CA2244238A1 - Agents cycliques peptidiques antifongiques - Google Patents

Agents cycliques peptidiques antifongiques Download PDF

Info

Publication number
CA2244238A1
CA2244238A1 CA002244238A CA2244238A CA2244238A1 CA 2244238 A1 CA2244238 A1 CA 2244238A1 CA 002244238 A CA002244238 A CA 002244238A CA 2244238 A CA2244238 A CA 2244238A CA 2244238 A1 CA2244238 A1 CA 2244238A1
Authority
CA
Canada
Prior art keywords
compound
mmol
hydroxy
formula
subtitled compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002244238A
Other languages
English (en)
Inventor
Stacy Kay Henle
William Wilson Turner Jr.
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9603151.3A external-priority patent/GB9603151D0/en
Application filed by Individual filed Critical Individual
Publication of CA2244238A1 publication Critical patent/CA2244238A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Composés peptidiques cycliques, utiles comme agents antifongiques et antiparasitaires, présentant une stabilité améliorée. L'invention porte en particulier sur des composés d'un dérivé cyclique d'échinocandine et des compositions pharmaceutiques issues de ces composés.
CA002244238A 1996-02-01 1997-01-29 Agents cycliques peptidiques antifongiques Abandoned CA2244238A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US1094696P 1996-02-01 1996-02-01
US60/010,946 1996-02-01
GB9603151.3 1996-02-15
GBGB9603151.3A GB9603151D0 (en) 1996-02-15 1996-02-15 Cyclic peptide antifungal agents

Publications (1)

Publication Number Publication Date
CA2244238A1 true CA2244238A1 (fr) 1997-08-07

Family

ID=26308710

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002244238A Abandoned CA2244238A1 (fr) 1996-02-01 1997-01-29 Agents cycliques peptidiques antifongiques

Country Status (5)

Country Link
EP (1) EP0881907A4 (fr)
JP (1) JP2001503015A (fr)
AU (1) AU1851797A (fr)
CA (1) CA2244238A1 (fr)
WO (1) WO1997027864A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6323176B1 (en) 1998-02-25 2001-11-27 Eli Lilly And Company Cyclic peptide antifungal agents
EP1107981B1 (fr) 1998-08-20 2005-01-26 Eli Lilly & Company Synthese des analogues peptidiques cycliques a systeme cyclique modifie
PT1137663E (pt) 1998-12-09 2006-12-29 Lilly Co Eli Purificação de compostos ciclopéptidos equinocandina
WO2000052037A1 (fr) 1999-03-03 2000-09-08 Eli Lilly And Company Complexes d'echinocandine/glucide
CA2362482A1 (fr) 1999-03-03 2000-09-08 Eli Lilly And Company Procedes permettant de preparer des compositions et des formulations pharmaceutiques orales d'echinocandine b
CA2362481C (fr) 1999-03-03 2008-11-04 Eli Lilly And Company Formulations pharmaceutiques d'echinocandine contenant des tensioactifs formant des micelles
KR20020002476A (ko) * 1999-03-03 2002-01-09 피터 지. 스트링거 결정질 에키노칸딘 암모늄염의 형성 및 음이온 교환
WO2004035563A1 (fr) * 2002-10-17 2004-04-29 Syngenta Participations Ag Derives de 3-heterocyclylpyridine utilises comme herbicides

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4293486A (en) * 1979-12-13 1981-10-06 Eli Lilly And Company Derivatives of S31794/F-1 nucleus
US4297277A (en) * 1979-12-13 1981-10-27 Eli Lilly And Company Derivatives of A-30912B nucleus
US4293489A (en) * 1979-12-13 1981-10-06 Eli Lilly And Company Derivatives of A-30912A nucleus
CZ288974B6 (cs) * 1992-03-19 2001-10-17 Eli Lilly And Company Acylový derivát echinocandinu, způsob jeho přípravy, farmaceutický prostředek s jeho obsahem a jeho pouľití
US5646111A (en) * 1995-04-07 1997-07-08 Eli Lilly And Company Cyclic peptide antifungal Agents
US5652213A (en) * 1995-05-26 1997-07-29 Eli Lilly And Company Cyclic peptide antifungal agents
AUPO381496A0 (en) * 1996-11-25 1996-12-19 Fujisawa Pharmaceutical Co., Ltd. New compound

Also Published As

Publication number Publication date
WO1997027864A1 (fr) 1997-08-07
AU1851797A (en) 1997-08-22
EP0881907A1 (fr) 1998-12-09
JP2001503015A (ja) 2001-03-06
EP0881907A4 (fr) 2000-05-10

Similar Documents

Publication Publication Date Title
EP0744405B1 (fr) Peptides cycliques ayant une activité antifongique
CA2091663C (fr) Agents antifongiques peptidiques cycliques et procede de preparation correspondant
AU702841B2 (en) Cyclic peptide antifungal agents
EP0744407B1 (fr) Peptides cycliques ayant activité antifongicide
EP0744406B1 (fr) Peptides cycliques ayant une activité antifongique
US5629289A (en) Cyclic peptide antifungal agents
EP0744404B1 (fr) Peptides cycliques ayant une activité antifongique
US5693611A (en) Cyclic peptide antifungal agents
CA2244238A1 (fr) Agents cycliques peptidiques antifongiques
US6384013B1 (en) Cyclic peptide antifungal agents and process for preparation thereof
EP0500170A2 (fr) Hexapeptides cycliques ayant une activité antibiotique

Legal Events

Date Code Title Description
EEER Examination request
FZDE Dead