttranscriptional effect Effects 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 238000011085 pressure filtration Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000009465 prokaryotic expression Effects 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000000644 propagated effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000012846 protein folding Effects 0.000 description 1
- 230000006916 protein interaction Effects 0.000 description 1
- 230000020978 protein processing Effects 0.000 description 1
- 238000000734 protein sequencing Methods 0.000 description 1
- 230000004850 protein–protein interaction Effects 0.000 description 1
- 230000017854 proteolysis Effects 0.000 description 1
- 230000006337 proteolytic cleavage Effects 0.000 description 1
- 239000000612 proton pump inhibitor Substances 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 238000010188 recombinant method Methods 0.000 description 1
- 229940126583 recombinant protein vaccine Drugs 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000007115 recruitment Effects 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 230000022532 regulation of transcription, DNA-dependent Effects 0.000 description 1
- 230000035806 respiratory chain Effects 0.000 description 1
- 230000028706 ribosome biogenesis Effects 0.000 description 1
- 229920002477 rna polymer Polymers 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 229930182490 saponin Natural products 0.000 description 1
- 150000007949 saponins Chemical class 0.000 description 1
- 235000017709 saponins Nutrition 0.000 description 1
- 230000009863 secondary prevention Effects 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000002864 sequence alignment Methods 0.000 description 1
- 101150011264 setB gene Proteins 0.000 description 1
- 238000010008 shearing Methods 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 210000002027 skeletal muscle Anatomy 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 229940031439 squalene Drugs 0.000 description 1
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 description 1
- 238000011272 standard treatment Methods 0.000 description 1
- 229940037649 staphylococcus haemolyticus Drugs 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 230000002483 superagonistic effect Effects 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 238000010189 synthetic method Methods 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 210000001138 tear Anatomy 0.000 description 1
- 238000012956 testing procedure Methods 0.000 description 1
- 229960004072 thrombin Drugs 0.000 description 1
- 229940113082 thymine Drugs 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 238000001890 transfection Methods 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical class [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 description 1
- 230000001810 trypsinlike Effects 0.000 description 1
- 238000010396 two-hybrid screening Methods 0.000 description 1
- 108010087967 type I signal peptidase Proteins 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 230000009452 underexpressoin Effects 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 238000002255 vaccination Methods 0.000 description 1
- 210000003934 vacuole Anatomy 0.000 description 1
- 125000002987 valine group Chemical group [H]N([H])C([H])(C(*)=O)C([H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 239000000304 virulence factor Substances 0.000 description 1
- 230000007923 virulence factor Effects 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 101150040194 waaA gene Proteins 0.000 description 1
- 238000001262 western blot Methods 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 229910052727 yttrium Inorganic materials 0.000 description 1
- DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/205—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Campylobacter (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
- C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
L'invention concerne des préparations obtenues par recombinaison ou pratiquement pures de polypeptides issus de H. Pylori, ainsi que les acides nucléiques codant ces polypeptides. Les polypeptides issus de H. Pylori sont utiles dans les diagnostics et les compositions de vaccins.
Applications Claiming Priority (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US62581196A | 1996-03-29 | 1996-03-29 | |
US08/625,811 | 1996-03-29 | ||
US75873196A | 1996-04-02 | 1996-04-02 | |
US08/758,731 | 1996-04-02 | ||
US73690596A | 1996-10-25 | 1996-10-25 | |
US08/736,905 | 1996-10-25 | ||
US73885996A | 1996-10-28 | 1996-10-28 | |
US08/738,859 | 1996-10-28 | ||
US76131896A | 1996-12-06 | 1996-12-06 | |
US08/761,318 | 1996-12-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2248985A1 true CA2248985A1 (fr) | 1997-10-09 |
Family
ID=27542009
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002248985A Abandoned CA2248985A1 (fr) | 1996-03-29 | 1997-03-27 | Acide nucleique et sequence d'acides amines pour lutter contre helicobacter pylori et compositions de vaccins |
Country Status (18)
Country | Link |
---|---|
EP (1) | EP0901530A1 (fr) |
JP (1) | JP2000501621A (fr) |
CN (1) | CN1220703A (fr) |
AU (1) | AU726892B2 (fr) |
BR (1) | BR9708456A (fr) |
CA (1) | CA2248985A1 (fr) |
CZ (1) | CZ297698A3 (fr) |
EE (1) | EE9800334A (fr) |
HU (1) | HUP0100267A3 (fr) |
ID (1) | ID18542A (fr) |
IL (1) | IL125808A0 (fr) |
IS (1) | IS4831A (fr) |
NO (1) | NO984517L (fr) |
NZ (1) | NZ332565A (fr) |
PL (1) | PL329045A1 (fr) |
SK (1) | SK130598A3 (fr) |
TR (1) | TR199801939T2 (fr) |
WO (1) | WO1997037044A1 (fr) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2217496A1 (fr) * | 1995-04-21 | 1996-10-24 | Csl Limited | Antigenes protecteurs d'helicobacter |
AU735391B2 (en) * | 1996-11-14 | 2001-07-05 | Human Genome Sciences, Inc. | Helicobacter polypeptides and corresponding polynucleotide molecules |
SE9702240D0 (sv) * | 1997-06-12 | 1997-06-12 | Astra Ab | Vaccine compositions III |
ES2294629T3 (es) * | 1998-05-01 | 2008-04-01 | Novartis Vaccines And Diagnostics, Inc. | Antigenos de neisseria y composiciones. |
AU4718999A (en) * | 1998-06-26 | 2000-01-17 | American Cyanamid Company | Novel antigens of (helicobacter pylori) |
DE19847628C2 (de) * | 1998-10-15 | 2000-10-19 | Chiron Behring Gmbh & Co | Helicobacter pylori-Impfstoff |
GB9825184D0 (en) * | 1998-11-17 | 1999-01-13 | Cortecs Uk Ltd | Antigen |
EP1173560A1 (fr) * | 1999-04-30 | 2002-01-23 | Hybrigenics S.A. | Collection d'adn procaryote d'helicobacter pylori permettant l'identification des interactions proteine-proteine utilisable pour deux systemes hybrides et applications |
SE0001988D0 (sv) * | 2000-05-29 | 2000-05-29 | A & Science Invest Ab | Novel polypeptides and use thereof |
AU2002218985A1 (en) * | 2000-11-15 | 2002-05-27 | Ludwig Deml | Helicobacter cysteine rich protein a (hcpa) and uses thereof |
US7033790B2 (en) | 2001-04-03 | 2006-04-25 | Curagen Corporation | Proteins and nucleic acids encoding same |
TW200303919A (en) * | 2001-12-05 | 2003-09-16 | Hiroyuki Ohno | Cytotoxic protein and the use |
EP3389703A1 (fr) * | 2015-12-14 | 2018-10-24 | Technische Universität München | Vaccins contre helicobacter pylori |
CN106868024B (zh) * | 2017-04-01 | 2020-03-17 | 山东新创生物科技有限公司 | 一种戈氏梭菌特异性pcr检测引物及方法 |
-
1997
- 1997-03-27 NZ NZ332565A patent/NZ332565A/xx unknown
- 1997-03-27 ID IDP971050A patent/ID18542A/id unknown
- 1997-03-27 EP EP97917731A patent/EP0901530A1/fr not_active Withdrawn
- 1997-03-27 SK SK1305-98A patent/SK130598A3/sk unknown
- 1997-03-27 CA CA002248985A patent/CA2248985A1/fr not_active Abandoned
- 1997-03-27 PL PL97329045A patent/PL329045A1/xx unknown
- 1997-03-27 BR BR9708456A patent/BR9708456A/pt not_active IP Right Cessation
- 1997-03-27 IL IL12580897A patent/IL125808A0/xx unknown
- 1997-03-27 HU HU0100267A patent/HUP0100267A3/hu unknown
- 1997-03-27 AU AU25984/97A patent/AU726892B2/en not_active Ceased
- 1997-03-27 CN CN97195113A patent/CN1220703A/zh active Pending
- 1997-03-27 EE EE9800334A patent/EE9800334A/xx unknown
- 1997-03-27 WO PCT/US1997/005223 patent/WO1997037044A1/fr not_active Application Discontinuation
- 1997-03-27 TR TR1998/01939T patent/TR199801939T2/xx unknown
- 1997-03-27 CZ CZ982976A patent/CZ297698A3/cs unknown
- 1997-03-27 JP JP9529649A patent/JP2000501621A/ja active Pending
-
1998
- 1998-08-21 IS IS4831A patent/IS4831A/is unknown
- 1998-09-28 NO NO984517A patent/NO984517L/no unknown
Also Published As
Publication number | Publication date |
---|---|
HUP0100267A2 (hu) | 2001-06-28 |
CN1220703A (zh) | 1999-06-23 |
EE9800334A (et) | 1999-04-15 |
IL125808A0 (en) | 1999-04-11 |
JP2000501621A (ja) | 2000-02-15 |
AU726892B2 (en) | 2000-11-23 |
HUP0100267A3 (en) | 2002-09-30 |
TR199801939T2 (xx) | 1999-02-22 |
ID18542A (id) | 1998-04-16 |
CZ297698A3 (cs) | 1999-02-17 |
SK130598A3 (en) | 1999-06-11 |
WO1997037044A1 (fr) | 1997-10-09 |
IS4831A (is) | 1998-08-21 |
AU2598497A (en) | 1997-10-22 |
NO984517D0 (no) | 1998-09-28 |
EP0901530A1 (fr) | 1999-03-17 |
NO984517L (no) | 1998-11-25 |
NZ332565A (en) | 2000-03-27 |
BR9708456A (pt) | 1999-08-03 |
PL329045A1 (en) | 1999-03-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
FZDE | Discontinued |