CA2244189A1 - Thiazolylbenzofuran derivatives and pharmaceutical compositions containing them - Google Patents
Thiazolylbenzofuran derivatives and pharmaceutical compositions containing them Download PDFInfo
- Publication number
- CA2244189A1 CA2244189A1 CA002244189A CA2244189A CA2244189A1 CA 2244189 A1 CA2244189 A1 CA 2244189A1 CA 002244189 A CA002244189 A CA 002244189A CA 2244189 A CA2244189 A CA 2244189A CA 2244189 A1 CA2244189 A1 CA 2244189A1
- Authority
- CA
- Canada
- Prior art keywords
- substituted
- compound
- salt
- carboxy
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9601235.6 | 1996-01-22 | ||
| GBGB9601235.6A GB9601235D0 (en) | 1996-01-22 | 1996-01-22 | Novel compounds |
| AUPO1111A AUPO111196A0 (en) | 1996-07-18 | 1996-07-18 | Novel compounds |
| AUPO1111 | 1996-07-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2244189A1 true CA2244189A1 (en) | 1997-07-31 |
Family
ID=25645218
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002244189A Abandoned CA2244189A1 (en) | 1996-01-22 | 1997-01-17 | Thiazolylbenzofuran derivatives and pharmaceutical compositions containing them |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5994378A (enExample) |
| EP (2) | EP1170009B1 (enExample) |
| JP (1) | JP2000503984A (enExample) |
| KR (1) | KR19990076788A (enExample) |
| CN (1) | CN1209809A (enExample) |
| AT (2) | ATE216384T1 (enExample) |
| CA (1) | CA2244189A1 (enExample) |
| DE (2) | DE69712042T2 (enExample) |
| EA (1) | EA199800650A1 (enExample) |
| ES (1) | ES2171878T3 (enExample) |
| HU (1) | HUP9900424A2 (enExample) |
| WO (1) | WO1997027190A1 (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9919413D0 (en) | 1999-08-18 | 1999-10-20 | Zeneca Ltd | Chemical compounds |
| AU7962200A (en) * | 1999-10-29 | 2001-05-14 | Wakunaga Pharmaceutical Co., Ltd | Novel indole derivatives and drugs containing the same as the active ingredient |
| CZ20032829A3 (cs) * | 2001-04-16 | 2005-03-16 | Tanabe Seiyaku Co., Ltd. | Heterocyklické sloučeniny |
| WO2003016291A1 (en) | 2001-08-10 | 2003-02-27 | Nippon Chemiphar Co., Ltd. | ACTIVATOR FOR PEROXISOME PROLIFERATOR-RESPONSIVE RECEPTOR δ |
| MXPA04003398A (es) | 2001-10-12 | 2004-11-22 | Nippon Chemiphar Co | Activador para el receptor o activado con el proliferador de peroxisoma. |
| EA200700243A1 (ru) * | 2004-07-14 | 2007-08-31 | ПиТиСи ТЕРАПЬЮТИКС, ИНК. | Способы лечения гепатита с |
| MX2007004525A (es) * | 2004-10-12 | 2007-09-19 | Decode Genetics Inc | Sulfonamidas biciclicas peri-sustituidas para enfermedad de arteria oclusiva. |
| WO2006046683A1 (en) * | 2004-10-25 | 2006-05-04 | Astellas Pharma Inc. | Thiazolylbenzofuran derivatives as leukotriene and prostaglandin d2 receptor antagonists |
| US8399666B2 (en) | 2005-11-04 | 2013-03-19 | Panmira Pharmaceuticals, Llc | 5-lipoxygenase-activating protein (FLAP) inhibitors |
| GB2431927B (en) * | 2005-11-04 | 2010-03-17 | Amira Pharmaceuticals Inc | 5-Lipoxygenase-activating protein (FLAP) inhibitors |
| US7977359B2 (en) | 2005-11-04 | 2011-07-12 | Amira Pharmaceuticals, Inc. | 5-lipdxygenase-activating protein (FLAP) inhibitors |
| AU2007214434B2 (en) * | 2006-02-15 | 2012-06-14 | Allergan, Inc. | Indole-3-carboxylic acid amide, ester, thioamide and thiol ester compounds bearing aryl or heteroaryl groups having sphingosine-1-phosphate (S1P) receptor antagonist biological activity |
| CN101460458A (zh) * | 2006-02-15 | 2009-06-17 | 阿勒根公司 | 具有1－磷酸－鞘氨醇(s1p)受体拮抗剂生物活性的带芳基或者杂芳基基团的吲哚－3－羧酸的酰胺、酯、硫代酰胺和硫羟酸酯化合物 |
| EP2014652B1 (en) | 2006-04-18 | 2014-08-06 | Nippon Chemiphar Co., Ltd. | Activating agent for peroxisome proliferator activated receptor |
| DE102006021733A1 (de) * | 2006-05-09 | 2007-11-22 | Bayer Healthcare Ag | 3-Tetrazolylindazole und 3-Tetrazolylpyrazolopyridine sowie ihre Verwendung |
| CA2652152A1 (en) * | 2006-05-16 | 2007-11-29 | Decode Genetics Ehf | Process for preparing 7-(acryloyl)indoles |
| DE102006043443A1 (de) * | 2006-09-15 | 2008-03-27 | Bayer Healthcare Ag | Neue aza-bicyclische Verbindungen und ihre Verwendung |
| EP2125723A1 (en) * | 2007-01-11 | 2009-12-02 | Allergan, Inc. | 6-substituted indole-3-carboxylic acid amide compounds having sphingosine-1-phosphate (s1p) receptor antagonist biological activity |
| US8524917B2 (en) | 2007-01-11 | 2013-09-03 | Allergan, Inc. | 6-substituted indole-3-carboxylic acid amide compounds having sphingosine-1-phosphate (S1P) receptor antagonist biological activity |
| MX2010011252A (es) | 2008-04-15 | 2010-11-30 | Nippon Chemiphar Co | Activador para el receptor activado por el proliferador de peroxisoma. |
| US8546431B2 (en) | 2008-10-01 | 2013-10-01 | Panmira Pharmaceuticals, Llc | 5-lipoxygenase-activating protein (FLAP) inhibitors |
| DE102008063992A1 (de) | 2008-12-19 | 2010-09-02 | Lerner, Zinoviy, Dipl.-Ing. | Neue aliphatisch substituierte Pyrazolopyridine und ihre Verwendung |
| NZ601967A (en) | 2010-03-12 | 2015-03-27 | Omeros Corp | Pde10 inhibitors and related compositions and methods |
| WO2012087833A1 (en) | 2010-12-22 | 2012-06-28 | Abbott Laboratories | Hepatitis c inhibitors and uses thereof |
| CA2901636A1 (en) | 2013-02-21 | 2014-08-28 | Adverio Pharma Gmbh | Forms of methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1h-pyrazolo[3,4-b]pyridino-3-yl]pyrimidino-5-yl}methyl carbamate |
| NZ716462A (en) | 2014-04-28 | 2017-11-24 | Omeros Corp | Optically active pde10 inhibitor |
| NZ630810A (en) | 2014-04-28 | 2016-03-31 | Omeros Corp | Processes and intermediates for the preparation of a pde10 inhibitor |
| HRP20211778T1 (hr) | 2014-08-29 | 2022-03-18 | Chdi Foundation, Inc. | Kontrastna sredstva za slikovnu dijagnostiku huntingtin proteina |
| CA2980801A1 (en) | 2015-04-24 | 2016-10-27 | Omeros Corporation | Pde10 inhibitors and related compositions and methods |
| CA3003611C (en) | 2015-11-04 | 2022-11-01 | Omeros Corporation | Solid state forms of a pde10 inhibitor |
| BR112020009361A2 (pt) | 2017-11-17 | 2020-10-13 | Cellix Bio Private Limited | composto de fórmula i, composição farmacêutica para tratar um distúrbio ocular ou complicações do mesmo, método de síntese de composto, método de tratamento de um distúrbio ocular ou complicações do mesmo em um indivíduo que precisa do mesmo e uso de um composto |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2600644B2 (ja) * | 1991-08-16 | 1997-04-16 | 藤沢薬品工業株式会社 | チアゾリルベンゾフラン誘導体 |
| JPH07179856A (ja) * | 1993-12-21 | 1995-07-18 | Canon Inc | 液晶性化合物、これを含有する液晶組成物、該液晶組成物を用いた液晶素子並びにこれらを用いた表示方法、表示装置 |
-
1997
- 1997-01-17 EP EP01123263A patent/EP1170009B1/en not_active Expired - Lifetime
- 1997-01-17 DE DE69712042T patent/DE69712042T2/de not_active Expired - Fee Related
- 1997-01-17 CA CA002244189A patent/CA2244189A1/en not_active Abandoned
- 1997-01-17 CN CN97191798A patent/CN1209809A/zh active Pending
- 1997-01-17 WO PCT/JP1997/000073 patent/WO1997027190A1/en not_active Ceased
- 1997-01-17 AT AT97900432T patent/ATE216384T1/de not_active IP Right Cessation
- 1997-01-17 AT AT01123263T patent/ATE263561T1/de not_active IP Right Cessation
- 1997-01-17 DE DE69728581T patent/DE69728581D1/de not_active Expired - Lifetime
- 1997-01-17 US US09/101,766 patent/US5994378A/en not_active Expired - Fee Related
- 1997-01-17 ES ES97900432T patent/ES2171878T3/es not_active Expired - Lifetime
- 1997-01-17 KR KR1019980704913A patent/KR19990076788A/ko not_active Ceased
- 1997-01-17 EA EA199800650A patent/EA199800650A1/ru unknown
- 1997-01-17 JP JP9526720A patent/JP2000503984A/ja not_active Ceased
- 1997-01-17 HU HU9900424A patent/HUP9900424A2/hu unknown
- 1997-01-17 EP EP97900432A patent/EP0880519B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1170009A3 (en) | 2002-01-16 |
| EP0880519B1 (en) | 2002-04-17 |
| US5994378A (en) | 1999-11-30 |
| ATE216384T1 (de) | 2002-05-15 |
| JP2000503984A (ja) | 2000-04-04 |
| EP0880519A1 (en) | 1998-12-02 |
| ES2171878T3 (es) | 2002-09-16 |
| WO1997027190A1 (en) | 1997-07-31 |
| EP1170009B1 (en) | 2004-04-07 |
| DE69712042T2 (de) | 2002-10-02 |
| CN1209809A (zh) | 1999-03-03 |
| HUP9900424A2 (hu) | 1999-05-28 |
| DE69712042D1 (de) | 2002-05-23 |
| EA199800650A1 (ru) | 1999-02-25 |
| EP1170009A2 (en) | 2002-01-09 |
| ATE263561T1 (de) | 2004-04-15 |
| DE69728581D1 (de) | 2004-05-13 |
| KR19990076788A (ko) | 1999-10-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US5994378A (en) | Thiazolylbenzofuran derivatives and pharmaceutical compositions containing them | |
| US5296495A (en) | Thiazolylbenzofuran derivatives and pharmaceutical composition comprising the same | |
| AU690620B2 (en) | Platelet activating factor antagonists: imidazopyridine indoles | |
| ES2293906T3 (es) | Compuestos de indazol y composiciones farmaceuticas para inhibir proteinas quinasas, y metodos para su uso. | |
| US6069156A (en) | Indole derivatives as cGMP-PDE inhibitors | |
| US5661159A (en) | Quinolylbenzofuran derivatives as leukotriene antagonists | |
| JP3119485B2 (ja) | 抗−エイズ薬としての置換インドール類 | |
| US20040077877A1 (en) | Indazole derivatives as JNK inhibitors and compositions and methods related thereto | |
| JPH10130147A (ja) | 異項環置換アシルアミノチアゾールを含む医薬組成物 | |
| KR20010031896A (ko) | 시클린 의존성 키나아제의 아미노티아졸 억제제 | |
| RS52396B (sr) | Derivati aminoindazola, postupak izrade i međuproizvodi ovog postupak kao medicinski produkti i farmaceutske kompozicije koje ih sadrže | |
| JP2005527463A (ja) | Ｃｎｓ疾患を治療するための５−ｈｔ６受容体アフィニティーを有する３−アリールスルホニル−７−ピペラジニル−インドール、−ベンゾフランおよび−ベンゾチオフェン | |
| JPH08507067A (ja) | Ｈｉｖ逆転写酵素阻害剤 | |
| WO2001032621A1 (en) | Novel indole derivatives and drugs containing the same as the active ingredient | |
| EP0303418A2 (en) | Substituted indolones, useful in the treatment of heart or asthmatic diseases | |
| JPH11508267A (ja) | ピラゾール化合物および医薬組成物 | |
| HUT70158A (en) | Process for producing 2-amido-4-phenyl-thiazol derivatives, and pharmaceutical compositions containing them | |
| CN101010297B (zh) | N-(1h-吲哚基)-1h-吲哚-2-羧酰胺衍生物，它们的制备方法和药用用途 | |
| JP2001526287A (ja) | 新たな薬学的に活性な化合物 | |
| JPH09509957A (ja) | 免疫調節剤としてのキノリン誘導体 | |
| CA2109498A1 (en) | Benzylidene derivatives | |
| JPH08119936A (ja) | 複素環式誘導体 | |
| JP3012338B2 (ja) | アリールおよびヘテロアリールアルコキシナフタレン誘導体 | |
| MX2007016541A (es) | Compuestos quimicos. | |
| AU1399197A (en) | Thiazolylbenzofuran derivatives and pharmaceutical compositions containing them |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |