CA2228221C - Papillomavirus polyprotein constructs - Google Patents
Papillomavirus polyprotein constructs Download PDFInfo
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- CA2228221C CA2228221C CA2228221A CA2228221A CA2228221C CA 2228221 C CA2228221 C CA 2228221C CA 2228221 A CA2228221 A CA 2228221A CA 2228221 A CA2228221 A CA 2228221A CA 2228221 C CA2228221 C CA 2228221C
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- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Applications Claiming Priority (3)
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| PCT/AU1996/000473 WO1997005164A1 (en) | 1995-07-27 | 1996-07-26 | Papillomavirus polyprotein constructs |
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| JP (2) | JPH11510688A (enExample) |
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| US7611713B2 (en) * | 1993-03-05 | 2009-11-03 | Pharmexa Inc. | Inducing cellular immune responses to hepatitis B virus using peptide compositions |
| AUPN015794A0 (en) * | 1994-12-20 | 1995-01-19 | Csl Limited | Variants of human papilloma virus antigens |
| US6509149B2 (en) * | 1995-06-06 | 2003-01-21 | Hybridon, Inc. | HPV-specific oligonucleotides |
| US6030771A (en) * | 1997-08-25 | 2000-02-29 | Centers For Disease Control And Prevention | Mosaic protein and restriction endonuclease assisted ligation method for making the same |
| US7964192B1 (en) | 1997-12-02 | 2011-06-21 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidgenic disease |
| US20080050367A1 (en) | 1998-04-07 | 2008-02-28 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
| TWI239847B (en) | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
| DK1108035T3 (da) * | 1998-09-04 | 2007-09-24 | Sanofi Pasteur Ltd | Behandling af cervixcancer |
| US20050100928A1 (en) * | 1999-09-16 | 2005-05-12 | Zycos Inc., A Delaware Corporation | Nucleic acids encoding polyepitope polypeptides |
| US7026443B1 (en) * | 1999-12-10 | 2006-04-11 | Epimmune Inc. | Inducing cellular immune responses to human Papillomavirus using peptide and nucleic acid compositions |
| ATE418997T1 (de) * | 2000-07-06 | 2009-01-15 | Univ Georgetown | Stabile (fixierte) formen von viralen l1 capsidproteinen, deren fusionsproteinen, und deren verwendungen |
| GB0017990D0 (en) * | 2000-07-21 | 2000-09-13 | Glaxo Group Ltd | Papilloma virus sequences |
| US20060177416A1 (en) | 2003-10-14 | 2006-08-10 | Medivas, Llc | Polymer particle delivery compositions and methods of use |
| CN1345775A (zh) | 2000-09-30 | 2002-04-24 | 养生堂有限公司 | 用于预防、诊断及治疗戊型肝炎病毒的多肽,及它们作为诊断试剂和疫苗 |
| AUPR446801A0 (en) | 2001-04-18 | 2001-05-17 | University Of Queensland, The | Novel compositions and uses therefor |
| WO2003068940A2 (en) * | 2002-02-14 | 2003-08-21 | Curagen Corporation | Complexes and methods of using same |
| MY139983A (en) | 2002-03-12 | 2009-11-30 | Janssen Alzheimer Immunotherap | Humanized antibodies that recognize beta amyloid peptide |
| AU2002950183A0 (en) * | 2002-07-12 | 2002-09-12 | The Council Of The Queensland Institute Of Medical Research | Expression of hydrophobic proteins |
| US7223408B2 (en) | 2002-10-03 | 2007-05-29 | Wyeth Holdings Corporation | Human papillomavirus polypeptides and immunogenic compositions |
| GB0222953D0 (en) * | 2002-10-03 | 2002-11-13 | Glaxo Group Ltd | Novel Compounds |
| AU2003284239B2 (en) * | 2002-10-21 | 2008-08-21 | Eisai Inc. | Compositions and methods for treating human papillomavirus-mediated disease |
| WO2004105681A2 (en) * | 2003-04-28 | 2004-12-09 | Innogenetics N.V. | Cd4+ human papillomavirus (hpv) epitopes |
| US20070160622A1 (en) * | 2005-12-07 | 2007-07-12 | Medivas, Llc | Method for assembling a polymer-biologic delivery composition |
| US20080160089A1 (en) * | 2003-10-14 | 2008-07-03 | Medivas, Llc | Vaccine delivery compositions and methods of use |
| WO2005089164A2 (en) * | 2003-12-31 | 2005-09-29 | Pharmexa Inc. | Inducing cellular immune responses to human papillomavirus using peptide and nucleic acid compositions |
| PE20061329A1 (es) | 2004-12-15 | 2006-12-08 | Neuralab Ltd | Anticuerpos ab humanizados para mejorar la cognicion |
| JP5178520B2 (ja) * | 2005-09-22 | 2013-04-10 | メディバス エルエルシー | 固体ポリマー送達組成物およびその使用法 |
| JP5192384B2 (ja) | 2005-09-22 | 2013-05-08 | メディバス エルエルシー | ビス−（α−アミノ）−ジオール−ジエステル含有ポリ（エステルアミド）およびポリ（エステルウレタン）組成物および使用の方法 |
| US8784810B2 (en) | 2006-04-18 | 2014-07-22 | Janssen Alzheimer Immunotherapy | Treatment of amyloidogenic diseases |
| EP2019645A4 (en) * | 2006-05-02 | 2013-03-06 | Medivas Llc | RELEASE OF OPHTHALMOLOGICAL ACTIVITIES OUTSIDE OR WITHIN THE EYE |
| US8101342B2 (en) * | 2006-08-28 | 2012-01-24 | Sungkyunkwan University Foundation For Corporate Collaboration | DNA vaccine for treating or preventing cervical cancer comprising a gene encoding HPV protein |
| US8003097B2 (en) | 2007-04-18 | 2011-08-23 | Janssen Alzheimer Immunotherapy | Treatment of cerebral amyloid angiopathy |
| US20090029937A1 (en) * | 2007-07-24 | 2009-01-29 | Cornell University | Biodegradable cationic polymer gene transfer compositions and methods of use |
| SI2182983T1 (sl) | 2007-07-27 | 2014-09-30 | Janssen Alzheimer Immunotherapy | Zdravljenje amiloidogenih bolezni s humaniziranimi protitelesi proti abeta |
| JO3076B1 (ar) | 2007-10-17 | 2017-03-15 | Janssen Alzheimer Immunotherap | نظم العلاج المناعي المعتمد على حالة apoe |
| CN102186484A (zh) * | 2008-08-13 | 2011-09-14 | 梅迪沃什有限公司 | Aabb-聚(酯肽)可生物降解聚合物及其使用方法 |
| US9067981B1 (en) | 2008-10-30 | 2015-06-30 | Janssen Sciences Ireland Uc | Hybrid amyloid-beta antibodies |
| US8642261B2 (en) * | 2008-10-31 | 2014-02-04 | Trovagene, Inc. | Genetic marker for detection of human papillomavirus |
| CA2653478A1 (en) * | 2009-01-23 | 2010-07-23 | Gregg Martin | Automated wash system for industrial vehicles |
| US9050287B2 (en) * | 2009-01-23 | 2015-06-09 | The Trustees Of The University Of Pennsylvania | Vaccines for human papilloma virus and methods for using the same |
| EP2723801B1 (en) | 2011-06-23 | 2017-01-18 | DSM IP Assets B.V. | New biodegradable polyesteramide copolymers for drug delivery |
| US9873765B2 (en) | 2011-06-23 | 2018-01-23 | Dsm Ip Assets, B.V. | Biodegradable polyesteramide copolymers for drug delivery |
| KR20140076613A (ko) * | 2011-10-12 | 2014-06-20 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 인간 파필로마 바이러스에 대한 백신 및 이것을 사용하는 방법 |
| AU2014248535B2 (en) | 2013-03-12 | 2017-03-30 | Inovio Pharmaceuticals, Inc. | Improved vaccines for human papilloma virus and methods for using the same |
| CN107106509B (zh) | 2014-12-18 | 2021-11-30 | 帝斯曼知识产权资产管理有限公司 | 用于递送酸敏感药物的药物递送系统 |
| US12404306B2 (en) | 2018-03-06 | 2025-09-02 | Precigen, Inc. | Human papillomavirus vaccines and uses of the same |
| CA3160955A1 (en) | 2019-11-12 | 2021-05-20 | Dsm Ip Assets B.V. | Polyesteramide copolymers possessing high glass transition temperatures |
| AU2021385551A1 (en) * | 2020-11-25 | 2023-06-22 | Precigen, Inc. | Human papilloma virus vaccines and uses of the same for hpv associated diseases |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2643817B1 (fr) * | 1989-03-06 | 1993-12-17 | Transgene Sa | Composition pharmaceutique, utile a titre preventif ou curatif contre les tumeurs induites par les papillomavirus |
| PT97073A (pt) * | 1990-03-20 | 1991-10-31 | Behringwerke Ag | Processo para a preparacao de epitopos soro-reactivos de proteinas de papillomavirus 16 humano (hpv) |
| DE4015044A1 (de) * | 1990-05-10 | 1991-11-14 | Behringwerke Ag | Seroreaktive epitope auf proteinen des menschlichen papillomavirus (hpv) 18 |
| WO1992005248A1 (en) * | 1990-09-26 | 1992-04-02 | Bristol-Myers Squibb Company | Human papilloma viral protein expression for use in vaccine compositions |
| KR100252371B1 (ko) * | 1990-12-12 | 2000-05-01 | 포터 더글라스 | 서브유니트 파필로마비루스 백신 및 그들에 사용하기 위한 펩티드 |
| US5464936A (en) * | 1990-12-21 | 1995-11-07 | Cetus Oncology Corporation | Compositions for identification of papillomavirus replication inhibitors |
| GB9105383D0 (en) * | 1991-03-14 | 1991-05-01 | Immunology Ltd | An immunotherapeutic for cervical cancer |
| GB9207701D0 (en) * | 1992-04-08 | 1992-05-27 | Cancer Res Campaign Tech | Papillomavirus e7 protein |
| AU6014094A (en) | 1992-12-02 | 1994-06-22 | Baylor College Of Medicine | Episomal vectors for gene therapy |
| NZ290089A (en) * | 1994-07-27 | 1999-05-28 | Queensland Inst Med Res | Recombinant polyepitope cytotoxic t lymphocyte (ctl) vaccines |
| DE4435907C2 (de) | 1994-10-07 | 1997-07-24 | Lutz Prof Dr Gissmann | Papillomavirusähnliche Partikel und deren Anwendung |
| AUPN015794A0 (en) * | 1994-12-20 | 1995-01-19 | Csl Limited | Variants of human papilloma virus antigens |
| WO1996026277A1 (en) * | 1995-02-24 | 1996-08-29 | Cantab Pharmaceuticals Research Limited | Polypeptides useful as immunotherapeutic agents and methods of polypeptide preparation |
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- 1995-07-27 AU AUPN4439A patent/AUPN443995A0/en not_active Abandoned
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- 1996-07-26 EP EP96924715A patent/EP0840747A4/en not_active Ceased
- 1996-07-26 WO PCT/AU1996/000473 patent/WO1997005164A1/en not_active Ceased
- 1996-07-26 CA CA2228221A patent/CA2228221C/en not_active Expired - Fee Related
- 1996-07-26 US US09/000,094 patent/US6365160B1/en not_active Expired - Lifetime
- 1996-07-26 EP EP07075286A patent/EP1847549A3/en not_active Ceased
- 1996-07-26 JP JP9507011A patent/JPH11510688A/ja not_active Ceased
- 1996-07-26 NZ NZ313108A patent/NZ313108A/xx not_active IP Right Cessation
- 1996-07-26 ZA ZA966381A patent/ZA966381B/xx unknown
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2001
- 2001-12-11 US US10/011,749 patent/US6726912B1/en not_active Expired - Fee Related
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2006
- 2006-10-19 JP JP2006285406A patent/JP2007054074A/ja not_active Withdrawn
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| Publication number | Publication date |
|---|---|
| US6726912B1 (en) | 2004-04-27 |
| EP1847549A3 (en) | 2008-01-16 |
| JPH11510688A (ja) | 1999-09-21 |
| EP0840747A1 (en) | 1998-05-13 |
| NZ313108A (en) | 1999-05-28 |
| ZA966381B (en) | 1997-05-02 |
| EP0840747A4 (en) | 2002-10-23 |
| EP1847549A2 (en) | 2007-10-24 |
| CA2228221A1 (en) | 1997-02-13 |
| WO1997005164A1 (en) | 1997-02-13 |
| AUPN443995A0 (en) | 1995-08-17 |
| US6365160B1 (en) | 2002-04-02 |
| JP2007054074A (ja) | 2007-03-08 |
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