CA2234058A1 - Derives isoquinoleine et collections combinatoires d'isoquinoleines - Google Patents

Derives isoquinoleine et collections combinatoires d'isoquinoleines Download PDF

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Publication number
CA2234058A1
CA2234058A1 CA002234058A CA2234058A CA2234058A1 CA 2234058 A1 CA2234058 A1 CA 2234058A1 CA 002234058 A CA002234058 A CA 002234058A CA 2234058 A CA2234058 A CA 2234058A CA 2234058 A1 CA2234058 A1 CA 2234058A1
Authority
CA
Canada
Prior art keywords
amino
phenyl
substituted
resin
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002234058A
Other languages
English (en)
Inventor
John S. Kiely
Michael Curt Griffith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Trega Biosciences Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2234058A1 publication Critical patent/CA2234058A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Structural Engineering (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'invention concerne la synthèse de composés hétérocycliques à base du noyau isoquinoléine. Plus particulièrement, l'invention concerne de nouvelles isoquinoléines ainsi que de nouvelles collections comprenant de nombreux composés de ce type, ainsi que des procédés pour constituer ces collections.
CA002234058A 1995-10-19 1996-10-18 Derives isoquinoleine et collections combinatoires d'isoquinoleines Abandoned CA2234058A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54549395A 1995-10-19 1995-10-19
US08/545,493 1995-10-19

Publications (1)

Publication Number Publication Date
CA2234058A1 true CA2234058A1 (fr) 1997-05-09

Family

ID=24176470

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002234058A Abandoned CA2234058A1 (fr) 1995-10-19 1996-10-18 Derives isoquinoleine et collections combinatoires d'isoquinoleines

Country Status (6)

Country Link
EP (1) EP0863877A4 (fr)
JP (1) JPH11514645A (fr)
KR (1) KR19990064338A (fr)
CN (1) CN1202888A (fr)
CA (1) CA2234058A1 (fr)
WO (1) WO1997016428A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1076649A4 (fr) * 1998-04-28 2010-06-02 Trega Biosciences Inc Composes a base d'isoquinoline tenant lieu de ligands de recepteurs de melanocortine et procedes d'utilisation
WO2000050406A1 (fr) * 1999-02-22 2000-08-31 Lion Bioscience Ag Derives d'isoquinoleines et banques combinatoires d'isoquinoleines
US6417195B1 (en) 1999-02-22 2002-07-09 Lion Bioscience Ag Isoquinoline derivatives and isoquinoline combinatorial libraries
AU2003249713A1 (en) * 2002-07-03 2004-01-23 Axys Pharmaceuticals, Inc. 3,4-dihydroisoquinolin-1-one derivatives as inducers of apoptosis
GB0820856D0 (en) * 2008-11-14 2008-12-24 Univ Leuven Kath Novel inhibitors of flavivirus replication
CN115197137B (zh) * 2022-07-07 2024-04-02 中国科学院成都生物研究所 异喹啉酮类化合物及其合成方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0590455T3 (da) * 1992-09-28 2001-01-22 Hoechst Ag Antiarrytmiske og cardioprotektive substiuerede 1(2H)-isoquinoliner, fremgangsmåde til deres fremstilling, lægemiddel indeh

Also Published As

Publication number Publication date
WO1997016428A1 (fr) 1997-05-09
CN1202888A (zh) 1998-12-23
AU705066B2 (en) 1999-05-13
KR19990064338A (ko) 1999-07-26
EP0863877A1 (fr) 1998-09-16
AU7457196A (en) 1997-05-22
EP0863877A4 (fr) 1999-07-21
JPH11514645A (ja) 1999-12-14

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Dead