CA2229595A1 - Method for treatment of cancer and infectious diseases and compositions useful in same - Google Patents
Method for treatment of cancer and infectious diseases and compositions useful in same Download PDFInfo
- Publication number
- CA2229595A1 CA2229595A1 CA002229595A CA2229595A CA2229595A1 CA 2229595 A1 CA2229595 A1 CA 2229595A1 CA 002229595 A CA002229595 A CA 002229595A CA 2229595 A CA2229595 A CA 2229595A CA 2229595 A1 CA2229595 A1 CA 2229595A1
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- cells
- heat shock
- shock protein
- subject
- antigen
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Classifications
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- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
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- A61K2039/53—DNA (RNA) vaccination
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- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6043—Heat shock proteins
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
- A61K2039/622—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier non-covalent binding
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
- A61K2039/625—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier binding through the biotin-streptavidin system or similar
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/828—Cancer
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
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- Virology (AREA)
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- Biophysics (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
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| US247995P | 1995-08-18 | 1995-08-18 | |
| US249095P | 1995-08-18 | 1995-08-18 | |
| US60/002,490 | 1995-08-18 | ||
| US60/002,479 | 1995-08-18 |
Publications (1)
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| CA2229595A1 true CA2229595A1 (en) | 1997-02-27 |
Family
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| CA002229595A Abandoned CA2229595A1 (en) | 1995-08-18 | 1996-08-16 | Method for treatment of cancer and infectious diseases and compositions useful in same |
| CA002229543A Abandoned CA2229543A1 (en) | 1995-08-18 | 1996-08-16 | Heat shock protein-based vaccines and immunotherapies |
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| CA002229543A Abandoned CA2229543A1 (en) | 1995-08-18 | 1996-08-16 | Heat shock protein-based vaccines and immunotherapies |
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| EP (2) | EP0888053A4 (OSRAM) |
| JP (2) | JP2000508884A (OSRAM) |
| AU (3) | AU712907B2 (OSRAM) |
| CA (2) | CA2229595A1 (OSRAM) |
| HU (1) | HUP9802819A2 (OSRAM) |
| IL (2) | IL123219A0 (OSRAM) |
| WO (3) | WO1997006685A1 (OSRAM) |
Families Citing this family (90)
| Publication number | Priority date | Publication date | Assignee | Title |
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| DK0700445T3 (da) | 1993-06-04 | 2002-05-13 | Whitehead Biomedical Inst | Stressproteiner og anvendelser deraf |
| US5997873A (en) | 1994-01-13 | 1999-12-07 | Mount Sinai School Of Medicine Of The City University Of New York | Method of preparation of heat shock protein 70-peptide complexes |
| US5961979A (en) * | 1994-03-16 | 1999-10-05 | Mount Sinai School Of Medicine Of The City University Of New York | Stress protein-peptide complexes as prophylactic and therapeutic vaccines against intracellular pathogens |
| US6773707B1 (en) | 1995-08-18 | 2004-08-10 | Sloan-Kettering Institute For Cancer Research | Heat shock protein-based vaccines and immunotherapies |
| US6719974B1 (en) | 1995-08-18 | 2004-04-13 | Sloan-Kettering Institute For Cancer Research | Heat shock protein-based vaccines and immunotherapies |
| US6761892B1 (en) | 1995-08-18 | 2004-07-13 | Sloan-Kettering Institute For Cancer Research | Heat shock protein-based vaccines and immunotherapies |
| AU712907B2 (en) | 1995-08-18 | 1999-11-18 | Sloan-Kettering Institute For Cancer Research | Method for treatment of cancer and infectious diseases and compositions useful in same |
| US6331299B1 (en) | 1995-08-18 | 2001-12-18 | Sloan-Kettering Institute For Cancer Research | Method for treatment of cancer and infectious disease and compositions useful in same |
| US5985270A (en) * | 1995-09-13 | 1999-11-16 | Fordham University | Adoptive immunotherapy using macrophages sensitized with heat shock protein-epitope complexes |
| US5837251A (en) * | 1995-09-13 | 1998-11-17 | Fordham University | Compositions and methods using complexes of heat shock proteins and antigenic molecules for the treatment and prevention of neoplastic diseases |
| US5935576A (en) | 1995-09-13 | 1999-08-10 | Fordham University | Compositions and methods for the treatment and prevention of neoplastic diseases using heat shock proteins complexed with exogenous antigens |
| US6130087A (en) * | 1996-10-07 | 2000-10-10 | Fordham University | Methods for generating cytotoxic T cells in vitro |
| AU736318B2 (en) * | 1996-11-26 | 2001-07-26 | Nventa Biopharmaceuticals Corporation | Immune responses using compositions containing stress proteins |
| US7157089B1 (en) | 1996-11-26 | 2007-01-02 | Stressgen Biotechnologies Corporation | Immune responses using compositions containing stress proteins |
| US6017540A (en) | 1997-02-07 | 2000-01-25 | Fordham University | Prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases with heat shock/stress protein-peptide complexes |
| US5830464A (en) | 1997-02-07 | 1998-11-03 | Fordham University | Compositions and methods for the treatment and growth inhibition of cancer using heat shock/stress protein-peptide complexes in combination with adoptive immunotherapy |
| CA2282426A1 (en) * | 1997-02-18 | 1998-08-20 | The Whitehead Institute For Biomedical Research | Use of heat shock proteins to deliver moieties into cells |
| US6709672B2 (en) | 1997-03-05 | 2004-03-23 | Biotech Tools S.A. | Pharmaceutical or food composition for treating pathologies associated with graft rejection or an allergic or autoimmune reaction |
| BE1011033A6 (fr) | 1997-03-05 | 1999-04-06 | Univ Bruxelles | Composition pharmaceutique et/ou alimentaire pour le traitement de pathologies liees a un rejet de greffe, une reaction allergique ou auto-immune ou du cancer. |
| DK1336621T3 (da) * | 1997-08-05 | 2006-07-31 | Stressgen Biotechnologies Corp | Immunsvar mod HPV-antigener fremkaldt af sammensætninger, som omfatter et HPV-antigen og et stressprotein eller en ekspressionsvektor i stand til at eksprimere disse proteiner |
| AU2005201826B2 (en) * | 1997-08-05 | 2008-01-17 | Nventa Biopharmaceuticals Corporation | Immune responses against HPV antigens elicited by compositions comprising an HPV antigen and a stress protein or an expression vector capable of expression of these proteins |
| AU779770B2 (en) * | 1997-08-05 | 2005-02-10 | Nventa Biopharmaceuticals Corporation | Immune responses against HPV antigens elicited by compositions comprising an HPV antigen and a stress protein or an expression vector capable of expression of these proteins |
| ES2191929T3 (es) | 1997-08-05 | 2003-09-16 | Stressgen Biotechnologies Corp | Respuestas inmunologicas contra los antigenos pvh estimuladas por composiciones que comprenden un antigeno pvh y una proteina de estres o un vector de expresion capaz de expresar dichas proteinas. |
| CA2308299A1 (en) * | 1997-10-31 | 1999-05-14 | Sloan-Kettering Institute For Cancer Research | Conjugate heat shock protein-binding peptides |
| WO1999023252A1 (en) * | 1997-11-05 | 1999-05-14 | Isis Innovation Limited | Cancer gene |
| US5948646A (en) | 1997-12-11 | 1999-09-07 | Fordham University | Methods for preparation of vaccines against cancer comprising heat shock protein-peptide complexes |
| ES2285832T3 (es) * | 1998-02-20 | 2007-11-16 | Univ Miami | Complejo de peptido antigenico-proteina de choque termico modificada. |
| AU5204199A (en) * | 1998-06-12 | 1999-12-30 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Compositions and methods for modulating proteolytic degradation of intracellulartargets |
| US6160088A (en) * | 1998-07-29 | 2000-12-12 | Sloan-Kettering Institute For Cancer | KDEL receptor inhibitors |
| US6451316B1 (en) | 1998-10-05 | 2002-09-17 | University Of Conneticut Health Center | Methods for generating antigen-reactive T cells in vitro |
| US6497880B1 (en) | 1998-12-08 | 2002-12-24 | Stressgen Biotechnologies Corporation | Heat shock genes and proteins from Neisseria meningitidis, Candida glabrata and Aspergillus fumigatus |
| EP1196772A2 (en) | 1999-07-08 | 2002-04-17 | Stressgen Biotechnologies Corporation | Induction of a th1-like response in vitro |
| AUPQ233799A0 (en) | 1999-08-19 | 1999-09-09 | Minister For Agriculture, Minister For Land And Water Conservation For And On Behalf Of The State Of New South Wales | Recombinant sub-unit vaccine |
| GB9919733D0 (en) * | 1999-08-19 | 1999-10-20 | Colaco Camilo | Vaccines against intracellular pathogens |
| AU7743100A (en) | 1999-09-30 | 2001-04-30 | Corixa Corporation | Stress protein compositions and methods for prevention and treatment of cancer and infectious disease |
| US7378096B2 (en) | 1999-09-30 | 2008-05-27 | Health Research, Inc. | Stress protein compositions and methods for prevention and treatment of cancer and infectious disease |
| US8128922B2 (en) | 1999-10-20 | 2012-03-06 | Johns Hopkins University | Superior molecular vaccine linking the translocation domain of a bacterial toxin to an antigen |
| US7030228B1 (en) | 1999-11-15 | 2006-04-18 | Miltenyi Biotec Gmbh | Antigen-binding fragments specific for dendritic cells, compositions and methods of use thereof antigens recognized thereby and cells obtained thereby |
| GB9930443D0 (en) * | 1999-12-22 | 2000-02-16 | King S College London | Novel use of heat shock proteins |
| DE60042704D1 (de) | 2000-01-14 | 2009-09-17 | Whitehead Biomedical Inst | Induktion zytotoxischer lymphozyten durch hitzeschockprotein-fusionsproteine hängt von der atp-bindungsdomäne in hsp ab und is cd4+ unabhängig |
| DE60130877T2 (de) * | 2000-04-14 | 2008-07-17 | Intercell Ag | Modifizierte peptide enthaltende pharmazeutische präparationen |
| WO2001078655A2 (en) * | 2000-04-17 | 2001-10-25 | Alan Houghton | Methods and compositions for heat shock protein mediated immunotherapy of melanoma |
| EP1286693A4 (en) | 2000-06-02 | 2005-07-13 | Univ Connecticut Health Ct | COMPLEXES OF ALPHA (2) MACROGLOBULIN AND ANTIGENIC MOLECULES FOR USE IN IMMUNOTHERAPY |
| BR0111956A (pt) | 2000-06-26 | 2003-05-13 | Stressgen Biotechnologies Corp | Tratamento do vìrus do papiloma humano |
| DK1363938T3 (en) | 2000-08-03 | 2014-03-24 | Univ Johns Hopkins | Molecular vaccine that connects an endoplasmic reticulum-chaperonepolypeptid with an antigen |
| NZ521694A (en) | 2002-09-30 | 2005-05-27 | Co2 Pac Ltd | Container structure for removal of vacuum pressure |
| US7132109B1 (en) | 2000-10-20 | 2006-11-07 | University Of Connecticut Health Center | Using heat shock proteins to increase immune response |
| BR0206995A (pt) | 2001-02-05 | 2005-08-16 | Stressgen Biotechnologies Corp | Tratamento do vìrus da hepatite b |
| GB0106161D0 (en) * | 2001-03-13 | 2001-05-02 | King S College London | Immunomodulators |
| US20040043419A1 (en) * | 2001-04-17 | 2004-03-04 | Rothman James E. | Javelinization of protein antigens to heat shock proteins |
| RU2335295C2 (ru) | 2001-08-20 | 2008-10-10 | Юниверсити Оф Коннектикут Хелт Сентер | Способы получения композиций, включающих хитшоковые белки или альфа-2-макроглобулин, пригодных для лечения злокачественной опухоли и инфекционного заболевания |
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| US6984389B2 (en) | 2002-04-25 | 2006-01-10 | University Of Connecticut Health Center | Using heat shock proteins to improve the therapeutic benefit of a non-vaccine treatment modality |
| JP2006501147A (ja) | 2002-04-25 | 2006-01-12 | ユニバーシティー オブ コネティカット ヘルス センター | 非ワクチン治療法の治療効果を改善するための熱ショックタンパク質の使用 |
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| WO2005065418A2 (en) * | 2003-12-31 | 2005-07-21 | Board Of Regents, The University Of Texas System | Compositions and methods of use of targeting peptides for diagnosis and therapy |
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| US9822154B2 (en) | 2012-12-14 | 2017-11-21 | Virginia Commonwealth University | Immune modulator for immunotherapy and vaccine formulation |
| FR3011850B1 (fr) * | 2013-10-15 | 2018-04-06 | Cfl Biotech | Vaccin therapeutique contre le cancer a base de proteines de stress rendues immunogenes |
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| CA3040123A1 (en) | 2016-10-11 | 2018-04-19 | University Of Miami | Vectors and vaccine cells for immunity against zika virus |
| WO2018187260A1 (en) | 2017-04-04 | 2018-10-11 | Heat Biologics, Inc. | Intratumoral vaccination |
| WO2019210055A2 (en) | 2018-04-26 | 2019-10-31 | Agenus Inc. | Heat shock protein-binding peptide compositions and methods of use thereof |
| US20220218814A1 (en) * | 2019-05-10 | 2022-07-14 | Academia Sinica | A vaccine comprising a nanoparticle encapsulating epitopes and adjuvant for neutralizing virus infection |
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| GB8727030D0 (en) | 1987-11-18 | 1987-12-23 | Imp Cancer Res Tech | Production of monoclonal antibodies |
| US5348945A (en) | 1990-04-06 | 1994-09-20 | Wake Forest University | Method of treatment with hsp70 |
| IL99821A (en) * | 1991-10-22 | 1996-07-23 | Yeda Res & Dev | Antitumor vaccines comprising cells transfected with a gene encoding human il-6 |
| IT1262896B (it) * | 1992-03-06 | 1996-07-22 | Composti coniugati formati da proteine heat shock (hsp) e oligo-poli- saccaridi, loro uso per la produzione di vaccini. | |
| GB9223816D0 (en) * | 1992-11-13 | 1993-01-06 | Medical Res Council | Heat shock proteins and the treatment of tumours |
| DK0700445T3 (da) | 1993-06-04 | 2002-05-13 | Whitehead Biomedical Inst | Stressproteiner og anvendelser deraf |
| US5750119A (en) | 1994-01-13 | 1998-05-12 | Mount Sinai School Of Medicine Of The City University Of New York | Immunotherapeutic stress protein-peptide complexes against cancer |
| US5997873A (en) * | 1994-01-13 | 1999-12-07 | Mount Sinai School Of Medicine Of The City University Of New York | Method of preparation of heat shock protein 70-peptide complexes |
| US5961979A (en) | 1994-03-16 | 1999-10-05 | Mount Sinai School Of Medicine Of The City University Of New York | Stress protein-peptide complexes as prophylactic and therapeutic vaccines against intracellular pathogens |
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| US5985270A (en) | 1995-09-13 | 1999-11-16 | Fordham University | Adoptive immunotherapy using macrophages sensitized with heat shock protein-epitope complexes |
| US5935576A (en) | 1995-09-13 | 1999-08-10 | Fordham University | Compositions and methods for the treatment and prevention of neoplastic diseases using heat shock proteins complexed with exogenous antigens |
| US5837251A (en) | 1995-09-13 | 1998-11-17 | Fordham University | Compositions and methods using complexes of heat shock proteins and antigenic molecules for the treatment and prevention of neoplastic diseases |
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| US6017540A (en) | 1997-02-07 | 2000-01-25 | Fordham University | Prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases with heat shock/stress protein-peptide complexes |
| CA2282426A1 (en) | 1997-02-18 | 1998-08-20 | The Whitehead Institute For Biomedical Research | Use of heat shock proteins to deliver moieties into cells |
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| ES2285832T3 (es) | 1998-02-20 | 2007-11-16 | Univ Miami | Complejo de peptido antigenico-proteina de choque termico modificada. |
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- 1996-08-16 CA CA002229595A patent/CA2229595A1/en not_active Abandoned
- 1996-08-16 CA CA002229543A patent/CA2229543A1/en not_active Abandoned
- 1996-08-16 WO PCT/US1996/013363 patent/WO1997006821A1/en not_active Ceased
- 1996-08-16 WO PCT/US1996/013360 patent/WO1997006828A1/en not_active Ceased
-
2000
- 2000-02-23 US US09/511,453 patent/US6605464B1/en not_active Expired - Fee Related
-
2001
- 2001-02-27 US US09/794,517 patent/US6656679B2/en not_active Expired - Fee Related
- 2001-02-27 US US09/794,832 patent/US6673348B2/en not_active Expired - Fee Related
- 2001-02-27 US US09/794,529 patent/US6641812B2/en not_active Expired - Fee Related
- 2001-08-09 US US09/925,803 patent/US20020198166A1/en not_active Abandoned
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2002
- 2002-06-13 US US10/170,713 patent/US20030185842A1/en not_active Abandoned
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2003
- 2003-02-14 US US10/367,668 patent/US20040071725A1/en not_active Abandoned
- 2003-02-14 US US10/367,580 patent/US20040071720A1/en not_active Abandoned
- 2003-02-14 US US10/367,658 patent/US20040071724A1/en not_active Abandoned
- 2003-02-14 US US10/367,593 patent/US20040071721A1/en not_active Abandoned
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| FZDE | Discontinued |