CA2229718A1 - Procede de preparation d'immunosuppresseurs macrolides a base d'imidazolyle - Google Patents

Procede de preparation d'immunosuppresseurs macrolides a base d'imidazolyle Download PDF

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Publication number
CA2229718A1
CA2229718A1 CA002229718A CA2229718A CA2229718A1 CA 2229718 A1 CA2229718 A1 CA 2229718A1 CA 002229718 A CA002229718 A CA 002229718A CA 2229718 A CA2229718 A CA 2229718A CA 2229718 A1 CA2229718 A1 CA 2229718A1
Authority
CA
Canada
Prior art keywords
acid
formula
compound
acetonitrile
ethyl acetate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002229718A
Other languages
English (en)
Inventor
David J. Mathre
Richard F. Shuman
Paul Sohar
Zhiguo Song
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9603378.2A external-priority patent/GB9603378D0/en
Application filed by Individual filed Critical Individual
Publication of CA2229718A1 publication Critical patent/CA2229718A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Transplantation (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

L'invention se rapporte à un procédé de préparation d'immunosuppresseurs tricyclo-macrolides à base d'imidazolméthyloxy substitué qui consiste à faire réagir un tricyclo-macrolide avec un trichloroacétimidate d'imidazolméthyle trichloroacétimidate en présence d'un acide. L'invention se rapporte également à un sel cristallin de tricyclo-macrolide imidazolméthyloxy substitué ainsi qu'à de nouveaux composés utiles au procédé de la présente invention.
CA002229718A 1995-08-24 1996-08-20 Procede de preparation d'immunosuppresseurs macrolides a base d'imidazolyle Abandoned CA2229718A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US272695P 1995-08-24 1995-08-24
US60/002,726 1995-08-24
GB9603378.2 1996-02-16
GBGB9603378.2A GB9603378D0 (en) 1996-02-16 1996-02-16 Process for the preparation of imidazolyl macrolide immunosuppressants
PCT/US1996/013609 WO1997008182A1 (fr) 1995-08-24 1996-08-20 Procede de preparation d'immunosuppresseurs macrolides a base d'imidazolyle

Publications (1)

Publication Number Publication Date
CA2229718A1 true CA2229718A1 (fr) 1997-03-06

Family

ID=26308747

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002229718A Abandoned CA2229718A1 (fr) 1995-08-24 1996-08-20 Procede de preparation d'immunosuppresseurs macrolides a base d'imidazolyle

Country Status (6)

Country Link
EP (1) EP0848717A1 (fr)
JP (1) JPH11512096A (fr)
AU (1) AU6900596A (fr)
CA (1) CA2229718A1 (fr)
WO (1) WO1997008182A1 (fr)
YU (1) YU47796A (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9713730D0 (en) 1997-06-30 1997-09-03 Ciba Geigy Ag Organic compounds
ES2367294T3 (es) 1998-03-26 2011-11-02 Astellas Pharma Inc. Preparación de liberación sostenida de un compuesto macrólido como tacrolimus.
EP1655302A3 (fr) * 1998-07-14 2006-08-23 Bayer HealthCare AG Derives d'artemisinine antiparasitaires (endoperoxydes)
GB9826656D0 (en) 1998-12-03 1999-01-27 Novartis Ag Organic compounds
EP1531793A1 (fr) 2002-07-23 2005-05-25 Novartis AG Composition d'onguent ophtalmique comprenant un medicament, une base d'onguent et un agent de solubilisation/dispersion
EP2583678A3 (fr) 2004-06-24 2013-11-13 Novartis Vaccines and Diagnostics, Inc. Immunopotentiateurs de petites molécules et dosages pour leur détection
EP2322499A4 (fr) 2008-08-07 2011-12-21 Kyorin Seiyaku Kk Procédé de fabrication d'un dérivé de bicycloý2.2.2¨octylamine
JPWO2010032723A1 (ja) * 2008-09-16 2012-02-09 杏林製薬株式会社 アミノアセチルピロリジンカルボニトリル誘導体の精製方法およびその塩

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5252732A (en) * 1991-09-09 1993-10-12 Merck & Co., Inc. D-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynylheteroarylmacrolides having immunosuppressive activity
US5247076A (en) * 1991-09-09 1993-09-21 Merck & Co., Inc. Imidazolidyl macrolides having immunosuppressive activity

Also Published As

Publication number Publication date
AU6900596A (en) 1997-03-19
JPH11512096A (ja) 1999-10-19
EP0848717A1 (fr) 1998-06-24
YU47796A (sh) 1999-07-28
WO1997008182A1 (fr) 1997-03-06

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Legal Events

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FZDE Dead