CA2238404A1 - Proteines, acides nucleiques et anticorps deltex de vertebres, et procedes et compositions relatifs a ceux-ci - Google Patents

Proteines, acides nucleiques et anticorps deltex de vertebres, et procedes et compositions relatifs a ceux-ci Download PDF

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Publication number
CA2238404A1
CA2238404A1 CA002238404A CA2238404A CA2238404A1 CA 2238404 A1 CA2238404 A1 CA 2238404A1 CA 002238404 A CA002238404 A CA 002238404A CA 2238404 A CA2238404 A CA 2238404A CA 2238404 A1 CA2238404 A1 CA 2238404A1
Authority
CA
Canada
Prior art keywords
protein
deltex
nucleic acid
notch
fragment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002238404A
Other languages
English (en)
Inventor
Spyridon Artavanis-Tsakonas
Kenji Matsuno
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yale University
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2238404A1 publication Critical patent/CA2238404A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

Séquences de nucléotides de gènes Deltex de vertébrés, et séquences d'acides aminés des protéines Deltex de vertébrés codées par ceux-ci. L'invention concerne également des fragments et d'autres dérivés et analogues des protéines Deltex de vertébrés, ainsi que les anticorps de ceux-ci. Les acides nucléiques codant pour ces fragments ou dérivés sont également compris dans l'invention. La production des protéines et dérivés cités, par exemple, par recombinaison, est décrite. Selon un mode de réalisation spécifique, l'invention porte sur les acides nucléiques et protéines Deltex chez l'homme. La présente invention porte également sur des procédés et des compositions thérapeutiques et diagnostiques à base de protéines, d'acides nucléiques et d'anticorps Deltex de vertébrés. L'invention concerne également des procédés d'inactivation d'une fonction Notch dans une cellule, des procédés d'identification d'un composé inhibant ou réduisant la liaison d'une protéine Deltex à une protéine Notch, et des procédés visant l'expansion de cellules à terminaisons non différenciées.
CA002238404A 1995-11-22 1996-11-22 Proteines, acides nucleiques et anticorps deltex de vertebres, et procedes et compositions relatifs a ceux-ci Abandoned CA2238404A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56196395A 1995-11-22 1995-11-22
US08/561,963 1995-11-22

Publications (1)

Publication Number Publication Date
CA2238404A1 true CA2238404A1 (fr) 1997-05-29

Family

ID=24244241

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002238404A Abandoned CA2238404A1 (fr) 1995-11-22 1996-11-22 Proteines, acides nucleiques et anticorps deltex de vertebres, et procedes et compositions relatifs a ceux-ci

Country Status (5)

Country Link
EP (1) EP0869802A4 (fr)
JP (1) JP2000502246A (fr)
AU (1) AU728798B2 (fr)
CA (1) CA2238404A1 (fr)
WO (1) WO1997018822A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE442373T1 (de) 1995-06-28 2009-09-15 Imp Cancer Res Tech Nukleotid- und proteinsequenzen von delta-genen von vertebraten und darauf basierende methoden
US5780300A (en) * 1995-09-29 1998-07-14 Yale University Manipulation of non-terminally differentiated cells using the notch pathway
US6692919B1 (en) 1997-07-23 2004-02-17 Yale University Activated forms of notch and methods based thereon
US6436650B1 (en) 1997-07-23 2002-08-20 Yale University Activated forms of notch and methods based thereon
EP1108018A1 (fr) * 1998-08-31 2001-06-20 AstraZeneca AB Gene zdx humain analogue au deltex
GB9824045D0 (en) * 1998-11-03 1998-12-30 European Molecular Biology Lab Embl Regulator protein
GB9912132D0 (en) * 1999-05-26 1999-07-28 Univ Manchester Notch regulator-related gene and uses thereof
GB0019242D0 (en) * 2000-08-04 2000-09-27 Lorantis Ltd Assay

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL101728A (en) * 1991-05-03 2007-08-19 Univ Yale Human Abandonment and Delta, Restrictive Areas of Effect in Tophoric Proteins, and Methods Based on Them
US5750652A (en) * 1994-01-21 1998-05-12 Yale University Deltex proteins

Also Published As

Publication number Publication date
AU728798B2 (en) 2001-01-18
EP0869802A4 (fr) 2001-11-14
AU1161497A (en) 1997-06-11
EP0869802A1 (fr) 1998-10-14
JP2000502246A (ja) 2000-02-29
WO1997018822A1 (fr) 1997-05-29

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued
FZDE Discontinued

Effective date: 20051122