CA2238976A1 - Procede relatif a la fabrication d'un antagoniste de l'endotheline - Google Patents

Procede relatif a la fabrication d'un antagoniste de l'endotheline Download PDF

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Publication number
CA2238976A1
CA2238976A1 CA 2238976 CA2238976A CA2238976A1 CA 2238976 A1 CA2238976 A1 CA 2238976A1 CA 2238976 CA2238976 CA 2238976 CA 2238976 A CA2238976 A CA 2238976A CA 2238976 A1 CA2238976 A1 CA 2238976A1
Authority
CA
Canada
Prior art keywords
group
recited
solvent
give
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA 2238976
Other languages
English (en)
Inventor
Paul N. Devine
David M. Tschaen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9603243.8A external-priority patent/GB9603243D0/en
Application filed by Individual filed Critical Individual
Publication of CA2238976A1 publication Critical patent/CA2238976A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)

Abstract

L'invention concerne un procédé relatif à la synthèse stéréosélective d'un composé représenté par la formule (I).
CA 2238976 1995-12-12 1996-12-09 Procede relatif a la fabrication d'un antagoniste de l'endotheline Abandoned CA2238976A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US875695P 1995-12-12 1995-12-12
US60/008,756 1995-12-12
GB9603243.8 1996-02-16
GBGB9603243.8A GB9603243D0 (en) 1996-02-16 1996-02-16 Process for the preparation of an endothelin antagonist

Publications (1)

Publication Number Publication Date
CA2238976A1 true CA2238976A1 (fr) 1997-06-19

Family

ID=26308722

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2238976 Abandoned CA2238976A1 (fr) 1995-12-12 1996-12-09 Procede relatif a la fabrication d'un antagoniste de l'endotheline

Country Status (5)

Country Link
EP (1) EP0873334A1 (fr)
JP (1) JP2000502998A (fr)
AU (1) AU703486B2 (fr)
CA (1) CA2238976A1 (fr)
WO (1) WO1997021700A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI226888B (en) * 1999-10-13 2005-01-21 Ube Industries A method for producing 3,4-methylenedioxy-mandelic acid
US7091230B2 (en) 2001-02-09 2006-08-15 Merck & Co., Inc. 2-aryloxy-2-arylalkanoic acids for diabetes and lipid disorders

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE189217T1 (de) * 1993-03-19 2000-02-15 Merck & Co Inc Phenoxyphenylessigsäurederivate
CA2195758A1 (fr) * 1994-08-08 1996-02-22 Scott W. Bagley Derives de l'acide phenoxyphenylacetique
US5538991A (en) * 1994-09-14 1996-07-23 Merck & Co., Inc. Endothelin antagonists bearing 5-membered heterocyclic amides

Also Published As

Publication number Publication date
AU1412297A (en) 1997-07-03
JP2000502998A (ja) 2000-03-14
WO1997021700A1 (fr) 1997-06-19
AU703486B2 (en) 1999-03-25
EP0873334A1 (fr) 1998-10-28

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Legal Events

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EEER Examination request
FZDE Dead