CA2229718A1 - Process for the preparation of imidazolyl macrolide immunosuppressants - Google Patents

Process for the preparation of imidazolyl macrolide immunosuppressants Download PDF

Info

Publication number
CA2229718A1
CA2229718A1 CA002229718A CA2229718A CA2229718A1 CA 2229718 A1 CA2229718 A1 CA 2229718A1 CA 002229718 A CA002229718 A CA 002229718A CA 2229718 A CA2229718 A CA 2229718A CA 2229718 A1 CA2229718 A1 CA 2229718A1
Authority
CA
Canada
Prior art keywords
acid
formula
compound
acetonitrile
ethyl acetate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002229718A
Other languages
English (en)
French (fr)
Inventor
David J. Mathre
Richard F. Shuman
Paul Sohar
Zhiguo Song
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9603378.2A external-priority patent/GB9603378D0/en
Application filed by Individual filed Critical Individual
Publication of CA2229718A1 publication Critical patent/CA2229718A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Transplantation (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CA002229718A 1995-08-24 1996-08-20 Process for the preparation of imidazolyl macrolide immunosuppressants Abandoned CA2229718A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US272695P 1995-08-24 1995-08-24
US60/002,726 1995-08-24
GBGB9603378.2A GB9603378D0 (en) 1996-02-16 1996-02-16 Process for the preparation of imidazolyl macrolide immunosuppressants
GB9603378.2 1996-02-16
PCT/US1996/013609 WO1997008182A1 (en) 1995-08-24 1996-08-20 Process for the preparation of imidazolyl macrolide immunosuppressants

Publications (1)

Publication Number Publication Date
CA2229718A1 true CA2229718A1 (en) 1997-03-06

Family

ID=26308747

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002229718A Abandoned CA2229718A1 (en) 1995-08-24 1996-08-20 Process for the preparation of imidazolyl macrolide immunosuppressants

Country Status (6)

Country Link
EP (1) EP0848717A1 (ja)
JP (1) JPH11512096A (ja)
AU (1) AU6900596A (ja)
CA (1) CA2229718A1 (ja)
WO (1) WO1997008182A1 (ja)
YU (1) YU47796A (ja)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9713730D0 (en) 1997-06-30 1997-09-03 Ciba Geigy Ag Organic compounds
ATE464900T1 (de) 1998-03-26 2010-05-15 Astellas Pharma Inc Retardpräparat mit makroliden wie tacrolimus
RU2236413C2 (ru) * 1998-07-14 2004-09-20 Байер Акциенгезельшафт Производные артемизинина, способ их получения, фармацевтическая композиция на их основе и способ лечения
GB9826656D0 (en) 1998-12-03 1999-01-27 Novartis Ag Organic compounds
WO2004009056A1 (en) 2002-07-23 2004-01-29 Novartis Ag Ophtalmic ointment composition comprising a drug, an ointment base and a solubiling/dispersing agent
WO2006115509A2 (en) 2004-06-24 2006-11-02 Novartis Vaccines And Diagnostics Inc. Small molecule immunopotentiators and assays for their detection
CA2732984A1 (en) 2008-08-07 2010-02-11 Kyorin Pharmaceutical Co., Ltd. Process for production of bicyclo[2.2.2]octylamine derivative
CA2737296A1 (en) * 2008-09-16 2010-03-25 Kyorin Pharmaceutical Co., Ltd. Method for purifying aminoacetylpyrrolidinecarbonitrile derivative and salt thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5247076A (en) * 1991-09-09 1993-09-21 Merck & Co., Inc. Imidazolidyl macrolides having immunosuppressive activity
US5252732A (en) * 1991-09-09 1993-10-12 Merck & Co., Inc. D-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynylheteroarylmacrolides having immunosuppressive activity

Also Published As

Publication number Publication date
WO1997008182A1 (en) 1997-03-06
EP0848717A1 (en) 1998-06-24
YU47796A (sh) 1999-07-28
JPH11512096A (ja) 1999-10-19
AU6900596A (en) 1997-03-19

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Legal Events

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FZDE Dead